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1. 发明申请

US20100239552A1 Combination Therapies for Treating Metabolic Disorders 审中-公开
标题翻译：治疗代谢紊乱的组合疗法
公开(公告)号：US20100239552A1
公开(公告)日：2010-09-23
申请号：US12724756
申请日：2010-03-16
申请人： Eric Mayoux , Luc Marti Clauzel , Silvia Garcia-Vicente , Marta Serrano Munoz , Antonio Zorzano Olarte , Alec Mian
发明人： Eric Mayoux , Luc Marti Clauzel , Silvia Garcia-Vicente , Marta Serrano Munoz , Antonio Zorzano Olarte , Alec Mian
IPC分类号： A61K31/385 , A61K31/05 , A61K31/357 , A61K31/198 , A61K31/185 , A61K31/10 , A61K31/122 , A61K31/09 , A61K31/121 , A61K31/192 , A61K31/60 , A61K31/618 , A61K31/603 , A61K31/167 , A61P3/06 , A61P3/10 , A61P9/00 , A61P3/04 , A61P29/00 , A61P39/06
CPC分类号： A61K31/198 , A61K31/00 , A61K31/192 , A61K31/196 , A61K31/385 , A61K31/60 , A61K45/06 , A61K2300/00
摘要： This invention is directed to pharmaceutical combinations comprising an antioxidant agent, an anti-inflammatory agent, and optionally at least one other anti-diabetic agent useful for treating metabolic disorders. This invention also encompasses pharmaceutically acceptable compositions comprising an antioxidant agent, an anti-inflammatory agent, optionally at least one other anti-diabetic agent, and at least one pharmaceutically acceptable carrier. The combinations and compositions of this invention are useful as methods for treating metabolic disorders including diabetes, particularly Type I and Type II diabetes, as well as diseases and disorders associated with diabetes, including but not limited to atherosclerosis, cardiovascular disease, inflammatory disorders, nephropathy, neuropathy, retinopathy, β-cell dysfunction, dyslipidemia, LADA, metabolic syndrome, hyperglycemia, insulin resistance, and/or chronic obstructive pulmonary disease in a mammal, particularly a diabetic mammal, and specifically a human patient. This invention is particularly directed to pharmaceutical compositions comprising an lipoic acid, one or more anti-inflammatories selected from the group consisting of diflunisal, diclofenac, dexibuprofen, dexketoprofen, naproxen, and salicylate, and optionally one or more pharmaceutically acceptable carriers. The compositions of this invention are useful as methods for treating metabolic disorders including type II diabetes, insulin resistance, beta-cell dysfunction, and hyperglycemia in a patient, particularly a diabetic patient.
摘要翻译：本发明涉及包含抗氧化剂，抗炎剂和任选的至少一种其它用于治疗代谢紊乱的其它抗糖尿病药物的药物组合。本发明还包括药学上可接受的组合物，其包含抗氧化剂，抗炎剂，任选的至少一种其它抗糖尿病药物和至少一种药学上可接受的载体。本发明的组合和组合物可用作治疗代谢紊乱的方法，包括糖尿病，特别是I型和II型糖尿病，以及与糖尿病相关的疾病和病症，包括但不限于动脉粥样硬化，心血管疾病，炎症性疾病，肾病，特别是糖尿病哺乳动物，特别是人类患者的神经病，视网膜病变，细胞功能障碍，血脂异常，LADA，代谢综合征，高血糖症，胰岛素抵抗和/或慢性阻塞性肺疾病。本发明特别涉及药物组合物，其包含硫辛酸，一种或多种选自二氟尼柳，双氯芬酸，右布洛芬，右克洛芬，萘普生和水杨酸酯的抗炎剂，以及任选的一种或多种药学上可接受的载体。本发明的组合物可用作治疗患者，特别是糖尿病患者中的II型糖尿病，胰岛素抵抗，β细胞功能障碍和高血糖症的代谢疾病的方法。

