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1. 发明授权

US10383372B2 Controlling method for electronic cigarette with multiple output modes and electronic cigarette 有权
公开(公告)号：US10383372B2
公开(公告)日：2019-08-20
申请号：US16213807
申请日：2018-12-07
申请人： Ya-Ling Ding
发明人： Ya-Ling Ding
IPC分类号： A24F47/00 , G01R19/165 , H05B3/00 , H05B1/02
摘要： A controlling method for an electronic cigarette with multiple output modes and an electronic cigarette are disclosed. The controlling method comprises receiving a first operation signal for switching between output modes when the electronic cigarette is in a standby state. An output mode is in a memory, the output mode corresponding to the first operation signal and displacing a previous output mode. When the electronic cigarette receives a smoking signal, outputs are controlled according to the output mode stored in the memory. Whether the smoking signal is interrupted is determined when the battery feeds power to the load. The electronic cigarette enters standby state when the smoking signal is interrupted, otherwise whether a duration of the smoking signal reaches a preset duration is determined. If yes, the load is stopped charging and a hint is generated for indicating that a working duration of the electronic cigarette is too long.

2. 发明申请

US20180177232A1 CONTROLLING METHOD FOR ELECTRONIC CIGARETTE WITH MULTIPLE OUTPUT MODES AND ELECTRONIC CIGARETTE 审中-公开
公开(公告)号：US20180177232A1
公开(公告)日：2018-06-28
申请号：US15391874
申请日：2016-12-28
申请人： YA-LING DING
发明人： YA-LING DING
IPC分类号： A24F47/00 , H05B1/02
CPC分类号： A24F47/008 , H05B1/0227 , H05B1/0244
摘要： A controlling method for an electronic cigarette with multiple output modes and an electronic cigarette are disclosed. The controlling method comprises receiving a first operation signal for switching between output modes when the electronic cigarette is in a standby state. An output mode is in a memory, the output mode corresponding to the first operation signal and displacing a previous output mode. When the electronic cigarette receives a smoking signal, outputs are controlled according to the output mode stored in the memory.

3. 发明授权

US5716834A Cloned factor C cDNA of the Singapore horseshoe crab, Carcinoscorpius rotundicauda and purification of factor C proenzyme 失效
标题翻译：新加坡马蹄蟹，Carcinoscorpius rotundicauda的克隆因子C cDNA和因子C酶原的纯化
公开(公告)号：US5716834A
公开(公告)日：1998-02-10
申请号：US296014
申请日：1994-08-19
申请人： Jeak Ling Ding , Bow Ho
发明人： Jeak Ling Ding , Bow Ho
IPC分类号： C12N9/50 , C12N15/55 , C12Q1/37 , C12N15/63
CPC分类号： C12N9/6408 , C12Y304/21084 , G01N33/579
摘要： Full-length and deletion subclones of cDNAs for Factor C of Carcinoscorpius rotundicauda are provided. These cDNAs have been cloned into .lambda.gt 22 and pGEM 11Zf(+). Further manipulations of the 5' and 3' ends of these cDNAs have been carried out, and these cDNAs have been further subcloned into other expression vectors such as pGEMEX-1, pET 3b, and the yeast shuttle vectors YEpsec 1 and pEMBLyex 4, and pPIC 9 and pHIL D2. Also provided are host cells transformed with expression vectors containing DNA molecules encoding proteins having Factor C-like enzymatic activity, methods of producing such proteins, methods for purifying Factor C zymogens, and methods for protecting Factor C zymogens from autoactivation by Gram negative bacterial endotoxin while the proenzyme is being purified and/or processed from amoebocyte lysates or from recombinant clones, or during storage or subsequent handling. This protection is afforded by the addition of 5-30% Me.sub.2 SO, which reversibly inhibits the Factor C zymogen.
摘要翻译：提供了番茄猕猴桃因子C的全长和缺失亚克隆。这些cDNA已经克隆到λgt22和pGEM11Zf（+）中。已经进行了这些cDNA的5'和3'端的进一步操作，并将这些cDNA进一步亚克隆到其他表达载体如pGEMEX-1，pET 3b和酵母穿梭载体YEpsec 1和pEMBLyex 4中，以及 pPIC 9和pHIL D2。还提供了用含有编码具有因子C样酶活性的蛋白质的DNA分子转化的宿主细胞，产生这种蛋白质的方法，产生这种蛋白质的方法，纯化因子C酶原的方法，以及保护因子C酶原从革兰氏阴性细菌内毒素自动激活的方法，正在从变形细胞裂解物或重组克隆纯化和/或加工，或在储存或后续处理过程中。这种保护是通过加入5-30％的Me2SO，可逆地抑制因子C酶原来提供的。

