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1. 发明授权

US07955677B2 Two-sided non-stick release film 有权
标题翻译：双面不粘剥离膜
公开(公告)号：US07955677B2
公开(公告)日：2011-06-07
申请号：US11296604
申请日：2005-12-07
申请人： Brad L. Barnett , Martin Fletcher , Kenneth J. Miller, II
发明人： Brad L. Barnett , Martin Fletcher , Kenneth J. Miller, II
IPC分类号： B32B37/00
CPC分类号： A61K9/703 , A61F2013/0296 , Y10T428/14 , Y10T428/149 , Y10T428/1495 , Y10T428/15 , Y10T428/24273 , Y10T428/24298 , Y10T428/24314 , Y10T428/24322 , Y10T428/24331
摘要： Assemblies for the adhesive attachment to the skin or mucosa of a host are disclosed. The assembly or transdermal patch includes an outer backing layer, a first layer of adhesive on the inner surface of the outer backing layer, an inner backing layer, and an intermediate release liner between the first layer of adhesive and the inner backing layer. The intermediate release liner includes a releasable surface on both its inner and outer surfaces.
摘要翻译：公开了用于粘合剂附着到宿主皮肤或粘膜的组件。组装体或透皮贴片包括外背衬层，在外背衬层的内表面上的第一粘合剂层，内背衬层，以及在第一粘合剂层和内背衬层之间的中间剥离衬垫。中间剥离衬垫包括其内表面和外表面上的可释放表面。

2. 发明申请

US20090238861A1 FENTANYL SUSPENSION-BASED SILICONE ADHESIVE FORMULATIONS AND DEVICES FOR TRANSDERMAL DELIVERY OF FENTANYL 审中-公开
标题翻译： FENTANYL基于悬浮液的硅胶粘合剂配方及用于FENTANYL的异常递送设备
公开(公告)号：US20090238861A1
公开(公告)日：2009-09-24
申请号：US12476401
申请日：2009-06-02
申请人： Kenneth J. Miller, II , Sharad K. Govil , Kuljit Singh Bhatia
发明人： Kenneth J. Miller, II , Sharad K. Govil , Kuljit Singh Bhatia
IPC分类号： A61F13/00 , A61K31/445
CPC分类号： A61K9/7069 , A61K31/445 , Y10T156/10
摘要： Silicone adhesive formulations are provided, in which fentanyl particles are suspended one or more a solvated silicone adhesives. The formulations can be used for manufacturing improved, matrix-type transdermal devices for administering fentanyl.
摘要翻译：提供了硅酮粘合剂制剂，其中芬太尼颗粒悬浮在一种或多种溶剂化硅氧烷粘合剂上。制剂可用于制造用于施用芬太尼的改进的基质型透皮装置。

3. 发明申请

US20090142390A1 TRANSDERMAL SYSTEMS CONTAINING MULTILAYER ADHESIVE MATRICES TO MODIFY DRUG DELIVERY 有权
标题翻译：包含多层粘合剂基体的变态系统修改药物递送
公开(公告)号：US20090142390A1
公开(公告)日：2009-06-04
申请号：US12272706
申请日：2008-11-17
申请人： Kristin Jackson , Kenneth J. Miller, II
发明人： Kristin Jackson , Kenneth J. Miller, II
IPC分类号： A61K9/70 , A61K31/565
CPC分类号： A61K9/7092 , A61F2013/00646 , A61F2013/0071 , A61F2013/00906 , A61K8/0208 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K9/7084
摘要： A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix.The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.
摘要翻译：含透皮药物的剂量单位包括：基本上不透过经皮递送的药物的背衬层; 与背衬层接触的第一聚合物粘合剂基质，其中分散有药物并具有药物的第一递送曲线; 与所述第一聚合物粘合剂基质接触的第二聚合物粘合剂基质，其中分散有药物并具有药物的第二递送分布，其中所述第二递送分布与所述第一递送分布不同; 以及与第二聚合物粘合剂基质接触的剥离衬垫。第一聚合物粘合剂基质可以比第二聚合物粘合剂基质更快或更慢地释放药物。通过选择两个基质，可以选择性地改变和控制药物通过皮肤的递送特征。

4. 发明授权

US08449907B2 Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl 有权
标题翻译：基于芬太尼悬浮液的硅胶制剂和芬太尼透皮给药装置
公开(公告)号：US08449907B2
公开(公告)日：2013-05-28
申请号：US13192178
申请日：2011-07-27
申请人： Kenneth J. Miller, II , Sharad K. Govil , Kuljit Singh Bhatia
发明人： Kenneth J. Miller, II , Sharad K. Govil , Kuljit Singh Bhatia
IPC分类号： A61F13/02 , A61F13/00 , A61L15/16 , A61K9/70
CPC分类号： A61K9/7069 , A61K31/445 , Y10T156/10
摘要： Silicone adhesive formulations are provided, in which fentanyl particles are suspended one or more a solvated silicone adhesives. The formulations can be used for manufacturing improved, matrix-type transdermal devices for administering fentanyl.
摘要翻译：提供了硅酮粘合剂制剂，其中芬太尼颗粒悬浮在一种或多种溶剂化硅氧烷粘合剂上。制剂可用于制造用于施用芬太尼的改进的基质型透皮装置。

