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1. 发明授权

US09381018B2 Device for rapid repair of body conduits 有权
公开(公告)号：US09381018B2
公开(公告)日：2016-07-05
申请号：US13149696
申请日：2011-05-31
申请人： Edward H. Cully , Jeffrey B. Duncan , Keith M. Flury , Paul D. Goodman , Wayne D. House , Vrad W. Levering , Philip P. Off , Daniel M. O'Shea , Michael J. Vonesh , Jason M. Wiersdorf
发明人： Edward H. Cully , Jeffrey B. Duncan , Keith M. Flury , Paul D. Goodman , Wayne D. House , Vrad W. Levering , Philip P. Off , Daniel M. O'Shea , Michael J. Vonesh , Jason M. Wiersdorf
IPC分类号： A61F2/84 , A61B17/11 , A61F2/07 , A61F2/97 , A61B17/06 , A61F2/06 , A61F2/30 , A61F2/89
CPC分类号： A61F2/07 , A61B17/06166 , A61B17/11 , A61B2017/1107 , A61F2/064 , A61F2/844 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2/958 , A61F2/97 , A61F2002/075 , A61F2002/30713 , A61F2220/0075 , A61F2220/0091 , A61F2250/0087
摘要： A self-expanding stent-graft provided in a diametrically compacted state for implantation and retained preferably by a constraining sheath, useful for the temporary or permanent repair of injured, partially or entirely transected body conduits including blood vessels. It may be used under direct visualization to quickly stop or substantially reduce loss of blood from such damaged vessels and to quickly re-establish perfusion distal to the injury site. The device would typically be implanted under emergency room conditions but also be used in field situations by trained medical technicians. After an end of the device is inserted into a blood vessel through the injury access, deployment preferably initiates from the device end in a direction moving toward the middle of the length of the device by directionally releasing the constraining sheath. In a preferred embodiment, the two opposing ends of the device are individually deployable from the compacted, small diameter intended for insertion into a vessel, to the larger diameter at which they fit interferably into a portion of the vessel.

2. 发明申请

US20120283775A1 Echogenic Sleeve 审中-公开
标题翻译：回声袖
公开(公告)号：US20120283775A1
公开(公告)日：2012-11-08
申请号：US13465378
申请日：2012-05-07
申请人： Edward H Cully , Keith M. FLURY
发明人： Edward H Cully , Keith M. FLURY
IPC分类号： A61B17/70
CPC分类号： A61B8/0841 , A61B2017/3413 , A61B2090/3925 , A61M25/0108
摘要： Devices with enhanced visualization in ultrasound imaging are provided.
摘要翻译：提供超声成像增强可视化设备。

3. 发明申请

US20110276012A1 PUNCTURABLE CATHETER 有权
标题翻译：可拆卸导管
公开(公告)号：US20110276012A1
公开(公告)日：2011-11-10
申请号：US13186198
申请日：2011-07-19
申请人： JOSEPH R. ARMSTRONG , Edward H. Cully , Keith M. Flury , Michael J. Vonesh
发明人： JOSEPH R. ARMSTRONG , Edward H. Cully , Keith M. Flury , Michael J. Vonesh
IPC分类号： A61M25/00
CPC分类号： A61M25/0043 , A61F2/958 , A61M25/005 , A61M25/0052 , A61M25/10 , A61M2025/0183 , A61M2025/0188 , A61M2025/1056 , A61M2025/1081
摘要： A catheter provided with a guidewire catheter lumen having a thin covering that is easily punctured by a guidewire at virtually any desired point along the catheter length. The thin covering may be integral with the catheter shaft, or may be a separate component that covers only the portion of the catheter shaft immediately adjacent the outer portion of the guidewire lumen, or may be a thin tubular construct that surrounds the entire catheter shaft. The covering is preferably relatively translucent, allowing for good visualization of the location of the end of the guidewire to enable puncturing of the covering at the desired location along the length of the catheter shaft. The covering is also preferably tear resistant at puncture sites. The catheter shaft is preferably made of a material having a color that provides good visibility against an operating field, and more preferably is phosphorescent either entirely or in part. Materials suitable for the catheter shaft are polymeric materials well known in the art; the catheter shaft may optionally be provided with metallic stiffening components such as wires or hypotubes along all or part of the catheter length.
摘要翻译：导管，其具有导线导管管腔，该导管管腔具有薄的覆盖层，其在导管长度的几乎任何所需点处被导丝容易地刺穿。薄的覆盖物可以与导管轴成一体，或者可以是仅覆盖导管轴的紧邻导丝管腔的外部的部分的单独的部件，或者可以是围绕整个导管轴的薄的管状结构。覆盖物优选地是相对半透明的，允许良好地可视化导丝端部的位置，以使得能够沿着导管轴的长度在期望的位置刺穿覆盖物。覆盖物也优选在穿刺部位具有抗撕裂性。导管轴优选由具有对操作场提供良好可见性的颜色的材料制成，更优选地，全部或部分地是磷光。适用于导管轴的材料是本领域公知的聚合材料; 导管轴可以可选地沿着导管长度的全部或部分设置有金属加强部件，例如电线或海波管。

