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1. 发明授权

US08080388B2 Stress protein compositions and methods for prevention and treatment of cancer and infectious disease 有权
标题翻译：应激蛋白组合物和预防和治疗癌症和传染病的方法
公开(公告)号：US08080388B2
公开(公告)日：2011-12-20
申请号：US12127499
申请日：2008-05-27
申请人： John R. Subjeck , Robert A. Henderson , Elizabeth A. Repasky , Latif Kazim , Xiang-Yang Wang , Masoud H. Manjili
发明人： John R. Subjeck , Robert A. Henderson , Elizabeth A. Repasky , Latif Kazim , Xiang-Yang Wang , Masoud H. Manjili
IPC分类号： C12N15/09 , C12N5/07 , C12N5/09 , C12N5/10
CPC分类号： A61K38/17 , A61K39/0011 , A61K39/04 , A61K39/385 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/55511 , A61K2039/55522 , A61K2039/6043 , A61K2039/622 , C07K14/47
摘要： Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide of the stress protein complex can be associated with a cancer or an infectious disease. Preferred immunogenic polypeptides include gp100, her2/neu ECD-PD, ICD and M. tuberculosis antigens. The pharmaceutical compositions of the invention can be used for the treatment or prevention of cancer or infectious disease.
摘要翻译：提供了包含应激蛋白复合物和编码相关分子的药物组合物或呈递这样的复合物的细胞。应激蛋白复合物包含与免疫原性多肽复合的hsp110或grp170多肽。应激蛋白复合物的免疫原性多肽可能与癌症或感染性疾病相关。优选的免疫原性多肽包括gp100，her2 / neu ECD-PD，ICD和结核分枝杆菌抗原。本发明的药物组合物可用于治疗或预防癌症或感染性疾病。

2. 发明申请

US20050202035A1 Stress protein compositions and methods for prevention and treatment of cancer and infectious disease 有权
标题翻译：应激蛋白组合物和预防和治疗癌症和传染病的方法
公开(公告)号：US20050202035A1
公开(公告)日：2005-09-15
申请号：US11103222
申请日：2005-04-11
申请人： John Subjeck , Robert Henderson , Elizabeth Repasky , Latif Kazim , Xiang-Yang Wang
发明人： John Subjeck , Robert Henderson , Elizabeth Repasky , Latif Kazim , Xiang-Yang Wang
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/04 , A61K39/385 , A61K48/00 , A61P31/06 , A61P35/00 , C07K14/195 , C07K14/47 , C07K14/82 , C07K19/00 , C12N5/06 , C12N5/10
CPC分类号： A61K38/17 , A61K39/0011 , A61K39/04 , A61K39/385 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/55511 , A61K2039/55522 , A61K2039/6043 , A61K2039/622 , C07K14/47
摘要： Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide of the stress protein complex can be associated with a cancer or an infectious disease. The pharmaceutical compositions of the invention can be administered to a subject, thereby providing methods for inhibiting M. tuberculosis-infection, for inhibiting tumor growth, for inhibiting the development of a cancer, and for the treatment or prevention of infectious disease. The invention further provides a method for producing T cells directed against a tumor cell or a M. tuberculosis-infected cell, wherein a T cell is contacted with an APC that is modified to present an hsp110 or grp170 polypeptide and an immunogenic polypeptide associated with a tumor or with the M. tuberculosis-infected cell. Included in the invention are T cells produced by this method and a pharmaceutical composition comprising such T cells. The T cells can be contacted with a M. tuberculosis-infected cell in a method for killing a M. tuberculosis-infected cell, or with a tumor cell in a method for killing a tumor cell.
摘要翻译：提供了包含应激蛋白复合物和编码相关分子的药物组合物或呈递这样的复合物的细胞。应激蛋白复合物包含与免疫原性多肽复合的hsp110或grp170多肽。应激蛋白复合物的免疫原性多肽可能与癌症或感染性疾病相关。本发明的药物组合物可以施用于受试者，从而提供抑制结核分枝杆菌感染，抑制肿瘤生长，抑制癌发展以及治疗或预防感染性疾病的方法。本发明还提供了一种用于产生针对肿瘤细胞或结核分枝杆菌感染的细胞的T细胞的方法，其中T细胞与被修饰以呈递hsp110或grp170多肽的APC和与肿瘤或结核分枝杆菌感染细胞。本发明中包括通过该方法生产的T细胞和包含这种T细胞的药物组合物。在用于杀死结核分枝杆菌感染的细胞或用杀死肿瘤细胞的方法中的肿瘤细胞的方法中，T细胞可以与结核分枝杆菌感染的细胞接触。

