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1. 发明授权

US08802088B2 Mixture of peptide-bound tryptophan and polypeptide-bound tryptophan 有权
标题翻译：肽结合的色氨酸和多肽结合的色氨酸的混合物
公开(公告)号：US08802088B2
公开(公告)日：2014-08-12
申请号：US12989869
申请日：2009-04-27
申请人： Cinderalla C. Gerhardt , Luppo Edens
发明人： Cinderalla C. Gerhardt , Luppo Edens
IPC分类号： A61K38/48 , C12Q1/34 , C12Q1/37 , A61K38/01 , A61K38/05 , A61K38/06 , A61K38/00 , C07K14/00 , C07K16/02 , A61K47/34 , C12Q1/06 , G01N33/68 , A61K38/47 , A61K38/02 , A61P25/00
CPC分类号： A61K38/47 , A23J3/341 , A23L33/18 , A61K31/405 , C12P21/06 , C12Y302/01017
摘要： The present invention relates to a composition which comprises tryptophan whereby 10 to 90%, preferably 20 to 80% of the tryptophan is present as free tryptophan or peptide-bound tryptophan and 10 to 90%, preferably 20 to 80% of the tryptophan is present as polypeptide-bound tryptophan.
摘要翻译：本发明涉及一种组合物，其包含色氨酸，由此存在色氨酸的10至90％，优选20至80％的游离色氨酸或肽结合的色氨酸，并且存在10至90％，优选20至80％的色氨酸存在作为多肽结合的色氨酸。

2. 发明申请

US20080113896A1 Blood Pressure Lowering Peptides in a Single Enzymatic Step 有权
标题翻译：血压降低单个酶步骤中的肽
公开(公告)号：US20080113896A1
公开(公告)日：2008-05-15
申请号：US11793390
申请日：2005-12-21
申请人： Luppo Edens , Andre de Roos , Olaf Leonardus Schouten , Philippus Antonius Deen
发明人： Luppo Edens , Andre de Roos , Olaf Leonardus Schouten , Philippus Antonius Deen
IPC分类号： A61K38/02 , A61P9/12 , C12P21/06
CPC分类号： C12P21/06 , A23J3/344 , A23L33/11 , A23L33/18 , A23L33/19 , A23V2002/00 , A61K38/00 , A23V2200/3262 , A23V2200/332 , A23V2200/326 , A23V2250/54246 , A23V2250/2136 , A23V2250/7052 , A23V2250/706 , A23V2250/7056
摘要： A process to produce IPP and VPP from a protein source that comprises the -I-P-P- and -V-P-P- sequence in its protein sequence and whereby at least 40% of -I-P-P- sequence present in the protein source is converted into the peptide IPP and at least 40% of the -V-P-P- sequence present in the protein source is converted into the peptide VPP, which comprises the use of a proline specific endoprotease and an amino-peptidase preferably in a single enzymatic step.
摘要翻译：从其蛋白质序列中包含-IPP-和-VPP-序列的蛋白质源产生IPP和VPP的过程，并且其中存在于蛋白质源中的-IPP-序列的至少40％被转化为肽IPP，并且在存在于蛋白质源中的-VPP序列的至少40％被转化为肽VPP，其包括优选在单个酶促步骤中使用脯氨酸特异性内切蛋白酶和氨基肽酶。

