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1. 发明申请

US20130273519A1 COMPOSITION FOR TREATING BLOOD AND SET OF DIAGNOSTIC KIT COMPRISING THE SAME TO DETECT AUTOIMMUNE DISEASE 审中-公开
标题翻译：用于治疗血液的组合物和包含该组合物的诊断试剂盒用于检测自身免疫疾病
公开(公告)号：US20130273519A1
公开(公告)日：2013-10-17
申请号：US13669187
申请日：2012-11-05
申请人： In Chan Youn , Kwang Meyung Kim , Kui Won Choi , Ick Chan Kwon , Jun Uk Chu , Jong Woong Park , Soo Young Yoon , Sung Jae Choi , Ae Ju Lee , Young Mo Kang
发明人： In Chan Youn , Kwang Meyung Kim , Kui Won Choi , Ick Chan Kwon , Jun Uk Chu , Jong Woong Park , Soo Young Yoon , Sung Jae Choi , Ae Ju Lee , Young Mo Kang
IPC分类号： C12Q1/37 , C12N5/078
CPC分类号： C12Q1/37 , C12N5/0634 , G01N2333/96494 , G01N2800/102
摘要： The present invention relates to a composition for treating blood, a set of a diagnostic kit comprising the same to detect an autoimmune disease, and a method of monitoring an autoimmune disease using the same.An autoimmune disease such as rheumatoid arthritis can be early diagnosed, and disease progression and a treatment response can be precisely predicted, using a technique of amplifying enzyme by stimulating blood obtained from patient.
摘要翻译：本发明涉及一种用于治疗血液的组合物，一套包含该组合物以检测自身免疫疾病的诊断试剂盒，以及使用该组合物监测自身免疫疾病的方法。可以早期诊断自身免疫性疾病，例如类风湿性关节炎，并且可以使用通过刺激从患者获得的血液来扩增酶的技术来精确预测疾病进展和治疗反应。

2. 发明授权

US08530047B2 Method for polymerizing a small oligonucleotide, and use of a high-molecular oligonucleotide prepared by the polymerization method 有权
标题翻译：聚合小寡核苷酸的方法，以及使用通过聚合法制备的高分子寡核苷酸
公开(公告)号：US08530047B2
公开(公告)日：2013-09-10
申请号：US13142876
申请日：2010-03-02
申请人： KwangMeyung Kim , Ick Chan Kwon , Kui Won Choi , Seung Young Lee , In Chan Youn , Myung Sook Huh , So Jin Lee
发明人： KwangMeyung Kim , Ick Chan Kwon , Kui Won Choi , Seung Young Lee , In Chan Youn , Myung Sook Huh , So Jin Lee
IPC分类号： B32B5/16
CPC分类号： C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/51 , C12N2320/32 , C12N2320/51
摘要： The oligonucleotide polymerization method of the present invention is advantageous in that an oligonucleotide with a small molecular weight can be easily polymerized into high-molecular weight oligonucleotides. Further, the high-molecular oligonucleotide prepared by the method of the present invention can bind to hydrophilic high-molecular materials or inorganic materials, and then can be stably delivered to a living body. Therefore, the high-molecular oligonucleotide prepared by the method of the present invention can be widely used for treating various diseases.
摘要翻译：本发明的寡聚体聚合方法的优点在于，可以容易地将分子量小的寡核苷酸聚合成高分子量寡核苷酸。此外，通过本发明的方法制备的高分子量寡核苷酸可以结合亲水性高分子材料或无机材料，然后可以稳定地递送到生物体。因此，通过本发明的方法制备的高分子寡核苷酸可广泛用于治疗各种疾病。

