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1. 发明申请

US20030111600A1 Method of chemical ionization at reduced pressures 有权
标题翻译：降低化学电离的方法
公开(公告)号：US20030111600A1
公开(公告)日：2003-06-19
申请号：US10316933
申请日：2002-12-12
申请人： MDS Inc., doing business as MDS Sciex
发明人： Bruce A. Thomson , Charles L. Jolliffe
IPC分类号： H01J049/10
CPC分类号： H01J49/0463 , H01J49/145
摘要： This invention comprises an apparatus and method for generating sample ions from sample molecules in which a mixture of a sample and a matrix are vaporized by a laser beam and subsequently ionized by reagent corona ions. The decoupling of the vaporization and ionization steps allows each process to be separately optimized. The vaporization and ionization steps can be done in a sub-atmospheric pressure region. Alternatively, the vaporization and ionization steps can be done in a higher pressure region. In addition, the reagent corona ions can be generated in a vacuum chamber or a chamber at atmospheric pressure. Alternatively, the reagent ions can be generated in a sub-atmospheric region while the laser desorption occurs in an atmospheric region.
摘要翻译：本发明包括用于从样品分子产生样品离子的装置和方法，其中样品和基质的混合物被激光束蒸发并随后被试剂电晕离子电离。蒸发和离子化步骤的去耦允许每个过程分别优化。蒸发和电离步骤可以在低于大气压的区域进行。或者，蒸发和电离步骤可以在更高的压力区域中进行。此外，试剂电晕离子可以在真空室或大气压下的室中产生。或者，试剂离子可以在亚大气压区域中产生，而激光解吸发生在大气区域。

2. 发明申请

US20030122071A1 Use of notched broadband waveforms in a linear ion trap 有权
标题翻译：在线性离子阱中使用缺口宽带波形
公开(公告)号：US20030122071A1
公开(公告)日：2003-07-03
申请号：US10322464
申请日：2002-12-19
申请人： MDS INC. doing business as MDS SCIEX
发明人： Jeffry B. Plomley , Frank A. Londry
IPC分类号： H01J049/42 , H01J049/40
CPC分类号： H01J49/005 , H01J49/004 , H01J49/4225 , H01J49/428
摘要： A method and apparatus for the analysis of a narrow range of fragment ions by application of a notched broadband waveform during ion accumulation within a quadrupole collision cell operated as a linear ion trap. The fragment ions are formed via the axial acceleration and collision activated dissociation of mass resolved precursor ions. A narrow band of frequencies is purposefully omitted from the spectrum, so that the secular frequency of a particular fragment ion will fall within this notch of absent frequencies and as a result will not experience resonant excitation and are retained in the linear ion trap. Simultaneously, all other ions are lost either through neutralization when they strike electrodes or through (additional) collision activated dissociation. Accordingly, a particular mass or range of masses, whose secular frequencies fall within the notch of absent frequencies in the notched broadband waveform, may be selectively accumulated during the collision activated dissociation event.
摘要翻译：一种用于通过在作为线性离子阱操作的四极碰撞池中的离子累积期间施加缺口宽带波形来分析窄范围的碎片离子的方法和装置。碎片离子通过质量分辨前体离子的轴向加速度和碰撞激活解离形成。从频谱中有目的地省略了一个窄带频率，使得特定片段离子的长期频率将落在缺失频率的该陷波范围内，结果将不会经历共振激发并保留在线性离子阱中。同时，当所有其他离子发射电极或通过（附加）碰撞激活解离时，通过中和而丢失。因此，可以在碰撞激活的解离事件期间选择性地累积特定的质量或质量范围，其质量或范围的长期频率落在缺口宽带波形中的缺失频率的陷波中。

3. 发明申请

US20030042415A1 Method of reducing space charge in a linear ion trap mass spectrometer 有权
公开(公告)号：US20030042415A1
公开(公告)日：2003-03-06
申请号：US10232588
申请日：2002-08-30
申请人： MDS Inc., doing business as MDS Sciex
发明人： James W. Hager
IPC分类号： H01J049/42
CPC分类号： H01J49/4265 , H01J49/4225 , Y10S430/143
摘要： A method of setting a fill time for a mass spectrometer including a linear ion is provided. The mass spectrometer is operated first in a transmission mode and ions are supplied to the mass spectrometer. Ions are detected as they pass through at least part of the mass spectrometer in a preset time period, to determine the ion current. From a desired maximum charge density for the ion trap and the ion current, a fill time for the ion trap is determined. The mass spectrometer is operated in a trapping mode to trap ions in the ion trap, and the ion trap is filled for the fill time, as just determined. This utilizes the ion trap to its maximum, while avoiding problems due to overfilling the trap, causing space charge effects.

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