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1. 发明授权

US08116508B2 Dual-mode loudspeaker 有权
标题翻译：双模式扬声器
公开(公告)号：US08116508B2
公开(公告)日：2012-02-14
申请号：US12286117
申请日：2008-09-26
申请人： Liangfeng Leon Xu , Chenguang Cai , Jani K. Nurminen , Xia S. Wang , Antti O. Salo , Koray Ozcan
发明人： Liangfeng Leon Xu , Chenguang Cai , Jani K. Nurminen , Xia S. Wang , Antti O. Salo , Koray Ozcan
IPC分类号： H04R1/00 , H04R9/06 , H04R11/02 , H04R25/00
CPC分类号： B06B1/0644 , H04R1/24 , H04R1/403 , H04R3/12 , H04R17/00 , H04R2201/003 , H04R2201/401 , H04R2203/12 , H04R2205/022 , H04R2217/03 , H04R2499/11
摘要： An apparatus uses a transducer to produce vibration in the ultrasonic frequency range and in the audible frequency range. A membrane or cantilever structure is coupled to the transducer to produce acoustic waves. When the vibration is in the audible frequency range, the membrane structure works like a conventional loudspeaker. When the vibration is in the ultrasonic frequency range, the ultrasonic signal is modulated by audio signal for creating better directivity. The acoustic waves in the ultrasonic frequency range can reproduce directional audible sound due to the nonlinear interaction of ultrasonic waves in air.
摘要翻译：一种装置使用换能器在超声频率范围和可听频率范围内产生振动。膜或悬臂结构耦合到换能器以产生声波。当振动处于可听频率范围时，膜结构类似传统的扬声器。当振动处于超声波频率范围时，超声波信号由音频信号调制，以产生更好的方向性。由于超声波在空气中的非线性相互作用，超声频率范围内的声波可以再现方向性的声音。

2. 发明申请

US20100148092A1 MICROARRAY READER BASED ON EVANESCENT WAVE DETECTION AND METHOD OF READING A MICROARRAY 有权
标题翻译：基于历史波检测的微型读取器和微波读取方法
公开(公告)号：US20100148092A1
公开(公告)日：2010-06-17
申请号：US12522188
申请日：2007-01-17
申请人： Yuan Zheng , Leon Xu , Zhenhong Sun
发明人： Yuan Zheng , Leon Xu , Zhenhong Sun
IPC分类号： G01N21/64 , G21H3/02
CPC分类号： G01N21/6452 , G01N21/648
摘要： A microarray reader (100) comprises a light source (102), beam shaping elements (104) positioned near the light source (102), a moving stage (124) supporting one or more of the light source (102) and beam shaping elements (104), an optical substrate (112) supporting an immobilized microarray, a reaction chamber (116) in contact with the optical substrate (112) and encapsulating buffer solution, a heating/cooling component (118) in contact with the reaction chamber (116), a synchronization circuit, an optical filter (108) and an imaging sensor (106) positioned near the optical filter (108).
摘要翻译：微阵列读取器（100）包括光源（102），位于光源（102）附近的光束成形元件（104），支撑光源（102）中的一个或多个的移动台（124）和光束成形元件（104），支撑固定化微阵列的光学基板（112），与所述光学基板（112）和封装缓冲溶液接触的反应室（116），与所述反应室接触的加热/冷却部件（118） 116），位于滤光器（108）附近的同步电路，滤光器（108）和成像传感器（106）。