3. 发明授权

US07976846B2 Stress protein compositions and methods for prevention and treatment of cancer and infectious disease 有权
标题翻译：应激蛋白组合物和预防和治疗癌症和传染病的方法
公开(公告)号：US07976846B2
公开(公告)日：2011-07-12
申请号：US11103222
申请日：2005-04-11
申请人： John R. Subjeck , Robert A. Henderson , Elizabeth A. Repasky , Latif Kazim , Xiang-Yang Wang
发明人： John R. Subjeck , Robert A. Henderson , Elizabeth A. Repasky , Latif Kazim , Xiang-Yang Wang
IPC分类号： A61K39/00 , A61K39/02 , A61K39/04 , A61K39/12
CPC分类号： A61K38/17 , A61K39/0011 , A61K39/04 , A61K39/385 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/55511 , A61K2039/55522 , A61K2039/6043 , A61K2039/622 , C07K14/47
摘要： Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide of the stress protein complex can be associated with a cancer or an infectious disease. The pharmaceutical compositions of the invention can be administered to a subject, thereby providing methods for inhibiting M. tuberculosis-infection, for inhibiting tumor growth, for inhibiting the development of a cancer, and for the treatment or prevention of infectious disease. The invention further provides a method for producing T cells directed against a tumor cell or a M. tuberculosis-infected cell, wherein a T cell is contacted with an APC that is modified to present an hsp110 or grp170 polypeptide and an immunogenic polypeptide associated with a tumor or with the M. tuberculosis-infected cell. Included in the invention are T cells produced by this method and a pharmaceutical composition comprising such T cells. The T cells can be contacted with a M. tuberculosis-infected cell in a method for killing a M. tuberculosis-infected cell, or with a tumor cell in a method for killing a tumor cell.
摘要翻译：提供了包含应激蛋白复合物和编码相关分子的药物组合物或呈递这样的复合物的细胞。应激蛋白复合物包含与免疫原性多肽复合的hsp110或grp170多肽。应激蛋白复合物的免疫原性多肽可能与癌症或感染性疾病相关。本发明的药物组合物可以施用于受试者，从而提供抑制结核分枝杆菌感染，抑制肿瘤生长，抑制癌发展以及治疗或预防感染性疾病的方法。本发明还提供了一种用于产生针对肿瘤细胞或结核分枝杆菌感染的细胞的T细胞的方法，其中T细胞与被修饰以呈递hsp110或grp170多肽的APC和与肿瘤或结核分枝杆菌感染细胞。本发明中包括通过该方法生产的T细胞和包含这种T细胞的药物组合物。在用于杀死结核分枝杆菌感染的细胞或用杀死肿瘤细胞的方法中的肿瘤细胞的方法中，T细胞可以与结核分枝杆菌感染的细胞接触。

4. 发明申请

US20080293103A1 STRESS PROTEIN COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF CANCER AND INFECTIOUS DISEASE 有权
标题翻译：应激蛋白组合物和预防和治疗癌症和感染性疾病的方法
公开(公告)号：US20080293103A1
公开(公告)日：2008-11-27
申请号：US12127499
申请日：2008-05-27
申请人： John R. Subjeck , Robert A. Henderson , Elizabeth A. Repasky , Latif Kazim , Xiang-Yang Wang , Masoud H. Manjili
发明人： John R. Subjeck , Robert A. Henderson , Elizabeth A. Repasky , Latif Kazim , Xiang-Yang Wang , Masoud H. Manjili
IPC分类号： C12P21/04 , C12N1/20 , C12N5/06
CPC分类号： A61K38/17 , A61K39/0011 , A61K39/04 , A61K39/385 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/55511 , A61K2039/55522 , A61K2039/6043 , A61K2039/622 , C07K14/47
摘要： Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide of the stress protein complex can be associated with a cancer or an infectious disease. Preferred immunogenic polypeptides include gp100, her2/neu ECD-PD, ICD and M. tuberculosis antigens. The pharmaceutical compositions of the invention can be used for the treatment or prevention of cancer or infectious disease.
摘要翻译：提供了包含应激蛋白复合物和编码相关分子的药物组合物或呈递这样的复合物的细胞。应激蛋白复合物包含与免疫原性多肽复合的hsp110或grp170多肽。应激蛋白复合物的免疫原性多肽可能与癌症或感染性疾病相关。优选的免疫原性多肽包括gp100，her2 / neu ECD-PD，ICD和结核分枝杆菌抗原。本发明的药物组合物可用于治疗或预防癌症或感染性疾病。

