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1. 发明授权

US08977340B2 System and method for collection and use of magnetic resonance data and microwave data to identify boundaries of interest 有权
标题翻译：用于收集和使用磁共振数据和微波数据以识别感兴趣边界的系统和方法
公开(公告)号：US08977340B2
公开(公告)日：2015-03-10
申请号：US13577788
申请日：2011-02-09
申请人： Amir H. Golnabi , Keith D. Paulsen , Paul M. Meaney
发明人： Amir H. Golnabi , Keith D. Paulsen , Paul M. Meaney
IPC分类号： A61B5/055 , A61B5/00 , A61B6/03 , G06T7/00 , A61B5/05
CPC分类号： A61B5/0035 , A61B5/0059 , A61B5/0507 , A61B5/055 , A61B5/4312 , A61B6/032 , G06T7/0012 , G06T2207/10081 , G06T2207/10088 , G06T2207/30068
摘要： A system and method for detecting permittivity and conductivity boundaries within a high resolution spatial image of a material is presented. Electrical properties of a material, such as permittivity and conductivity, may assist in identification of physical properties of the material. Structural boundaries within tissue may be identified in spatial images, such as MR images. Image reconstruction algorithms may combine these structural boundaries with microwave images of the tissue to determine the permittivity and conductivity parameters within the structural boundaries. In the case of soft tissue, the microwave images may be captured simultaneously with the spatial images. The microwave images may be taken at a different time from the spatial image for rigid tissue. The method may be employed for two dimensional or three dimensional image reconstruction.
摘要翻译：提出了一种用于在材料的高分辨率空间图像内检测介电常数和电导率边界的系统和方法。材料的电学性质，例如介电常数和电导率可有助于识别材料的物理性质。可以在诸如MR图像的空间图像中识别组织内的结构边界。图像重建算法可以将这些结构边界与组织的微波图像结合，以确定结构边界内的介电常数和电导率参数。在软组织的情况下，微波图像可以与空间图像同时捕获。可以在与刚性组织的空间图像不同的时间拍摄微波图像。该方法可以用于二维或三维图像重建。

2. 发明申请

US20140375337A1 Planar Probe And System For Measuring Dielectric Properties Of Biological Materials 有权
标题翻译：用于测量生物材料介电性能的平面探头和系统
公开(公告)号：US20140375337A1
公开(公告)日：2014-12-25
申请号：US14117368
申请日：2012-05-11
申请人： Paul M. Meaney , Tina Zhou , Andrea Borsic , Alexander T. Farkas , Keith D. Paulsen
发明人： Paul M. Meaney , Tina Zhou , Andrea Borsic , Alexander T. Farkas , Keith D. Paulsen
IPC分类号： G01N27/02 , G01N33/483 , G01N33/49
CPC分类号： G01N27/02 , G01N27/221 , G01N33/4833 , G01N33/49 , G01N2333/435
摘要： A probe sensor has a printed circuit comprising a coplanar transmission line, a ground plane, a plated-through contact via, and a part-circular ring of ground vias surrounding the contact via. The coplanar transmission line and ground plane are formed on a first layer of the printed circuit, and the contact via and part-circular ring of ground vias are plated with a conductive biocompatible material on a second layer of the printed circuit. A system uses a network analyzer with the probe to measure electrical properties of biological tissue. Also described is a method of using the system to determine qualities of stored blood.
摘要翻译：探头传感器具有印刷电路，该印刷电路包括共面传输线，接地平面，电镀通孔接触通孔和围绕接触通孔的接地通孔的部分圆形环。共面传输线和接地平面形成在印刷电路的第一层上，并且接地通路的接触通孔和部分圆形环在印刷电路的第二层上镀有导电生物相容性材料。系统使用带有探针的网络分析仪来测量生物组织的电学性质。还描述了使用该系统来确定储存血液的质量的方法。

