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1. 发明申请

US20100029910A1 NANOGRAPHITE STRUCTURE/METAL NANOPARTICLE COMPOSITE 有权
标题翻译：纳米结构/金属纳米复合材料
公开(公告)号：US20100029910A1
公开(公告)日：2010-02-04
申请号：US11767583
申请日：2007-06-25
申请人： Kiyotaka Shiba , Kenichi Sano , Kenji Iwahori
发明人： Kiyotaka Shiba , Kenichi Sano , Kenji Iwahori
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B32/18 , C01B2202/02
摘要： The present invention makes it possible to efficiently recognize carbon nanotubes, carbon nanohorns or modifiers thereof and to support functional compounds by fusing the ability of ferritin molecules capable of forming nanoparticles of inorganic metal atoms or inorganic metal compounds. In addition, because ferritin molecules are capable of forming two-dimensional crystals at the interface, the present invention makes it possible to align carbon nanotubes, carbon nanohorns with the use of the molecular arrangement ability of ferritin fused with nanographite structure recognition peptides. A nanographite structure/metal nanoparticle composite is constructed, wherein a nanoparticle of an inorganic metal atom or an inorganic metal compound is retained in an interior space of a protein in which a nanographite structure recognition peptide is fused or chemically bound to a surface of a cage protein such as ferritin, and wherein a plurality of nanoparticles of an inorganic metal atom or an inorganic metal compound are supported on a nanographite structure with the use of affinity of the nanographite structure recognition peptide to the nanographite structure.
摘要翻译：本发明使得能够有效地识别碳纳米管，碳纳米角或其改性剂，并且通过融合能够形成无机金属原子或无机金属化合物的纳米颗粒的铁蛋白分子的能力来支持功能性化合物。此外，由于铁蛋白分子能够在界面处形成二维晶体，因此本发明可以利用与纳米结构识别肽融合的铁蛋白的分子排列能力来对准碳纳米管，碳纳米角。构建纳米结构/金属纳米颗粒复合物，其中无机金属原子或无机金属化合物的纳米颗粒保留在蛋白质的内部空间中，其中纳米结构识别肽与笼的表面融合或化学结合蛋白质如铁蛋白，并且其中使用纳米尺度结构识别肽与纳米尺度结构的亲和力将纳米尺度结构上的无机金属原子或无机金属化合物的多个纳米颗粒负载在纳米尺度结构上。

2. 发明授权

US07439334B2 Method of arrangement of titanium-binding ferritin and inorganic particles 有权
标题翻译：钛结合铁蛋白和无机颗粒的排列方法
公开(公告)号：US07439334B2
公开(公告)日：2008-10-21
申请号：US11354864
申请日：2006-02-16
申请人： Ichiro Yamashita , Kiyotaka Shiba
发明人： Ichiro Yamashita , Kiyotaka Shiba
IPC分类号： C07K14/00 , H01L21/00 , H01L21/314 , H01L21/471
CPC分类号： C07K14/47 , C07K2319/00 , G01N33/553
摘要： A method for selectively arranging ferritin modified with a peptide, which specifically binds to titanium, to titanium formed on a substrate surface is provided.The method for arranging ferritin of the present invention is characterized in that ferritin is selectively bound on titanium on a substrate by modifying the N-terminal part of ferritin with a peptide which specifically binds to titanium. Also, the method for arranging ferritin of the present invention is characterized in that selectivity for titanium can be markedly improved by adding a nonionic surface activating agent.
摘要翻译：提供了一种选择性地将由钛特异性结合的肽修饰的铁蛋白修饰成在基底表面上形成的钛的方法。本发明的铁蛋白的配置方法的特征在于，通过用特异性结合钛的肽修饰铁蛋白的N末端部分，将铁蛋白选择性地结合在底物上的钛上。此外，本发明的铁蛋白的配置方法的特征在于，通过添加非离子表面活性剂，能够显着提高钛的选择性。

