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1. 发明授权

US07659348B2 Crosslinked (meth)acrylamide particles, process for their production and their use 有权
标题翻译：交联的（甲基）丙烯酰胺颗粒，其生产和使用的过程
公开(公告)号：US07659348B2
公开(公告)日：2010-02-09
申请号：US11247157
申请日：2005-10-12
申请人： Kazuaki Muranaka , Maho Yamanaka , Kosuke Araki
发明人： Kazuaki Muranaka , Maho Yamanaka , Kosuke Araki
IPC分类号： C08F20/56 , C08C19/22 , G01N30/02 , B01D15/34
CPC分类号： B01J39/26 , B01J20/261 , B01J20/267 , B01J20/28004 , B01J20/285 , B01J41/20 , B01J43/00 , B01J2220/54 , C08F8/00 , C08F220/58
摘要： Crosslinked (meth)acrylamide particles in the form of substantially spherical fine particles having particle sizes of from 1 to 1000 μm made of a polymer of a N-alkoxymethyl(meth)acrylamide and a polyfunctional unsaturated monomer copolymerizable with the N-alkoxymethyl(meth)acrylamide, wherein the structural units derived from the N-alkoxymethyl(meth)acrylamide are crosslinked by a crosslink having a structure represented by the formula 1 (wherein X is hydrogen or a methyl group, and each of R8 and R9 is another structural unit derived from the N-alkoxymethyl(meth)acrylamide and bonded to the nitrogen atom in another structural unit derived from the N-alkoxymethyl(meth)acrylamide monomer via a methylene group).
摘要翻译：交联的（甲基）丙烯酰胺颗粒，其形式为粒径为1-1000μm的基本上为球形的细颗粒，其由N-烷氧基甲基（甲基）丙烯酰胺和可与N-烷氧基甲基（甲基）丙烯酸烷基酯共聚的多官能不饱和单体制成，丙烯酰胺，其中衍生自N-甲氧基甲基（甲基）丙烯酰胺的结构单元通过具有式1表示的结构的交联（其中X是氢或甲基，并且R 8和R 9各自是衍生自由N-烷氧基甲基（甲基）丙烯酰胺和通过亚甲基与N-烷氧基甲基（甲基）丙烯酰胺单体衍生的另一结构单元中的氮原子结合）。

2. 发明申请

US20080223720A1 MICROCHANNEL STRUCTURE AND FINE-PARTICLE PRODUCTION METHOD USING THE SAME 有权
标题翻译：微通道结构和微粒生产方法
公开(公告)号：US20080223720A1
公开(公告)日：2008-09-18
申请号：US11847788
申请日：2007-08-30
申请人： Maho Yamanaka , Akira Kawai , Koji Katayama , Hiroki Takamiya
发明人： Maho Yamanaka , Akira Kawai , Koji Katayama , Hiroki Takamiya
IPC分类号： G01N27/26
CPC分类号： B01F3/0807 , B01F5/0475 , B01F5/0478 , B01F13/0059 , B01F13/1013 , B01F13/1022 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00889 , B01J2219/00891 , B01J2219/00903 , Y10T137/0396
摘要： A microchannel structure including a dispersed-phase introduction channel which communicates with a dispersed-phase introduction inlet; a continuous-phase introduction channel which communicates with a continuous-phase introduction inlet; a discharge channel which communicates with a discharge outlet; a fine-particle formation channel; and a plurality of branch channels for dispersed-phase introduction which are microchannels; wherein one end of the fine-particle formation channel in a fluid traveling direction communicates with the continuous-phase introduction channel whereas the other end thereof communicates with the discharge channel; and wherein a side part of the dispersed-phase introduction channel and side part of the fine-particle formation channel communicate via the plurality of branch channel for dispersed-phase introduction.
摘要翻译：一种微通道结构，包括与分散相引入口连通的分散相导入通道; 与连续相导入口连通的连续相导入流路; 排出通道，其与排出口连通; 细颗粒形成通道; 以及用于分散相导入的多个分支通道，它们是微通道; 其特征在于，所述细粒形成流路的流体行进方向的一端与所述连续相导入流路连通，而所述微粒形成流路的另一端与所述排出流路连通。并且其中分散相导入通道的侧部和细颗粒形成通道的侧部通过多个用于分散相引入的分支通道连通。

