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1. 发明申请

US20130344523A1 AGENT FOR SEARCHING FOR PROTEIN CRYSTALLIZATION CONDITIONS AND METHOD OF SEARCHING FOR PROTEIN CRYSTALLIZATION CONDITIONS 审中-公开
标题翻译：用于蛋白质结晶条件的搜索代理和蛋白质结晶条件的搜索方法
公开(公告)号：US20130344523A1
公开(公告)日：2013-12-26
申请号：US14000041
申请日：2012-03-29
申请人： Keiichi Kurosaka , Munehiro Kubota , Kengo Sakaguchi , Keita Ino , Itsumi Udagawa , Kazuki Iwabata , Yoichi Takakusagi , Yasutaka Seki
发明人： Keiichi Kurosaka , Munehiro Kubota , Kengo Sakaguchi , Keita Ino , Itsumi Udagawa , Kazuki Iwabata , Yoichi Takakusagi , Yasutaka Seki
IPC分类号： G01N23/20
CPC分类号： G01N23/20 , C07K1/306 , C30B7/00 , C30B29/54 , C30B29/58
摘要： An agent for searching for protein crystallization conditions, containing a water-swellable layered silicate having a fluorine atom and a hydroxyl group, wherein the fluorine atom is covalently bonded to the silicate by isomorphous substitution with the hydroxyl group. A method of searching for protein crystallization conditions, which comprises a step of mixing the agent for searching for protein crystallization conditions described above and a solution in which a protein is dissolved.
摘要翻译：一种用于搜索蛋白质结晶条件的试剂，其含有具有氟原子和羟基的水溶胀性层状硅酸盐，其中氟原子通过与羟基的同晶取代共价键合到硅酸盐上。一种搜索蛋白质结晶条件的方法，其包括混合上述蛋白质结晶条件的试剂和溶解有蛋白质的溶液的步骤。

2. 发明申请

US20090253644A1 Radiosensitizer 审中-公开
标题翻译：放射增敏剂
公开(公告)号：US20090253644A1
公开(公告)日：2009-10-08
申请号：US12455859
申请日：2009-06-08
申请人： Ippei Sakimoto , Masahiko Miura , Keiko Kataoka , Kengo Sakaguchi , Fumio Sugawara , Keisuke Ohta , Takayuki Yamazaki
发明人： Ippei Sakimoto , Masahiko Miura , Keiko Kataoka , Kengo Sakaguchi , Fumio Sugawara , Keisuke Ohta , Takayuki Yamazaki
IPC分类号： A61K31/7012 , A61P35/00
CPC分类号： C07H15/04 , A61K31/7032 , A61K41/0038
摘要： A radiosensitizer comprising, as an active ingredient, at least one kind of compound selected from the group consisting of a compound represented by the following general formula (1): (wherein R101 represents an acyl residue of higher fatty acid, and R102 represents a hydrogen atom or an acyl residue of higher fatty acid), and a pharmaceutically acceptable salt thereof.
摘要翻译： 1.一种放射增敏剂，其含有作为活性成分的至少一种选自下述通式（1）表示的化合物的化合物：（式中，R 101表示高级脂肪酸的酰基，R 102表示氢原子或高级脂肪酸的酰基残基）及其药学上可接受的盐。

3. 发明授权

US07186888B2 Cold stress-responsive CRTintP gene and use thereof 失效
标题翻译：冷应激反应性CRTintP基因及其用途
公开(公告)号：US07186888B2
公开(公告)日：2007-03-06
申请号：US10304454
申请日：2002-11-25
申请人： Setsuko Komatsu , Arun Sharma , Junji Hashimoto , Kengo Sakaguchi
发明人： Setsuko Komatsu , Arun Sharma , Junji Hashimoto , Kengo Sakaguchi
IPC分类号： C12N15/82 , C12N15/09 , C12N15/29 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8273 , C07K14/415
摘要： The invention relates to isolated genes encoding polypeptides that interact with calreticulin (CRT), plants and plant cells transformed with the CRT genes for resistance against cold stress, and methods of producing the transformed plants and cells.
摘要翻译：本发明涉及编码与钙网蛋白（CRT）相互作用的多肽的分离基因，用CRT抗性基因转化的植物和植物细胞以抵抗寒冷胁迫，以及产生转化的植物和细胞的方法。