2. 发明申请

US20080070987A1 META-XYLYLENEDIAMINE VANADATE SALTS 审中-公开
公开(公告)号：US20080070987A1
公开(公告)日：2008-03-20
申请号：US11748282
申请日：2007-05-14
申请人： Francesc Yraola Font , Silvia Garcia Vicente , Juan Fernandez Recio , Fernando Albericio Palomera , Antonio Zorzano Olarte , Miriam Royo Exposito , Luc Marti Clauzel
发明人： Francesc Yraola Font , Silvia Garcia Vicente , Juan Fernandez Recio , Fernando Albericio Palomera , Antonio Zorzano Olarte , Miriam Royo Exposito , Luc Marti Clauzel
IPC分类号： A61K31/185 , A61P3/10 , C07C269/00
CPC分类号： C07C311/18 , C07B2200/07 , C07C233/36 , C07C233/78 , C07C235/50 , C07C237/22 , C07C237/34 , C07C271/20
摘要： The invention provides compounds of Formula (I): and Formula (II) or a pharmaceutically-acceptable salt, solvate, or hydrate thereof. Compounds of this invention, or pharmaceutical compositions thereof, are useful for treating diabetes, elevated plasma glucose levels, and/or ketoacidosis in mammals.
摘要翻译：本发明提供式（I）：和式（II）化合物或其药学上可接受的盐，溶剂化物或水合物。本发明的化合物或其药物组合物可用于治疗哺乳动物中的糖尿病，升高的血浆葡萄糖水平和/或酮症酸中毒。

3. 发明申请

US20100234452A1 Anti-Inflammatory and Antioxidant Conjugates Useful for Treating Metabolic Disorders 有权
标题翻译：用于治疗代谢紊乱的抗炎和抗氧化剂缀合物
公开(公告)号：US20100234452A1
公开(公告)日：2010-09-16
申请号：US12724892
申请日：2010-03-16
申请人： Alec Mian , Luc Marti Clauzel , Eric Mayoux , Silvia Garcia-Vicente , Marta Serrano Munoz , Antonio Zorzano Olarte , Julio Cesar Castro Palomino Laria
发明人： Alec Mian , Luc Marti Clauzel , Eric Mayoux , Silvia Garcia-Vicente , Marta Serrano Munoz , Antonio Zorzano Olarte , Julio Cesar Castro Palomino Laria
IPC分类号： A61K31/385 , A61K31/197 , C07C321/16 , A61K31/24 , C07D339/04 , A61P3/00
CPC分类号： C07D339/04 , A61K31/166 , A61K31/185 , A61K31/192 , A61K31/197 , A61K31/198 , A61K31/24 , A61K31/385 , C07C309/15 , C07C317/44 , C07C323/20 , C07C323/59 , C07C323/60 , C07C327/34 , C07C329/06 , C07C2602/08
摘要： The present invention is directed to methods for treating metabolic disorders with compounds that are conjugates. The conjugates of the present invention are comprised of salicylic acid, triflusal, diflusinal, salsalate, IMD-0354, ibuprofen, diclofenac, licofelone, or HTB, and one or more antioxidants.
摘要翻译：本发明涉及用缀合物化合物治疗代谢紊乱的方法。本发明的缀合物由水杨酸，三氟醋酸盐，二氟苯磺酸盐，鲸蜡酸盐，IMD-0354，布洛芬，双氯芬酸，licofelone或HTB以及一种或多种抗氧化剂组成。

