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1. 发明申请

US20060257931A1 Method of arrangement of titanium-binding ferritin and inorganic particles 有权
标题翻译：钛结合铁蛋白和无机颗粒的排列方法
公开(公告)号：US20060257931A1
公开(公告)日：2006-11-16
申请号：US11354864
申请日：2006-02-16
申请人： Ichiro Yamashita , Kiyotaka Shiba
发明人： Ichiro Yamashita , Kiyotaka Shiba
IPC分类号： G01N33/53 , H01L51/00
CPC分类号： C07K14/47 , C07K2319/00 , G01N33/553
摘要： A method for selectively arranging ferritin modified with a peptide, which specifically binds to titanium, to titanium formed on a substrate surface is provided. The method for arranging ferritin of the present invention is characterized in that ferritin is selectively bound on titanium on a substrate by modifying the N-terminal part of ferritin with a peptide which specifically binds to titanium. Also, the method for arranging ferritin of the present invention is characterized in that selectivity for titanium can be markedly improved by adding a nonionic surface activating agent.
摘要翻译：提供了一种选择性地将由钛特异性结合的肽修饰的铁蛋白修饰成在基底表面上形成的钛的方法。本发明的铁蛋白的配置方法的特征在于，通过用特异性结合钛的肽修饰铁蛋白的N末端部分，将铁蛋白选择性地结合在底物上的钛上。此外，本发明的铁蛋白的配置方法的特征在于，通过添加非离子表面活性剂，能够显着提高钛的选择性。

2. 发明授权

US07439334B2 Method of arrangement of titanium-binding ferritin and inorganic particles 有权
标题翻译：钛结合铁蛋白和无机颗粒的排列方法
公开(公告)号：US07439334B2
公开(公告)日：2008-10-21
申请号：US11354864
申请日：2006-02-16
申请人： Ichiro Yamashita , Kiyotaka Shiba
发明人： Ichiro Yamashita , Kiyotaka Shiba
IPC分类号： C07K14/00 , H01L21/00 , H01L21/314 , H01L21/471
CPC分类号： C07K14/47 , C07K2319/00 , G01N33/553
摘要： A method for selectively arranging ferritin modified with a peptide, which specifically binds to titanium, to titanium formed on a substrate surface is provided.The method for arranging ferritin of the present invention is characterized in that ferritin is selectively bound on titanium on a substrate by modifying the N-terminal part of ferritin with a peptide which specifically binds to titanium. Also, the method for arranging ferritin of the present invention is characterized in that selectivity for titanium can be markedly improved by adding a nonionic surface activating agent.
摘要翻译：提供了一种选择性地将由钛特异性结合的肽修饰的铁蛋白修饰成在基底表面上形成的钛的方法。本发明的铁蛋白的配置方法的特征在于，通过用特异性结合钛的肽修饰铁蛋白的N末端部分，将铁蛋白选择性地结合在底物上的钛上。此外，本发明的铁蛋白的配置方法的特征在于，通过添加非离子表面活性剂，能够显着提高钛的选择性。

3. 发明申请

US20050277160A1 Peptide capable of binding to nanographite structures 有权
标题翻译：能够结合纳米尺度结构的肽
公开(公告)号：US20050277160A1
公开(公告)日：2005-12-15
申请号：US11098763
申请日：2005-04-04
申请人： Kiyotaka Shiba , Daisuke Kase , Sumio Iijima
发明人： Kiyotaka Shiba , Daisuke Kase , Sumio Iijima
IPC分类号： C12N15/09 , C07K7/06 , C07K7/08 , C07K17/14 , C07K19/00 , C12N7/00 , C12Q1/70 , C12Q1/68 , A61K38/10 , G01N33/53
CPC分类号： B82Y30/00 , C07K7/06 , C07K7/08 , C07K17/14
摘要： It is intended to provide a peptide or a phage recognizing nanographite structures and thus enabling efficient recognition, binding, separation and alignment of nanographite structures such as carbon nanohoms or carbon nanotubes, an artificial protein or a chimeric molecule comprising the above-described peptide bonded to a functional peptide, a protein, a labeling, etc., and a complex of the above-described peptide molecule, artificial protein or chimeric molecule with a nanographite structure. By panning peptide-presenting phages bonded to nanographite structures, a nanographite structure-binding peptide capable of specifically recognizing nanographite structures such as carbon nanohoms or carbon nanotubes is obtained.
摘要翻译：本发明旨在提供一种识别纳米尺度结构的肽或噬菌体，从而能够有效地识别，结合，分离和取代纳米石墨结构如碳纳米管或碳纳米管，人造蛋白或包含上述肽的嵌合分子功能性肽，蛋白质，标记等，以及上述肽分子，人造蛋白质或嵌合分子与纳米石墨结构的复合物。通过淘选结合纳米尺度结构的肽呈递噬菌体，可以获得能够特异性识别纳米尺度结构如纳米碳纳米管或碳纳米管的纳米结构结合肽。