5. 发明申请

US20120061018A1 METHOD FOR MAKING A MULTILAYER ADHESIVE LAMINATE 有权
标题翻译：制造多层粘合层压板的方法
公开(公告)号：US20120061018A1
公开(公告)日：2012-03-15
申请号：US13299747
申请日：2011-11-18
申请人： Kenneth J. Miller, II
发明人： Kenneth J. Miller, II
IPC分类号： B32B38/04
CPC分类号： B32B37/02 , A61F13/0253 , B32B37/0053 , B32B38/04 , B32B38/1816 , B32B2038/045 , C09J7/00 , C09J7/10 , C09J7/38 , C09J2201/36 , C09J2201/606 , Y10T156/1059 , Y10T156/1062 , Y10T156/1069 , Y10T156/1075 , Y10T156/1077
摘要： A method allows for rapid manufacture of relatively thick adhesive coatings using a continuous process, where a single thin coating is continuously converted into a single thicker adhesive laminate. An exemplary process includes the steps of: (1) producing a web having a first surface with an adhesive layer and a second surface with a release liner; (2) slitting the web longitudinally into a first section and a second section; (3) laminating a backing film to the adhesive layer of the first section; (4) removing the release liner of the laminate of step (3) exposing the adhesive layer of the first section; and (5) laminating the second section to the laminate of step (4), wherein the adhesive layer of the laminate of step (4) is combined with the adhesive layer of the second section.
摘要翻译：一种方法允许使用连续方法快速制造相对厚的粘合剂涂层，其中单个薄涂层被连续地转换成单个较厚的粘合剂层压体。示例性方法包括以下步骤：（1）制备具有带有粘合剂层的第一表面和具有剥离衬垫的第二表面的网; （2）将幅材纵向切割成第一部分和第二部分; （3）将背衬膜层压到第一部分的粘合剂层上; （4）去除暴露第一部分的粘合剂层的步骤（3）的层压体的剥离衬垫; 和（5）将第二部分层合到步骤（4）的层压体中，其中步骤（4）的层压体的粘合剂层与第二部分的粘合剂层组合。

6. 发明申请

US20100086582A1 AMORPHOUS ROTIGOTINE TRANSDERMAL SYSTEM 审中-公开
标题翻译：非晶转运系统
公开(公告)号：US20100086582A1
公开(公告)日：2010-04-08
申请号：US12571509
申请日：2009-10-01
申请人： Jiansheng Tang , Joseph M. Deverich , Kenneth J. Miller, II , Russell D. Beste
发明人： Jiansheng Tang , Joseph M. Deverich , Kenneth J. Miller, II , Russell D. Beste
IPC分类号： A61K31/381 , A61K9/70 , A61P25/16
CPC分类号： A61K9/7038 , A61K31/381
摘要： The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of rotigotine substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing a supersaturated amount of rotigotine substantially in amorphous form. Further, the present invention refers to a method of stabilizing and a method of reestablishing the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.
摘要翻译：本发明涉及一种透皮递送装置，其包括背层，粘合剂基质层，其包含在粘合剂基质内基本上无定形形式的过饱和浓度的罗替戈汀和释放衬垫。本发明还涉及一种制备含有基本上无定形形式的过饱和量的罗替戈汀的粘合剂基质的方法。此外，本发明涉及一种稳定化方法和在其制造，储存，运输和处理过程中重新建立间 - 稳定非晶药物透皮系统的方法。

7. 发明申请

US20100084084A1 Method for Making a Multilayer Adhesive Laminate 有权
标题翻译：制造多层粘合层压板的方法
公开(公告)号：US20100084084A1
公开(公告)日：2010-04-08
申请号：US12571560
申请日：2009-10-01
申请人： Kenneth J. Miller, II
发明人： Kenneth J. Miller, II
IPC分类号： B32B37/02 , B32B38/04
CPC分类号： B32B37/02 , A61F13/0253 , B32B37/0053 , B32B38/04 , B32B38/1816 , B32B2038/045 , C09J7/00 , C09J7/10 , C09J7/38 , C09J2201/36 , C09J2201/606 , Y10T156/1059 , Y10T156/1062 , Y10T156/1069 , Y10T156/1075 , Y10T156/1077
摘要： A method allows for rapid manufacture of relatively thick adhesive coatings using a continuous process, where a single thin coating is continuously converted into a single thicker adhesive laminate. An exemplary process includes the steps of: (1) producing a web having a first surface with an adhesive layer and a second surface with a release liner; (2) slitting the web longitudinally into a first section and a second section, each section having a first surface with an adhesive layer and a second surface with a release liner; (3) laminating a backing film to the adhesive layer of the first section; (4) removing the release liner of the laminate of step (3) exposing the adhesive layer of the first section; (5) positioning the laminate of step (4) and the second section so the exposed adhesive layer of the laminate of step (4) faces the adhesive layer of the second section; and (6) laminating the second section to the laminate of step (4), wherein the adhesive layer of the laminate of step (4) is combined with the adhesive layer of the second section. The resultant laminate of this exemplary process has one surface having a backing film, one surface having a release liner, and an inner area having an adhesive layer.
摘要翻译：一种方法允许使用连续方法快速制造相对厚的粘合剂涂层，其中单个薄涂层被连续地转换成单个较厚的粘合剂层压体。示例性方法包括以下步骤：（1）制备具有带有粘合剂层的第一表面和具有剥离衬垫的第二表面的网; （2）将幅材纵向切割成第一部分和第二部分，每个部分具有带有粘合剂层的第一表面和具有剥离衬垫的第二表面; （3）将背衬膜层压到第一部分的粘合剂层上; （4）去除暴露第一部分的粘合剂层的步骤（3）的层压体的剥离衬垫; （5）将步骤（4）和第二部分的层叠体定位，使步骤（4）的层压体的暴露的粘合剂层面向第二部分的粘合剂层; 和（6）将第二部分层合到步骤（4）的层压体中，其中步骤（4）的层压体的粘合剂层与第二部分的粘合剂层组合。该示例性方法的所得层压体具有一个具有背衬膜的表面，一个具有剥离衬垫的表面和具有粘合剂层的内部区域。

