专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110293531A1 Porphyrazine Optical and Dual Optical/MR Contrast and Therapeutic Agents 失效
标题翻译：四氮卟啉光学和双光学/ MR对比和治疗剂
公开(公告)号：US20110293531A1
公开(公告)日：2011-12-01
申请号：US13062031
申请日：2009-09-04
申请人： Anthony G.M. Barrett , Evan R. Trivedi , Brian M. Hoffman
发明人： Anthony G.M. Barrett , Evan R. Trivedi , Brian M. Hoffman
IPC分类号： A61K49/06 , A61K49/00 , A61K31/7068 , A61P35/00 , A61K31/704 , A61K31/519 , C07D487/22 , A61K31/409
CPC分类号： A61K51/0451 , A61K31/409 , A61K47/546 , A61K47/547 , A61K49/0002 , A61K49/122 , A61K51/0482 , A61K51/065
摘要： Porphyrazines capable of localizing in a tumor of a mammal are disclosed. The porphyrazines are used in methods of imaging a tumor and in methods of treating tumors, either alone or in combination with a chemotherapeutic agent and/or radiation.
摘要翻译：公开了能够定位在哺乳动物肿瘤中的紫菜碱。四氮杂卟啉用于成像肿瘤的方法和单独或与化学治疗剂和/或辐射组合治疗肿瘤的方法中。

2. 发明申请

US20100261683A1 Selective Inhibitors for Cyclin-Dependent Kinases 有权
标题翻译：细胞周期依赖型激酶的选择性抑制剂
公开(公告)号：US20100261683A1
公开(公告)日：2010-10-14
申请号：US12631373
申请日：2009-12-04
申请人： Ashutosh S. Jogalekar , James P. Snyder , Dennis C. Liotta , Anthony G.M. Barrett , RCDS Coombes , Simak Ali , Aleksandra Siwicka , Jan Brackow , Bodo Scheiper
发明人： Ashutosh S. Jogalekar , James P. Snyder , Dennis C. Liotta , Anthony G.M. Barrett , RCDS Coombes , Simak Ali , Aleksandra Siwicka , Jan Brackow , Bodo Scheiper
IPC分类号： A61K31/635 , C07D487/04 , A61K31/519 , A61P35/00 , C12N9/12
CPC分类号： A61K31/519 , C07D487/04
摘要： This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from inappropriate activity of cyclin-dependent kinases, including cancer, viral infections (e.g., HIV) neurodegenerative disorders (e.g. Alzheimer's disease), and cardiovascular disorders (e.g. atherosclerosis). Moreover, certain members of this class are particularly useful for inhibiting cyclin-dependent kinase 7 and are especially useful for the treatment of breast cancer.
摘要翻译：本发明提供一类可用于特异性抑制细胞周期蛋白依赖性激酶的化合物。这类化合物可用于治疗由细胞周期蛋白依赖性激酶（包括癌症，病毒感染（例如HIV））神经变性疾病（例如阿尔茨海默病）和心血管疾病（例如动脉粥样硬化）的不适当活动引起的疾病。此外，该类的某些成员特别可用于抑制细胞周期蛋白依赖性激酶7，并且特别可用于治疗乳腺癌。

3. 发明申请

US20070099983A1 Aminocyclohexyl ether compounds and uses thereof 审中-公开
标题翻译：氨基环己基醚化合物及其用途
公开(公告)号：US20070099983A1
公开(公告)日：2007-05-03
申请号：US10555364
申请日：2003-10-31
申请人： G.M. Barrett , Lewis Choi , Dough Chou , Grace Jung , Bertrand Plouvier , Yuzhong Liu , Jeff Zhu , Tao Sheng
发明人： G.M. Barrett , Lewis Choi , Dough Chou , Grace Jung , Bertrand Plouvier , Yuzhong Liu , Jeff Zhu , Tao Sheng
IPC分类号： A61K31/4015 , C07D207/02
CPC分类号： A61K31/40 , A61K31/455 , A61K31/4965 , A61K31/519 , C07D207/12
摘要： Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
摘要翻译：公开了氨基环己基醚化合物。本发明的化合物可以掺入组合物和试剂盒中。本发明还公开了化合物和组合物的用途，包括治疗心律失常。