4. 发明申请

US20100049294A1 Controlled deployable medical device and method of making the same 审中-公开
公开(公告)号：US20100049294A1
公开(公告)日：2010-02-25
申请号：US12478331
申请日：2009-06-04
申请人： Stanislaw L. Zukowski , Edward H. Cully , Keith M. Flury , Michelle L. Gendron
发明人： Stanislaw L. Zukowski , Edward H. Cully , Keith M. Flury , Michelle L. Gendron
IPC分类号： A61F2/84
CPC分类号： A61F2/954 , A61F2/07 , A61F2002/065 , A61F2002/9505 , A61F2002/9511 , A61F2002/9534
摘要： Controlled deployable medical devices that are retained inside a body passage and in one particular application to vascular devices used in repairing arterial dilations, e.g., aneurysms. Such devices can be adjusted during deployment, thereby allowing at least one of a longitudinal or radial re-positioning, resulting in precise alignment of the device to an implant target site.

5. 发明授权

US07556641B2 Deployment system for an expandable device 有权
标题翻译：可扩展设备的部署系统
公开(公告)号：US07556641B2
公开(公告)日：2009-07-07
申请号：US10892934
申请日：2004-07-16
申请人： Edward H. Cully , Keith M. Flury , Michael J. Vonesh
发明人： Edward H. Cully , Keith M. Flury , Michael J. Vonesh
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958 , A61F2/97 , A61F2002/9511
摘要： The present invention is directed to a deployment system for an endoluminal device. The deployment system includes a confining sheath placed around a compacted endoluminal device. A deployment line is provided in the system that is an integral extension of the sheath. As the deployment line is actuated, the sheath retracts from around the compacted endoluminal device. As the sheath retracts from around the endoluminal device, material from the sheath may be converted into deployment line. Once the sheath is retracted from around the compacted endoluminal device, the endoluminal device expands in configuration and repairs vascular or cardiac structures of an implant recipient. Any remaining sheath material is removed from the implantation site along with the deployment line. The deployment system also includes an endo-prosthesis mounting member placed between the endoluminal device and an underlying catheter. The endo-prosthesis mounting member serves to cushion and retain the endoluminal device when constrained by the sheath and may assist in expansion of the endoluminal device when unconstrained by the sheath.The present invention is also directed to a deployment system having a deployment assembly that simultaneously expands an endo-prosthesis mounting member while removing a sheath from an expandable medical device.
摘要翻译：本发明涉及一种用于腔内装置的部署系统。部署系统包括围绕压实的腔内装置放置的限制鞘。在系统中提供了一个部署线，该线是护套的整体延伸。随着部署线被致动，护套从紧凑的腔内装置周围缩回。当护套从内腔装置周围缩回时，来自护套的材料可以被转换成展开线。一旦护套从紧凑的腔内装置周围缩回，腔内装置在构型上扩张并修复植入物接受者的血管或心脏结构。任何剩余的护套材料与植入线一起从植入部位移除。所述展开系统还包括放置在腔内装置和下面的导管之间的内腔假体安装构件。假体内固定构件用于在被护套约束时缓冲和保持内腔装置，并且可以在不受护套约束时有助于内腔装置的膨胀。本发明还涉及一种具有展开组件的展开系统，所述展开组件在从可扩张医疗装置移除护套的同时同时展开内衣假体安装构件。