3. 发明授权

US5629188A Human alanyl-tRNA synthetase proteins, nucleic acids and tester strains comprising same 失效
标题翻译：人丙氨酰-tRNA合成酶蛋白，包含其的核酸和测试菌株
公开(公告)号：US5629188A
公开(公告)日：1997-05-13
申请号：US426236
申请日：1995-04-21
申请人： Kiyotaka Shiba , Paul R. Schimmel , Tracy L. Ripmaster
发明人： Kiyotaka Shiba , Paul R. Schimmel , Tracy L. Ripmaster
IPC分类号： C12N9/00 , C07H21/04 , C12N1/14 , C12N1/20
CPC分类号： C12N9/93
摘要： Isolated, recombinant nucleic acids which encode alanyl-tRNA synthetase (AlaRS) of human origin have been used to make expression constructs and transformed host cells for the production of recombinant human AlaRS. The recombinant enzyme has been purified, and is active in the specific aminoacylation of tRNA by alanine. The isolated, recombinant human AlaRS is also recognized by antibodies made by patients with the particular autoimmune disease known as "antisynthetase syndrome" in which the patients produce antibodies against the human alanyl-tRNA synthetase in their own cells. Thus, the isolated, recombinant enzyme, and antibodies made specifically thereto, can be useful in assays to diagnose and monitor this disease. The essential alanyl-tRNA synthetases of microbes pathogenic in humans can be the targets of inhibitory agents having antimicrobial activity. The human alanyl-tRNA synthetase, isolated and purified, can be used to assess the toxic effect in humans of such an inhibitory agent in various biochemical activity assays. This human enzyme can also be expressed in "tester strains," whose cells rely upon the function of the human alanyl-tRNA synthetase for tRNA.sup.Ala charging. Such tester strains can be used to test for any toxic effects of an antimicrobial agent that specifically interacts with the heterologous human AlaRS gene or gene product.
摘要翻译：已经使用编码人来源的丙氨酰-tRNA合成酶（AlaRS）的分离的重组核酸来制备表达构建体和转化的宿主细胞用于重组人AlaRS的产生。重组酶已经纯化，并且在丙氨酸特异性氨酰化tRNA中具有活性。分离的重组人AlaRS也被称为“反合成酶综合征”的特定自身免疫性疾病患者产生的抗体识别，其中患者在其自身的细胞中产生抗人丙氨酰-tRNA合成酶的抗体。因此，分离的重组酶和特异性制备的抗体可用于诊断和监测该疾病的测定中。人类致病微生物的必需丙氨酰-tRNA合成酶可以是具有抗微生物活性的抑制剂的靶标。分离和纯化的人丙氨酰-tRNA合成酶可以用于在各种生物化学活性测定中评估这种抑制剂在人体中的毒性作用。这种人类酶也可以在“测试菌株”中表达，其细胞依赖于人类丙氨酰-tRNA合成酶对tRNAAla充电的功能。这样的测试菌株可用于测试与异源人AlaRS基因或基因产物特异性相互作用的抗微生物剂的任何毒性作用。