4. 发明授权

US5912341A Heteroatom-functionalized porphyrazines and multimetallic complexes and polymers derived therefrom 失效
标题翻译：杂原子官能化的四氮杂卟啉和多金属络合物及其衍生的聚合物
公开(公告)号：US5912341A
公开(公告)日：1999-06-15
申请号：US928415
申请日：1997-09-12
申请人： Brian M. Hoffman , Anthony G.M. Barrett
发明人： Brian M. Hoffman , Anthony G.M. Barrett
IPC分类号： C07D487/22 , C07D491/22 , C07D495/22 , C07D497/22 , C07D498/22 , C07F1/00 , C07F1/08 , C07F3/00 , C07F5/00 , C07F5/06 , C07F7/22 , C07F7/24 , C07F7/30 , C07F9/6561 , C07F9/6564 , C07F15/00 , C07F15/04 , C09B47/00 , C09B47/04 , C09B62/00
CPC分类号： C07D487/22 , C07D491/22 , C07D497/22 , C07D498/22 , C07F9/6561
摘要： Porphyrazine compounds having moieties substituted at the eight peripheral .beta.-pyrrole positions are disclosed. The porphyrazine compounds have the general structural formula: ##STR1## wherein M is H.sub.2 or a metal capable of complexing with the pyrrole nitrogen atoms, and A, B, C, and D are independently selected from the group consisting of a thio moiety, an amino moiety, an oxo moiety, a phospho moiety, a seleno moiety, a telluro moiety and a noncoordinating moiety, like a hydrocarbon moiety, with the proviso that not all of A, B, C, and D are a thio moiety and that not all of A, B, C, and D are a hydrocarbon moiety. The porphyrazine compounds, depending on the identity of A, B, C, and D, are capable of complexing one to four metal ions to the periphery of the porphyrazine to form a multimetallic porphyrazine. Multimetallic porphyrazine compounds can be linked peripherally to form a linear, i.e., ribbon, polymer or a two-dimension, i.e., sheet polymer. The porphyrazine compounds, and the multimetallic complexes and polymers derived therefrom, are useful in, or as, magnet materials, molecular metal conductors, pharmaceuticals, imaging agents, and dyes.
摘要翻译：公开了在八个外围β-吡咯位置取代部分的四氮杂卟啉化合物。四氮杂卟啉化合物具有以下通式的结构式：其中M为H 2或能与吡咯氮原子络合的金属，A，B，C和D独立地选自硫基部分，氨基部分，氧基部分，磷酸部分，硒部分，尾流部分和非配位部分，如烃部分，条件是不是全部A，B，C和D都是硫基部分，并且不全部是A ，B，C和D是烃部分。取决于A，B，C和D的同一性，四氮杂卟啉化合物能够将1-4个金属离子络合到四氮杂卟啉的周边以形成多金属四氮杂卟啉。多金属四氮杂卟啉化合物可以在外周连接以形成线性，即带状聚合物或二维即片状聚合物。四氮杂卟啉化合物及其衍生的多金属络合物和聚合物可用于或作为磁体材料，分子金属导体，药物，成像剂和染料。

5. 发明申请

US20120041198A1 Process for Preparing 5,7 Diaminopyrazolo [1,5-a] Pyrimidine Compounds 有权
标题翻译：制备5,7二氨基吡唑并[1,5-a]嘧啶化合物的方法
公开(公告)号：US20120041198A1
公开(公告)日：2012-02-16
申请号：US13156969
申请日：2011-06-09
申请人： Dennis C. Liotta , James P. Snyder , Ashutosh S. Jogalekar , Anthony G.M. Barrett , Matthew John Fuchter , Matthew J. Cook , Sebastian H.B. Kroll
发明人： Dennis C. Liotta , James P. Snyder , Ashutosh S. Jogalekar , Anthony G.M. Barrett , Matthew John Fuchter , Matthew J. Cook , Sebastian H.B. Kroll
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Processes for the preparation of certain 5,7-diaminopyrazolo[1,5-α]pyrimidine compounds comprising the reaction of a primary or secondary amine and a protected 5-halo-7-aminopyrazolo[1,5-α]pyrimidine compound in solvent system comprising water and one or more organic solvents, optionally in the presence of an exogenous base.
摘要翻译：制备某些5,7-二氨基吡唑并[1,5-α]嘧啶化合物的方法，包括将伯胺或仲胺与受保护的5-卤代-7-氨基吡唑并[1,5-a]嘧啶化合物在溶剂中的反应系统，其包含水和一种或多种有机溶剂，任选地在外源性碱的存在下。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式