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1. 发明授权

US07368252B2 Agglutination accelerator for immunological measurement 有权
标题翻译：用于免疫测定的凝集促进剂
公开(公告)号：US07368252B2
公开(公告)日：2008-05-06
申请号：US10626502
申请日：2003-07-23
申请人： Kyoichi Sumida , Koji Wada , Kazuhiko Ishihara
发明人： Kyoichi Sumida , Koji Wada , Kazuhiko Ishihara
IPC分类号： G01N33/567
CPC分类号： G01N33/6842 , C08F30/02 , G01N33/57434 , G01N33/68
摘要： An object of the present invention is to provide an immunoassay of PSA using an agglutination accelerator, which has an agglutination accelerating effect equal to or stronger than the known agglutination accelerator; hardly generates non-specific turbidity; and hardly generates salting out even in a solution with a high salt concentration. The present invention relates to an immunoassay of a prostate-specific antigen comprising performing an antigen-antibody reaction in the presence of a polymer having a monomer unit derived from a monomer represented by the following general formula [2]: (wherein R1-R3 are each independently a hydrogen atom or an alkyl group optionally having a hydroxyl group; R4 is an alkylene group; R5 is an alkylene group optionally having a substituent and optionally having an oxygen atom in a chain; R6 is a hydrogen atom or a methyl group, and X is an oxygen atom or a —NH— group), and a kit of reagent for an immunoassay comprising a reagent containing an agglutination accelerator for the immunoassay.
摘要翻译：本发明的目的是提供使用凝集促进剂的PSA的免疫测定法，凝集促进剂的凝集促进效果等于或大于已知的凝集促进剂; 几乎不产生非特异性浊度; 即使在盐浓度高的溶液中也难以产生盐析。本发明涉及前列腺特异性抗原的免疫测定法，包括在具有来源于下述通式[2]表示的单体的单体单元的聚合物存在下进行抗原抗体反应：（其中R < 1〜3个O 3各自独立地为氢原子或任选具有羟基的烷基; R 4为亚烷基; R 5为任选具有取代基且任选在链中具有氧原子的亚烷基; R 6是氢原子或甲基，X是氧原子或-NH - 组）和用于免疫测定的试剂盒，其包含含有用于免疫测定的凝集促进剂的试剂。

2. 发明申请

US20050069967A1 Reagent for an immunoassay 失效
标题翻译：免疫测定试剂
公开(公告)号：US20050069967A1
公开(公告)日：2005-03-31
申请号：US10867912
申请日：2004-06-15
申请人： Kyoichi Sumida , Minoru Fujita , Hiromichi Adachi
发明人： Kyoichi Sumida , Minoru Fujita , Hiromichi Adachi
IPC分类号： G01N33/543 , G01N33/577 , G01N33/53
CPC分类号： G01N33/54313
摘要： The present invention relates to (1) A reagent for an immunoassay of a target substance existing in a free form and a bound form in a specimen, comprising a latex 1 which is immobilized with a monoclonal antibody 1 for the target substance, and a latex 2 which has a different mean particle size from the latex 1 and is immobilized with a monoclonal antibody 2 having a different recognition site for the target substance from the antibody 1, (2) An immunoassay method comprising reacting the target substance with the reagent of (1) and determining an amount of the substance based on the result of an agglutination reaction among the target substance, the latex1 and the latex2, and (3) A reagent kit comprising a reagent of (1) and a reagent containing an agglutination accelerator for an antigen-antibody reaction.
摘要翻译：本发明涉及（1）一种试样中游离形式和结合形式存在的目标物质的免疫测定试剂，其特征在于，包含用目标物质单克隆抗体1固定的胶乳1和胶乳 2，其具有与胶乳1不同的平均粒度，并且用来自抗体1的靶物质具有不同识别位点的单克隆抗体2固定化。（2）一种免疫测定方法，包括使目标物质与（ 1），并且基于目标物质，胶乳1和胶乳2之间的凝集反应结果确定物质的量，和（3）包含试剂（1）的试剂盒和含有凝集促进剂的试剂抗原 - 抗体反应。