4. 发明申请

US20190104770A1 CONTROLLING METHOD FOR ELECTRONIC CIGARETTE WITH MULTIPLE OUTPUT MODES AND ELECTRONIC CIGARETTE 审中-公开
公开(公告)号：US20190104770A1
公开(公告)日：2019-04-11
申请号：US16213807
申请日：2018-12-07
申请人： YA-LING DING
发明人： YA-LING DING
IPC分类号： A24F47/00 , G01R19/165
CPC分类号： A24F47/008 , G01R19/16542 , H05B1/02 , H05B3/0014 , H05B2203/021
摘要： A controlling method for an electronic cigarette with multiple output modes and an electronic cigarette are disclosed. The controlling method comprises receiving a first operation signal for switching between output modes when the electronic cigarette is in a standby state. An output mode is in a memory, the output mode corresponding to the first operation signal and displacing a previous output mode. When the electronic cigarette receives a smoking signal, outputs are controlled according to the output mode stored in the memory. Whether the smoking signal is interrupted is determined when the battery feeds power to the load. The electronic cigarette enters standby state when the smoking signal is interrupted, otherwise whether a duration of the smoking signal reaches a preset duration is determined. If yes, the load is stopped charging and a hint is generated for indicating that a working duration of the electronic cigarette is too long.

5. 发明申请

US20100098846A1 PATTERNED SOFT ADHESIVES AND METHOD OF MANUFACTURE 审中-公开
标题翻译：图案软胶粘剂及其制造方法
公开(公告)号：US20100098846A1
公开(公告)日：2010-04-22
申请号：US12568202
申请日：2009-09-28
申请人： Jian Ling Ding , Rengan Kannabiran , Kathryn Moon , Robert Braiewa , Brian Thomas
发明人： Jian Ling Ding , Rengan Kannabiran , Kathryn Moon , Robert Braiewa , Brian Thomas
IPC分类号： B05D5/10 , B05C1/08
CPC分类号： C09J7/38 , C09J2201/28
摘要： A method is disclosed for making a soft adhesive tape. The method comprises providing a soft adhesive, rolling a gravure cylinder on the soft adhesive to meter the soft adhesive, depositing the metered soft adhesive from the gravure cylinder onto a carrier web, and transferring the soft adhesive to a backing substrate. In exemplary implementations, the method includes drying or curing the metered soft adhesive on the carrier web before transferring the soft adhesive to the backing substrate. A system is disclosed for making a layer of soft adhesive. The system comprises an applicator containing a soft adhesive, a gravure cylinder to meter the soft adhesive from the applicator, and a carrier web passing through the gravure cylinder, the carrier web supporting the metered soft adhesive deposited by the gravure cylinder. In exemplary implementations, a dryer may be included for curing the metered soft adhesive on the carrier web.
摘要翻译：公开了制造软胶带的方法。该方法包括提供软粘合剂，在软粘合剂上滚动凹版滚筒以测量软粘合剂，将来自凹版滚筒的计量软粘合剂沉积到载体网上，并将软粘合剂转移到背衬基材上。在示例性实施方案中，该方法包括在将软粘合剂转移到背衬基材之前干燥或固化载体网上的计量软粘合剂。公开了一种用于制造软粘合剂层的系统。该系统包括一个包含软粘合剂的涂抹器，一个用于对来自涂布器的柔软粘合剂进行计量的凹版滚筒，以及一个穿过凹版滚筒的载体网，支撑着由凹版滚筒沉积的计量软粘合剂的载体网。在示例性实施方案中，可以包括干燥器以固化载体网上的计量软粘合剂。