4. 发明授权

US6063595A Method of forming a macromolecular microgene polymer 失效
标题翻译：形成大分子微基因聚合物的方法
公开(公告)号：US6063595A
公开(公告)日：2000-05-16
申请号：US871809
申请日：1997-06-09
申请人： Kiyotaka Shiba
发明人： Kiyotaka Shiba
IPC分类号： C12N15/09 , C07H21/04 , C12N15/10 , C12N15/66 , C12Q1/68 , C12P21/06 , C12P19/34
CPC分类号： C12Q1/686 , C12N15/10 , C12N15/66
摘要： A method of forming a macromolecular microgene polymer comprises allowing DNA polymerase to act on oligonucleotides A and B complementary at least partially to each other to effect polymerase chain reaction. According to the present invention, there can be obtained a polymer consisting of a repeating microgene, which is efficiently and simply formed.
摘要翻译：形成大分子微基因聚合物的方法包括允许DNA聚合酶对彼此至少部分互补的寡核苷酸A和B起作用以进行聚合酶链式反应。根据本发明，可以获得由有效且简单地形成的重复微根组成的聚合物。

5. 发明授权

US07537786B2 Complex of drug-carbon nanohorn and a process for producing the complex 有权
标题翻译：药物 - 碳纳米角复合物及其制备方法
公开(公告)号：US07537786B2
公开(公告)日：2009-05-26
申请号：US11212645
申请日：2005-08-29
申请人： Sumio Iijima , Masako Yudasaka , Kumiko Ajima , Tatsuya Murakami , Kiyotaka Shiba
发明人： Sumio Iijima , Masako Yudasaka , Kumiko Ajima , Tatsuya Murakami , Kiyotaka Shiba
IPC分类号： A61K9/14 , A61K33/24 , A61K38/16
CPC分类号： A61K9/167 , A61K9/1617 , A61K31/573 , A61K33/24 , Y10S977/734 , Y10S977/744 , Y10S977/906
摘要： The present invention provides a carbon nanohorn complex that is excellent in characteristics of adsorption or inclusion of drugs and release, in particular, a sustained release of drugs as a novel drug carrier in drug delivery systems, as well as a process for producing the complex. The complex of drug and carbon nanohorns comprises a steroidal or metal-containing drug being adsorbed onto the oxidized carbon nanohorns, or included in pores opened thereof.
摘要翻译：本发明提供一种碳纳米角复合物，其特征在于吸附或包裹药物，特别是药物递送系统中作为新型药物载体的药物的持续释放以及生产该复合物的方法。药物和碳纳米角的复合物包含吸附在氧化的碳纳米角上的甾体或含金属的药物，或包含在其中打开的孔中。

6. 发明授权

US07498403B2 Peptides capable of binding to titanium silver silicone 有权
标题翻译：能够结合钛银硅酮的肽
公开(公告)号：US07498403B2
公开(公告)日：2009-03-03
申请号：US10566535
申请日：2004-07-30
申请人： Kiyotaka Shiba , Kenichi Sano
发明人： Kiyotaka Shiba , Kenichi Sano
IPC分类号： A61K38/08 , A61K38/10
CPC分类号： C07K7/06 , C07K7/08 , G01N33/5308 , G01N33/553 , G01N33/56983 , G01N33/84 , G01N2500/00
摘要： The present invention provides a peptide sequence, a phage, an artificial protein or a chimeric molecule having a binding ability to titanium, silver, silicon, necessary to confer higher capacity of titanium, silver, silicon material with the use of soft matters, or to provide a complex of a peptide, a phage, an artificial protein or a chimeric molecule, and titanium, having the peptide sequence and functional peptide sequence. By bringing into contact a population of phage wherein said phage of said population collectively express a library of different peptide sequence, recovering titanium bound to phage particles via peptide sequence by centrifugation, proliferating the obtained phage particles in bacteria, and repeating panning operation and concentrating titanium binding phage clones. Among the phage clones, peptide RKLPDAPGMHTW (SEQ ID NO: 3) and the like is identified. As for a peptide having a binding ability to titanium, silver, silicon, RKLPDA (SEQ ID NO: 1) or RALPDA (SEQ ID NO: 2) can be exemplified.
摘要翻译：本发明提供了具有与钛，银，硅的结合能力的肽序列，噬菌体，人造蛋白或嵌合分子，其必须赋予使用软质的钛，银，硅材料更高的容量，或提供具有肽序列和功能性肽序列的肽，噬菌体，人造蛋白或嵌合分子的复合物和钛。通过与所述群体的噬菌体接触，其中所述群体的所述噬菌体共同表达不同肽序列的文库，通过离心回收通过肽序列与噬菌体颗粒结合的钛，使获得的噬菌体颗粒在细菌中增殖，并重复平移操作并浓缩钛结合噬菌体克隆。在噬菌体克隆中，鉴定了肽RKLPDAPGMHTW（SEQ ID NO：3）等。对于具有钛，银，硅，RKLPDA（SEQ ID NO：1）或RALPDA（SEQ ID NO：2）的结合能力的肽。