4. 发明授权

US08796417B2 Three-dimensional structure of functional material 有权
标题翻译：功能材料的三维结构
公开(公告)号：US08796417B2
公开(公告)日：2014-08-05
申请号：US11915480
申请日：2006-05-24
申请人： Kiyotaka Shiba , Kenichi Sano
发明人： Kiyotaka Shiba , Kenichi Sano
IPC分类号： C07K7/06 , B32B5/16 , C23C28/04 , C07K14/79 , C07K7/08 , B82Y30/00 , C23C26/00
CPC分类号： C23C26/00 , B82Y30/00 , C07K7/06 , C07K7/08 , C07K14/79 , C23C28/042 , C23C28/048 , Y10T428/25 , Y10T428/31725
摘要： It is to provide an inorganic thin film of titanium dioxide or the like which is controlled at the nanoscale and a three-dimensional structure of a functional material such as semiconductor nanoparticles. A three-dimensional structure of an inorganic material is manufactured by introducing onto a surface of an inorganic substrate ferritin presenting on its surface a plurality of inorganic material-binding peptides; binding the ferritin in a monolayer onto the inorganic substrate; introducing an inorganic material onto the ferritin which is bound in a monolayer, while the inorganic material-binding peptides is having a binding and/or biomineralization ability for the inorganic material; forming a biomineral layer utilizing the biomineralization ability of the inorganic material-binding peptides; and subsequently repeating one or more times the steps (a) and (b) of a multilayering operation: (a) introducing onto the biomineral layer thus formed the ferritin having a binding ability to the biomineral layer, and binding the ferritin in a monolayer onto the biomineral layer; (b) introducing the inorganic material onto the surface of the ferritin which is bound in a monolayer, and forming a biomineral layer.
摘要翻译：提供以纳米级控制的二氧化钛等的无机薄膜和诸如半导体纳米颗粒的功能材料的三维结构。无机材料的三维结构通过在其表面上呈现多个无机材料结合肽的无机底物铁蛋白的表面上引入而制造; 将单层铁蛋白结合到无机基底上; 将无机材料引入到单层结合的铁蛋白上，而无机材料结合肽具有对于无机材料的结合和/或生物矿化能力; 利用无机材料结合肽的生物矿化能力形成生物矿物层; 并随后重复一次或多次多层操作的步骤（a）和（b）：（a）将由此形成的生物矿物层引入具有生物矿物层的结合能力的铁蛋白，并将单层铁蛋白结合到生物矿物层; （b）将无机材料引入到以单层结合的铁蛋白的表面上，并形成生物矿物层。

5. 发明授权

US08017729B2 Nanographite structure/metal nanoparticle composite 有权
标题翻译：纳米晶体结构/金属纳米颗粒复合材料
公开(公告)号：US08017729B2
公开(公告)日：2011-09-13
申请号：US11767583
申请日：2007-06-25
申请人： Kiyotaka Shiba , Kenichi Sano , Kenji Iwahori
发明人： Kiyotaka Shiba , Kenichi Sano , Kenji Iwahori
IPC分类号： A61K38/00 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/47 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B32/18 , C01B2202/02
摘要： The present invention makes it possible to efficiently recognize carbon nanotubes, carbon nanohorns or modifiers thereof and to support functional compounds by fusing the ability of ferritin molecules capable of forming nanoparticles of inorganic metal atoms or inorganic metal compounds. In addition, because ferritin molecules are capable of forming two-dimensional crystals at the interface, the present invention makes it possible to align carbon nanotubes, carbon nanohorns with the use of the molecular arrangement ability of ferritin fused with nanographite structure recognition peptides. A nanographite structure/metal nanoparticle composite is constructed, wherein a nanoparticle of an inorganic metal atom or an inorganic metal compound is retained in an interior space of a protein in which a nanographite structure recognition peptide is fused or chemically bound to a surface of a cage protein such as ferritin, and wherein a plurality of nanoparticles of an inorganic metal atom or an inorganic metal compound are supported on a nanographite structure with the use of affinity of the nanographite structure recognition peptide to the nanographite structure.
摘要翻译：本发明使得能够有效地识别碳纳米管，碳纳米角或其改性剂，并且通过融合能够形成无机金属原子或无机金属化合物的纳米颗粒的铁蛋白分子的能力来支持功能性化合物。此外，由于铁蛋白分子能够在界面处形成二维晶体，因此本发明可以利用与纳米结构识别肽融合的铁蛋白的分子排列能力来对准碳纳米管，碳纳米角。构建纳米结构/金属纳米颗粒复合物，其中无机金属原子或无机金属化合物的纳米颗粒保留在蛋白质的内部空间中，其中纳米结构识别肽与笼的表面融合或化学结合蛋白质如铁蛋白，并且其中使用纳米尺度结构识别肽与纳米尺度结构的亲和力将纳米尺度结构上的无机金属原子或无机金属化合物的多个纳米颗粒负载在纳米尺度结构上。

