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1. 发明申请

US20180362916A1 Automated Bioreactor Sampling and Glucose monitoring System 审中-公开
公开(公告)号：US20180362916A1
公开(公告)日：2018-12-20
申请号：US15957908
申请日：2018-04-20
申请人： Timothy Ray Ho , Lewis Ho
发明人： Timothy Ray Ho , Lewis Ho
IPC分类号： C12M1/36 , C12M1/34 , C12M1/00 , C12M1/12 , C12M3/00
CPC分类号： C12M41/48 , C12M23/04 , C12M23/48 , C12M29/00 , C12M29/14 , C12M41/12 , C12M41/32
摘要： Disclosed herein is an improved automatic sampling and biochemical monitoring system for a microbial or cell culture or a biochemical reaction in a bioreactor.

2. 发明申请

US20100267142A1 SCALABLE PACKED-BED CELL CULTURE DEVICE 审中-公开
标题翻译：可扩展的包装细胞培养装置
公开(公告)号：US20100267142A1
公开(公告)日：2010-10-21
申请号：US12761810
申请日：2010-04-16
申请人： Gary Wang , King-Ming Chang , Lewis Ho
发明人： Gary Wang , King-Ming Chang , Lewis Ho
IPC分类号： C12N5/071 , C12M1/36 , C12N1/20
CPC分类号： C12M41/44 , C12M25/18
摘要： A scalable packed-bed cell culture device includes a matrix vessel, a mixing vessel, a communicating means, a driving means and a controlling means. The matrix vessel includes porous matrixes packed therein. The mixing vessel includes a mixing means configured for mixing a culture medium. The communicating means is connected between the matrix vessel and the mixing vessel. The driving means is configured for driving the culture medium to flow between the matrix vessel and the mixing vessel. The controlling means configured for controlling the culture medium to submerge the porous matrixes at high level, and to emerge the porous matrixes at low level. An inoculation method and a culture method for scalable packed-bed cell culture device is also herein provided for eliminating the limitation of aeration or oxygenation during culture, alleviating the gradient effect, eliminating the channeling effect in conventional packed-bed bioreactors.
摘要翻译：可膨胀的填充床细胞培养装置包括矩阵容器，混合容器，连通装置，驱动装置和控制装置。基质容器包括填充在其中的多孔基体。混合容器包括配置用于混合培养基的混合装置。连通装置连接在矩阵容器和混合容器之间。驱动装置被构造成用于驱动培养基在矩阵容器和混合容器之间流动。所述控制装置被配置为控制所述培养基以高水平淹没所述多孔基质，并且以低水平出现所述多孔基质。本文还提供了一种用于可膨胀的填充床细胞培养装置的接种方法和培养方法，用于消除培养期间通气或氧合的限制，减轻梯度效应，消除常规填充床生物反应器中的通道效应。

3. 发明申请

US20130071872A1 DEVICE AND METHOD FOR SINGLE-USED MATRIX SAMPLING 审中-公开
标题翻译：用于单用矩阵采样的装置和方法
公开(公告)号：US20130071872A1
公开(公告)日：2013-03-21
申请号：US13617414
申请日：2012-09-14
申请人： Lewis HO , Karen Chen , King-Ming Chang
发明人： Lewis HO , Karen Chen , King-Ming Chang
IPC分类号： G01N1/14 , C12Q1/02
CPC分类号： C12M33/04 , A61L2/07
摘要： A single-used matrix sampling device for the single-used, disposable or autoclavble packed-bed bioreactor is provided herein. The present invention includes a tube means and a matrix collecting means. The matrix collecting means configured for collecting the cell culture matrix includes a receptacle and a pulling means connected to the receptacle or the matrix collecting means could be scoop-like in configuration; the tube means is configured for preventing the matrix collecting means from being contaminated while mechanically or pneumatically sampling; and the tube means could be sealed to enclose the sampled matrix collecting means after sampling. A single-used matrix sampling method for a single-used, disposable or autoclavble packed-bed bioreactor is also provided. The present invention could be utilized to aseptically collect the cell culture matrix from the packed-bed bioreactor without requiring to face the risks of contamination.
摘要翻译：本文提供了一次性，一次性或高压灭菌填充床生物反应器的单次使用的矩阵取样装置。本发明包括管装置和矩阵收集装置。配置用于收集细胞培养基质的基质收集装置包括容器和连接到容器的牵引装置或矩阵收集装置，其构型可以是勺状的; 管装置构造成用于在机械或气动取样时防止基质收集装置被污染; 并且管装置可以被密封以在采样之后包围采样的矩阵收集装置。还提供了一次性，一次性或高压灭菌填充床生物反应器的单次使用的矩阵取样方法。本发明可用于从填充床生物反应器中无菌收集细胞培养基质，而不需要面对污染的风险。