7. 发明授权

US07243031B2 Method of designing multifunctional base sequence 失效
标题翻译：多功能碱基序列设计方法
公开(公告)号：US07243031B2
公开(公告)日：2007-07-10
申请号：US10746036
申请日：2003-12-29
申请人： Yoko Satou , Masato Kitajima , Kiyotaka Shiba
发明人： Yoko Satou , Masato Kitajima , Kiyotaka Shiba
IPC分类号： G06F19/00 , C12N15/11 , C07K14/00
CPC分类号： C12N15/1034 , C07K7/08
摘要： A multifunctional base sequence method largely shortens the calculation time and reduces the volume of memory consumption of a processor by carrying out calculation with the advance exclusion of base sequences in which translation termination codons emerge in the second and third reading frames, which are to be excluded in the end. Focusing on the fact that a dipeptide sequence already contains information about the translation products of the second and third reading frames, proteins are analyzed and calculated as duplicated connective products of dipeptide sequences, and are not analyzed as connective products of 20 kinds of amino acids.
摘要翻译：多功能碱基序列方法大大缩短了计算时间，并通过执行计算来减少处理器的存储器消耗量，其中基本序列的预先排除，其中翻译终止密码在第二和第三读取帧中出现，这将被排除到底。针对二肽序列已经包含关于第二和第三阅读框的翻译产物的信息的事实，蛋白质被分析和计算为二肽序列的重复连接产物，并且不作为20种氨基酸的连接产物进行分析。

8. 发明申请

US20070112174A1 Peptides capable of binding to titanium silver silicone 有权
标题翻译：能够结合钛银硅酮的肽
公开(公告)号：US20070112174A1
公开(公告)日：2007-05-17
申请号：US10566535
申请日：2004-07-30
申请人： Kiyotaka Shiba , Kenichi Sano
发明人： Kiyotaka Shiba , Kenichi Sano
IPC分类号： C07K7/06 , C07K7/08 , C40B40/10
CPC分类号： C07K7/06 , C07K7/08 , G01N33/5308 , G01N33/553 , G01N33/56983 , G01N33/84 , G01N2500/00
摘要： The present invention provides a peptide sequence, a phage, an artificial protein or a chimeric molecule having a binding ability to titanium, silver, silicon, necessary to confer higher capacity of titanium, silver, silicon material with the use of soft matters, or to provide a complex of a peptide, a phage, an artificial protein or a chimeric molecule, and titanium, having the peptide sequence and functional peptide sequence. By bringing into contact a population of phage wherein said phage of said population collectively express a library of different peptide sequence, recovering titanium bound to phage particles via peptide sequence by centrifugation, proliferating the obtained phage particles in bacteria, and repeating panning operation and concentrating titanium binding phage clones. Among the phage clones, peptide RKLPDAPGMHTW and the like is identified. As for a peptide having a binding ability to titanium, silver, silicon, RKLPDA or RALPDA can be exemplified.
摘要翻译：本发明提供了具有与钛，银，硅的结合能力的肽序列，噬菌体，人造蛋白或嵌合分子，其必须赋予使用软质的钛，银，硅材料更高的容量，或提供具有肽序列和功能性肽序列的肽，噬菌体，人造蛋白或嵌合分子的复合物和钛。通过与所述群体的噬菌体接触，其中所述群体的所述噬菌体共同表达不同肽序列的文库，通过离心回收通过肽序列与噬菌体颗粒结合的钛，使获得的噬菌体颗粒在细菌中增殖，并重复平移操作并浓缩钛结合噬菌体克隆。在噬菌体克隆中，鉴定了肽RKLPDAPGMHTW等。对于具有与钛的结合能力的肽，可以例举银，硅，RKLPDA或RALPDA。