6. 发明申请

US20100040862A1 Three-Dimensional Structure of Functional Material 有权
标题翻译：功能材料的三维结构
公开(公告)号：US20100040862A1
公开(公告)日：2010-02-18
申请号：US11915480
申请日：2006-05-24
申请人： Kiyotaka Shiba , Kenichi Sano
发明人： Kiyotaka Shiba , Kenichi Sano
IPC分类号： B32B5/16 , C07K7/06 , C07K7/08 , C07K14/795 , B05D1/36 , B32B27/34
CPC分类号： C23C26/00 , B82Y30/00 , C07K7/06 , C07K7/08 , C07K14/79 , C23C28/042 , C23C28/048 , Y10T428/25 , Y10T428/31725
摘要： It is to provide an inorganic thin film of titanium dioxide or the like which is controlled at the nanoscale and a three-dimensional structure of a functional material such as semiconductor nanoparticles. A three-dimensional structure of an inorganic material is manufactured by introducing onto a surface of an inorganic substrate ferritin presenting on its surface a plurality of inorganic material-binding peptides; binding the ferritin in a monolayer onto the inorganic substrate; introducing an inorganic material onto the ferritin which is bound in a monolayer, while the inorganic material-binding peptides is having a binding and/or biomineralization ability for the inorganic material; forming a biomineral layer utilizing the biomineralization ability of the inorganic material-binding peptides; and subsequently repeating one or more times the steps (a) and (b) of a multilayering operation: (a) introducing onto the biomineral layer thus formed the ferritin having a binding ability to the biomineral layer, and binding the ferritin in a monolayer onto the biomineral layer; (b) introducing the inorganic material onto the surface of the ferritin which is bound in a monolayer, and forming a biomineral layer.
摘要翻译：提供以纳米级控制的二氧化钛等的无机薄膜和诸如半导体纳米颗粒的功能材料的三维结构。无机材料的三维结构通过在其表面上呈现多个无机材料结合肽的无机底物铁蛋白的表面上引入而制造; 将单层铁蛋白结合到无机基底上; 将无机材料引入到单层结合的铁蛋白上，而无机材料结合肽具有对于无机材料的结合和/或生物矿化能力; 利用无机材料结合肽的生物矿化能力形成生物矿物层; 并随后重复一次或多次多层操作的步骤（a）和（b）：（a）将由此形成的生物矿物层引入具有生物矿物层的结合能力的铁蛋白，并将单层铁蛋白结合到生物矿物层; （b）将无机材料引入到以单层结合的铁蛋白的表面上，并形成生物矿物层。

7. 发明授权

US07462462B2 Peptide capable of binding to nanographite structures 有权
标题翻译：能够结合纳米尺度结构的肽
公开(公告)号：US07462462B2
公开(公告)日：2008-12-09
申请号：US11098763
申请日：2005-04-04
申请人： Kiyotaka Shiba , Daisuke Kase , Sumio Iijima
发明人： Kiyotaka Shiba , Daisuke Kase , Sumio Iijima
IPC分类号： G01N33/53 , A61K38/00 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： B82Y30/00 , C07K7/06 , C07K7/08 , C07K17/14
摘要： It is intended to provide a peptide or a phage recognizing nanographite structures and thus enabling efficient recognition, binding, separation and alignment of nanographite structures such as carbon nanohorns or carbon nanotubes, an artificial protein or a chimeric molecule comprising the above-described peptide bonded to a functional peptide, a protein, a labeling, etc., and a complex of the above-described peptide molecule, artificial protein or chimeric molecule with a nanographite structure. By panning peptide-presenting phages bonded to nanographite structures, a nanographite structure-binding peptide capable of specifically recognizing nanographite structures such as carbon nanohorns or carbon nanotubes is obtained.
摘要翻译：本发明旨在提供一种识别纳米尺度结构的肽或噬菌体，从而能够有效地识别，结合，分离和取向纳米尺度结构例如碳纳米管或碳纳米管，人造蛋白或包含上述肽的嵌合分子功能性肽，蛋白质，标记等，以及上述肽分子，人造蛋白质或嵌合分子与纳米石墨结构的复合物。通过筛选结合纳米尺度结构的肽呈递噬菌体，可以获得能够特异性识别纳米尺度结构如纳米碳纳米管或碳纳米管的纳米结构结合肽。