3. 发明授权

US07323327B2 Genes encoding novel proteolytic enzymes 失效
标题翻译：编码新型蛋白水解酶的基因
公开(公告)号：US07323327B2
公开(公告)日：2008-01-29
申请号：US10469204
申请日：2002-02-22
申请人： Luppo Edens , Albertus Van Dijk , Philipp Krubasik , Kaj Albermann , Alexander Stock , Erik Kimpel , Sabine Klugbauer , Christian Wagner , Andreas Fritz , Wilk Von Gustedt , Oliver Heinrich , Dieter Maier , Fabio Spreafico , Ulrike Folkers , Sylvia Hopper , Wolfram Kemmner , Pamela Tan , Josephine Stiebler , Richard Albang
发明人： Luppo Edens , Albertus Van Dijk , Philipp Krubasik , Kaj Albermann , Alexander Stock , Erik Kimpel , Sabine Klugbauer , Christian Wagner , Andreas Fritz , Wilk Von Gustedt , Oliver Heinrich , Dieter Maier , Fabio Spreafico , Ulrike Folkers , Sylvia Hopper , Wolfram Kemmner , Pamela Tan , Josephine Stiebler , Richard Albang
IPC分类号： C12N9/62 , C12N15/00 , C12N1/00 , C07H21/04
CPC分类号： A23J3/16 , A23J3/343 , A23J3/344 , A23J3/346 , A23L2/02 , A23L2/84 , A23L33/18 , A23L33/40 , C07K2319/00 , C12H1/003 , C12N9/62 , C12Q1/37 , G01N33/56961 , G01N33/573 , G01N2333/38
摘要： The invention relates to newly identified gene sequences that encode novel proteases obtainable from Aspergillus niger. The invention features the full length gene sequence of the novel genes, their cDNA sequences as well as the full-length functional protein and fragments thereof. The invention also relates to methods of using these enzymes in industrial processes and methods of diagnosing fungal infections. Also included in the invention are cells transformed with DNA according to the invention and cells wherein a protease according to the invention is genetically modified to enhance or reduce its activity and/or level of expression.
摘要翻译：本发明涉及新鉴定的编码从黑曲霉获得的新型蛋白酶的基因序列。本发明的特征在于新基因的全长基因序列，其cDNA序列以及全长功能蛋白及其片段。本发明还涉及在工业过程中使用这些酶的方法和诊断真菌感染的方法。本发明还包括用根据本发明的DNA转化的细胞和其中根据本发明的蛋白酶被遗传修饰以增强或降低其活性和/或表达水平的细胞。

4. 发明申请

US20050064403A1 Novel Genes Encoding Novel Proteolytic Enzymes 失效
标题翻译：编码新型蛋白水解酶的新基因
公开(公告)号：US20050064403A1
公开(公告)日：2005-03-24
申请号：US10469204
申请日：2002-02-22
申请人： Luppo Edens , Dijk Alard , Philipp Krubasik , Kaj Albermann , Stock Alexander , Erik Kimpel , Sabine Klugbauer , Christian Wagner , Andreas Fritz , Gustedt Wilk , Oliver Heinrich , Dieter Maier , Fabio Spreafico , Ulrike Folkers , Sylvia Hopper , Wolfram Kemmner , Pamela Tan , Josephine Stiebler , Richard Albang
发明人： Luppo Edens , Dijk Alard , Philipp Krubasik , Kaj Albermann , Stock Alexander , Erik Kimpel , Sabine Klugbauer , Christian Wagner , Andreas Fritz , Gustedt Wilk , Oliver Heinrich , Dieter Maier , Fabio Spreafico , Ulrike Folkers , Sylvia Hopper , Wolfram Kemmner , Pamela Tan , Josephine Stiebler , Richard Albang
IPC分类号： A23J3/16 , A23J3/34 , A23L1/29 , A23L1/305 , A23L2/02 , A23L2/84 , C07K16/40 , C12H1/00 , C12N9/62 , C12N15/57 , C12N15/63 , C12Q1/37 , G01N33/569 , G01N33/573 , C12Q1/68 , C07H21/04 , C12N9/64
CPC分类号： A23J3/16 , A23J3/343 , A23J3/344 , A23J3/346 , A23L2/02 , A23L2/84 , A23L33/18 , A23L33/40 , C07K2319/00 , C12H1/003 , C12N9/62 , C12Q1/37 , G01N33/56961 , G01N33/573 , G01N2333/38
摘要： The invention relates to newly identified gene sequences that encode novel proteases obtainable from Aspergillus niger. The invention features the full length gene sequence of the novel genes, their cDNA sequences as well as the full-length functional protein and fragments thereof. The invention also relates to methods of using these enzymes in industrial processes and methods of diagnosing fungal infections. Also included in the invention are cells transformed with DNA according to the invention and cells wherein a protease according to the invention is genetically modified to enhance or reduce its activity and/or level of expression.
摘要翻译：本发明涉及新鉴定的编码从黑曲霉获得的新型蛋白酶的基因序列。本发明的特征在于新基因的全长基因序列，其cDNA序列以及全长功能蛋白及其片段。本发明还涉及在工业过程中使用这些酶的方法和诊断真菌感染的方法。本发明还包括用根据本发明的DNA转化的细胞和其中根据本发明的蛋白酶被遗传修饰以增强或降低其活性和/或表达水平的细胞。