3. 发明申请

US20110033910A1 CELL SELECTION APPARATUS, AND CELL SELECTION METHOD USING THE SAME 审中-公开
标题翻译：细胞选择装置和使用该细胞选择装置的细胞选择方法
公开(公告)号：US20110033910A1
公开(公告)日：2011-02-10
申请号：US12937603
申请日：2009-04-15
申请人： Maho Yamanaka , Takahiro Maruyama , Toru Futami
发明人： Maho Yamanaka , Takahiro Maruyama , Toru Futami
IPC分类号： C12N13/00 , C12M1/42
CPC分类号： G01N33/5438 , G01N33/569
摘要： The cell selection apparatus includes: a cell selection vessel which has a pair of electrodes and a sheet-like insulating material having a plurality of micropores, with a recognition molecule bindable to the specific substance being disposed on a bottom face of the micropore; and a power supply, wherein the power supply includes a cell-immobilization power supply and a cell-taking power supply. The cell selection method uses the cell selection apparatus, including; introducing cells into a cell selection area; immobilizing these cells in the micropores; effecting a binding reaction between the specific substance and the recognition molecule; thereafter, taking out a cell of which the specific substance is not or is weakly bound to the recognition molecule, from the micropore; otherwise alternatively, leaving a cell of which the specific substance on the surface of the cell is strongly bound to the recognition molecule, behind in the micropore.
摘要翻译：细胞选择装置包括：具有一对电极的细胞选择容器和具有多个微孔的片状绝缘材料，具有与所述特定物质结合的识别分子设置在所述微孔的底面上; 以及电源，其中所述电源包括电池固定电源和单电池电源。小区选择方法使用小区选择装置，包括：将细胞引入细胞选择区域; 将这些细胞固定在微孔中; 实现特定物质与识别分子之间的结合反应; 此后从微孔中取出特定物质不与识别分子结合的细胞; 或者，留下细胞表面上的特定物质的细胞与识别分子强烈结合在微孔后面。

4. 发明授权

US08524173B2 Microchannel structure and fine-particle production method using the same 有权
标题翻译：微通道结构和微粒生产方法使用相同
公开(公告)号：US08524173B2
公开(公告)日：2013-09-03
申请号：US11847788
申请日：2007-08-30
申请人： Maho Yamanaka , Akira Kawai , Koji Katayama , Hiroki Takamiya
发明人： Maho Yamanaka , Akira Kawai , Koji Katayama , Hiroki Takamiya
IPC分类号： B01F3/08
CPC分类号： B01F3/0807 , B01F5/0475 , B01F5/0478 , B01F13/0059 , B01F13/1013 , B01F13/1022 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00889 , B01J2219/00891 , B01J2219/00903 , Y10T137/0396
摘要： A microchannel structure including a dispersed-phase introduction channel which communicates with a dispersed-phase introduction inlet; a continuous-phase introduction channel which communicates with a continuous-phase introduction inlet; a discharge channel which communicates with a discharge outlet; a fine-particle formation channel; and a plurality of branch channels for dispersed-phase introduction which are microchannels; wherein one end of the fine-particle formation channel in a fluid traveling direction communicates with the continuous-phase introduction channel whereas the other end thereof communicates with the discharge channel; and wherein a side part of the dispersed-phase introduction channel and side part of the fine-particle formation channel communicate via the plurality of branch channel for dispersed-phase introduction.
摘要翻译：一种微通道结构，包括与分散相引入口连通的分散相导入通道; 与连续相导入口连通的连续相导入流路; 排出通道，其与排出口连通; 细颗粒形成通道; 以及用于分散相导入的多个分支通道，它们是微通道; 其特征在于，所述细粒形成流路的流体行进方向的一端与所述连续相导入流路连通，而所述微粒形成流路的另一端与所述排出流路连通。并且其中分散相导入通道的侧部和细颗粒形成通道的侧部通过多个用于分散相引入的分支通道连通。

5. 发明申请

US20060084765A1 Crosslinked (meth)acrylamide particles, process for their production and their use 有权
标题翻译：交联的（甲基）丙烯酰胺颗粒，其生产和使用的过程
公开(公告)号：US20060084765A1
公开(公告)日：2006-04-20
申请号：US11247157
申请日：2005-10-12
申请人： Kazuaki Muranaka , Maho Yamanaka , Kosuke Araki
发明人： Kazuaki Muranaka , Maho Yamanaka , Kosuke Araki
IPC分类号： C08F20/56
CPC分类号： B01J39/26 , B01J20/261 , B01J20/267 , B01J20/28004 , B01J20/285 , B01J41/20 , B01J43/00 , B01J2220/54 , C08F8/00 , C08F220/58
摘要： Crosslinked (meth)acrylamide particles in the form of substantially spherical fine particles having particle sizes of from 1 to 1000 μm made of a polymer of a N-alkoxymethyl(meth)acrylamide and a polyfunctional unsaturated monomer copolymerizable with the N-alkoxymethyl(meth)acrylamide, wherein the structural units derived from the N-alkoxymethyl(meth)acrylamide are crosslinked by a crosslink having a structure represented by the formula 1 (wherein X is hydrogen or a methyl group, and each of R8 and R9 is another structural unit derived from the N-alkoxymethyl(meth)acrylamide and bonded to the nitrogen atom in another structural unit derived from the N-alkoxymethyl(meth)acrylamide monomer via a methylene group).
摘要翻译：交联的（甲基）丙烯酰胺颗粒，其形式为粒径为1-1000μm的基本上为球形的细颗粒，其由N-烷氧基甲基（甲基）丙烯酰胺的聚合物和可与N-烷氧基甲基（甲基）丙烯酸烷基酯共聚的多官能不饱和单体制成，丙烯酰胺，其中衍生自N-甲氧基甲基（甲基）丙烯酰胺的结构单元通过具有由式1表示的结构的交联（其中X是氢或甲基，并且R SUB 8 >和R 9是来自N-烷氧基甲基（甲基）丙烯酰胺的另一结构单元，并且通过亚甲基与N-烷氧基甲基（甲基）丙烯酰胺单体衍生的另一结构单元中的氮原子键合）。

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