6. 发明授权

US06923982B2 Calendered hydrocolloid dressing 失效
标题翻译：压延水胶体敷料
公开(公告)号：US06923982B2
公开(公告)日：2005-08-02
申请号：US09925063
申请日：2001-08-08
申请人： Scott C. Barnes , Jim Jian Ling Ding
发明人： Scott C. Barnes , Jim Jian Ling Ding
IPC分类号： A61F13/02 , A61L15/24 , A61L15/28 , A61L15/58 , A61F13/00
CPC分类号： A61L15/24 , A61L15/28 , C08L23/04 , C08L1/28
摘要： A calendered hydrocolloid dressing for the wound care and a one step method of manufacturing the hydrocolloidal dressing are described. In particular, the invention is concerned with a hydrocolloid dressing which is absorbent, non-damaging to the skin and comfortable to the user preferably having at least a thermoplastic elastomer backing and water absorbent polymeric adhesive layer.
摘要翻译：描述了用于伤口护理的压延水胶体敷料和制造水胶体敷料的一步法。特别地，本发明涉及一种水胶体敷料，其是吸收性的，对皮肤无破坏性并且使用者舒适，优选具有至少热塑性弹性体背衬和吸水性聚合物粘合剂层。

7. 发明申请

US20080113906A1 Sushi Peptide Multimer 有权
标题翻译：寿司肽多聚体
公开(公告)号：US20080113906A1
公开(公告)日：2008-05-15
申请号：US10563551
申请日：2004-07-02
申请人： Jeak Ling Ding , Bow Ho
发明人： Jeak Ling Ding , Bow Ho
IPC分类号： A61K38/17 , C07K14/47 , C07H21/04 , C12N15/63 , C12N5/06 , C12N1/20 , C12P21/00 , A61P31/04 , G01N33/554
CPC分类号： C12Y304/21084 , A61K38/00 , C12N9/6408 , Y10S435/975 , Y10S530/81 , Y10S930/28
摘要： Endotoxin, also known as lipopolysaccharides (LPS), is the major mediator of septic shock due to Gram-negative bacterial infection. Chemically synthesized S3 peptide, derived from Sushi3 domain of Factor C, which is the endotoxin-sensitive serine protease of the limulus coagulation cascade, binds and neutralizes LPS activity. Fluorescent tagged-S3 is shown to detect LPS-containing bacteria. For large-scale production of S3 and to mimic other pathogen-recognizing molecules, tandem multimers of the S3 gene were constructed and expressed in E. coli. Tetramer of S3 for example is shown to display an enhanced inhibitory effect on LPS-induced activities. An affinity matrix based on tetramer of S3 is also shown to be particularly efficient at removing LPS.
摘要翻译：内毒素也被称为脂多糖（LPS），是革兰氏阴性细菌感染引起的败血性休克的主要介质。衍生自因子C的Sushi3结构域的化学合成的S3肽，其是鲎凝血级联的内毒素敏感的丝氨酸蛋白酶，其结合并中和LPS活性。荧光标记的S3显示检测含LPS细菌。为了大规模生产S3并模拟其他病原体识别分子，构建了S3基因的串联多聚体并在大肠杆菌中表达。 S3的四聚体显示出增强的对LPS诱导的活性的抑制作用。基于S3的四聚体的亲和基质也显示出在去除LPS时特别有效。

8. 发明授权

US07368023B2 Zirconium-rich bulk metallic glass alloys 有权
标题翻译：富锆块状金属玻璃合金
公开(公告)号：US07368023B2
公开(公告)日：2008-05-06
申请号：US10963413
申请日：2004-10-12
申请人： Y. Austin Chang , Hongbo Cao , Dong Ma , Ling Ding , Ker-chang Hsieh
发明人： Y. Austin Chang , Hongbo Cao , Dong Ma , Ling Ding , Ker-chang Hsieh
IPC分类号： C22C45/10
CPC分类号： C22C45/10
摘要： Zirconium-rich bulk metallic glass alloys include quinary alloys containing zirconium, aluminum, titanium, copper and nickel. The bulk metallic glass alloys may be provided as completely amorphous pieces having cross-sectional diameters of at least about 5 mm or even greater.
摘要翻译：富含锆的块状金属玻璃合金包括含有锆，铝，钛，铜和镍的二元合金。块状金属玻璃合金可以被提供为具有至少约5mm或甚至更大截面直径的完全非晶片。

