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    • 2. 发明申请
    • IONIC COMPLEX NANOPARTICLES FOR DETECTING HEPARANASE ACTIVITIES AND METHOD FOR PREPARING THE SAME
    • 用于检测HEPARANASE活性的离子复合纳米颗粒及其制备方法
    • US20100233085A1
    • 2010-09-16
    • US12472405
    • 2009-05-27
    • Ick-Chan KWONKwang-Meyung KIMKui-Won CHOIKyeong-Soon PARKSeul-Ki LEE
    • Ick-Chan KWONKwang-Meyung KIMKui-Won CHOIKyeong-Soon PARKSeul-Ki LEE
    • A61K49/00C12Q1/34
    • C12Q1/34A61K49/0054G01N2333/924
    • Disclosed are Ionic complex nanoparticles for detecting heparanase activities and a method for preparing the same. More specifically, disclosed are Ionic complex nanoparticles for detecting heparanase activities, wherein negative-ion substrate polymers specifically degraded by heparanase and positive-ion biocompatible polymers ionically bind to each other, and fluorophores or quenchers bind to each of the polymers. The ionic complex nanoparticles for detecting heparanase activities may be applied to a method for screening novel drugs such as inhibitors that prevent over-expression of heparanase. Various cells and tissues where over-expression of heparanase occurs may be non-invasively imaged in cancer cells, cancer tissues, and tissues of various inflammatory diseases. Accordingly, the ionic complex nanoparticles for detecting heparanase activities may be effectively used to early diagnose various diseases and incurable diseases including autoimmune diseases such as cancers, osteoarthritis, rheumatoid arthritis, and dementia.
    • 公开了用于检测乙酰肝素酶活性的离子复合纳米粒子及其制备方法。 更具体地,公开了用于检测乙酰肝素酶活性的离子复合纳米颗粒,其中由肝素酶和阳离子生物相容性聚合物特异性降解的负离子底物聚合物彼此离子地结合,并且荧光团或猝灭剂与每种聚合物结合。 用于检测乙酰肝素酶活性的离子络合物纳米颗粒可以应用于筛选新型药物的方法,例如防止肝素酶过度表达的抑制剂。 发生肝素酶过度表达的各种细胞和组织可能在癌细胞,癌组织和各种炎性疾病的组织中非侵入性成像。 因此,用于检测乙酰肝素酶活性的离子络合物纳米颗粒可以有效地用于早期诊断各种疾病和不治之症,包括自身免疫疾病如癌症,骨关节炎,类风湿性关节炎和痴呆。
    • 3. 发明授权
    • Ionic complex nanoparticles for detecting heparanase activities and method for preparing the same
    • 用于检测肝素酶活性的离子复合纳米颗粒及其制备方法
    • US08323622B2
    • 2012-12-04
    • US12472405
    • 2009-05-27
    • Ick-Chan KwonKwang-Meyung KimKui-Won ChoiKyeong-Soon ParkSeul-Ki Lee
    • Ick-Chan KwonKwang-Meyung KimKui-Won ChoiKyeong-Soon ParkSeul-Ki Lee
    • A61B5/00
    • C12Q1/34A61K49/0054G01N2333/924
    • Disclosed are Ionic complex nanoparticles for detecting heparanase activities and a method for preparing the same. More specifically, disclosed are Ionic complex nanoparticles for detecting heparanase activities, wherein negative-ion substrate polymers specifically degraded by heparanase and positive-ion biocompatible polymers ionically bind to each other, and fluorophores or quenchers bind to each of the polymers. The ionic complex nanoparticles for detecting heparanase activities may be applied to a method for screening novel drugs such as inhibitors that prevent over-expression of heparanase. Various cells and tissues where over-expression of heparanase occurs may be non-invasively imaged in cancer cells, cancer tissues, and tissues of various inflammatory diseases. Accordingly, the ionic complex nanoparticles for detecting heparanase activities may be effectively used to early diagnose various diseases and incurable diseases including autoimmune diseases such as cancers, osteoarthritis, rheumatoid arthritis, and dementia.
