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1. 发明授权

US09125854B2 Compositions and methods of enhancing immune responses to flagellated bacterium 有权
标题翻译：增强对鞭毛细菌的免疫应答的组合物和方法
公开(公告)号：US09125854B2
公开(公告)日：2015-09-08
申请号：US12740631
申请日：2008-10-30
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： A61K39/02 , A61K39/112 , A61K39/00
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/552 , Y02A50/482
摘要： Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
摘要翻译：提供了包含fliC和CD154多肽的疫苗和包含fliC多肽的肠炎沙门氏杆菌疫苗载体。还提供了增强针对鞭毛细菌的免疫应答的电弧法和减少与鞭毛细菌感染相关的发病率的方法。

2. 发明申请

US20110159026A1 COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO FLAGELLATED BACTERIUM 有权
标题翻译：增强对细菌细菌的免疫反应的组合物和方法
公开(公告)号：US20110159026A1
公开(公告)日：2011-06-30
申请号：US12740631
申请日：2008-10-30
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： A61K39/112 , A61P37/04 , A61P31/04
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/552 , Y02A50/482
摘要： Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
摘要翻译：提供了包含fliC和CD154多肽的疫苗和包含fliC多肽的肠炎沙门氏杆菌疫苗载体。还提供了增强针对鞭毛细菌的免疫应答的电弧法和减少与鞭毛细菌感染相关的发病率的方法。

3. 发明申请

US20110109070A1 WRAP-AROUND AIRBAG DEVICE 有权
标题翻译：缠绕安全气囊装置
公开(公告)号：US20110109070A1
公开(公告)日：2011-05-12
申请号：US12939570
申请日：2010-11-04
申请人： Hiroki Tanaka , Jonathan David Ruddy , Dennis Ames Burton , Kimberly Cole
发明人： Hiroki Tanaka , Jonathan David Ruddy , Dennis Ames Burton , Kimberly Cole
IPC分类号： B60R21/26
CPC分类号： B60R21/206 , B60R21/232 , B60R21/233 , B60R21/2334 , B60R21/2338 , B60R21/235 , B60R21/261 , B60R2021/0032 , B60R2021/0051 , B60R2021/0053 , B60R2021/23169 , B60R2021/23308 , B60R2021/23316 , B60R2021/23324 , B60R2021/23382
摘要： An airbag device for a vehicle including at least one airbag housing interface chamber that attaches to an airbag housing; at least one airbag cushion chamber downstream of the at least one interface chamber; an elbow that fluidly connects the housing interface chamber with the cushion chamber and configured so that it controllably regulates gas flow into the at least one airbag cushion chamber; the elbow having an internal configuration, which includes at least one opening that permits back and forth gas flow between the elbow and the at least one airbag cushion chamber, and which controls the directional deployment of the airbag cushion chamber so that upon deployment the downstream end of the cushion chamber exits an airbag housing outwardly in a first direction and then in at least one second direction, so that the direction of deployment of the cushion chamber changes in direction to thereby wrap at least partially around a structure of a vehicle of the vehicle and at least temporarily interpose the cushion chamber between any occupant and the vehicle structure.
摘要翻译：一种用于车辆的气囊装置，包括至少一个附接到气囊壳体的气囊壳体接口室; 在所述至少一个界面室下游的至少一个安全气囊垫室; 将所述壳体接口室与所述缓冲室流体连接并且构造成使得其可控地调节进入所述至少一个气囊缓冲室的气体流量的弯头; 肘部具有内部构造，其包括至少一个开口，其允许在肘部和至少一个气囊缓冲室之间来回流动，并且其控制安全气囊缓冲室的定向展开，使得在展开后，下游端缓冲室的第一方向向外离开安全气囊，然后在至少一个第二方向上离开安全气囊，使得缓冲室的展开方向在方向上变化，从而至少部分地围绕车辆的车辆结构并且至少临时地将缓冲室介入任何乘员和车辆结构之间。

4. 发明授权

US08956849B2 Compositions and methods of enhancing immune responses to Eimeria 有权
标题翻译：增强对艾美球虫免疫反应的组合物和方法
公开(公告)号：US08956849B2
公开(公告)日：2015-02-17
申请号：US12740608
申请日：2008-11-03
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
IPC分类号： C07H21/04 , C07H21/02 , C12N7/00 , C12N7/01 , C12N15/00 , C07K14/705 , C07K14/455 , A61K39/00
CPC分类号： A61K39/002 , A61K2039/523 , A61K2039/53 , C07K14/455 , C07K14/70575 , C07K2319/03 , Y02A50/412
摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
摘要翻译：提供了包含TRAP多肽和包含TRAP多肽的肠炎沙门氏菌载体的疫苗。疫苗还可以包括能够结合CD40的CD154多肽。还提供了增强针对Apicomplexan寄生虫的免疫应答的方法和降低与Apicomplexan寄生虫感染相关的发病率的方法。

5. 发明申请

US20110027309A1 COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES 有权
标题翻译：组合物和增强免疫应答的方法
公开(公告)号：US20110027309A1
公开(公告)日：2011-02-03
申请号：US12441851
申请日：2007-09-18
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： A61K39/00 , C12N15/63 , A61K39/02 , A61K39/145 , A61K39/112 , C12N1/21 , C12N15/64 , A61P37/04 , A61P31/16
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
摘要翻译：本文提供了肠炎沙门氏菌13A菌株和包含这些菌株的组合物。还提供了增强针对甲型流感的免疫应答的方法和降低与甲型流感感染相关的发病率的方法。还公开了通过表达能够结合CD40的CD154多肽增强对疫苗载体的免疫应答的方法。公开了开发细菌疫苗载体的方法。还公开了在细菌中产生无疤痕位点突变的方法。