5. 发明授权

US06368595B2 Topical application of enzymes using a peelable film 失效
标题翻译：使用可剥离膜局部应用酶
公开(公告)号：US06368595B2
公开(公告)日：2002-04-09
申请号：US09380805
申请日：1999-10-25
申请人： Luppo Edens , Bertus Noordam
发明人： Luppo Edens , Bertus Noordam
IPC分类号： A61K3846
CPC分类号： A61K8/0208 , A61K8/66 , A61K8/8129 , A61K9/7007 , A61Q7/02 , A61Q19/00 , A61Q19/08 , A61Q19/10
摘要： The present invention discloses a method for topical application of an enzyme, wherein the enzyme becomes incorporated in a peelable film, for instance a polyvinyl alcohol film, after its application. In this way, the release of enzyme-containing dust particles from the site of application is prevented.
摘要翻译：本发明公开了一种局部施用酶的方法，其中在施用之后将酶并入可剥离膜，例如聚乙烯醇膜中。以这种方式，防止了从施用部位释放含酶粉尘颗粒。

6. 发明授权

US4891316A DNA sequences encoding the various allelic forms of mature thaumatin, and cloning vehicles, etc. 失效
标题翻译：编码成熟的马蹄拟糖的各种等位基因形式的DNA序列和克隆载体等
公开(公告)号：US4891316A
公开(公告)日：1990-01-02
申请号：US742139
申请日：1985-06-07
申请人： Cornelis T. Verrips , Adrianus M. Ledeboer , Luppo Edens , Robert Klok , Jan Maat
发明人： Cornelis T. Verrips , Adrianus M. Ledeboer , Luppo Edens , Robert Klok , Jan Maat
IPC分类号： C12N15/09 , C07H21/04 , C07K14/43 , C12N1/20 , C12N1/21 , C12N15/31 , C12N15/66 , C12N15/70 , C12P19/34 , C12P21/00 , C12P21/02 , C12R1/19
CPC分类号： C07K14/43 , C12N15/66 , C12N15/70
摘要： The invention relates to DNA sequences encoding the various allelic forms of mature thaumatin, and cloning vehicles comprising said DNA sequences and their use in transforming microorganisms.
摘要翻译：本发明涉及编码成熟的马蹄拟糖的各种等位基因形式的DNA序列，以及包含所述DNA序列的克隆载体及其在转化微生物中的用途。

7. 发明授权

US08986773B2 Process for the preparation of packaged heat-preserved aqueous drink comprising casein micelles and tryptophan-rich peptides, and product so obtained 有权
标题翻译：用于制备包含酪蛋白胶束和富含色氨酸的肽的包装保温含水饮料的方法，以及如此获得的产品
公开(公告)号：US08986773B2
公开(公告)日：2015-03-24
申请号：US12989876
申请日：2009-04-09
申请人： Rudolf Beckhoven Van , Arjen Bot , Alexander Duchateau , Luppo Edens , Joris Kloek , Andre L Ross De
发明人： Rudolf Beckhoven Van , Arjen Bot , Alexander Duchateau , Luppo Edens , Joris Kloek , Andre L Ross De
IPC分类号： A23J1/00 , A23L1/305 , A23C9/152 , A23C11/08 , A23L2/52 , A23L2/66
CPC分类号： A23L1/3056 , A23C9/1526 , A23C11/08 , A23L2/52 , A23L2/66 , A23L33/18 , A23L33/19 , A23V2002/00 , A23V2250/54246 , A23V2250/065
摘要： A process to prepare packaged pasteurized or sterilized aqueous drinkable products which comprise casein micelles (e.g. from dairy protein) and peptide-fractions, which peptide fractions are rich in tryptophan, and the products so-obtained. The process requires a heat preservation at a specific pH.
摘要翻译：制备包含酪蛋白胶束（例如乳蛋白质）和肽级分的包装的巴氏灭菌或灭菌的含水可饮用产品的方法，该肽部分富含色氨酸，以及如此获得的产物。该方法需要在特定pH下进行保温。

