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1. 发明申请

US20130319595A1 FENTANYL SUSPENSION-BASED SILICONE ADHESIVE FORMULATIONS AND DEVICES FOR TRANSDERMAL DELIVERY OF FENTANYL 审中-公开
公开(公告)号：US20130319595A1
公开(公告)日：2013-12-05
申请号：US13872329
申请日：2013-04-29
申请人： Kenneth J. Miller , Sharad K. Govil , Kuljit Singh Bhatia
发明人： Kenneth J. Miller , Sharad K. Govil , Kuljit Singh Bhatia
IPC分类号： A61K9/70
CPC分类号： A61K9/7069 , A61K31/445 , Y10T156/10
摘要： Silicone adhesive formulations are provided, in which fentanyl particles are suspended one or more a solvated silicone adhesives. The formulations can be used for manufacturing improved, matrix-type transdermal devices for administering fentanyl.

2. 发明授权

US07955677B2 Two-sided non-stick release film 有权
标题翻译：双面不粘剥离膜
公开(公告)号：US07955677B2
公开(公告)日：2011-06-07
申请号：US11296604
申请日：2005-12-07
申请人： Brad L. Barnett , Martin Fletcher , Kenneth J. Miller, II
发明人： Brad L. Barnett , Martin Fletcher , Kenneth J. Miller, II
IPC分类号： B32B37/00
CPC分类号： A61K9/703 , A61F2013/0296 , Y10T428/14 , Y10T428/149 , Y10T428/1495 , Y10T428/15 , Y10T428/24273 , Y10T428/24298 , Y10T428/24314 , Y10T428/24322 , Y10T428/24331
摘要： Assemblies for the adhesive attachment to the skin or mucosa of a host are disclosed. The assembly or transdermal patch includes an outer backing layer, a first layer of adhesive on the inner surface of the outer backing layer, an inner backing layer, and an intermediate release liner between the first layer of adhesive and the inner backing layer. The intermediate release liner includes a releasable surface on both its inner and outer surfaces.
摘要翻译：公开了用于粘合剂附着到宿主皮肤或粘膜的组件。组装体或透皮贴片包括外背衬层，在外背衬层的内表面上的第一粘合剂层，内背衬层，以及在第一粘合剂层和内背衬层之间的中间剥离衬垫。中间剥离衬垫包括其内表面和外表面上的可释放表面。

3. 发明申请

US20090238861A1 FENTANYL SUSPENSION-BASED SILICONE ADHESIVE FORMULATIONS AND DEVICES FOR TRANSDERMAL DELIVERY OF FENTANYL 审中-公开
标题翻译： FENTANYL基于悬浮液的硅胶粘合剂配方及用于FENTANYL的异常递送设备
公开(公告)号：US20090238861A1
公开(公告)日：2009-09-24
申请号：US12476401
申请日：2009-06-02
申请人： Kenneth J. Miller, II , Sharad K. Govil , Kuljit Singh Bhatia
发明人： Kenneth J. Miller, II , Sharad K. Govil , Kuljit Singh Bhatia
IPC分类号： A61F13/00 , A61K31/445
CPC分类号： A61K9/7069 , A61K31/445 , Y10T156/10
摘要： Silicone adhesive formulations are provided, in which fentanyl particles are suspended one or more a solvated silicone adhesives. The formulations can be used for manufacturing improved, matrix-type transdermal devices for administering fentanyl.
摘要翻译：提供了硅酮粘合剂制剂，其中芬太尼颗粒悬浮在一种或多种溶剂化硅氧烷粘合剂上。制剂可用于制造用于施用芬太尼的改进的基质型透皮装置。

4. 发明申请

US20090142390A1 TRANSDERMAL SYSTEMS CONTAINING MULTILAYER ADHESIVE MATRICES TO MODIFY DRUG DELIVERY 有权
标题翻译：包含多层粘合剂基体的变态系统修改药物递送
公开(公告)号：US20090142390A1
公开(公告)日：2009-06-04
申请号：US12272706
申请日：2008-11-17
申请人： Kristin Jackson , Kenneth J. Miller, II
发明人： Kristin Jackson , Kenneth J. Miller, II
IPC分类号： A61K9/70 , A61K31/565
CPC分类号： A61K9/7092 , A61F2013/00646 , A61F2013/0071 , A61F2013/00906 , A61K8/0208 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K9/7084
摘要： A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix.The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.
摘要翻译：含透皮药物的剂量单位包括：基本上不透过经皮递送的药物的背衬层; 与背衬层接触的第一聚合物粘合剂基质，其中分散有药物并具有药物的第一递送曲线; 与所述第一聚合物粘合剂基质接触的第二聚合物粘合剂基质，其中分散有药物并具有药物的第二递送分布，其中所述第二递送分布与所述第一递送分布不同; 以及与第二聚合物粘合剂基质接触的剥离衬垫。第一聚合物粘合剂基质可以比第二聚合物粘合剂基质更快或更慢地释放药物。通过选择两个基质，可以选择性地改变和控制药物通过皮肤的递送特征。

5. 外观设计

USD355457S Jumping frog 失效
公开(公告)号：USD355457S
公开(公告)日：1995-02-14
申请号：US11785
申请日：1993-08-16
申请人： Kenneth J. Miller
设计人： Kenneth J. Miller