3. 发明申请

US20130150287A1 RECOMBINANT PROTEIN FOR INTRACELLULAR DELIVERY OF siRNA AND COMPOSITION COMPRISING THE SAME 有权
标题翻译：用于细胞内递送siRNA的重组蛋白和包含其的组合物
公开(公告)号：US20130150287A1
公开(公告)日：2013-06-13
申请号：US13313580
申请日：2011-12-07
申请人： Hyung-Jun AHN , Ick-Chan Kwon , Kui-Won Choi
发明人： Hyung-Jun AHN , Ick-Chan Kwon , Kui-Won Choi
IPC分类号： A61K47/48 , A61P25/28 , A61P27/02 , A61P31/12 , C07K19/00 , A61P35/00
CPC分类号： C12N15/87 , A61K9/5184 , A61K47/62 , A61K47/6901 , C07K2319/00 , C07K2319/85
摘要： The present invention relates to a recombinant protein for siRNA delivery, which allows the efficient intracellular and in vivo delivery of siRNA. More particularly, the present invention relates to a recombinant protein that allows a siRNA binding protein to be located in the interior cavity of a capsid protein of HBV (Hepatitis B virus), in which siRNAs of interest bind to the siRNA binding protein to be encapsulated within the capsid shell, thereby providing stability against the external attack such as nucleases and achieving the efficient intracellular and in vivo delivery of siRNA by its release into the cytosolic space after cell uptake.
摘要翻译：本发明涉及用于siRNA递送的重组蛋白，其允许siRNA的有效的细胞内和体内递送。更具体地，本发明涉及允许siRNA结合蛋白位于HBV（乙型肝炎病毒）的衣壳蛋白的内腔中的重组蛋白，其中感兴趣的siRNA与要结合的siRNA结合蛋白结合在壳壳内，从而提供对外部攻击（例如核酸酶）的稳定性，并且通过在细胞摄取后释放到细胞溶质空间中实现siRNA的有效的细胞内和体内递送。

4. 发明申请

US20120253423A1 Artificial Nerve Networking System and Method for Functional Recovery of Damaged Nerve 有权
标题翻译：人工神经网络系统和损伤神经功能恢复方法
公开(公告)号：US20120253423A1
公开(公告)日：2012-10-04
申请号：US13166250
申请日：2011-06-22
申请人： In Chan Youn , Kui Won Choi , Jun-Kyo Francis Suh , Ji Yoon Kang , Jin Seok Kim , Jun Uk Chu , Ick Chan Kwon , Kwang Meyung Kim
发明人： In Chan Youn , Kui Won Choi , Jun-Kyo Francis Suh , Ji Yoon Kang , Jin Seok Kim , Jun Uk Chu , Ick Chan Kwon , Kwang Meyung Kim
IPC分类号： A61N1/00 , A61B17/00
CPC分类号： A61N1/36103 , A61N1/0551 , A61N1/0556 , A61N1/36057 , A61N1/36139 , A61N1/37288
摘要： Disclosed are a system and a method for artificial nerve networking capable of restoring a damaged nerve and allowing selective detection, analysis, transmission and stimulation of a signal from the damaged nerve. The artificial nerve networking system according to an embodiment of the present disclosure includes: a first nerve conduit connected at one end of a damaged nerve; a second nerve conduit connected at the other end of the damaged nerve; and an artificial nerve networking unit electrically connected to the first nerve conduit and the second nerve conduit and recovering the function of the damaged nerve by transmitting and receiving a signal to and from the damaged nerve.
摘要翻译：公开了一种用于人造神经网络的系统和方法，其能够恢复受损的神经，并允许选择性地检测，分析，传输和刺激来自受损神经的信号。根据本公开的实施例的人造神经网络系统包括：在受损神经的一端连接的第一神经导管; 在受损神经的另一端连接的第二神经管; 以及人造神经网络单元，电连接到第一神经导管和第二神经导管，并且通过向受损神经传导和接收信号来恢复损伤的神经的功能。