8. 发明授权

US09205062B2 Transdermal systems containing multilayer adhesive matrices to modify drug delivery 有权
公开(公告)号：US09205062B2
公开(公告)日：2015-12-08
申请号：US12272706
申请日：2008-11-17
申请人： Kristin Jackson , Kenneth J. Miller, II
发明人： Kristin Jackson , Kenneth J. Miller, II
IPC分类号： A61F13/00 , A61K9/70 , A61K8/02
CPC分类号： A61K9/7092 , A61F2013/00646 , A61F2013/0071 , A61F2013/00906 , A61K8/0208 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K9/7084
摘要： A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix.The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.

9. 发明授权

US08524272B2 Transdermal patch incorporating active agent migration barrier layer 有权
标题翻译：包含活性剂迁移阻挡层的透皮贴剂
公开(公告)号：US08524272B2
公开(公告)日：2013-09-03
申请号：US10641654
申请日：2003-08-15
申请人： Kenneth J. Miller, II
发明人： Kenneth J. Miller, II
IPC分类号： A61F13/02 , A61F13/00 , A61F5/00 , A61F15/00 , A61K9/70 , A61L15/16 , A61L15/00
CPC分类号： A61M35/00 , A61F2013/0296 , A61K9/703 , A61K9/7084
摘要： Devices for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch. One outer layer functions as the primary adhesive layer for adhering the patch to the host. The other inner layer contains at least one active agent to be administered to the host. The inner layer is bonded to the outer layer through an opening provided in an interposed active agent impermeable release layer. The release layer separates a circumferential portion of the active agent containing inner layer from the outer adhesive layer to inhibit migration of the active agent therebetween.
摘要翻译：用于将一种或多种活性剂施用于主体的皮肤或粘膜的装置形成为双盘补片的性质。一个外层用作将贴剂粘附到主体上的主要粘合剂层。另一个内层含有至少一种要施用于宿主的活性剂。内层通过提供在插入的活性剂不渗透释放层中的开口结合到外层。释放层将含有内层的活性剂的周边部分与外部粘合剂层分离，以抑制活性剂在其间的迁移。

10. 发明申请

US20090234308A1 Transdermal systems having control delivery system 审中-公开
标题翻译：具有控制传递系统的透皮系统
公开(公告)号：US20090234308A1
公开(公告)日：2009-09-17
申请号：US12454782
申请日：2009-05-22
申请人： Kristin Jackson , Kenneth J. Miller, II , Pavan Bhat
发明人： Kristin Jackson , Kenneth J. Miller, II , Pavan Bhat
IPC分类号： A61M35/00 , B32B38/08 , C09J5/00
CPC分类号： A61K9/7061 , A61F13/0276 , A61F13/0283 , A61F13/0289 , A61F2013/0296 , A61K9/7053 , A61K9/7092 , A61K31/00 , A61K31/137 , A61K31/565 , A61K47/10 , A61K47/12
摘要： Transdermal delivery systems are disclosed including a backing layer, a polymer membrane within the backing layer, an adhesive layer for attaching the delivery system to the patient's skin or mucosa, and a releasable layer covering the adhesive layer prior to use, the polymer membrane impregnated with sufficient fluid medium to alter the rate of transmission of an active agent through the polymer membrane, with the amount of fluid medium being greater than the amount retained by the fluid membrane upon drying.
摘要翻译：公开了透皮递送系统，其包括背衬层，背衬层内的聚合物膜，用于将递送系统附着到患者皮肤或粘膜的粘合剂层，以及在使用之前覆盖粘合剂层的可释放层，所述聚合物膜浸渍足够的流体介质来改变活性剂通过聚合物膜的传播速率，流体介质的量大于干燥时由流体膜保留的量。

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