4. 发明申请

US20120250450A1 EXTERNAL MIXING DEVICE 审中-公开
标题翻译：外部混合装置
公开(公告)号：US20120250450A1
公开(公告)日：2012-10-04
申请号：US13436126
申请日：2012-03-30
申请人： Lewis Ho , King-Ming Chang
发明人： Lewis Ho , King-Ming Chang
IPC分类号： B01F15/02
CPC分类号： B01F5/10 , B01F5/0268 , B01F5/16 , B01F15/0085 , B01F2215/0032
摘要： An external mixing device comprises: arranging an inlet and an outlet on the single-use container; a sterilizable or a single-use pump head connected to the inlet and outlet with a mixer installed inside. Driven by a driving device, the mixer makes the liquid circulate continuously between the pump head and the single-use container. The external mixing device further comprises a sensor chamber installed with a plurality of sensors and extra ports, which are used for introducing solution or gas inside or for sampling and detecting liquid properties. A single-use connector is used to connect the single-use container to the external mixing device, which can be operated aseptically under general environment. The external mixing device is small-sized with the advantage of simplified operation procedures.
摘要翻译：外部混合装置包括：在一次性容器上布置入口和出口; 一个可灭菌或一次性使用的泵头，连接到入口和出口，里面装有一个混合器。由驱动装置驱动，混合器使液体在泵头和一次性容器之间连续循环。外部混合装置还包括安装有多个传感器和额外端口的传感器室，其用于将溶液或气体引入或用于取样和检测液体性质。一次性连接器用于将一次性容器连接到外部混合装置，可在一般环境下无菌操作。外部混合装置小型化，具有操作简单的优点。

5. 发明申请

US20050186669A1 Apparatus and method for preparing and culturing cells 审中-公开
标题翻译：用于制备和培养细胞的装置和方法
公开(公告)号：US20050186669A1
公开(公告)日：2005-08-25
申请号：US11059523
申请日：2005-02-17
申请人： Lewis Ho , Yu-Chi Wang , King-Ming Chang
发明人： Lewis Ho , Yu-Chi Wang , King-Ming Chang
IPC分类号： C12M1/02 , C12M1/04 , C12M1/12 , C12M1/24 , C12M1/34 , C12M1/40 , C12M1/42 , C12M3/00 , C12N5/02 , C12N5/06 , C12N5/08
CPC分类号： C12M23/14 , B01F11/0017 , C12M27/16
摘要： An apparatus and method for preparing and culturing cells includes a chamber having an inlet and an outlet for introducing culture medium and air. A cell growth substrate placed in the chamber for cells anchored or embedded. The preferred embodiment of invention claims a novel process for controlling the platform form to tilt at one end, to maintain the seesaw and rocking movement for cultured process. The seesaw movement or rocking movement efficiently the nutrition, carbon dioxide and oxygen transfer during cultured process for production of cellular protein products or harvesting the cells.
摘要翻译：用于制备和培养细胞的装置和方法包括具有用于引入培养基和空气的入口和出口的室。将细胞生长基质放置在室中用于锚定或嵌入的细胞。本发明的优选实施例要求用于控制平台形式在一端倾斜的新颖方法，以保持用于培养过程的跷跷板和摇摆运动。跷跷板运动或摇摆运动有效地在培养过程中的营养，二氧化碳和氧转移以产生细胞蛋白质产物或收获细胞。

6. 发明授权

US5095179A Extensive morse code processing system 失效
标题翻译：广泛的莫尔斯码处理系统
公开(公告)号：US5095179A
公开(公告)日：1992-03-10
申请号：US558576
申请日：1990-07-26
申请人： Lewis Ho
发明人： Lewis Ho
IPC分类号： H04L15/00
CPC分类号： H04L15/00
摘要： An extensive morse code processing system includes a microprocessor unit, a transmitter processing unit, a receiver processing unit, a display unit, a keyboard unit, and a radio unit. Whenever a data key on the keyboard is pressed, the ASCII code of the pressed key is received by the microprocessor unit and is converted into a binary line code. The line code is processed by the transmitter unit and is then transmitted as morse code signals by the radio unit. Morse code signals received by the radio unit are converted by the receiver unit into the corresponding binary line code. The line code from the receiver unit serves as input to the microprocessor unit which converts the line code into standard ASCII. The microprocessor then actuates the display unit to display the received characters. Exchange of data between the microprocessor unit and a a computer is also possible through an RS-232 interface adapter interconnecting the computer and the microprocessor unit.
摘要翻译：广泛的莫尔斯码处理系统包括微处理器单元，发射机处理单元，接收机处理单元，显示单元，键盘单元和无线电单元。每当按下键盘上的数据键时，按下的键的ASCII代码由微处理器单元接收并转换为二进制代码。线路码由发射机单元处理，然后由无线电单元作为莫尔斯码信号传输。由无线电单元接收的莫尔斯电码信号由接收机单元转换成相应的二进制码。来自接收器单元的线路代码作为将线路代码转换成标准ASCII的微处理器单元的输入。然后微处理器致动显示单元以显示所接收的字符。通过将计算机和微处理器单元互连的RS-232接口适配器，也可以在微处理器单元和计算机之间交换数据。