6. 发明授权

US06702845B1 Compacted implantable medical devices and method of compacting such devices 有权
标题翻译：压实的可植入医疗装置和压实这种装置的方法
公开(公告)号：US06702845B1
公开(公告)日：2004-03-09
申请号：US10346822
申请日：2003-01-17
申请人： Edward H. Cully , Keith M. Flury
发明人： Edward H. Cully , Keith M. Flury
IPC分类号： B21D3900
CPC分类号： A61F2/95 , A61F2002/9511 , A61F2002/9522 , Y10T29/49929 , Y10T29/53987
摘要： An expandable implantable device is provided having a very small introductory profile. The small introductory profile is achieved by de-coupling the forces necessary to initially constrain the expandable device from the forces necessary to achieve full compaction of the device. As a result, the device can be made from more delicate materials that do not have to withstand overly aggressive compaction forces in order to achieve a fully compacted introductory profile.
摘要翻译：提供具有非常小的介绍性简介的可扩张的可植入装置。通过将最初限制可扩张装置所必需的力从实现装置的完全压实所必需的力解耦来实现小的介绍性外形。因此，该装置可以由不必承受过度侵蚀性的压实力的更细腻的材料制成，以便实现完全压实的介绍性简档。

7. 发明授权

US09119937B2 Puncturable catheter 有权
标题翻译：可导管
公开(公告)号：US09119937B2
公开(公告)日：2015-09-01
申请号：US13186198
申请日：2011-07-19
申请人： Joseph R. Armstrong , Edward H. Cully , Keith M. Flury , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Keith M. Flury , Michael J. Vonesh
IPC分类号： A61M25/00 , A61M25/10 , A61F2/958 , A61M25/01
CPC分类号： A61M25/0043 , A61F2/958 , A61M25/005 , A61M25/0052 , A61M25/10 , A61M2025/0183 , A61M2025/0188 , A61M2025/1056 , A61M2025/1081
摘要： A catheter provided with a guidewire catheter lumen having a thin covering that is easily punctured by a guidewire at virtually any desired point along the catheter length. The thin covering may be integral with the catheter shaft, or may be a separate component that covers only the portion of the catheter shaft immediately adjacent the outer portion of the guidewire lumen, or may be a thin tubular construct that surrounds the entire catheter shaft. The covering is preferably relatively translucent, allowing for good visualization of the location of the end of the guidewire to enable puncturing of the covering at the desired location along the length of the catheter shaft. The covering is also preferably tear resistant at puncture sites. The catheter shaft is preferably made of a material having a color that provides good visibility against an operating field, and more preferably is phosphorescent either entirely or in part. Materials suitable for the catheter shaft are polymeric materials well known in the art; the catheter shaft may optionally be provided with metallic stiffening components such as wires or hypotubes along all or part of the catheter length.
摘要翻译：导管，其具有导线导管管腔，该导管管腔具有薄的覆盖层，其在导管长度的几乎任何所需点处被导丝容易地刺穿。薄的覆盖物可以与导管轴成一体，或者可以是仅覆盖导管轴的紧邻导丝管腔的外部的部分的单独的部件，或者可以是围绕整个导管轴的薄的管状结构。覆盖物优选地是相对半透明的，允许良好地可视化导丝端部的位置，以使得能够沿着导管轴的长度在期望的位置刺穿覆盖物。覆盖物也优选在穿刺部位具有抗撕裂性。导管轴优选由具有对操作场提供良好可见性的颜色的材料制成，更优选地，全部或部分地是磷光。适用于导管轴的材料是本领域公知的聚合材料; 导管轴可以可选地沿着导管长度的全部或部分设置有金属加强部件，例如电线或海波管。

8. 发明申请

US20120283763A1 Device with Echogenic Coating 审中-公开
标题翻译：具有回生涂层的装置
公开(公告)号：US20120283763A1
公开(公告)日：2012-11-08
申请号：US13465354
申请日：2012-05-07
申请人： Edward H. Cully , Keith M. Flury
发明人： Edward H. Cully , Keith M. Flury
IPC分类号： A61B17/32 , A61B5/00
CPC分类号： A61B8/0841 , A61B90/39 , A61B2090/3925 , A61L27/34 , A61L27/50 , A61L31/10 , A61L31/18 , C08L27/12
摘要： Devices with enhanced visualization in ultrasound imaging are provided.
摘要翻译：提供超声成像增强可视化设备。