4. 发明申请

US20060194279A1 Protein-refolding material 审中-公开
标题翻译：蛋白质重折叠材料
公开(公告)号：US20060194279A1
公开(公告)日：2006-08-31
申请号：US10563870
申请日：2004-07-07
申请人： Fujio Mizukami , Yoshimichi Kiyozumi , Takuji Ikeda , Akiko Kawai , Takako Nagase , Kengo Sakaguchi , Hiroyuki Chiku
发明人： Fujio Mizukami , Yoshimichi Kiyozumi , Takuji Ikeda , Akiko Kawai , Takako Nagase , Kengo Sakaguchi , Hiroyuki Chiku
IPC分类号： C12P21/06 , C07K14/47 , C07K14/195 , C12N9/00
CPC分类号： C07K1/1133 , C07K1/1136 , C07K14/245
摘要： The present invention provides a method for refolding protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention comprises a method, refolding kit, refolding agent, and molding that activate a native function or activity inherent to a protein through treatment with zeolite beta of protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention also comprises a method for producing an active protein that utilizes the same. As compared with conventional methods, the present invention can provide a novel method for activating protein function that is highly versatile and generalizable, that employs a simple and easy protocol, and that is inexpensive and enables repeated use of the function activator.
摘要翻译：本发明提供了一种重新折叠由例如大肠杆菌产生的蛋白质的方法，其由于尚未形成的高级结构而不活跃，或由于某种原因由于构象变化而失活的蛋白质。本发明包括一种方法，重折叠试剂盒，重折叠剂和模制品，其通过用例如由大肠杆菌产生的蛋白质的β沸石处理而激活蛋白质固有的天然功能或活性，其由于尚未形成由于某些原因由于构象变化而导致高阶结构或蛋白质失活。本发明还包括一种制备利用其的活性蛋白质的方法。与常规方法相比，本发明可以提供一种新颖的激活蛋白质功能的方法，该蛋白质功能具有高度通用性和可广泛性，采用简单易用的方案，价格便宜，能重复使用功能活化剂。

5. 发明授权

US06759522B2 Sulforhamnosylacyglycerol derivatives and use thereof as medicaments 失效
标题翻译：磺酰乳糖甘油衍生物及其作为药物的用途
公开(公告)号：US06759522B2
公开(公告)日：2004-07-06
申请号：US09939338
申请日：2001-08-24
申请人： Takayuki Yamazaki , Fumio Sugawara , Keisuke Ohta , Kazuyoshi Masaki , Kotaro Nakayama , Kengo Sakaguchi , Noriyuki Sato , Hiroeki Sahara , Tatsuya Fujita
发明人： Takayuki Yamazaki , Fumio Sugawara , Keisuke Ohta , Kazuyoshi Masaki , Kotaro Nakayama , Kengo Sakaguchi , Noriyuki Sato , Hiroeki Sahara , Tatsuya Fujita
IPC分类号： C07H1500
CPC分类号： C07H15/06 , C07H15/04
摘要： Novel sulforhamnosylacylglycerol derivatives represented by General Formula (1): where R101 represents an acyl residue of a higher fatty acid and R102 represents a hydrogen atom or an acyl residue of a higher fatty acid. The derivatives represented by General formula (1) are useful as, a DNA polymerase inhibitor and an anticancer agent.
摘要翻译：由通式（1）表示的新型磺基乳糖醛酸甘油衍生物：其中R101表示高级脂肪酸的酰基，R102表示氢原子或高级脂肪酸的酰基残基。由通式（1）表示的衍生物可用作DNA聚合酶抑制剂和抗癌剂。