    • 公开了用于检测乙酰肝素酶活性的离子复合纳米粒子及其制备方法。 更具体地,公开了用于检测乙酰肝素酶活性的离子复合纳米颗粒,其中由肝素酶和阳离子生物相容性聚合物特异性降解的负离子底物聚合物彼此离子地结合,并且荧光团或猝灭剂与每种聚合物结合。 用于检测乙酰肝素酶活性的离子络合物纳米颗粒可以应用于筛选新型药物的方法,例如防止肝素酶过度表达的抑制剂。 发生肝素酶过度表达的各种细胞和组织可能在癌细胞,癌组织和各种炎性疾病的组织中非侵入性成像。 因此,用于检测乙酰肝素酶活性的离子络合物纳米颗粒可以有效地用于早期诊断各种疾病和不治之症,包括自身免疫疾病如癌症,骨关节炎,类风湿性关节炎和痴呆。
    • 5. 发明授权
    • Gold nanoparticle based protease imaging probes and use thereof
    • 基于金纳米颗粒的蛋白酶成像探针及其用途
    • US08551727B2
    • 2013-10-08
    • US12595078
    • 2008-04-10
    • Ick-Chan KwonKui-Won ChoiKwang-Meyung KimCheol-Hee AhnIn-Chan YounSeul-Ki LeeKyeong-Soon Park
    • Ick-Chan KwonKui-Won ChoiKwang-Meyung KimCheol-Hee AhnIn-Chan YounSeul-Ki LeeKyeong-Soon Park
    • C12Q1/37C12Q1/34B82B3/00C12N11/14C12N11/18
    • A61K49/0056A61K49/0032A61K49/0065A61K49/0093C12Q1/37
    • Disclosed are a metal nanoparticle onto which a peptide substrate specifically degraded by protease and fluorophore are chemically modified for selectively imaging protease expressed in cell and in tissue in a human body, and the use thereof. Also, a quantitative analysis method of protease using the metal nanoparticle, a cell imaging method and a drug screening method of inhibiting a protease overexpression are provided. In detail, the present invention is directed to a metal nanoparticle having a peptide substrate and fluorophore coupled thereto, the peptide substrate and the fluorophore being specifically degraded by due to a protease activated in various ways in cell and in a human body to exhibit fluorescence. Hence, the metal nanoparticle can be used to rapidly screen activation and inhibition of the protease in the imaging manner. Also, the metal nanoparticle is capable of being selectively absorbed into a cell and a tissue so as to be possibly used as a sensor for real-time cell imaging and early diagnosis of non-invasive diseases.
    • 公开了一种金属纳米颗粒,其上通过蛋白酶和荧光团特异性降解的肽底物被化学修饰以选择性地成像在细胞和人体组织中表达的蛋白酶及其用途。 另外,提供了使用金属纳米粒子的蛋白酶的定量分析方法,细胞成像方法和抑制蛋白酶过表达的药物筛选方法。 详细地说,本发明涉及一种具有肽底物和与其连接的荧光团的金属纳米颗粒,肽底物和荧光团由于在细胞和人体中以各种方式活化的蛋白酶而被特异性地降解以显示出荧光。 因此,金属纳米颗粒可用于以成像方式快速筛选蛋白酶的活化和抑制。 此外,金属纳米粒子能够被选择性地吸收到细胞和组织中,以便可能用作用于实时细胞成像和非侵入性疾病的早期诊断的传感器。
    • 6. 发明申请
    • GOLD NANOPARTICLE BASED PROTEASE IMAGING PROBES AND USE THEREOF
    • 基于金纳米粒子的蛋白成像探针及其应用
    • US20100124757A1
    • 2010-05-20
    • US12595078
    • 2008-04-10
    • Ick-Chan KwonKui-Won ChoiKwang-Meyung KimCheol-Hee AhnIn-Chan YounSeul-Ki LeeKyeong-Soon Park
    • Ick-Chan KwonKui-Won ChoiKwang-Meyung KimCheol-Hee AhnIn-Chan YounSeul-Ki LeeKyeong-Soon Park
    • C12Q1/37C07K2/00
    • A61K49/0056A61K49/0032A61K49/0065A61K49/0093C12Q1/37
    • Disclosed are a metal nanoparticle onto which a peptide substrate specifically degraded by protease and fluorophore are chemically modified for selectively imaging protease expressed in cell and in tissue in a human body, and the use thereof. Also, a quantitative analysis method of protease using the metal nanoparticle, a cell imaging method and a drug screening method of inhibiting a protease overexpression are provided. In detail, the present invention is directed to a metal nanoparticle having a peptide substrate and fluorophore coupled thereto, the peptide substrate and the fluorophore being specifically degraded by due to a protease activated in various ways in cell and in a human body to exhibit fluorescence. Hence, the metal nanoparticle can be used to rapidly screen activation and inhibition of the protease in the imaging manner. Also, the metal nanoparticle is capable of being selectively absorbed into a cell and a tissue so as to be possibly used as a sensor for real-time cell imaging and early diagnosis of non-invasive diseases.
    • 公开了一种金属纳米颗粒,其上通过蛋白酶和荧光团特异性降解的肽底物被化学修饰以选择性地成像在细胞和人体组织中表达的蛋白酶及其用途。 另外,提供了使用金属纳米粒子的蛋白酶的定量分析方法,细胞成像方法和抑制蛋白酶过表达的药物筛选方法。 详细地说,本发明涉及一种具有肽底物和与其连接的荧光团的金属纳米颗粒,肽底物和荧光团由于在细胞和人体中以各种方式活化的蛋白酶而被特异性地降解以显示出荧光。 因此,金属纳米颗粒可用于以成像方式快速筛选蛋白酶的活化和抑制。 此外,金属纳米粒子能够被选择性地吸收到细胞和组织中,以便可能用作用于实时细胞成像和非侵入性疾病的早期诊断的传感器。