3. 发明申请

US20100129937A1 METHOD FOR MEASURING HYALURONIC ACID USING HYALURONIC ACID BINDING PROTEIN 审中-公开
标题翻译：用羟丙酸结合蛋白测定羟丙酸的方法
公开(公告)号：US20100129937A1
公开(公告)日：2010-05-27
申请号：US12578576
申请日：2009-10-13
申请人： KYOICHI SUMIDA , KAZUNARI FUJIO , SHINZO KOBATAKE
发明人： KYOICHI SUMIDA , KAZUNARI FUJIO , SHINZO KOBATAKE
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , G01N21/82 , G01N2400/40
摘要： An object of the present invention is to provide a method utilizing a carrier for measuring hyaluronic acid wherein deposition of carrier is less, a storage stability is good and an accuracy in measurement has same high degree as that performed by the conventional reagents, and a reagent kit for the same. Also, the present invention relates to “a method for measuring hyaluronic acid, comprising forming a hyaluronic acid/HABP complex by contacting hyaluronic acid in a sample with HABP, reacting said complex with an anti-HABP antibody-supported carrier, measuring optical change by agglutination product generated by said reaction and calculating the quantity of hyaluronic acid from the measured value” and “a reagent kit for the measurement of hyaluronic acid comprising a reagent comprising a hyaluronic acid binding protein and a reagent comprising an anti-hyaluronic acid binding protein antibody-supported carrier”.
摘要翻译：本发明的目的是提供一种利用载体测量透明质酸的方法，其中载体沉积少，储存稳定性好，测量精度与常规试剂相同程度高，试剂套件相同。另外，本发明涉及“透明质酸测定方法，其包括通过使样品中的透明质酸与HABP接触而形成透明质酸/ HABP复合物，使所述配合物与抗HABP抗体负载的载体反应，通过由所述反应产生的凝集产物和从测量值计算透明质酸的量“和”用于测量透明质酸的试剂盒，其包含透明质酸结合蛋白的试剂和包含抗透明质酸结合蛋白抗体的试剂支持的运营商“。

4. 发明申请

US20070259380A1 Method for Measuring Hyaluronic Acid Using Hyaluronic Acid Binding Protein 审中-公开
标题翻译：透明质酸结合蛋白测定透明质酸的方法
公开(公告)号：US20070259380A1
公开(公告)日：2007-11-08
申请号：US11597191
申请日：2005-05-10
申请人： Kyoichi Sumida , Kazunari Fujio , Shinzo Kobatake
发明人： Kyoichi Sumida , Kazunari Fujio , Shinzo Kobatake
IPC分类号： G01N33/53
CPC分类号： G01N33/543 , G01N21/82 , G01N2400/40
摘要： An object of the present invention is to provide a method utilizing a carrier for measuring hyaluronic acid wherein deposition of carrier is less, a storage stability is good and an accuracy in measurement has same high degree as that performed by the conventional reagents, and a reagent kit for the same. Also, the present invention relates to “a method for measuring hyaluronic acid, comprising forming a hyaluronic acid/HABP complex by contacting hyaluronic acid in a sample with HABP, reacting said complex with an anti-HABP antibody-supported carrier, measuring optical change by agglutination product generated by said reaction and calculating the quantity of hyaluronic acid from the measured value” and “a reagent kit for the measurement of hyaluronic acid comprising a reagent comprising a hyaluronic acid binding protein and a reagent comprising an anti-hyaluronic acid binding protein antibody-supported carrier”.
摘要翻译：本发明的目的是提供一种利用载体测量透明质酸的方法，其中载体沉积少，储存稳定性好，测量精度与常规试剂相同程度高，试剂套件相同。另外，本发明涉及“透明质酸测定方法，其包括通过使样品中的透明质酸与HABP接触而形成透明质酸/ HABP复合物，使所述配合物与抗HABP抗体负载的载体反应，通过由所述反应产生的凝集产物和从测量值计算透明质酸的量“和”用于测量透明质酸的试剂盒，其包含透明质酸结合蛋白的试剂和包含抗透明质酸结合蛋白抗体的试剂支持的运营商“。