5. 发明授权

US07378096B2 Stress protein compositions and methods for prevention and treatment of cancer and infectious disease 有权
标题翻译：应激蛋白组合物和预防和治疗癌症和传染病的方法
公开(公告)号：US07378096B2
公开(公告)日：2008-05-27
申请号：US10161028
申请日：2002-06-03
申请人： John R. Subjeck , Robert A. Henderson , Elizabeth A. Repasky , Latif Kazim , Xiang-Yang Wang , Masoud H. Manjili
发明人： John R. Subjeck , Robert A. Henderson , Elizabeth A. Repasky , Latif Kazim , Xiang-Yang Wang , Masoud H. Manjili
IPC分类号： A61K39/00 , A61K47/42 , A61K46/42
CPC分类号： A61K38/17 , A61K39/0011 , A61K39/04 , A61K39/385 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/55511 , A61K2039/55522 , A61K2039/6043 , A61K2039/622 , C07K14/47
摘要： Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide of the stress protein complex can be associated with a cancer or an infectious disease. Preferred immunogenic polypeptides include gp100, her2/neu ECD-PD, ICD and M. tuberculosis antigens. The pharmaceutical compositions of the invention can be used for the treatment or prevention of cancer or infectious disease.
摘要翻译：提供了包含应激蛋白复合物和编码相关分子的药物组合物或呈递这样的复合物的细胞。应激蛋白复合物包含与免疫原性多肽复合的hsp110或grp170多肽。应激蛋白复合物的免疫原性多肽可能与癌症或感染性疾病相关。优选的免疫原性多肽包括gp100，her2 / neu ECD-PD，ICD和结核分枝杆菌抗原。本发明的药物组合物可用于治疗或预防癌症或感染性疾病。

6. 发明授权

US06984384B1 Stress protein compositions and methods for prevention and treatment of cancer and infectious disease 有权
标题翻译：应激蛋白组合物和预防和治疗癌症和传染病的方法
公开(公告)号：US06984384B1
公开(公告)日：2006-01-10
申请号：US09676340
申请日：2000-09-29
申请人： John R. Subjeck , Robert A. Henderson , Elizabeth A. Repasky , Latif Kazim , Xiang-Yang Wang
发明人： John R. Subjeck , Robert A. Henderson , Elizabeth A. Repasky , Latif Kazim , Xiang-Yang Wang
IPC分类号： A61K39/00 , A61K47/42
CPC分类号： A61K38/17 , A61K39/0011 , A61K39/04 , A61K39/385 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/55511 , A61K2039/55522 , A61K2039/6043 , A61K2039/622 , C07K14/47
摘要： Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide of the stress protein complex can be associated with a cancer or an infectious disease. The pharmaceutical compositions of the invention can be administered to a subject, thereby providing methods for inhibiting M. tuberculosis-infection, for inhibiting tumor growth, for inhibiting the development of a cancer, and for the treatment or prevention of infectious disease. The invention further provides a method for producing T cells directed against a tumor cell or a M. tuberculosis-infected cell, wherein a T cell is contacted with an APC that is modified to present an hsp110 or grp170 polypeptide and an immunogenic polypeptide associated with a tumor or with the M. tuberculosis-infected cell. Included in the invention are T cells produced by this method and a pharmaceutical composition comprising such T cells. The T cells can be contacted with a M. tuberculosis-infected cell in a method for killing a M. tuberculosis-infected cell, or with a tumor cell in a method for killing a tumor cell.
摘要翻译：提供了包含应激蛋白复合物和编码相关分子的药物组合物或呈递这样的复合物的细胞。应激蛋白复合物包含与免疫原性多肽复合的hsp110或grp170多肽。应激蛋白复合物的免疫原性多肽可能与癌症或感染性疾病相关。本发明的药物组合物可以施用于受试者，从而提供抑制结核分枝杆菌感染，抑制肿瘤生长，抑制癌发展以及治疗或预防感染性疾病的方法。本发明还提供了一种用于产生针对肿瘤细胞或结核分枝杆菌感染的细胞的T细胞的方法，其中T细胞与被修饰以呈递hsp110或grp170多肽的APC和与肿瘤或结核分枝杆菌感染细胞。本发明中包括通过该方法生产的T细胞和包含这种T细胞的药物组合物。在用于杀死结核分枝杆菌感染的细胞或用杀死肿瘤细胞的方法中的肿瘤细胞的方法中，T细胞可以与结核分枝杆菌感染的细胞接触。

7. 发明申请

US20080103095A1 STRESS PROTEIN COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF CANCER AND INFECTIOUS DISEASE 有权
公开(公告)号：US20080103095A1
公开(公告)日：2008-05-01
申请号：US10161028
申请日：2002-06-03
申请人： John R. Subjeck , Robert A. Henderson , Elizabeth A. Repasky , Latif Kazim , Xiang-Yang Wang , Masoud H. Manjili
发明人： John R. Subjeck , Robert A. Henderson , Elizabeth A. Repasky , Latif Kazim , Xiang-Yang Wang , Masoud H. Manjili
IPC分类号： A61K38/17 , A61K48/00 , C12N5/08
CPC分类号： A61K38/17 , A61K39/0011 , A61K39/04 , A61K39/385 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/55511 , A61K2039/55522 , A61K2039/6043 , A61K2039/622 , C07K14/47
摘要： Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide of the stress protein complex can be associated with a cancer or an infectious disease. Preferred immunogenic polypeptides include gp100, her2/neu ECD-PD, ICD and M. tuberculosis antigens. The pharmaceutical compositions of the invention can be used for the treatment or prevention of cancer or infectious disease.

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