3. 发明授权

US07629115B2 Cell-based platform for high throughput screening 有权
标题翻译：基于细胞的高通量筛选平台
公开(公告)号：US07629115B2
公开(公告)日：2009-12-08
申请号：US11129074
申请日：2005-05-13
申请人： Yuandong Gu , Leon Xu , Jicang Zhou
发明人： Yuandong Gu , Leon Xu , Jicang Zhou
IPC分类号： C12Q1/00
CPC分类号： B01L3/5085 , B01L2300/069 , B01L2300/0819 , B01L2300/165
摘要： The present invention relates to an apparatus for testing multiple sample compounds for their biological effect comprising a porous block having substantially planar top and bottom surfaces. The top surface comprises a plurality of cell adhesive regions and cell dis-adhesive regions and the bottom surface provides multiple sites to load the sample compounds. These sites are located opposite from the cell adhesive regions on the top surface of the porous block. In certain embodiments, the invention further comprises at least one dissolvable layer which provides multiple sites to load the sample compounds.
摘要翻译：本发明涉及一种用于测试多种样品化合物的生物效应的装置，包括具有基本平坦的顶表面和底表面的多孔块。顶表面包括多个细胞粘附区域和细胞分离区域，并且底表面提供多个位点以加载样品化合物。这些位置与多孔块的顶表面上的细胞粘合剂区域相对。在某些实施方案中，本发明还包括至少一个可溶性层，其提供多个位点以加载样品化合物。

4. 发明申请

US20080176768A1 HYDROGEL MICROARRAY WITH EMBEDDED METAL NANOPARTICLES 审中-公开
标题翻译：具有嵌入金属纳米颗粒的HYDROGEL MICROARRAY
公开(公告)号：US20080176768A1
公开(公告)日：2008-07-24
申请号：US11626104
申请日：2007-01-23
申请人： Yuan Zheng , Jicang Zhou , Leon Xu
发明人： Yuan Zheng , Jicang Zhou , Leon Xu
IPC分类号： C40B50/18 , C40B40/16
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00502 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , G01N21/6428 , G01N21/648
摘要： A method of creating a metal nanoparticle hydrogel biological array comprises placing a plurality of metal nanoparticles in each of a plurality of wells on a substrate, and placing a biomolecular probe material into the plurality of wells. Hydrogel precursors are placed in each of the plurality of wells; and are polymerized to form hydrogel such that the metal nanoparticles are embedded in the hydrogel.
摘要翻译：制备金属纳米颗粒水凝胶生物阵列的方法包括将多个金属纳米颗粒放置在基底上的多个孔中的每一个中，并将生物分子探针材料放置到多个孔中。将水凝胶前体置于多个孔中的每一个中; 并聚合形成水凝胶，使得金属纳米颗粒嵌入水凝胶中。

5. 发明授权

US06449260B1 Multimedia automatic call distribution system 失效
标题翻译：多媒体自动通话分配系统
公开(公告)号：US06449260B1
公开(公告)日：2002-09-10
申请号：US09071759
申请日：1998-05-01
申请人： Michael Sassin , Markku Korpi , Richard W. Crouch , Leon Xu , Uwe Wrede , Robert W. Stephens
发明人： Michael Sassin , Markku Korpi , Richard W. Crouch , Leon Xu , Uwe Wrede , Robert W. Stephens
IPC分类号： H04Q902
CPC分类号： H04M3/51 , H04M3/5183 , H04M7/006
摘要： An automatic call distribution system utilizes a number of H.323 compatible devices. An automatic call distribution (ACD) server (52) interfaces with a computer telephony interface gateway (54) to route calls to agents or to a music/video server (56). Calls are received by a gateway and supplied to a gatekeeper that determines an IP address of the destination. The ACD server selects the destination in response to the number of agents available. In addition, customer calls can be received via e-mail, facsimile or the Internet. The call distribution system can instruct an agent to return an e-mail or facsimile message or to call a customer if desired. Calls from one H.323 device can be routed to another H.323 device by a third party application by sending a call control message to the device's application program interface that executes the message as if it were generated at the device itself.
摘要翻译：自动呼叫分配系统利用多个H.323兼容设备。自动呼叫分配（ACD）服务器（52）与计算机电话接口网关（54）接口以将呼叫路由到代理或音乐/视频服务器（56）。呼叫由网关接收并提供给确定目的地的IP地址的网守。 ACD服务器根据可用代理程序的数量选择目的地。此外，客户来电可以通过电子邮件，传真或互联网接收。呼叫分配系统可以指示代理返回电子邮件或传真消息，或者如果需要呼叫客户。一个H.323设备的呼叫可以由第三方应用程序通过向设备的应用程序接口发送呼叫控制消息来路由到另一个H.323设备，该接口执行该消息，就好像它是在设备本身生成的。