6. 发明授权

US4867868A Selective flotation of inorganic sulfides from coal 失效
标题翻译：从煤中选择性浮选无机硫化物
公开(公告)号：US4867868A
公开(公告)日：1989-09-19
申请号：US200100
申请日：1988-05-31
申请人： Kenneth J. Miller , Wu-Wey Wen
发明人： Kenneth J. Miller , Wu-Wey Wen
IPC分类号： B03D1/001 , B03D1/02
CPC分类号： B03D1/02 , B03D1/008 , B03D1/012 , B03D2201/02 , B03D2201/04 , B03D2201/06 , B03D2203/02 , B03D2203/08
摘要： Pyritic sulfur is removed from coal or other carbonaceous material through the use of humic acid as a coal flotation depressant. Following the removal of coarse pyrite, the carbonaceous material is blended with humic acid, a pyrite flotation collector and a frothing agent within a flotation cell to selectively float pyritic sulfur leaving clean coal as an underflow.
摘要翻译：通过使用腐殖酸作为煤浮选抑制剂，从煤或其他碳质材料中除去硫铁矿。除去粗黄铁矿后，碳质材料与浮选槽内的腐殖酸，黄铁矿浮选捕收剂和起泡剂混合，以选择性地将黄铁矿硫离开清洁煤作为下溢。

7. 发明授权

US09198877B2 Transdermal systems containing multilayer adhesive matrices to modify drug delivery 有权
标题翻译：包含多层粘合剂基质以改变药物递送的透皮系统
公开(公告)号：US09198877B2
公开(公告)日：2015-12-01
申请号：US13129638
申请日：2009-11-17
申请人： Kristin Jackson , Kenneth J. Miller
发明人： Kristin Jackson , Kenneth J. Miller
IPC分类号： A61K9/70 , A61F13/00
CPC分类号： A61K9/7092 , A61F2013/00646 , A61F2013/0071 , A61F2013/00906 , A61K8/0208 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K9/7084
摘要： A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.
摘要翻译：含透皮药物的剂量单位包括：基本上不透过经皮递送的药物的背衬层; 与背衬层接触的第一聚合物粘合剂基质，其中分散有药物并具有药物的第一递送曲线; 与所述第一聚合物粘合剂基质接触的第二聚合物粘合剂基质，其中分散有药物并具有药物的第二递送分布，其中所述第二递送分布与所述第一递送分布不同; 以及与第二聚合物粘合剂基质接触的剥离衬垫。第一聚合物粘合剂基质可以比第二聚合物粘合剂基质更快或更慢地释放药物。通过选择两个基质，可以选择性地改变和控制药物通过皮肤的递送特征。

8. 发明申请

US20080226698A1 Amorphous drug transdermal systems, manufacturing methods, and stabilization 审中-公开
标题翻译：无定形药物透皮系统，制造方法和稳定性
公开(公告)号：US20080226698A1
公开(公告)日：2008-09-18
申请号：US11725159
申请日：2007-03-16
申请人： Jiansheng Tang , Joseph M. Deverich , Kenneth J. Miller , Russell D. Beste
发明人： Jiansheng Tang , Joseph M. Deverich , Kenneth J. Miller , Russell D. Beste
IPC分类号： A61K31/215 , A61F13/02 , A61K31/4353 , A61K31/4355 , A61K9/70 , A61P43/00
CPC分类号： A61K9/7053 , A61K9/7069
摘要： The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of an active agent substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing at least one supersaturated active agent substantially in amorphous form. Further, the present invention refers to a method to stabilize and a method to reestablish the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.
摘要翻译：本发明涉及一种透皮递送装置，其包括背衬层，包含过饱和浓度的基本上为无定形形式的粘合剂基质中的活性剂的粘合剂基质层和释放衬垫。本发明还涉及制备含有至少一种基本上为无定形形式的过饱和活性剂的粘合剂基质的方法。此外，本发明涉及一种稳定化方法以及在其制造，储存，运输和处理过程中重新建立间 - 稳定非晶药物透皮系统的方法。

9. 发明授权

US09731490B2 Method for making a multilayer adhesive laminate 有权
公开(公告)号：US09731490B2
公开(公告)日：2017-08-15
申请号：US13299747
申请日：2011-11-18
申请人： Kenneth J. Miller
发明人： Kenneth J. Miller
IPC分类号： B32B38/04 , B32B37/12 , C09J7/02 , B32B38/18 , C09J7/00 , A61F13/02 , B32B37/00
CPC分类号： B32B37/02 , A61F13/0253 , B32B37/0053 , B32B38/04 , B32B38/1816 , B32B2038/045 , C09J7/00 , C09J7/10 , C09J7/38 , C09J2201/36 , C09J2201/606 , Y10T156/1059 , Y10T156/1062 , Y10T156/1069 , Y10T156/1075 , Y10T156/1077
摘要： A method allows for rapid manufacture of relatively thick adhesive coatings using a continuous process, where a single thin coating is continuously converted into a single thicker adhesive laminate. An exemplary process includes the steps of: (1) producing a web having a first surface with an adhesive layer and a second surface with a release liner; (2) slitting the web longitudinally into a first section and a second section; (3) laminating a backing film to the adhesive layer of the first section; (4) removing the release liner of the laminate of step (3) exposing the adhesive layer of the first section; and (5) laminating the second section to the laminate of step (4), wherein the adhesive layer of the laminate of step (4) is combined with the adhesive layer of the second section.

10. 发明授权

US09205062B2 Transdermal systems containing multilayer adhesive matrices to modify drug delivery 有权
公开(公告)号：US09205062B2
公开(公告)日：2015-12-08
申请号：US12272706
申请日：2008-11-17
申请人： Kristin Jackson , Kenneth J. Miller, II
发明人： Kristin Jackson , Kenneth J. Miller, II
IPC分类号： A61F13/00 , A61K9/70 , A61K8/02
CPC分类号： A61K9/7092 , A61F2013/00646 , A61F2013/0071 , A61F2013/00906 , A61K8/0208 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K9/7084
摘要： A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix.The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.

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