4. 发明授权

US08575217B2 Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders 有权
标题翻译：用于治疗代谢紊乱的抗炎和抗氧化缀合物
公开(公告)号：US08575217B2
公开(公告)日：2013-11-05
申请号：US12724892
申请日：2010-03-16
申请人： Alec Mian , Luc Marti Clauzel , Eric Mayoux , Silvia Garcia-Vicente , Marta Serrano Munoz , Antonio Zorzano Olarte , Julio Cesar Castro Palomino Laria
发明人： Alec Mian , Luc Marti Clauzel , Eric Mayoux , Silvia Garcia-Vicente , Marta Serrano Munoz , Antonio Zorzano Olarte , Julio Cesar Castro Palomino Laria
IPC分类号： A01N37/12 , A01N37/44 , A01N37/00 , A61K31/195 , A61K31/185 , A61K31/21
CPC分类号： C07D339/04 , A61K31/166 , A61K31/185 , A61K31/192 , A61K31/197 , A61K31/198 , A61K31/24 , A61K31/385 , C07C309/15 , C07C317/44 , C07C323/20 , C07C323/59 , C07C323/60 , C07C327/34 , C07C329/06 , C07C2602/08
摘要： The present invention is directed to methods for treating metabolic disorders with compounds that are conjugates. The conjugates of the present invention are comprised of salicylic acid, triflusal, diflusinal, salsalate, IMD-0354, ibuprofen, diclofenac, licofelone, or HTB, and one or more antioxidants.
摘要翻译：本发明涉及用缀合物化合物治疗代谢紊乱的方法。本发明的缀合物由水杨酸，三氟醋酸盐，二氟苯磺酸盐，鲸蜡酸盐，IMD-0354，布洛芬，双氯芬酸，licofelone或HTB以及一种或多种抗氧化剂组成。

5. 发明申请

US20080227809A1 Arylalkylamine Vanadium (V) Salts for the Treatment and/or Prevention of Diabetes Mellitus 审中-公开
标题翻译：用于治疗和/或预防糖尿病的芳基烷基胺钒（V）盐
公开(公告)号：US20080227809A1
公开(公告)日：2008-09-18
申请号：US11571439
申请日：2005-07-01
申请人： Miriam Royo Exposito , Luc Marti Clauzel , Anna Abella Marti , Silvia Garcia Vicente , Xavier Testar Ymbert , Antonio Zorzano Olarte , Manuel Palacin Prieto , Fernando Albericio Palomera , Francesc Yraola Font , Alec Mian
发明人： Miriam Royo Exposito , Luc Marti Clauzel , Anna Abella Marti , Silvia Garcia Vicente , Xavier Testar Ymbert , Antonio Zorzano Olarte , Manuel Palacin Prieto , Fernando Albericio Palomera , Francesc Yraola Font , Alec Mian
IPC分类号： A61K31/439 , C07D453/00 , A61P3/10
CPC分类号： C07C211/65
摘要： This invention provides compounds and pharmaceutical compositions thereof for treating human type 1 and type 2 diabetes, particularly insulin-resistant diabetes.
摘要翻译：本发明提供了用于治疗人1型和2型糖尿病，特别是胰岛素抵抗性糖尿病的化合物及其药物组合物。

6. 发明申请

US20150025006A1 Pharmaceutical Combinations Including Anti-Inflammatory and Antioxidant Conjugates Useful for Treating Metabolic Disorders 审中-公开
标题翻译：包括用于治疗代谢紊乱的抗炎和抗氧化剂缀合物的药物组合
公开(公告)号：US20150025006A1
公开(公告)日：2015-01-22
申请号：US14344529
申请日：2012-09-14
申请人： Julio Cesar Castro Palomino Laria , Luc Marti Clauzel , Antonio Zorzano Olarte , Silvia Garcia Vicente , Alec Mian
发明人： Julio Cesar Castro Palomino Laria , Luc Marti Clauzel , Antonio Zorzano Olarte , Silvia Garcia Vicente , Alec Mian
IPC分类号： A61K31/265 , A61K38/23 , A61K38/22 , A61K31/155 , A61K38/26
CPC分类号： A61K31/265 , A61K31/155 , A61K31/192 , A61K31/216 , A61K31/235 , A61K31/381 , A61K38/2207 , A61K38/23 , A61K38/26 , A61K38/33 , A61K45/06 , A61K47/55 , A61K2300/00
摘要： One aspect of the present invention is a pharmaceutical combination comprising (a) an anti-inflammatory agent/anti-oxidant agent conjugate; and (b) an insulin secretogogue, an insulin sensitizer, an alpha-glucosidase inhibitor, a peptide analog, or a combination thereof. Another aspect of the invention relates to methods of treating metabolic disorders with such conjugates.
摘要翻译：本发明的一个方面是药物组合，其包含（a）抗炎剂/抗氧化剂缀合物; 和（b）胰岛素分泌途径，胰岛素敏化剂，α-葡糖苷酶抑制剂，肽类似物或其组合。本发明的另一方面涉及用这种缀合物治疗代谢紊乱的方法。

