专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100003283A1 LIPID A DEFICIENT MUTANTS OF NEISSERIA MENINGITIDIS 有权
标题翻译： LIPID一个缺乏突变体的NEISSERIA MENINGITIDIS
公开(公告)号：US20100003283A1
公开(公告)日：2010-01-07
申请号：US12254681
申请日：2008-10-20
申请人： Michael A. Apicella , Deborah Post
发明人： Michael A. Apicella , Deborah Post
IPC分类号： A61K39/095 , C12N1/21 , C07H21/04 , C07K14/22 , C07K16/12 , A61P31/04
CPC分类号： C12N9/1029 , A61K2035/11 , C07K14/22
摘要： The invention provides lipid A deficient mutant Neisseria meningitidis cells, pharmaceutical compositions incorporating such cells, and methods of using such cells.
摘要翻译：本发明提供脂质A缺陷突变体脑膜炎奈瑟氏球菌细胞，并入这种细胞的药物组合物，以及使用这种细胞的方法。

2. 发明授权

US07510717B2 Non-toxic mutants of pathogenic gram-negative bacteria 失效
标题翻译：病原性革兰氏阴性细菌的无毒突变体
公开(公告)号：US07510717B2
公开(公告)日：2009-03-31
申请号：US11330527
申请日：2006-01-12
申请人： Michael A. Apicella , Melvin G. Sunshine , Na-Gyong Lee , Rasappa Arumugham , Bradford W. Gibson
发明人： Michael A. Apicella , Melvin G. Sunshine , Na-Gyong Lee , Rasappa Arumugham , Bradford W. Gibson
IPC分类号： A61K39/385 , A61K39/116 , A61K39/02 , A61K39/102 , A61K39/00 , A01N43/04 , C07H1/00
CPC分类号： A61K39/0275 , A61K39/0283 , A61K39/095 , A61K39/102 , A61K39/104 , A61K39/1045 , A61K39/105 , A61K2039/522 , A61K2039/55577 , A61K2039/70 , C12N9/1025 , C12N15/01 , C12R1/01 , Y02A50/47 , Y02A50/476 , Y02A50/482 , Y10S424/831
摘要： A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional htrB protein, resulting in a mutant that lacks one or more secondary acyl chains contained in the wild type gram-negative bacterial pathogen, and displays substantially reduced toxicity as compared to the wild type strain. Also, the present invention provides methods for using a vaccine formulation containing the htrB mutant, the endotoxin isolated therefrom, or the endotoxin isolated therefrom which is then conjugated to a carrier protein, to immunize an individual against infections caused by gram-negative bacterial pathogens by administering a prophylactically effective amount of the vaccine formulation.
摘要翻译：提供了用于鉴定，分离和产生革兰氏阴性细菌病原体的htrB突变体的方法。所述方法包括使革兰氏阴性细菌病原体的htrB基因突变，使得缺乏功能性htrB蛋白，导致缺少野生型革兰氏阴性细菌病原体中所含的一个或多个二级酰基链的突变体，以及与野生型菌株相比显示显着降低的毒性。此外，本发明提供了使用含有htrB突变体，从其分离的内毒素或从其分离的内毒素的疫苗制剂的方法，然后将其与载体蛋白缀合，以免疫个体免受革兰氏阴性细菌病原体引起的感染，施用预防有效量的疫苗制剂。

3. 发明授权

US07413729B2 Sialic acid permease system 有权
标题翻译：唾液酸通透酶系统
公开(公告)号：US07413729B2
公开(公告)日：2008-08-19
申请号：US11331735
申请日：2006-01-13
申请人： Michael A. Apicella , Anthony Zaleski , Bradford W. Gibson , Simon Allen
发明人： Michael A. Apicella , Anthony Zaleski , Bradford W. Gibson , Simon Allen
IPC分类号： A61K49/00
CPC分类号： C12Q1/25 , C07K14/705 , C12Q1/025 , C12Q1/18 , G01N2800/12
摘要： This invention relates to purified sialic acid permease systems, and inhibitory agents of sialic acid permease systems.
摘要翻译：本发明涉及纯化的唾液酸通透酶系统和唾液酸通透酶系统的抑制剂。