9. 发明授权

US09433745B2 Puncturing tool for puncturing catheter shafts 有权
标题翻译：穿刺导管轴穿刺工具
公开(公告)号：US09433745B2
公开(公告)日：2016-09-06
申请号：US10868252
申请日：2004-06-14
申请人： Edward H. Cully , Sherif A. Eskaros , Keith M. Flury , James W. Mann , Benjamin M. Trapp , Michael J. Vonesh
发明人： Edward H. Cully , Sherif A. Eskaros , Keith M. Flury , James W. Mann , Benjamin M. Trapp , Michael J. Vonesh
IPC分类号： A61M5/178 , A61M25/00 , A61M25/01
CPC分类号： A61M25/00 , A61M2025/0175
摘要： Puncturing tools that cause an aperture to be pierced through the wall of a guidewire lumen of a catheter shaft at a location at which it is desired to have a guidewire exit the guidewire lumen.
摘要翻译：刺穿工具，其导致孔被刺穿穿过导管轴的导丝管腔的壁，在期望导丝线离开导丝管腔的位置处。

10. 发明授权

US09375215B2 Device for rapid repair of body conduits 有权
标题翻译：快速修复身体导管的装置
公开(公告)号：US09375215B2
公开(公告)日：2016-06-28
申请号：US11624513
申请日：2007-01-18
申请人： Edward H. Cully , Jeffrey B. Duncan , Keith M. Flury , Paul D. Goodman , Wayne D. House , Vrad W. Levering , Philip P. Off , Daniel M. O'Shea , Michael J. Vonesh , Jason M. Wiersdorf
发明人： Edward H. Cully , Jeffrey B. Duncan , Keith M. Flury , Paul D. Goodman , Wayne D. House , Vrad W. Levering , Philip P. Off , Daniel M. O'Shea , Michael J. Vonesh , Jason M. Wiersdorf
IPC分类号： A61F2/94 , A61B17/11 , A61F2/07 , A61F2/97 , A61B17/06 , A61F2/06 , A61F2/30 , A61F2/89
CPC分类号： A61F2/07 , A61B17/06166 , A61B17/11 , A61B2017/1107 , A61F2/064 , A61F2/844 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2/958 , A61F2/97 , A61F2002/075 , A61F2002/30713 , A61F2220/0075 , A61F2220/0091 , A61F2250/0087
摘要： A self-expanding stent-graft provided in a diametrically compacted state for implantation and retained preferably by a constraining sheath, useful for the temporary or permanent repair of injured, partially or entirely transected body conduits including blood vessels. It may be used under direct visualization to quickly stop or substantially reduce loss of blood from such damaged vessels and to quickly re-establish perfusion distal to the injury site. The device would typically be implanted under emergency room conditions but also be used in field situations by trained medical technicians. After an end of the device is inserted into a blood vessel through the injury access, deployment preferably initiates from the device end in a direction moving toward the middle of the length of the device by directionally releasing the constraining sheath. In a preferred embodiment, the two opposing ends of the device are individually deployable from the compacted, small diameter intended for insertion into a vessel, to the larger diameter at which they fit interferably into a portion of the vessel.
摘要翻译：自扩张的支架移植物以径向压实状态提供用于植入，并且优选地由约束护套保持，其用于临时或永久性修复包括血管的受损部分或全部横断的身体导管。它可以在直接可视化下使用，以快速停止或显着减少来自这些受损血管的血液损失，并迅速重建在损伤部位远端的灌注。该设备通常将在急诊室条件下植入，但也由经过培训的医疗技术人员在现场使用。在装置的一端通过伤口进入插入血管之后，展开优选地通过定向释放约束护套从朝向装置长度方向移动的方向从装置端开始。在优选实施例中，装置的两个相对的端部可单独地从用于插入容器的压实的小直径扩展到可干燥地配合到容器的一部分中的较大的直径。

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