9. 发明授权

US06645724B1 Assays for endotoxin 有权
标题翻译：内毒素检测
公开(公告)号：US06645724B1
公开(公告)日：2003-11-11
申请号：US09287368
申请日：1999-04-07
申请人： Jeak Ling Ding , Bow Ho
发明人： Jeak Ling Ding , Bow Ho
IPC分类号： A61K3902
CPC分类号： G01N33/579 , C07K14/43509 , C12N2799/026
摘要： The horseshoe crab, Carcinoscorpius rotundicauda Factor C cDNA (CrFC21) has been cloned into a shuttle baculoviral vector and another vector suitable for expression in insect cells. The recombinant baculoviral DNA was then transfected into the insect cells for expression of recombinant Factor C. Recombinant Factor C was found to be immunoreactive and is capable of binding both free and bound/immobilized lipid A. It is enzymatically active when triggered by LPS. The rFC is probably of the two-chain form, being cleaved into the heavy and light chains after activation by Gram negative bacterial endotoxin. As low as 0.01 pg (0.001 ng/ml) of LPS was detectable by the rFC, thus, indicating its potentials as a novel generation of “limulus amoebocyte lysate.”
摘要翻译：马蹄蟹Carcinoscorpius rotundicauda因子C cDNA（CrFC21）已经克隆到穿梭杆状病毒载体和另一种适合在昆虫细胞中表达的载体。然后将重组杆状病毒DNA转染到昆虫细胞中用于表达重组因子C.重组因子C被发现是免疫反应性的，并且能够结合游离和结合/固定的脂质A.当LPS诱导时，其酶促活性。 rFC可能是双链形式，在革兰氏阴性细菌内毒素激活后被切割成重链和轻链。通过rFC检测到低达0.01pg（0.001ng / ml）的LPS，因此，表明其作为新一代“鲎变形细胞裂解物”的潜力。

10. 发明授权

US5985590A Expression of Carcinoscorpius rotundicauda Factor C in eukaryotes 失效
标题翻译： Carcinoscorpius rotundicauda因子C在真核生物中的表达
公开(公告)号：US5985590A
公开(公告)日：1999-11-16
申请号：US877620
申请日：1997-06-18
申请人： Jeak Ling Ding , Bow Ho
发明人： Jeak Ling Ding , Bow Ho
IPC分类号： C12N9/50 , C12N15/55 , C12Q1/37
CPC分类号： C12N9/6408 , C12Y304/21084 , G01N33/579
摘要： CrFC21 cDNA was cloned into two mammalian vectors: pCIneo and pCDNAI, both of which carry the strong CMV promoter for expression in mammalian cell lines. Various CrFC cDNA constructs transformed into P. pastoris and S. cerevisiae were expressed to yield full-length recombinant Factor C (rCrFC) protein of .about.130 kDa which is immunoreactive. The rCrFC is expressed in an intracellular, insoluble form. Intracellular localization of the nascent protein provides protection from premature digestion by proteases secreted by the host cell. Subsequent to its synthesis, rCrFC is solubilized and purified under pyrogen-free conditions. Using established protocols, the protein can be denatured and renatured to recover its biological functionality. By manipulation of the 5' end of CrFC26, truncated constructs containing this cDNA are expressed by S. cerevisiae to give immunoreactive rCrFC. The rCrFC produced from both CrFC21 and CrFC26 constructs, solubilized by Triton X-100 or SDS, is found to be immunoreactive. Solubilized rCrFC was purified as a proenzyme and reversibly protected from activation by addition of Me.sub.2 SO.
摘要翻译：将CrFC21 cDNA克隆到两个哺乳动物细胞系中的pCIneo和pCDNAI两个哺乳动物载体，两者都携带强CMV启动子进行表达。转化到巴斯德毕赤氏酵母和酿酒酵母中的各种CrFC cDNA构建体被表达以产生具有免疫反应性的DIFFERENCE 130kDa的全长重组因子C（rCrFC）蛋白。 rCrFC以细胞内，不溶性形式表达。新生蛋白质的细胞内定位提供了保护免受由宿主细胞分泌的蛋白酶的过早消化。在合成之后，rCrFC在无热原条件下溶解和纯化。使用既定的方案，蛋白质可以变性和复性以恢复其生物学功能。通过操纵CrFC26的5'末端，含有该cDNA的截短构建体由酿酒酵母表达，得到免疫反应性rCrFC。发现由Triton X-100或SDS溶解的CrFC21和CrFC26构建体产生的rCrFC是免疫反应性的。将溶解的rCrFC纯化为酶原，并通过加入Me 2 SO可逆地保护免于活化。

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