5. 发明申请

US20110274930A1 METHOD FOR POLYMERIZING A SMALL OLIGONUCLEOTIDE, AND USE OF A HIGH-MOLECULAR OLIGONUCLEOTIDE PREPARED BY THE POLYMERIZATION METHOD 有权
标题翻译：用于聚合低聚核苷酸的方法，以及通过聚合方法制备的高分子量寡核苷酸的用途
公开(公告)号：US20110274930A1
公开(公告)日：2011-11-10
申请号：US13142876
申请日：2010-03-02
申请人： KwangMeyung Kim , Iek Chan Kwon , Kui Won Choi , Seung Young Lee , In Chan Youn , Myung Sook Huh , So Jin Lee
发明人： KwangMeyung Kim , Iek Chan Kwon , Kui Won Choi , Seung Young Lee , In Chan Youn , Myung Sook Huh , So Jin Lee
IPC分类号： C07H21/02 , B32B5/16 , C08G73/04
CPC分类号： C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/51 , C12N2320/32 , C12N2320/51
摘要： The present invention relates to a high-molecular weight oligonucleotides polymerization method which increases in vivo stability, and to the use of a high-molecular weight oligonucleotides prepared by the polymerization method.The oligonucleotide polymerization method of the present invention is advantageous in that an oligonucleotide with a small molecular weight can be easily polymerized into high-molecular weight oligonucleotides. Further, the high-molecular oligonucleotide prepared by the method of the present invention can bind to hydrophilic high-molecular materials or inorganic materials, and then can be stably delivered to a living body. Therefore, the high-molecular oligonucleotide prepared by the method of the present invention can be widely used for treating various diseases.
摘要翻译：本发明涉及增加体内稳定性的高分子量寡核苷酸聚合方法以及通过聚合方法制备的高分子量寡核苷酸的用途。本发明的寡聚体聚合方法的优点在于，可以容易地将分子量小的寡核苷酸聚合成高分子量寡核苷酸。此外，通过本发明的方法制备的高分子量寡核苷酸可以结合亲水性高分子材料或无机材料，然后可以稳定地递送到生物体。因此，通过本发明的方法制备的高分子寡核苷酸可广泛用于治疗各种疾病。

6. 发明申请

US20100233085A1 IONIC COMPLEX NANOPARTICLES FOR DETECTING HEPARANASE ACTIVITIES AND METHOD FOR PREPARING THE SAME 有权
标题翻译：用于检测HEPARANASE活性的离子复合纳米颗粒及其制备方法
公开(公告)号：US20100233085A1
公开(公告)日：2010-09-16
申请号：US12472405
申请日：2009-05-27
申请人： Ick-Chan KWON , Kwang-Meyung KIM , Kui-Won CHOI , Kyeong-Soon PARK , Seul-Ki LEE
发明人： Ick-Chan KWON , Kwang-Meyung KIM , Kui-Won CHOI , Kyeong-Soon PARK , Seul-Ki LEE
IPC分类号： A61K49/00 , C12Q1/34
CPC分类号： C12Q1/34 , A61K49/0054 , G01N2333/924
摘要： Disclosed are Ionic complex nanoparticles for detecting heparanase activities and a method for preparing the same. More specifically, disclosed are Ionic complex nanoparticles for detecting heparanase activities, wherein negative-ion substrate polymers specifically degraded by heparanase and positive-ion biocompatible polymers ionically bind to each other, and fluorophores or quenchers bind to each of the polymers. The ionic complex nanoparticles for detecting heparanase activities may be applied to a method for screening novel drugs such as inhibitors that prevent over-expression of heparanase. Various cells and tissues where over-expression of heparanase occurs may be non-invasively imaged in cancer cells, cancer tissues, and tissues of various inflammatory diseases. Accordingly, the ionic complex nanoparticles for detecting heparanase activities may be effectively used to early diagnose various diseases and incurable diseases including autoimmune diseases such as cancers, osteoarthritis, rheumatoid arthritis, and dementia.
摘要翻译：公开了用于检测乙酰肝素酶活性的离子复合纳米粒子及其制备方法。更具体地，公开了用于检测乙酰肝素酶活性的离子复合纳米颗粒，其中由肝素酶和阳离子生物相容性聚合物特异性降解的负离子底物聚合物彼此离子地结合，并且荧光团或猝灭剂与每种聚合物结合。用于检测乙酰肝素酶活性的离子络合物纳米颗粒可以应用于筛选新型药物的方法，例如防止肝素酶过度表达的抑制剂。发生肝素酶过度表达的各种细胞和组织可能在癌细胞，癌组织和各种炎性疾病的组织中非侵入性成像。因此，用于检测乙酰肝素酶活性的离子络合物纳米颗粒可以有效地用于早期诊断各种疾病和不治之症，包括自身免疫疾病如癌症，骨关节炎，类风湿性关节炎和痴呆。