7. 发明授权

US08466197B2 Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders 有权
标题翻译：硫代碳酸酯作为抗炎和抗氧化化合物，可用于治疗代谢紊乱
公开(公告)号：US08466197B2
公开(公告)日：2013-06-18
申请号：US13235031
申请日：2011-09-16
申请人： Julio Cesar Castro Palomino Laria , Luc Marti Clauzel , Antonio Zorzano Olarte , Silvia Garcia Vicente , Alec Mian
发明人： Julio Cesar Castro Palomino Laria , Luc Marti Clauzel , Antonio Zorzano Olarte , Silvia Garcia Vicente , Alec Mian
IPC分类号： A61K31/265 , C07C329/06
CPC分类号： C07C329/06
摘要： The invention is directed to thiocarbonate compounds of Formula (I)-(III) and methods of treating atherosclerosis, neuropathy, nephropathy, retinopathy, inflammatory disorders, COPD, cardiovascular diseases, metabolic disorders, type I diabetes mellitus, type II diabetes mellitus, LADA, Wolfram Syndrome 1, Wolcott-Rallison syndrome, metabolic syndrome, dyslipidemia, hyperglycemia, or insulin resistance. The compounds of the invention are also useful for protecting pancreatic beta-cells and for reducing free fatty acids, triglycerides, advanced glycated end products, ROS, lipid peroxidation, tissue and plasma TNFalpha and IL6 levels, or for delaying or preventing cardiovascular complications associated with atherosclerosis.
摘要翻译：本发明涉及式（I） - （III）的硫代碳酸酯化合物和治疗动脉粥样硬化，神经病，肾病，视网膜病，炎症性疾病，COPD，心血管疾病，代谢紊乱，I型糖尿病，II型糖尿病，LADA ，Wolfram综合征1，Wolcott-Rallison综合征，代谢综合征，血脂异常，高血糖或胰岛素抵抗。本发明的化合物还可用于保护胰腺β-细胞和用于减少游离脂肪酸，甘油三酯，晚期糖基化终产物，ROS，脂质过氧化，组织和血浆TNFalpha和IL6水平，或用于延迟或预防与动脉粥样硬化。

8. 发明申请

US20120149769A1 Thiocarbonates as Anti-Inflammatory and Antioxidant Compounds Useful For Treating Metabolic Disorders 有权
标题翻译：硫代碳酸酯作为抗炎和抗氧化剂可用于治疗代谢紊乱
公开(公告)号：US20120149769A1
公开(公告)日：2012-06-14
申请号：US13235031
申请日：2011-09-16
申请人： Julio Cesar Castro Palomino Laria , Luc Marti Clauzel , Antonio Zorzano Olarte , Silvia Garcia Vicente , Alec Mian
发明人： Julio Cesar Castro Palomino Laria , Luc Marti Clauzel , Antonio Zorzano Olarte , Silvia Garcia Vicente , Alec Mian
IPC分类号： A61K31/265 , A61P3/00 , A61P37/06 , A61P3/06 , C07C329/06 , A61P3/10
CPC分类号： C07C329/06
摘要： The invention is directed to thiocarbonate compounds of Formula (I)-(III) and methods of treating atherosclerosis, neuropathy, nephropathy, retinopathy, inflammatory disorders, COPD, cardiovascular diseases, metabolic disorders, type I diabetes mellitus, type II diabetes mellitus, LADA, Wolfram Syndrome 1, Wolcott-Rallison syndrome, metabolic syndrome, dyslipidemia, hyperglycemia, or insulin resistance. The compounds of the invention are also useful for protecting pancreatic beta-cells and for reducing free fatty acids, triglycerides, advanced glycated end products, ROS, lipid peroxidation, tissue and plasma TNFalpha and IL6 levels, or for delaying or preventing cardiovascular complications associated with atherosclerosis.
摘要翻译：本发明涉及式（I） - （III）的硫代碳酸酯化合物和治疗动脉粥样硬化，神经病，肾病，视网膜病，炎症性疾病，COPD，心血管疾病，代谢紊乱，I型糖尿病，II型糖尿病，LADA ，Wolfram综合征1，Wolcott-Rallison综合征，代谢综合征，血脂异常，高血糖或胰岛素抵抗。本发明的化合物还可用于保护胰腺β-细胞和用于减少游离脂肪酸，甘油三酯，晚期糖基化终产物，ROS，脂质过氧化，组织和血浆TNFalpha和IL6水平，或用于延迟或预防与动脉粥样硬化。