9. 发明授权

US5759833A Human isoleucyl-tRNA synthetase proteins, nucleic acids and tester strains comprising same 失效
标题翻译：人类异亮氨酰-tRNA合成酶蛋白，包含其的核酸和测试菌株
公开(公告)号：US5759833A
公开(公告)日：1998-06-02
申请号：US468557
申请日：1995-06-06
申请人： Kiyotaka Shiba , Janice E. Kranz , Paul R. Schimmel
发明人： Kiyotaka Shiba , Janice E. Kranz , Paul R. Schimmel
IPC分类号： C12N9/00 , C07H21/04 , C12N1/14 , C12N15/00
CPC分类号： C12N9/93
摘要： Isolated, recombinant nucleic acids which encode an isoleucyl-tRNA synthetase (IleRS) of human origin have been used to make expression constructs and transformed host cells for the production of a recombinant human IleRS. A recombinant enzyme has been purified, and is active in the specific aminoacylation of tRNA by isoleucine. Isolated, recombinant enzyme, and antibodies made specifically thereto, can be useful in assays to diagnose and monitor the autoimmune disease known as "antisynthetase syndrome." The essential isoleucyl-tRNA synthetases of microbes pathogenic in humans can be the targets of inhibitory agents having antimicrobial activity. A human isoleucyl-tRNA synthetase, isolated and purified, can be used to assess the toxic effect in humans of such an inhibitory agent in various biochemical activity assays. This human enzyme can also be expressed in "tester strains," whose cells rely upon the function of the human isoleucyl-tRNA synthetase for tRNA.sup.Ile charging. Such tester strains can be used to test for any toxic effects of an antimicrobial agent that specifically interacts with a heterologous human IleRS gene or gene product.
摘要翻译：已经使用编码人来源的异亮氨酰-tRNA合成酶（IleRS）的分离的重组核酸来制备表达构建体和转化的宿主细胞以产生重组人IleRS。重组酶已被纯化，并且在异亮氨酸的特异性氨基酰化tRNA中具有活性。分离的重组酶和特异性制备的抗体可用于诊断和监测被称为“抗体合成酶综合征”的自身免疫疾病的测定中。人类致病微生物的基本的异亮氨酰-tRNA合成酶可以是具有抗微生物活性的抑制剂的靶标。分离和纯化的人类异亮氨酰-tRNA合成酶可用于评估在各种生物化学活性测定中人类对这种抑制剂的毒性作用。这种人类酶也可以在“测试菌株”中表达，其细胞依赖于人类异亮氨酰-tRNA合成酶的功能用于tRNA充电。这样的测试菌株可用于测试与异源人IleRS基因或基因产物特异性相互作用的抗微生物剂的任何毒性作用。

10. 发明申请

US20100029910A1 NANOGRAPHITE STRUCTURE/METAL NANOPARTICLE COMPOSITE 有权
标题翻译：纳米结构/金属纳米复合材料
公开(公告)号：US20100029910A1
公开(公告)日：2010-02-04
申请号：US11767583
申请日：2007-06-25
申请人： Kiyotaka Shiba , Kenichi Sano , Kenji Iwahori
发明人： Kiyotaka Shiba , Kenichi Sano , Kenji Iwahori
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B32/18 , C01B2202/02
摘要： The present invention makes it possible to efficiently recognize carbon nanotubes, carbon nanohorns or modifiers thereof and to support functional compounds by fusing the ability of ferritin molecules capable of forming nanoparticles of inorganic metal atoms or inorganic metal compounds. In addition, because ferritin molecules are capable of forming two-dimensional crystals at the interface, the present invention makes it possible to align carbon nanotubes, carbon nanohorns with the use of the molecular arrangement ability of ferritin fused with nanographite structure recognition peptides. A nanographite structure/metal nanoparticle composite is constructed, wherein a nanoparticle of an inorganic metal atom or an inorganic metal compound is retained in an interior space of a protein in which a nanographite structure recognition peptide is fused or chemically bound to a surface of a cage protein such as ferritin, and wherein a plurality of nanoparticles of an inorganic metal atom or an inorganic metal compound are supported on a nanographite structure with the use of affinity of the nanographite structure recognition peptide to the nanographite structure.
摘要翻译：本发明使得能够有效地识别碳纳米管，碳纳米角或其改性剂，并且通过融合能够形成无机金属原子或无机金属化合物的纳米颗粒的铁蛋白分子的能力来支持功能性化合物。此外，由于铁蛋白分子能够在界面处形成二维晶体，因此本发明可以利用与纳米结构识别肽融合的铁蛋白的分子排列能力来对准碳纳米管，碳纳米角。构建纳米结构/金属纳米颗粒复合物，其中无机金属原子或无机金属化合物的纳米颗粒保留在蛋白质的内部空间中，其中纳米结构识别肽与笼的表面融合或化学结合蛋白质如铁蛋白，并且其中使用纳米尺度结构识别肽与纳米尺度结构的亲和力将纳米尺度结构上的无机金属原子或无机金属化合物的多个纳米颗粒负载在纳米尺度结构上。

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