6. 发明授权

US08741565B2 Oligonucleotide microarray for identification of pathogens 有权
标题翻译：用于鉴定病原体的寡核苷酸微阵列
公开(公告)号：US08741565B2
公开(公告)日：2014-06-03
申请号：US11617563
申请日：2006-12-28
申请人： Yuandong Gu , Leon Xu
发明人： Yuandong Gu , Leon Xu
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/689 , C12Q1/6837 , C12Q1/701 , Y02A50/57
摘要： A method for detecting a target nucleic acid of a pathogen in a test sample, the method comprising preparing a target nucleic acid detecting reagent and contacting the target nucleic acid detecting reagent with an oligonucleotide microarray. A kit for detecting a target nucleic acid of a pathogen in a test sample is also described. The kit comprises at least one primer pair and an oligonucleotide microarray comprising at least one probe.
摘要翻译：一种用于检测测试样品中病原体的靶核酸的方法，所述方法包括制备靶核酸检测试剂并使靶核酸检测试剂与寡核苷酸芯片阵列接触。还描述了用于检测测试样品中病原体的靶核酸的试剂盒。该试剂盒包含至少一个引物对和包含至少一个探针的寡核苷酸微阵列。

7. 发明授权

US08124944B2 Microarray reader based on evanescent wave detection and method of reading a microarray 有权
标题翻译：基于ev逝波检测的微阵列阅读器和读取微阵列的方法
公开(公告)号：US08124944B2
公开(公告)日：2012-02-28
申请号：US12522188
申请日：2007-01-17
申请人： Yuan Zheng , Leon Xu , Zhenhong Sun
发明人： Yuan Zheng , Leon Xu , Zhenhong Sun
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/648
摘要： A microarray reader (100) comprises a light source (102), beam shaping elements (104) positioned near the light source (102), a moving stage (124) supporting one or more of the light source (102) and beam shaping elements (104), an optical substrate (112) supporting an immobilized microarray, a reaction chamber (116) in contact with the optical substrate (112) and encapsulating buffer solution, a heating/cooling component (118) in contact with the reaction chamber (116), a synchronization circuit, an optical filter (108) and an imaging sensor (106) positioned near the optical filter (108).
摘要翻译：微阵列读取器（100）包括光源（102），位于光源（102）附近的光束成形元件（104），支撑光源（102）中的一个或多个的移动台（124）和光束成形元件（104），支撑固定化微阵列的光学基板（112），与所述光学基板（112）和封装缓冲溶液接触的反应室（116），与所述反应室接触的加热/冷却部件（118） 116），位于滤光器（108）附近的同步电路，滤光器（108）和成像传感器（106）。