5. 发明授权

US07279339B2 Reagent for an immunoassay 失效
标题翻译：免疫测定试剂
公开(公告)号：US07279339B2
公开(公告)日：2007-10-09
申请号：US10867912
申请日：2004-06-15
申请人： Kyoichi Sumida , Minoru Fujita , Hiromichi Adachi
发明人： Kyoichi Sumida , Minoru Fujita , Hiromichi Adachi
IPC分类号： G01N33/543
CPC分类号： G01N33/54313
摘要： The present invention relates to (1) A reagent for an immunoassay of a target substance existing in a free form and a bound form in a specimen, comprising a latex 1 which is immobilized with a monoclonal antibody 1 for the target substance, and a latex 2 which has a different mean particle size from the latex 1 and is immobilized with a monoclonal antibody 2 having a different recognition site for the target substance from the antibody 1, (2) An immunoassay method comprising reacting the target substance with the reagent of (1) and determining an amount of the substance based on the result of an agglutination reaction among the target substance, the latex1 and the latex2, and (3) A reagent kit comprising a reagent of (1) and a reagent containing an agglutination accelerator for an antigen-antibody reaction.
摘要翻译：本发明涉及（1）一种试样中游离形式和结合形式存在的目标物质的免疫测定试剂，其特征在于，包含用目标物质单克隆抗体1固定的胶乳1和胶乳 2，其具有与胶乳1不同的平均粒度，并且用来自抗体1的靶物质具有不同识别位点的单克隆抗体2固定化。（2）一种免疫测定方法，包括使目标物质与（ 1），并且基于目标物质，胶乳1和胶乳2之间的凝集反应结果确定物质的量，和（3）包含试剂（1）的试剂盒和含有凝集促进剂的试剂抗原 - 抗体反应。

6. 发明申请

US20060172351A1 Reagent for an immunoassay 审中-公开
标题翻译：免疫测定试剂
公开(公告)号：US20060172351A1
公开(公告)日：2006-08-03
申请号：US11394463
申请日：2006-03-30
申请人： Kyoichi Sumida , Minoru Fujita , Hiromichi Adachi
发明人： Kyoichi Sumida , Minoru Fujita , Hiromichi Adachi
IPC分类号： G01N33/574
CPC分类号： G01N33/54313
摘要： The present invention relates to (1) A reagent for an immunoassay of a target substance existing in a free form and a bound form in a specimen, comprising a latex 1 which is immobilized with a monoclonal antibody 1 for the target substance, and a latex 2 which has a different mean particle size from the latex 1 and is immobilized with a monoclonal antibody 2 having a different recognition site for the target substance from the antibody 1, (2) An immunoassay method comprising reacting the target substance with the reagent of (1) and determining an amount of the substance based on the result of an agglutination reaction among the target substance, the latex1 and the latex2, and (3) A reagent kit comprising a reagent of (1) and a reagent containing an agglutination accelerator for an antigen-antibody reaction.
摘要翻译：本发明涉及（1）一种试样中游离形式和结合形式存在的目标物质的免疫测定试剂，其特征在于，包含用目标物质单克隆抗体1固定的胶乳1和胶乳 2，其具有与胶乳1不同的平均粒度，并且用来自抗体1的靶物质具有不同识别位点的单克隆抗体2固定化。（2）一种免疫测定方法，包括使目标物质与（ 1），基于目标物质，胶乳1和胶乳2之间的凝集反应结果确定物质的量，（3）包含试剂（1）的试剂盒和含有凝集物的试剂促进剂用于抗原 - 抗体反应。

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