7. 发明申请

US20100184955A1 ANTICANCER PRODRUG SENSITIVE TO TARGET PROTEASE 审中-公开
公开(公告)号：US20100184955A1
公开(公告)日：2010-07-22
申请号：US12355833
申请日：2009-01-19
申请人： Sang-Yoon Kim , Beom-Suk Lee , Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyng Kim , Ju-Hee Ryu , Seul-Ki Lee
发明人： Sang-Yoon Kim , Beom-Suk Lee , Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyng Kim , Ju-Hee Ryu , Seul-Ki Lee
IPC分类号： C07K14/76
CPC分类号： A61K47/643 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/61 , A61K47/65
摘要： Provided is an anticancer prodrug sensitive to a target protease. The anticancer prodrug includes an anticancer drug, peptide that is specifically decomposed by the target protease excessively secreted by cancer cells, and a polymer that is specifically accumulated at a target cancer site. When the inactive anticancer prodrug is administered, the anticancer prodrug is accumulated at the target caner site and then the peptide is decomposed by irradiation of radioactive rays, thereby releasing an active anticancer drug at the target caner site. Accordingly, destruction of normal cells can be minimized and a high anticancer therapeutic effect can be obtained by using a small amount of the anticancer drug administered and a small amount of radioactive rays irradiated.
摘要翻译：提供对靶蛋白酶敏感的抗癌药物。抗癌药物包括抗癌药物，被癌细胞过度分泌的靶蛋白酶特异性分解的肽以及特异性聚集在靶癌部位的聚合物。当施用无活性抗癌前药时，抗癌前药在靶标位点处积聚，然后通过放射线照射分解肽，从而在靶标位点释放活性抗癌药物。因此，通过使用少量施用的抗癌药物和少量的放射线照射，可以使正常细胞的破坏最小化，可以获得高抗癌治疗效果。

8. 发明申请

US20130338422A1 ANTICANCER PRODRUG ACTIVATED BY RADIATION OR ULTRAVIOLET TREATMENT AND USE THEREOF 有权
标题翻译：通过辐射或超紫外线治疗及其使用活化的抗癌药物
公开(公告)号：US20130338422A1
公开(公告)日：2013-12-19
申请号：US14001745
申请日：2011-03-02
申请人： Ju-Hee Ryu , Kwang-Meyung Kim , Ick-Chan Kwon , Kui-Won Choi , Sang-Yoon Kim , Beom-Suk Lee , Dae-Yoon Chi , Hee-Seup Kil , Hyun-Ju Sung
发明人： Ju-Hee Ryu , Kwang-Meyung Kim , Ick-Chan Kwon , Kui-Won Choi , Sang-Yoon Kim , Beom-Suk Lee , Dae-Yoon Chi , Hee-Seup Kil , Hyun-Ju Sung
IPC分类号： A61K41/00 , A61N5/06 , A61N5/10
CPC分类号： A61K41/0042 , A61K31/704 , A61K38/00 , A61K47/64 , A61N5/062 , A61N5/1001
摘要： The present invention relates to an anticancer prodrug consisting of peptide of acetyl-SEQ ID NO: 1-linker-anticancer drug. The anticancer prodrug effectively provides an anticancer drug unstable in acid or base, such as doxorubicin, in a form of prodrug. Thus, the anticancer prodrug exists as a non-toxic inactive form when administered into the body, but effectively releases the anticancer drug as an active ingredient in the target area in the presence of caspase activated by radiation or UV treatment after administered into the body. Accordingly, the anticancer drug exhibits selective anticancer effects on cancer cells, thereby maximizing the therapeutic effect and minimizing the side-effects of chemotherapy.
摘要翻译：本发明涉及一种由乙酰基-SEQ ID NO.1-接头 - 抗癌药物的肽组成的抗癌药物。抗癌前药有效地提供了在酸或碱中不稳定的抗癌药物，例如以前药形式的多柔比星。因此，当施用于体内时，抗癌前药以无毒无活性形式存在，但在施用于体内后，通过辐射或UV治疗活化的半胱天冬酶存在下，有效地将抗癌药物作为活性成分释放到目标区域。因此，抗癌药物对癌细胞具有选择性的抗癌作用，从而最大化治疗效果并使化疗的副作用最小化。

