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    • 2. 发明申请
    • AGENT FOR PREVENTING ARTERIOSCLEROSIS
    • 用于预防椎弓根病的药物
    • US20110009616A1
    • 2011-01-13
    • US12306364
    • 2007-06-29
    • Akinobu KishiKoji YuasaTaiji MatsukawaTakeki MatsuiYasumasa YamadaIchiro Yamada
    • Akinobu KishiKoji YuasaTaiji MatsukawaTakeki MatsuiYasumasa YamadaIchiro Yamada
    • C07D487/22
    • C07D487/22A23L33/10
    • The invention provides antiarterioscierosis agents containing as the active ingredient porphyrin derivatives or ester derivatives thereof as represented by the general formula (1) or (2); and foods or pharmaceutical compositions containing the agents. The porphyrin derivatives and the ester derivatives thereof exhibit an effect of inhibiting the bonding of oxidized LDL to LOX-1 expressed in vascular endothelial cells, macrophage an so on and an antagonistic effect of inhibiting the incorporation of oxidized LDL into cells through LOX-1, and are highly safe. [Chemical formula 1] (wherein R1 and R2 are each a hydrocarbon group having 1 to 4 carbon atoms or the like; and R3 to R8 are each a hydrocarbon group having 1 to 2 carbon atoms, formyl, or the like) [Chemical formula 2] (wherein R1 and R2 are each a hydrocarbon group having 1 to 4 carbon atoms or the like; and R3 to R8 are each a hydrocarbon group having 1 to 2 carbon atoms, formyl, or the like)
    • 本发明提供含有由通式(1)或(2)表示的作为活性成分的卟啉衍生物或其酯衍生物的抗动脉粥样硬化剂; 以及含有这些试剂的食品或药物组合物。 卟啉衍生物及其酯衍生物表现出抑制氧化的LDL与在血管内皮细胞中表达的LOX-1的结合,巨噬细胞等的作用,以及通过LOX-1抑制氧化的LDL掺入细胞的拮抗作用, 并且是高度安全的。 [化学式1](其中R 1和R 2各自为具有1至4个碳原子的烃基等; R 3至R 8各自为具有1至2个碳原子的烃基,甲酰基等)[化学式 2](其中,R 1和R 2各自为具有1〜4个碳原子的烃基等,R 3〜R 8分别为碳原子数1〜2的烃基,甲酰基等)
    • 6. 发明授权
    • Semiconductor laser device
    • 半导体激光器件
    • US07738524B2
    • 2010-06-15
    • US11494444
    • 2006-07-28
    • Masanao OchiaiKoji Yuasa
    • Masanao OchiaiKoji Yuasa
    • H01S5/00
    • H01S5/028B82Y20/00H01S5/0282H01S5/0287H01S5/16H01S5/34333
    • A semiconductor laser device, which has a protective film at an end surface thereof, is adaptable to demands for higher outputs or shorter wavelengths. The semiconductor laser device according to the present invention includes a dielectric film on at least one end surface of an optical resonator, in which the dielectric film includes a first dielectric layer and a second dielectric layer comprised of the same elements and disposed in sequence from the end surface side of the semiconductor, the first dielectric layer including a layer made of a single crystal material and the second dielectric layer including a layer made of an amorphous material.
    • 在其端面具有保护膜的半导体激光器件适用于要求更高输出或更短波长的要求。 根据本发明的半导体激光器件包括在光学谐振器的至少一个端面上的电介质膜,其中介电膜包括第一介电层和由相同元件组成的第二介电层,并且从第 所述第一电介质层包括由单晶材料制成的层,所述第二电介质层包括由非晶材料制成的层。