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1. 发明授权

US08243999B2 Method and system for the diagnosis of disease using retinal image content and an archive of diagnosed human patient data 有权
标题翻译：用于使用视网膜图像内容诊断疾病的诊断方法和系统以及诊断的人类患者数据的归档
公开(公告)号：US08243999B2
公开(公告)日：2012-08-14
申请号：US11416834
申请日：2006-05-03
申请人： Kenneth William Tobin, Jr. , Thomas P. Karnowski , Edward Chaum
发明人： Kenneth William Tobin, Jr. , Thomas P. Karnowski , Edward Chaum
IPC分类号： G06K9/00
CPC分类号： G06K9/0061 , A61B3/12 , G06K9/00617
摘要： A method for diagnosing diseases having retinal manifestations including retinal pathologies includes the steps of providing a CBIR system including an archive of stored digital retinal photography images and diagnosed patient data corresponding to the retinal photography images, the stored images each indexed in a CBIR database using a plurality of feature vectors, the feature vectors corresponding to distinct descriptive characteristics of the stored images. A query image of the retina of a patient is obtained. Using image processing, regions or structures in the query image are identified. The regions or structures are then described using the plurality of feature vectors. At least one relevant stored image from the archive based on similarity to the regions or structures is retrieved, and an eye disease or a disease having retinal manifestations in the patient is diagnosed based on the diagnosed patient data associated with the relevant stored image(s).
摘要翻译：用于诊断具有视网膜表现的疾病（包括视网膜病变）的方法包括以下步骤：提供CBIR系统，其包括存储的数字视网膜摄影图像的存档和与视网膜摄影图像相对应的诊断的患者数据，所存储的图像每个索引在CBIR数据库中，使用多个特征向量，对应于所存储图像的不同描述特征的特征向量。获得患者视网膜的查询图像。使用图像处理，识别查询图像中的区域或结构。然后使用多个特征向量来描述区域或结构。基于与区域或结构的相似性，归档归档中的至少一个相关的存储图像，并且基于与相关的存储图像相关联的诊断的患者数据来诊断眼病或患者中具有视网膜表现的疾病，。

2. 发明授权

US06421409B1 Ultra-high resolution computed tomography imaging 失效
标题翻译：超高分辨率计算机断层成像
公开(公告)号：US06421409B1
公开(公告)日：2002-07-16
申请号：US09496879
申请日：2000-02-02
申请人： Michael J. Paulus , Hamed Sari-Sarraf , Kenneth William Tobin, Jr. , Shaun S. Gleason , Clarence E. Thomas, Jr.
发明人： Michael J. Paulus , Hamed Sari-Sarraf , Kenneth William Tobin, Jr. , Shaun S. Gleason , Clarence E. Thomas, Jr.
IPC分类号： A61B603
CPC分类号： G01T1/29 , Y10S378/901
摘要： A method for ultra-high resolution computed tomography imaging, comprising the steps of: focusing a high energy particle beam, for example x-rays or gamma-rays, onto a target object; acquiring a 2-dimensional projection data set representative of the target object; generating a corrected projection data set by applying a deconvolution algorithm, having an experimentally determined a transfer function, to the 2-dimensional data set; storing the corrected projection data set; incrementally rotating the target object through an angle of approximately 180°, and after each the incremental rotation, repeating the radiating, acquiring, generating and storing steps; and, after the rotating step, applying a cone-beam algorithm, for example a modified tomographic reconstruction algorithm, to the corrected projection data sets to generate a 3-dimensional image. The size of the spot focus of the beam is reduced to not greater than approximately 1 micron, and even to not greater than approximately 0.5 microns.
摘要翻译：一种用于超高分辨率计算机断层摄影成像的方法，包括以下步骤：将高能粒子束（例如x射线或γ射线）聚焦到目标物体上; 获取代表目标对象的二维投影数据集; 通过将具有实验确定的传递函数的去卷积算法应用于所述二维数据集来生成校正投影数据集; 存储校正的投影数据集; 逐渐旋转目标物体大约180°的角度，并且在每次增量旋转之后，重复辐射，获取，产生和存储步骤; 并且在旋转步骤之后，将锥束算法（例如修改的断层摄影重建算法）应用于校正的投影数据集以生成三维图像。光束的焦点尺寸减小到不大于约1微米，甚至不大于约0.5微米。

3. 发明授权

US06195412B1 Confocal coded aperture imaging 失效
标题翻译：共聚焦编码孔径成像
公开(公告)号：US06195412B1
公开(公告)日：2001-02-27
申请号：US09266055
申请日：1999-03-10
申请人： Kenneth William Tobin, Jr. , Clarence E. Thomas, Jr.
发明人： Kenneth William Tobin, Jr. , Clarence E. Thomas, Jr.
IPC分类号： G01T1161
CPC分类号： G01T1/295
摘要： A method for imaging a target volume comprises the steps of: radiating a small bandwidth of energy toward the target volume; focusing the small bandwidth of energy into a beam; moving the target volume through a plurality of positions within the focused beam; collecting a beam of energy scattered from the target volume with a non-diffractive confocal coded aperture; generating a shadow image of said aperture from every point source of radiation in the target volume; and, reconstructing the shadow image into a 3-dimensional image of the every point source by mathematically correlating the shadow image with a digital or analog version of the coded aperture. The method can comprise the step of collecting the beam of energy scattered from the target volume with a Fresnel zone plate.
摘要翻译：用于对目标体积进行成像的方法包括以下步骤：向目标体积辐射小的能量带宽; 将能量的小带宽集中在光束中; 通过聚焦光束内的多个位置移动目标体积; 以非衍射共焦编码孔径收集从目标体积散射的能量束; 从目标体积中的每个点辐射源产生所述孔径的阴影图像; 并且通过数字地将阴影图像与编码孔径的数字或模拟版本相关联，将影子图像重建成每个点源的3维图像。该方法可以包括用菲涅耳带板收集从目标体积散射的能量束的步骤。

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