8. 发明申请

US20120107847A1 TESTING EFFICACY FOR CELIAC DISEASE 审中-公开
标题翻译： CELIAC疾病的测试效果
公开(公告)号：US20120107847A1
公开(公告)日：2012-05-03
申请号：US13381865
申请日：2010-06-24
申请人： Maaike Johanna Bruins , Luppo Edens
发明人： Maaike Johanna Bruins , Luppo Edens
IPC分类号： G01N33/566 , G06Q90/00 , G06Q50/22 , C12N9/50
CPC分类号： G01N33/564 , G01N2800/06 , G06Q99/00
摘要： We describe a method to determine effectiveness of a compound or composition in treatment of celiac disease or gluten intolerance, the method comprising: administration of the compound or composition to one or more human patients who were on a gluten-free diet for 10 years or less, preferably 6 years or less; challenge with gluten of the one or more human patients who were administered the compound or composition; and determining whether there is a change in condition of celiac disease or gluten intolerance of the one or more patients that results from administration of the compound or composition and challenge with gluten; whereby no significant change in condition indicates that the compound or composition would be effective in treating celiac disease or gluten intolerance.
摘要翻译：我们描述了一种确定化合物或组合物治疗乳糜泻或麸质不耐症的有效性的方法，该方法包括：将化合物或组合物施用于一个或多个无麸质饮食10年以上的人类患者，优选6年以下; 对施用化合物或组合物的一个或多个人类患者的面筋进行挑战; 以及确定由所述化合物或组合物的施用引起的一种或多种患者的腹腔疾病或麸质不耐受状况是否发生变化，并用面筋进行攻击; 因此条件没有显着变化表明化合物或组合物将有效治疗乳糜泻或麸质不耐受。

9. 发明申请

US20110165287A1 PROCESS FOR THE PREPARATION OF PACKAGED HEAT-PRESERVED AQUEOUS DRINK COMPRISING CASEIN MICELLES AND TRYPTOPHAN-RICH PEPTIDES, AND PRODUCT SO OBTAINED 有权
标题翻译：制备包装加热保存的含有壳聚糖和三木糖的肽的水性饮料的方法和获得的产品
公开(公告)号：US20110165287A1
公开(公告)日：2011-07-07
申请号：US12989876
申请日：2009-04-09
申请人： Rudolf Beckhoven Van , Arjen Bot , Alexander Duchateau , Luppo Edens , Joris Kloek , Andre L. Ross De
发明人： Rudolf Beckhoven Van , Arjen Bot , Alexander Duchateau , Luppo Edens , Joris Kloek , Andre L. Ross De
IPC分类号： A23L3/3571 , B65D85/80 , B65B55/00
CPC分类号： A23L1/3056 , A23C9/1526 , A23C11/08 , A23L2/52 , A23L2/66 , A23L33/18 , A23L33/19 , A23V2002/00 , A23V2250/54246 , A23V2250/065
摘要： A process to prepare packaged pasteurised or sterilised aqueous drinkable products which comprise casein micelles (e.g. from dairy protein) and peptide-fractions, which peptide fractions are rich in tryptophan, and the products so-obtained. The process requires a heat preservation at a specific pH.
摘要翻译：制备包含酪蛋白胶束（例如乳蛋白质）和肽级分的包装的巴氏灭菌或灭菌的含水可饮用产品的方法，该肽部分富含色氨酸，以及如此获得的产物。该方法需要在特定pH下进行保温。

10. 发明申请

US20110086803A1 PEPTIDES CONTAINING TRYPTOPHAN 审中-公开
标题翻译：含有TRYPTOPHAN的肽
公开(公告)号：US20110086803A1
公开(公告)日：2011-04-14
申请号：US12447332
申请日：2007-10-30
申请人： Andre Leonardus De Roos , Luppo Edens , Rudolf Franciscus Van Beckhoven , Alexander Lucia Leonardus Duchateau , Joris Kloek
发明人： Andre Leonardus De Roos , Luppo Edens , Rudolf Franciscus Van Beckhoven , Alexander Lucia Leonardus Duchateau , Joris Kloek
IPC分类号： A61K38/17 , C12P21/06
CPC分类号： A61K38/06 , A23K20/147 , A23L33/18 , A61K38/05 , C12P13/22 , C12P21/06
摘要： The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45.
摘要翻译：本发明涉及一种制备包含水溶性肽并且Trp / LNAA比大于0.15的组合物的方法，其包括水解溶菌酶，优选鸡蛋溶菌酶，以制备DH为5至45的水解产物。

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