9. 发明申请

US20100222538A1 NOVEL PHOTOSENSITIZER BASED ON POLYMER DERIVATIVES-PHOTOSENSITIZER CONJUGATES FOR PHOTODYNAMIC THERAPY 有权
标题翻译：基于聚合物衍生物的新型光敏剂 - 光致变色治疗光敏剂
公开(公告)号：US20100222538A1
公开(公告)日：2010-09-02
申请号：US12595103
申请日：2008-04-23
申请人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Jong-Ho Kim , Kyeong-Soon Park
发明人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Jong-Ho Kim , Kyeong-Soon Park
IPC分类号： C08F251/00
CPC分类号： A61K41/0071 , A61K47/61 , A61K47/6929
摘要： Disclosed is a novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy capable of being selectively accumulated in cancerous tissues and producing singlet oxygen or free radical by laser irradiation. The polymer derivatives-photosensitizer conjugates for photodynamic therapy are prepared as nano-sized particles, and have excellent selection and accumulation ratio for cancerous tissues. The photosensitizer conjugates can produce singlet oxygen or free radical by a specific laser wavelength. Owing to the excellent selection and accumulation ratio for cancerous tissues, the conjugates minimizes photo-cytotoxicity of the conventional photosensitizer having a low molecular amount. Accordingly, the conjugates are very useful as a photosensitizes for photodynamic therapy with reduced side effects and excellent therapeutic effectiveness.
摘要翻译：公开了一种基于用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物的新型光敏剂，其能够选择性地积累在癌组织中并通过激光照射产生单线态氧或自由基。用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物制备为纳米尺寸颗粒，并且对于癌组织具有优异的选择和积累比。光敏剂共轭物可以通过特定的激光波长产生单线态氧或自由基。由于癌组织的优异的选择和积累比，共轭物使具有低分子量的常规光敏剂的光细胞毒性最小化。因此，缀合物对于具有降低的副作用和优异治疗有效性的光动力疗法的光敏剂是非常有用的。

10. 发明授权

US08614285B2 Photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy 有权
标题翻译：基于聚合物衍生物的光敏剂 - 用于光动力疗法的光敏剂共轭物
公开(公告)号：US08614285B2
公开(公告)日：2013-12-24
申请号：US12595103
申请日：2008-04-23
申请人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Jong-Ho Kim , Kyeong-Soon Park
发明人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Jong-Ho Kim , Kyeong-Soon Park
IPC分类号： C08F251/00 , A61K31/555
CPC分类号： A61K41/0071 , A61K47/61 , A61K47/6929
摘要： Disclosed is a novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy capable of being selectively accumulated in cancerous tissues and producing singlet oxygen or free radical by laser irradiation. The polymer derivatives-photosensitizer conjugates for photodynamic therapy are prepared as nano-sized particles, and have excellent selection and accumulation ratio for cancerous tissues. The photosensitizer conjugates can produce singlet oxygen or free radical by a specific laser wavelength. Owing to the excellent selection and accumulation ratio for cancerous tissues, the conjugates minimizes photo-cytotoxicity of the conventional photosensitizer having a low molecular amount. Accordingly, the conjugates are very useful as a photosensitizes for photodynamic therapy with reduced side effects and excellent therapeutic effectiveness.
摘要翻译：公开了一种基于用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物的新型光敏剂，其能够选择性地积累在癌组织中并通过激光照射产生单线态氧或自由基。用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物制备为纳米尺寸颗粒，并且对于癌组织具有优异的选择和积累比。光敏剂共轭物可以通过特定的激光波长产生单线态氧或自由基。由于癌组织的优异的选择和积累比，共轭物使具有低分子量的常规光敏剂的光细胞毒性最小化。因此，缀合物对于具有降低的副作用和优异治疗有效性的光动力疗法的光敏剂是非常有用的。

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