9. 发明申请

US20090298923A1 Salicylate Conjugates Useful for Treating Metabolic Disorders 审中-公开
标题翻译：水杨酸盐缀合物可用于治疗代谢紊乱
公开(公告)号：US20090298923A1
公开(公告)日：2009-12-03
申请号：US12465201
申请日：2009-05-13
申请人： Alec Mian , Luc Marti Clauzel , Eric Mayoux , Silvia Garcia-Vicente , Marta Serrano Munoz , Antonio Zorzano Olarte
发明人： Alec Mian , Luc Marti Clauzel , Eric Mayoux , Silvia Garcia-Vicente , Marta Serrano Munoz , Antonio Zorzano Olarte
IPC分类号： A61K31/385 , A61K31/197 , A61K31/216 , A61P9/10
CPC分类号： A61K47/481 , A61K31/166 , A61K31/185 , A61K31/192 , A61K31/198 , A61K47/55
摘要： The present invention is directed to methods for treating metabolic disorders with compounds that are conjugates. The conjugates of the present invention are comprised of salicylic acid, triflusal, diflusinal, salsalate, IMD-0354, ibuprofen, diclofenac, licofelone, or HTB, and one or more antioxidants.
摘要翻译：本发明涉及用缀合物化合物治疗代谢紊乱的方法。本发明的缀合物由水杨酸，三氟醋酸盐，二氟苯磺酸盐，鲸蜡酸盐，IMD-0354，布洛芬，双氯芬酸，licofelone或HTB以及一种或多种抗氧化剂组成。

10. 发明申请

US20080269282A1 Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof 审中-公开
标题翻译：用于抑制含铜胺氧化物的化合物及其用途
公开(公告)号：US20080269282A1
公开(公告)日：2008-10-30
申请号：US11573089
申请日：2005-08-02
申请人： Luc Marti Clauzel , Silvia Garcia Vicente , Francesc Yraola Font , Miriam Royo Exposito , Fernando Albericio Palomera , Antonio Zorzano Olarte
发明人： Luc Marti Clauzel , Silvia Garcia Vicente , Francesc Yraola Font , Miriam Royo Exposito , Fernando Albericio Palomera , Antonio Zorzano Olarte
IPC分类号： A61K31/165 , C07C233/01 , C07C237/00 , C07D209/04 , A61K31/404 , A61K31/47 , A61P27/06 , A61P3/00 , A61P17/00 , A61P37/00 , A61P19/02 , A61P29/00 , C07C381/00 , C07D215/00
CPC分类号： C07D207/16 , C07C233/51 , C07C237/44 , C07C259/06 , C07C259/08 , C07C259/10 , C07C2601/08 , C07C2602/08 , C07D209/18 , C07D209/42 , C07D215/36 , C07D401/06
摘要： This invention is directed to inhibitors of copper-containing amine oxidases (E.C.1.4.3.6) including semicarbazide-sensitive amine oxidase (SSAO; also known as vascular adhesion protein-1, VAP-I), and their therapeutic use in inflammatory diseases, diabetes and its associated complications, atherosclerosis, neurodegenerative diseases, obesity, hypertension and cancer.
摘要翻译：本发明涉及包含氨基脲敏感性胺氧化酶（SSAO;也称为血管粘附蛋白-1，VAP-1）的含铜胺氧化酶（EC1.4.3.6）及其在炎性疾病，糖尿病中的治疗用途的抑制剂及其相关并发症，动脉粥样硬化，神经退行性疾病，肥胖症，高血压和癌症。

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