7. 发明授权

US10590374B2 Automatic multi-tray and multi-plate bioreactor systems for adherent cultures 有权
公开(公告)号：US10590374B2
公开(公告)日：2020-03-17
申请号：US15954595
申请日：2018-04-17
申请人： Timothy Ray Ho , Lewis Ho
发明人： Timothy Ray Ho , Lewis Ho
IPC分类号： C12M1/12 , C12M1/36 , C12M1/00 , C12M3/06
摘要： Described herein is an improved automatic bioreactor system utilizing a multi-tray or multi-plate cell culture vessel for cultivating adherent cells.

8. 发明授权

US10669520B2 Automated bioreactor sampling and glucose monitoring system 审中-公开
公开(公告)号：US10669520B2
公开(公告)日：2020-06-02
申请号：US15957908
申请日：2018-04-20
申请人： Timothy Ray Ho , Lewis Ho
发明人： Timothy Ray Ho , Lewis Ho
IPC分类号： C12M1/36 , C12M1/34 , C12M3/00 , C12M1/12 , C12M1/00
摘要： Disclosed herein is an improved automatic sampling and biochemical monitoring system for a microbial or cell culture or a biochemical reaction in a bioreactor.

9. 发明申请

US20180371394A1 Automatic Multi-tray and Multi-plate Bioreactor Systems for Adherent Cultures 审中-公开
公开(公告)号：US20180371394A1
公开(公告)日：2018-12-27
申请号：US15954595
申请日：2018-04-17
申请人： Timothy Ray Ho , Lewis Ho
发明人： Timothy Ray Ho , Lewis Ho
IPC分类号： C12M1/12 , C12M1/00 , C12M1/36
CPC分类号： C12M25/06 , C12M23/04 , C12M23/06 , C12M23/50 , C12M27/16 , C12M29/06 , C12M29/24 , C12M29/26 , C12M41/48
摘要： Disclosed herein is an improved automatic bioreactor system utilizing a multi-tray or multi-plate cell culture vessel for cultivating adherent cells.

10. 发明申请

US20060292690A1 Method of making cell growth surface 审中-公开
标题翻译：细胞生长表面的方法
公开(公告)号：US20060292690A1
公开(公告)日：2006-12-28
申请号：US11471576
申请日：2006-06-21
申请人： Tzu-Ying Liu , Ing-Kae Wang , Sing-Ying Hsieh , Lewis Ho , Yu-Chi Wang , King-Ming Chang
发明人： Tzu-Ying Liu , Ing-Kae Wang , Sing-Ying Hsieh , Lewis Ho , Yu-Chi Wang , King-Ming Chang
IPC分类号： C12N5/06
CPC分类号： C12N5/0068 , C12M25/14 , C12N2533/70
摘要： The present invention discloses a three-dimensional porous growth surface made from polysaccharide material, especially the alginic acid, to enhance cell growth surface, promote cell adherence, immobilization and propagation, maintain surface structure integrity, enable programmable degradation, and thus increase cellular production. The present invention teaches several methods: a method to enhance the integrity of the growth surface by protecting the growth surface in a rigid solid support; a method of use for enhancing the performance of the surface; and a method of modifying a growth surface for eukaryotic and/or prokaryotic cells comprising the steps of increasing surface area by creating porous and 3-D structure, treating a surface to encourage cell attachment, promoting cell growth and proliferation, and disposing the growth surface in any conventional cell cultivating device. The growth surface is able to program degradation and release the cell/tissue mass after the culture is completed.
摘要翻译：本发明公开了一种由多糖材料特别是藻酸制成的三维多孔生长表面，以增强细胞生长表面，促进细胞粘附，固定和繁殖，保持表面结构完整性，实现可编程降解，从而增加细胞生产。本发明教导了几种方法：通过保护刚性固体支持物中的生长表面来增强生长表面完整性的方法; 用于增强表面性能的方法; 以及一种修饰真核细胞和/或原核细胞的生长表面的方法，包括以下步骤：通过产生多孔和3-D结构来增加表面积，处理表面以促进细胞附着，促进细胞生长和增殖，以及处置生长表面在任何常规的细胞培养装置中。生长表面能够在培养完成后编程降解和释放细胞/组织块。

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