4. 发明授权

US07189554B2 Two-component system that controls bacterial membrane synthesis 有权
标题翻译：控制细菌膜合成的双组分体系
公开(公告)号：US07189554B2
公开(公告)日：2007-03-13
申请号：US10288986
申请日：2002-11-05
申请人： Michael A. Apicella , Andrew Preston
发明人： Michael A. Apicella , Andrew Preston
IPC分类号： C12N1/21
CPC分类号： C12R1/36 , C07K14/22 , G01N33/56911 , G01N33/571 , G01N2333/22 , Y10S435/871
摘要： The present invention discloses a mutant Neisseria having extensive membrane blebbing, both an indicium and a cause of virulence in the gonococcus and meningococcus. Methods are disclosed for making and characterizing the mutant, bmrRS. Methods are disclosed for isolating bmrRS membranes for use as a vaccine. Methods are also disclosed for the use of the mutant for determining the virulence of clinical samples of N. gonorrhoeae and N. meningitidis. Methods are also disclosed for the screening of antibiotics targeted to virulent Neisseria.
摘要翻译：本发明公开了具有广泛的膜泡的突变型奈瑟氏球菌，它们是淋球菌和脑膜炎球菌中的毒性和毒力原因。公开了制备和表征突变体bmrRS的方法。公开了用于分离用作疫苗的bmrRS膜的方法。还公开了使用该突变体测定淋病奈瑟氏球菌和脑膜炎奈瑟氏球菌的临床样品的毒力的方法。还公开了筛选针对有毒奈瑟氏球菌的抗生素的方法。

5. 发明授权

US4859421A Disposable antigen concentrator and detector 失效
标题翻译：一次性抗原浓缩器和检测器
公开(公告)号：US4859421A
公开(公告)日：1989-08-22
申请号：US65424
申请日：1987-06-23
申请人： Michael A. Apicella
发明人： Michael A. Apicella
IPC分类号： B01L3/00 , G01N33/53 , G01N33/543
CPC分类号： B01L3/505 , G01N33/5304 , G01N33/54366 , Y10S436/808 , Y10S436/809
摘要： The present invention relates to a disposable test kit which contains selected reactants, or reagents, necessary for the rapid concentration and detection of selected antigens from biologic extracts. Typically, and preferably, the time required for concentration and detection is less than one hour. The present kit includes internal false position and false negative controls and suitably has a standard color code to assist in the interpretation of the test results. The present kit is a unitary, compartmented package having a reaction chamber, preferably centrally located thereon, and at least one reagent storage chamber. Each reagent storage chamber is connected to the reaction chamber through a valve means which allows fluid flow from the reagent chamber to the reaction chamber, but inhibits flow from the reaction chamber to the reagent chamber. The top portions of the reagent chambers are fabricated of a flexible, or pliable, material, preferably transparent or semi-transparent. Manual pressure applied to the top portion of a reagent chamber causes the contents of the reagent chamber to be controllably transferred through the valve means to the reaction chamber.
摘要翻译：本发明涉及一次性测试试剂盒，其包含从生物提取物快速浓缩和检测所选抗原所必需的选定反应物或试剂。通常，优选地，浓缩和检测所需的时间小于1小时。本套件包括内部虚假位置和假阴性对照，并且适当地具有标准颜色代码以帮助解释测试结果。本试剂盒是具有反应室的整体隔室包装，优选地位于其上方，以及至少一个试剂储存室。每个试剂储存室通过阀装置连接到反应室，阀装置允许流体从试剂室流向反应室，但是阻止从反应室流向试剂室。试剂室的顶部由柔性或柔韧的材料制成，优选透明或半透明。施加到试剂室顶部的手动压力使试剂室的内容物通过阀装置被可控地转移到反应室。

6. 发明授权

US07297340B2 Vaccine and method for preventing biofilm formation 有权
标题翻译：疫苗和预防生物膜形成的方法
公开(公告)号：US07297340B2
公开(公告)日：2007-11-20
申请号：US10753980
申请日：2004-01-07
申请人： Michael A. Apicella
发明人： Michael A. Apicella
IPC分类号： A61K39/102
CPC分类号： C07K14/285 , A61K39/102
摘要： The present invention is directed to compounds and methods for immunizing a patient against a biofilm-producing bacterial infection and a vaccine related thereto.
摘要翻译：本发明涉及用于免疫患者免受生物膜产生细菌感染的化合物和方法以及与之相关的疫苗。