6. 发明申请

US20070144831A1 Foldable chair and ladder combination 有权
标题翻译：折叠椅和梯子组合
公开(公告)号：US20070144831A1
公开(公告)日：2007-06-28
申请号：US11318109
申请日：2005-12-23
申请人： Kimberly Cole
发明人： Kimberly Cole
IPC分类号： A47C13/00
CPC分类号： A47C12/02
摘要： A combination chair and ladder assembly including a center leg, a rear leg and a front leg wherein the rear leg is pivotally connected to the center leg and swings outwardly away from the center leg. The assembly includes a lower step or platform assembly including a first platform having first and second portions with a hinge connecting the first and second portions. The front leg is connected to the first platform. In addition, the chair and ladder assembly may include an upper step or platform assembly having a plurality of platforms pivotally connected to the center leg and to a front support member. The lower step or platform assembly operates independently of the upper step or platform assembly.
摘要翻译：组合的椅子和梯子组件，包括中心腿，后腿和前腿，其中后腿可枢转地连接到中心腿并且从中心腿向外摆动。组件包括下台阶或平台组件，其包括具有第一和第二部分的第一平台，第一和第二部分具有连接第一和第二部分的铰链。前腿连接到第一个平台。此外，椅子和梯子组件可以包括具有枢转地连接到中心腿和前支撑构件的多个平台的上台阶或平台组件。下阶梯或平台组件独立于上台阶或平台组件而工作。

7. 发明授权

US08393636B2 Wrap-around airbag device 有权
标题翻译：环绕安全气囊装置
公开(公告)号：US08393636B2
公开(公告)日：2013-03-12
申请号：US12939570
申请日：2010-11-04
申请人： Hiroki Tanaka , Jonathan David Ruddy , Dennis Ames Burton , Kimberly Cole
发明人： Hiroki Tanaka , Jonathan David Ruddy , Dennis Ames Burton , Kimberly Cole
IPC分类号： B60R21/206 , B60R21/233
CPC分类号： B60R21/206 , B60R21/232 , B60R21/233 , B60R21/2334 , B60R21/2338 , B60R21/235 , B60R21/261 , B60R2021/0032 , B60R2021/0051 , B60R2021/0053 , B60R2021/23169 , B60R2021/23308 , B60R2021/23316 , B60R2021/23324 , B60R2021/23382
摘要： An airbag device for a vehicle including at least one airbag housing interface chamber that attaches to an airbag housing; at least one airbag cushion chamber downstream of the at least one interface chamber; an elbow that fluidly connects the housing interface chamber with the cushion chamber and configured so that it controllably regulates gas flow into the at least one airbag cushion chamber; the elbow having an internal configuration, which includes at least one opening that permits back and forth gas flow between the elbow and the at least one airbag cushion chamber, and which controls the directional deployment of the airbag cushion chamber so that upon deployment the downstream end of the cushion chamber exits an airbag housing outwardly in a first direction and then in at least one second direction, so that the direction of deployment of the cushion chamber changes in direction to thereby wrap at least partially around a structure of a vehicle of the vehicle and at least temporarily interpose the cushion chamber between any occupant and the vehicle structure.
摘要翻译：一种用于车辆的气囊装置，包括至少一个附接到气囊壳体的气囊壳体接口室; 在所述至少一个界面室下游的至少一个安全气囊垫室; 将所述壳体接口室与所述缓冲室流体连接并且构造成使得其可控地调节进入所述至少一个气囊缓冲室的气体流量的弯头; 肘部具有内部构造，其包括至少一个开口，其允许在肘部和至少一个气囊缓冲室之间来回流动，并且其控制安全气囊缓冲室的定向展开，使得在展开后，下游端缓冲室的第一方向向外离开安全气囊，然后在至少一个第二方向上离开安全气囊，使得缓冲室的展开方向在方向上变化，从而至少部分地围绕车辆的车辆结构并且至少临时地将缓冲室介入任何乘员和车辆结构之间。

8. 发明申请

US20110111015A1 COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA 有权
标题翻译：组合物和增强对艾美儿免疫应答的方法
公开(公告)号：US20110111015A1
公开(公告)日：2011-05-12
申请号：US12740608
申请日：2008-11-03
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
IPC分类号： A61K9/127 , A61K39/00 , A61K39/12 , A61K39/02 , A61K39/112 , A61K39/07 , A61K39/108 , A61K39/002 , A61K39/012 , A61K39/015 , A61P37/04 , A61P33/02
CPC分类号： A61K39/002 , A61K2039/523 , A61K2039/53 , C07K14/455 , C07K14/70575 , C07K2319/03 , Y02A50/412
摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD4Q. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
摘要翻译：提供了包含TRAP多肽和包含TRAP多肽的肠炎沙门氏菌载体的疫苗。疫苗还可以包括能够结合CD4Q的CD154多肽。还提供了增强针对Apicomplexan寄生虫的免疫应答的方法和降低与Apicomplexan寄生虫感染相关的发病率的方法。

9. 发明授权

US08604178B2 Compositions and methods of enhancing immune responses 有权
标题翻译：增强免疫反应的组合物和方法
公开(公告)号：US08604178B2
公开(公告)日：2013-12-10
申请号：US12441851
申请日：2007-09-18
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： C07H21/02 , A61K49/00 , A61K39/112
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
摘要翻译：本文提供了肠炎沙门氏菌13A菌株和包含这些菌株的组合物。还提供了增强针对甲型流感的免疫应答的方法和降低与甲型流感感染相关的发病率的方法。还公开了通过表达能够结合CD40的CD154多肽增强对疫苗载体的免疫应答的方法。公开了开发细菌疫苗载体的方法。还公开了在细菌中产生无疤痕位点突变的方法。

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