6. 发明授权

US06670361B2 Method of treating cancer 失效
标题翻译：癌症治疗方法
公开(公告)号：US06670361B2
公开(公告)日：2003-12-30
申请号：US10047384
申请日：2002-01-14
申请人： Takayuki Yamazaki , Fumio Sugawara , Keisuke Ohta , Kazuyoshi Masaki , Kotaro Nakayama , Kengo Sakaguchi
发明人： Takayuki Yamazaki , Fumio Sugawara , Keisuke Ohta , Kazuyoshi Masaki , Kotaro Nakayama , Kengo Sakaguchi
IPC分类号： A61K3170
CPC分类号： C07H13/00
摘要： An anticancer drug includes a compound represented by Formula (1): where R101 represents an acyl moiety of a saturated higher fatty acid, and R102 represents a hydrogen atom or an acyl moiety of a saturated higher fatty acid, and/or a pharmaceutically acceptable salt thereof.
摘要翻译：抗癌药包括由式（1）表示的化合物：其中R 101表示饱和高级脂肪酸的酰基部分，R 102表示氢原子或饱和高级脂肪酸的酰基部分，和/或其药学上可接受的盐其中。

7. 发明申请

US20100298246A1 Sulfonated sugar compounds, pharmaceutical compositions which contain the same, and methods of treating tumors with the same 审中-公开
标题翻译：磺化糖化合物，含有它们的药物组合物，以及用其治疗肿瘤的方法
公开(公告)号：US20100298246A1
公开(公告)日：2010-11-25
申请号：US12804808
申请日：2010-07-30
申请人： Keisuke Ohta , Masahiko Miura , Kengo Sakaguchi , Fumio Sugawara , Noriyuki Sato , Hiroeki Sahara , Nobuaki Takahashi , Yoko Mori , Takayuki Yamazaki , Kazuyoshi Masaki , Hiroshi Murata
发明人： Keisuke Ohta , Masahiko Miura , Kengo Sakaguchi , Fumio Sugawara , Noriyuki Sato , Hiroeki Sahara , Nobuaki Takahashi , Yoko Mori , Takayuki Yamazaki , Kazuyoshi Masaki , Hiroshi Murata
IPC分类号： A61K31/7032 , C07H15/06 , A61P35/00
CPC分类号： C07H15/06 , A61K31/7028 , A61K41/0038 , C07H15/10
摘要： Sulfoquinovosylacyl propanediol compounds represented by formula (I): wherein R1 is an acyl residue of a fatty acid, Y is a number of 1, 2 or 3, and M represents a cation having a positive charge equal to Y and pharmaceutically acceptable salts thereof are effective for treating tumors.
摘要翻译：由式（I）表示的磺基奎诺糖基酰基丙二醇化合物：其中R1是脂肪酸的酰基残基，Y是1,2或3的数，M表示正电荷等于Y的阳离子及其药学上可接受的盐是有效治疗肿瘤。

8. 发明申请

US20070219145A1 Radiosensitizer 审中-公开
标题翻译：放射增敏剂
公开(公告)号：US20070219145A1
公开(公告)日：2007-09-20
申请号：US10593538
申请日：2005-06-24
申请人： Ippei Sakimoto , Masahiko Miura , Keiko Kataoka , Kengo Sakaguchi , Fumio Sugawara , Keisuke Ohta , Takayuki Yamazaki
发明人： Ippei Sakimoto , Masahiko Miura , Keiko Kataoka , Kengo Sakaguchi , Fumio Sugawara , Keisuke Ohta , Takayuki Yamazaki
IPC分类号： A61K31/7032 , A61P35/00
CPC分类号： C07H15/04 , A61K31/7032 , A61K41/0038
摘要： A radiosensitizer comprising, as an active ingredient, at least one kind of compound selected from the group consisting of a compound represented by the following general formula (1): (wherein R101 represents an acyl residue of higher fatty acid, and R102 represents a hydrogen atom or an acyl residue of higher fatty acid), and a pharmaceutically acceptable salt thereof.
摘要翻译：一种放射增敏剂，其包含作为活性成分的至少一种选自由以下通式（1）表示的化合物的化合物：（其中R 101表示较高的酰基残基）脂肪酸和R 102代表氢原子或高级脂肪酸的酰基残基）及其药学上可接受的盐。

