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1. 发明授权

US07378096B2 Stress protein compositions and methods for prevention and treatment of cancer and infectious disease 有权
标题翻译：应激蛋白组合物和预防和治疗癌症和传染病的方法
公开(公告)号：US07378096B2
公开(公告)日：2008-05-27
申请号：US10161028
申请日：2002-06-03
申请人： John R. Subjeck , Robert A. Henderson , Elizabeth A. Repasky , Latif Kazim , Xiang-Yang Wang , Masoud H. Manjili
发明人： John R. Subjeck , Robert A. Henderson , Elizabeth A. Repasky , Latif Kazim , Xiang-Yang Wang , Masoud H. Manjili
IPC分类号： A61K39/00 , A61K47/42 , A61K46/42
CPC分类号： A61K38/17 , A61K39/0011 , A61K39/04 , A61K39/385 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/55511 , A61K2039/55522 , A61K2039/6043 , A61K2039/622 , C07K14/47
摘要： Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide of the stress protein complex can be associated with a cancer or an infectious disease. Preferred immunogenic polypeptides include gp100, her2/neu ECD-PD, ICD and M. tuberculosis antigens. The pharmaceutical compositions of the invention can be used for the treatment or prevention of cancer or infectious disease.
摘要翻译：提供了包含应激蛋白复合物和编码相关分子的药物组合物或呈递这样的复合物的细胞。应激蛋白复合物包含与免疫原性多肽复合的hsp110或grp170多肽。应激蛋白复合物的免疫原性多肽可能与癌症或感染性疾病相关。优选的免疫原性多肽包括gp100，her2 / neu ECD-PD，ICD和结核分枝杆菌抗原。本发明的药物组合物可用于治疗或预防癌症或感染性疾病。

2. 发明授权

US07198782B2 Method for the treatment of diabetes 失效
标题翻译：治疗糖尿病的方法
公开(公告)号：US07198782B2
公开(公告)日：2007-04-03
申请号：US10397507
申请日：2003-03-26
申请人： Kenji Sakamoto
发明人： Kenji Sakamoto
IPC分类号： A61K46/42 , A61K38/04 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08
摘要： A method for efficiently searching novel physiologically active substances under a certain predictability. This searching method comprises, among receptors of cells producing an antagonist to a substance in vivo or receptors of cells producing an antagonist to the cells per se, finding a receptor having amino acid sequences of two or more sizes by comparing the cDNA sequences of the receptor, and then examining which region in the longer receptor is missed in the shorter receptor by comparing the above cDNA sequences. By using this method, remedies for diabetes comprising a peptide having the amino acid sequence represented by SEQ ID NO:1 or 5, insulin production regulators comprising a peptide having the amino acid sequence represented by SEQ ID NO:2, and gastric secretion inhibitors comprising a peptide having the amino acid sequence represented by SEQ ID NO:3 or 4 are provided.
摘要翻译：一种以某种可预测性有效地搜索新的生理活性物质的方法。该搜索方法包括在体内产生拮抗剂的细胞的受体或产生细胞本身的拮抗剂的细胞的受体之间，通过比较受体的cDNA序列，找到具有两个或更多个大小的氨基酸序列的受体，然后通过比较上述cDNA序列检查较长受体中哪个区域在较短的受体中错过。通过使用该方法，包括具有SEQ ID NO：1或5所示的氨基酸序列的肽的糖尿病治疗剂，包含具有SEQ ID NO：2所示的氨基酸序列的肽的胰岛素生成调节剂，以及含有提供具有由SEQ ID NO：3或4表示的氨基酸序列的肽。

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