8. 发明申请

US20060193919A1 Complex of drug-carbon nanohorn and a process for producing the complex 有权
公开(公告)号：US20060193919A1
公开(公告)日：2006-08-31
申请号：US11212645
申请日：2005-08-29
申请人： Sumio Iijima , Masako Yudasaka , Kumiko Ajima , Tatsuya Murakami , Kiyotaka Shiba
发明人： Sumio Iijima , Masako Yudasaka , Kumiko Ajima , Tatsuya Murakami , Kiyotaka Shiba
IPC分类号： A61K38/14 , A61K33/24 , A61K31/573 , A61K9/14
CPC分类号： A61K9/167 , A61K9/1617 , A61K31/573 , A61K33/24 , Y10S977/734 , Y10S977/744 , Y10S977/906
摘要： The present invention provides a carbon nanohorn complex that is excellent in characteristics of adsorption or inclusion of drugs and release, in particular, a sustained release of drugs as a novel drug carrier in drug delivery systems, as well as a process for producing the complex. The complex of drug and carbon nanohorns comprises a steroidal or metal-containing drug being adsorbed onto the oxidized carbon nanohorns, or included in pores opened thereof.

9. 发明授权

US5824474A Method for detecting nucleic acid 失效
标题翻译：检测核酸的方法
公开(公告)号：US5824474A
公开(公告)日：1998-10-20
申请号：US592293
申请日：1996-02-08
申请人： Akio Matsuhisa , Kiyotaka Shiba , Yoshikazu Mikawa , Yuichiro Kishi
发明人： Akio Matsuhisa , Kiyotaka Shiba , Yoshikazu Mikawa , Yuichiro Kishi
IPC分类号： C12Q1/68 , G01N27/447 , G01N33/50 , G01N33/58 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6816 , C12Q1/6813
摘要： A method of detecting a nucleic acid which comprises bringing a solid carrier suspected to carry or contain a nucleic acid into contact with a polyamine to which a label capable of generating a detectable signal or a precursor thereof is bound, to form a complex between said nucleic acid and said polyamine, said precursor converting into said label, if used, removing the polyamine which has not formed any complex before or after the conversion of said precursor and then detecting said label.
摘要翻译： PCT No.PCT / JP93 / 01124 Sec。 371日期1996年2月8日 102（e）日期1996年2月8日PCT提交1993年8月10日PCT公布。出版物WO95 / 04832 日期1996年2月16日一种检测核酸的方法，其包括将怀疑携带或含有核酸的固体载体与可产生可检测信号的标记或其前体的多胺接触形成所述核酸和所述多胺之间的复合物，所述前体转化成所述标记（如果使用的话），除去在所述前体转化之前或之后未形成任何复合物的多胺，然后检测所述标记。

10. 发明申请

US20060257931A1 Method of arrangement of titanium-binding ferritin and inorganic particles 有权
标题翻译：钛结合铁蛋白和无机颗粒的排列方法
公开(公告)号：US20060257931A1
公开(公告)日：2006-11-16
申请号：US11354864
申请日：2006-02-16
申请人： Ichiro Yamashita , Kiyotaka Shiba
发明人： Ichiro Yamashita , Kiyotaka Shiba
IPC分类号： G01N33/53 , H01L51/00
CPC分类号： C07K14/47 , C07K2319/00 , G01N33/553
摘要： A method for selectively arranging ferritin modified with a peptide, which specifically binds to titanium, to titanium formed on a substrate surface is provided. The method for arranging ferritin of the present invention is characterized in that ferritin is selectively bound on titanium on a substrate by modifying the N-terminal part of ferritin with a peptide which specifically binds to titanium. Also, the method for arranging ferritin of the present invention is characterized in that selectivity for titanium can be markedly improved by adding a nonionic surface activating agent.
摘要翻译：提供了一种选择性地将由钛特异性结合的肽修饰的铁蛋白修饰成在基底表面上形成的钛的方法。本发明的铁蛋白的配置方法的特征在于，通过用特异性结合钛的肽修饰铁蛋白的N末端部分，将铁蛋白选择性地结合在底物上的钛上。此外，本发明的铁蛋白的配置方法的特征在于，通过添加非离子表面活性剂，能够显着提高钛的选择性。

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