9. 发明授权

US07148200B2 Method for treating cancer 失效
标题翻译：癌症治疗方法
公开(公告)号：US07148200B2
公开(公告)日：2006-12-12
申请号：US10678193
申请日：2003-10-02
申请人： Takayuki Yamazaki , Fumio Sugawara , Keisuke Ohta , Kazuyoshi Masaki , Kotaro Nakayama , Kengo Sakaguchi , Noriyuki Sato , Hiroeki Sahara , Tatsuya Fujita
发明人： Takayuki Yamazaki , Fumio Sugawara , Keisuke Ohta , Kazuyoshi Masaki , Kotaro Nakayama , Kengo Sakaguchi , Noriyuki Sato , Hiroeki Sahara , Tatsuya Fujita
IPC分类号： A61K31/70 , C07G3/00 , C08B37/00 , C07H11/00 , C12N9/99
CPC分类号： A61K31/70 , A61K31/7032 , C07H15/06
摘要： A method for treating a cancer. The cancer excluding an adenocarcinoma and being epithelioma, glioma, sarcoma, melanoma, lymphoma or leukemia; or the cancer is an adenocarcinoma cancer excluding colon cancer, lung cancer and gastric cancer. The method comprises administering to a subject in need thereof and suffering from cancer, a pharmaceutically effective amount of at least one sulfoquinovosylacylglycerol compound represented by formula (1): wherein R101 represents an acyl residue of an unsaturated fatty acid and R102 represents a hydrogen atom and/or at least one pharmaceutically acceptable salt thereof.
摘要翻译：一种治疗癌症的方法。不包括腺癌并且是上皮瘤，神经胶质瘤，肉瘤，黑素瘤，淋巴瘤或白血病的癌症; 或癌症是排除结肠癌，肺癌和胃癌的腺癌。该方法包括向有需要的受试者和患有癌症的药物有效量的至少一种由式（1）表示的磺基秋水诺酰基甘油化合物：其中R 101表示不饱和脂肪酸的酰基残基酸和R 102代表氢原子和/或其至少一种药学上可接受的盐。

10. 发明申请

US20060252703A1 Method for treating cancer 失效
标题翻译：癌症治疗方法
公开(公告)号：US20060252703A1
公开(公告)日：2006-11-09
申请号：US11480657
申请日：2006-07-03
申请人： Takayuki Yamazaki , Fumio Sugawara , Keisuke Ohta , Kazuyoshi Masaki , Kotaro Nakayama , Kengo Sakaguchi , Noriyuki Sato , Hiroeki Sahara , Tatsuya Fujita
发明人： Takayuki Yamazaki , Fumio Sugawara , Keisuke Ohta , Kazuyoshi Masaki , Kotaro Nakayama , Kengo Sakaguchi , Noriyuki Sato , Hiroeki Sahara , Tatsuya Fujita
IPC分类号： A61K31/70
CPC分类号： A61K31/70 , A61K31/7032 , C07H15/06
摘要： A method for treating an adenocarcinoma excluding colon cancer, lung cancer and gastric cancer, comprising administering to a subject in need thereof and suffering from adenocarcinoma cancer, a pharmaceutically effective amount of at least one sulfoquinovosylacylglycerol compound represented by formula (1): wherein R101 represents an acyl residue of an unsaturated higher fatty acid, and R102 represents a hydrogen atom, and/or at least one pharmaceutically acceptable salt thereof.
摘要翻译：一种治疗不包括结肠癌，肺癌和胃癌的腺癌的方法，包括向有需要的受试者和患有腺癌的药物有效量的至少一种由式（1）表示的磺基秋水诺酰基甘油化合物：其中R < 表示不饱和高级脂肪酸的酰基残基，R 102表示氢原子，和/或其至少一种药学上可接受的盐。

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