8. 发明授权

US08063203B2 Compositions and methods of making a photoactive agent 有权
标题翻译：制备光敏剂的组合物和方法
公开(公告)号：US08063203B2
公开(公告)日：2011-11-22
申请号：US12917353
申请日：2010-11-01
申请人： Leon Xu , Alexander J. Pallenberg
发明人： Leon Xu , Alexander J. Pallenberg
IPC分类号： C07D487/22
CPC分类号： C07D491/22
摘要： An improved two stage reaction process for production of mono-L-aspartyl chlorin e6. In a first stage, the activation reaction between chlorin e6 and a carbodiimide produces a previously unknown anhydride in an activation reaction product. This reaction product is purified to remove a significant proportion of the precursors of di-L-aspartyl chlorin e6. The purified activation reaction product contains a higher concentration of the previously unknown anhydride. This purified reaction product is used in a second stage: a coupling reaction of the purified activation reaction product with aspartate. The coupling reaction produces a coupling reaction product that has significantly reduced di-L-aspartyl chlorin e6 concentration. This reduced di-L-aspartyl chlorin e6 concentration facilitates purification of mono-L-aspartyl chlorin e6 from the coupling reaction mixture.
摘要翻译：用于生产单-L-天冬氨酰二氢卟酚e6的改进的两阶段反应方法。在第一阶段，二氢卟酚e6与碳二亚胺之间的活化反应在活化反应产物中产生以前未知的酸酐。将该反应产物纯化以除去相当大比例的二-L-天冬氨酰二氢卟酚e6的前体。纯化的活化反应产物含有较高浓度的先前未知的酸酐。该纯化的反应产物用于第二阶段：纯化的活化反应产物与天冬氨酸的偶联反应。偶联反应产生显着降低二-L-天冬氨酰二氢卟吩e6浓度的偶联反应产物。这种减少的二-L-天冬氨酰二氢卟吩e6浓度有助于从偶联反应混合物中纯化单-L-天冬氨酰二ine素e6。

9. 发明申请

US20100197517A1 REACTION BUFFER FOR MICROARRAY 有权
标题翻译：微波反应缓冲器
公开(公告)号：US20100197517A1
公开(公告)日：2010-08-05
申请号：US12520987
申请日：2006-12-29
申请人： Leon Xu , Zhenhong Sun
发明人： Leon Xu , Zhenhong Sun
IPC分类号： C40B30/04 , C12Q1/68 , C40B50/00
CPC分类号： C12Q1/6837 , C12Q1/686 , C12Q2527/125 , C12Q2531/113 , C12Q2565/501
摘要： Embodiments of the present invention relate to a buffer composition for an integrated nucleic acid amplification and hybridization reaction. The buffer comprise about 50-20 OmM of a salt, about 10-30 mM Tris-HCI, about 2-10M Water soluble magnesium salt, about 0.05-1.5% surfactant, about 0.05-0.15 mg/ml stabilizing protein about 50-300 nM of one or more primers, about 20-15 OuM of one or more dNTPs, about 5-15% glycerine, about 0.5-1.5% formamide and at least about 5 unit/ml polymerase.
摘要翻译：本发明的实施方案涉及用于整合的核酸扩增和杂交反应的缓冲组合物。缓冲液包含约50〜20mM的盐，约10-30mM Tris-HCl，约2-10M水溶性镁盐，约0.05-1.5％表面活性剂，约0.05-0.15mg / ml稳定蛋白约50-300 nM的一种或多种引物，约20-15OuM一种或多种dNTP，约5-15％甘油，约0.5-1.5％甲酰胺和至少约5单位/ ml聚合酶。

10. 发明申请

US20080199861A1 Real-time microarray apparatus and methods related thereto 审中-公开
标题翻译：实时微阵列装置及其相关方法
公开(公告)号：US20080199861A1
公开(公告)日：2008-08-21
申请号：US11706448
申请日：2007-02-15
申请人： Yuandong Gu , Leon Xu
发明人： Yuandong Gu , Leon Xu
IPC分类号： C12Q1/68 , C12M1/00
CPC分类号： B01L7/52 , B01L3/5027 , B01L2200/143 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , B01L2300/18 , B01L2400/0427 , B01L2400/0487 , G01N21/648
摘要： Embodiments of the invention relate to a real-time microarray apparatus comprising an upper substrate, a lower substrate, a buffer positioned between the upper and lower substrate, a microarray positioned on either the upper substrate or the lower substrate, a heater positioned near the microarray, a pump positioned near the buffer and microarray and an imaging sensor positioned near the microarray.
摘要翻译：本发明的实施例涉及一种实时微阵列装置，包括上基板，下基板，位于上基板和下基板之间的缓冲器，位于上基板或下基板上的微阵列，位于微阵列附近的加热器位于缓冲液和微阵列附近的泵和位于微阵列附近的成像传感器。

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