7. 发明授权

US07261901B2 Vaccine and compositions for the prevention and treatment of neisserial infections 有权
标题翻译：用于预防和治疗neisserial感染的疫苗和组合物
公开(公告)号：US07261901B2
公开(公告)日：2007-08-28
申请号：US10665990
申请日：2003-09-19
申请人： Michael A. Apicella , Jennifer L. Edwards
发明人： Michael A. Apicella , Jennifer L. Edwards
IPC分类号： A61K39/095 , A61K39/02 , C12P21/04 , C07H21/04 , C07K1/00
CPC分类号： C07K16/2845 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/22 , C07K16/1217 , C07K16/40 , C07K2317/77
摘要： The present invention is directed to novel polypeptides, polynucleotides and vaccines for use against Neisseria gonorrhoeae colonization or infection and/or Neisseria meningitidis colonization or infection. The vaccines contain an immunogenic amount of a neisserial protein.
摘要翻译：本发明涉及用于针对淋病奈瑟氏球菌定植或感染和/或脑膜炎奈瑟氏球菌定植或感染的新型多肽，多核苷酸和疫苗。疫苗含有免疫原性量的奈瑟氏球蛋白。

8. 发明授权

US06743607B2 Production of complex carbohydrates 有权
标题翻译：生产复杂的碳水化合物
公开(公告)号：US06743607B2
公开(公告)日：2004-06-01
申请号：US09991374
申请日：2001-11-16
申请人： Michael A. Apicella , Bradford W. Gibson , Nancy J. Phillips
发明人： Michael A. Apicella , Bradford W. Gibson , Nancy J. Phillips
IPC分类号： C12P1904
CPC分类号： C12N9/1051 , C12P19/04 , C12P19/18
摘要： Compositions and methods for making complex carbohydrates in a bacterial production cell are disclosed. The complex carbohydrates that can be made include oligosaccharides and polysaccharides of bacterial or mammalian origin.
摘要翻译：公开了在细菌生产细胞中制备复合碳水化合物的组合物和方法。可以制备的复合碳水化合物包括细菌或哺乳动物来源的寡糖和多糖。

9. 发明授权

US06518037B2 Two-component system that controls bacterial membrane synthesis 有权
标题翻译：控制细菌膜合成的双组分体系
公开(公告)号：US06518037B2
公开(公告)日：2003-02-11
申请号：US09439226
申请日：1999-11-12
申请人： Michael A. Apicella , Andrew Preston
发明人： Michael A. Apicella , Andrew Preston
IPC分类号： C12Q118
CPC分类号： C12R1/36 , C07K14/22 , G01N33/56911 , G01N33/571 , G01N2333/22 , Y10S435/871
摘要： The present invention discloses a mutant Neisseria having extensive membrane blebbing, both an indicium and a cause of virulence in the gonococcus and meningococcus. Methods are disclosed for making and characterizing the mutant, bmrRS. Methods are disclosed for isolating bmrRS membranes for use as a vaccine. Methods are also disclosed for the use of the mutant for determining the virulence of clinical samples of N. gonorrhoeae and N. meningitidis. Methods are also disclosed for the screening of antibiotics targeted to virulent Neisseria.
摘要翻译：本发明公开了具有广泛的膜泡的突变型奈瑟氏球菌，它们是淋球菌和脑膜炎球菌中的毒性和毒力原因。公开了制备和表征突变体bmrRS的方法。公开了用于分离用作疫苗的bmrRS膜的方法。还公开了使用该突变体测定淋病奈瑟氏球菌和脑膜炎奈瑟氏球菌的临床样品的毒力的方法。还公开了筛选针对有毒奈瑟氏球菌的抗生素的方法。

10. 发明授权

US08097260B2 Lipid a deficient mutants of Neisseria meningitidis 有权
标题翻译：脂质脑膜炎奈瑟球菌缺乏突变体
公开(公告)号：US08097260B2
公开(公告)日：2012-01-17
申请号：US12254681
申请日：2008-10-20
申请人： Michael A. Apicella , Deborah Post
发明人： Michael A. Apicella , Deborah Post
IPC分类号： A61K39/095 , A61K39/02 , A61K39/00 , A01N63/00
CPC分类号： C12N9/1029 , A61K2035/11 , C07K14/22
摘要： The invention provides lipid A deficient mutant Neisseria meningitidis cells, pharmaceutical compositions incorporating such cells, and methods of using such cells.
摘要翻译：本发明提供脂质A缺陷突变体脑膜炎奈瑟氏球菌细胞，并入这种细胞的药物组合物，以及使用这种细胞的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式