3. 发明申请

US20130338479A1 Apparatus And Method For Surgical Instrument With Integral Automated Tissue Classifier 审中-公开
标题翻译：具有整体自动组织分类器的手术器械的装置和方法
公开(公告)号：US20130338479A1
公开(公告)日：2013-12-19
申请号：US13140748
申请日：2009-12-18
申请人： Brian William Pogue , Venkataramanan Krishnaswamy , Keith D. Paulsen , Pilar Beatriz Garcia Allende , Olga Maria Conde , José Miguel Lopez-Higuera
发明人： Brian William Pogue , Venkataramanan Krishnaswamy , Keith D. Paulsen , Pilar Beatriz Garcia Allende , Olga Maria Conde , José Miguel Lopez-Higuera
IPC分类号： A61B5/00 , A61B5/145
CPC分类号： A61B5/0068 , A61B5/0059 , A61B5/0062 , A61B5/0071 , A61B5/14546 , A61B5/7264 , A61B5/7267 , A61B5/742 , A61B2576/00 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0218 , G01J3/06 , G01J3/10 , G01J3/2823 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/6417 , G01N2021/6471 , G01N2021/6484 , G01N2201/0221 , G01N2201/0618 , G01N2201/1296 , G06F19/3481 , G16H40/63
摘要： A method and apparatus is described for optically scanning a field of view, the field of view including at least part of an organ as exposed during surgery, and for identifying and classifying areas of tumor within the field of view. The apparatus obtains a spectrum at each pixel of the field of view, and classifies pixels with a kNN-type or neural network classifier previously trained on samples of tumor and organ classified by a pathologist. Embodiments use statistical parameters extracted from each pixel and neighboring pixels. Results are displayed as a color-encoded map of tissue types to the surgeon. In variations, the apparatus provides light at one or more fluorescence stimulus wavelengths and measures the fluorescence light spectrum emitted from tissue corresponding to each stimulus wavelength. The measured emitted fluorescence light spectra are further used by the classifier to identify tissue types in the field of view.
摘要翻译：描述了用于光学扫描视野的方法和装置，视野包括在外科手术期间暴露的器官的至少一部分，以及用于识别和分类视野内的肿瘤区域。该装置在视场的每个像素处获得光谱，并且使用先前已经由病理学家分类的肿瘤和器官样本训练的kNN型或神经网络分类器对像素进行分类。实施例使用从每个像素和相邻像素提取的统计参数。结果显示为外科医生的组织类型的颜色编码图。在变型中，该装置在一个或多个荧光刺激波长处提供光，并测量从对应于每个刺激波长的组织发射的荧光光谱。测量的发射荧光光谱被分类器进一步用于鉴定视野中的组织类型。

4. 发明申请

US20130204118A1 SYSTEM AND METHOD FOR COLLECTION & USE OF MAGNETIC RESONANCE DATA & MICROWAVE DATA TO IDENTIFY BOUNDARIES OF INTEREST 有权
标题翻译：用于收集和使用磁共振数据和微波数据识别边界的系统和方法
公开(公告)号：US20130204118A1
公开(公告)日：2013-08-08
申请号：US13577788
申请日：2011-02-09
申请人： Amir H. Golnabi , Keith D. Paulsen , Paul M. Meaney
发明人： Amir H. Golnabi , Keith D. Paulsen , Paul M. Meaney
IPC分类号： A61B5/00 , A61B6/03 , A61B5/055
CPC分类号： A61B5/0035 , A61B5/0059 , A61B5/0507 , A61B5/055 , A61B5/4312 , A61B6/032 , G06T7/0012 , G06T2207/10081 , G06T2207/10088 , G06T2207/30068
摘要： A system and method for detecting permittivity and conductivity boundaries within a high resolution spatial image of a material is presented. Electrical properties of a material, such as permittivity and conductivity, may assist in identification of physical properties of the material. Structural boundaries within tissue may be identified in spatial images, such as MR images. Image reconstruction algorithms may combine these structural boundaries with microwave images of the tissue to determine the permittivity and conductivity parameters within the structural boundaries. In the case of soft tissue, the microwave images may be captured simultaneously with the spatial images. The microwave images may be taken at a different time from the spatial image for rigid tissue. The method may be employed for two dimensional or three dimensional image reconstruction.
摘要翻译：提出了一种用于在材料的高分辨率空间图像内检测介电常数和电导率边界的系统和方法。材料的电学性质，例如介电常数和电导率可有助于识别材料的物理性质。可以在诸如MR图像的空间图像中识别组织内的结构边界。图像重建算法可以将这些结构边界与组织的微波图像结合，以确定结构边界内的介电常数和电导率参数。在软组织的情况下，微波图像可以与空间图像同时捕获。可以在与刚性组织的空间图像不同的时间拍摄微波图像。该方法可以用于二维或三维图像重建。

5. 发明申请

US20110153254A1 System And Method For Calibration For Image-Guided Surgery 有权
标题翻译：用于图像引导手术的校准系统和方法
公开(公告)号：US20110153254A1
公开(公告)日：2011-06-23
申请号：US12994044
申请日：2009-05-22
申请人： Alexander Hartov , Keith D. Paulsen , David William Roberts
发明人： Alexander Hartov , Keith D. Paulsen , David William Roberts
IPC分类号： G06F19/00 , G10K15/00
CPC分类号： G01S7/5205 , A61B5/06 , A61B5/064 , A61B8/0816 , A61B8/4245 , A61B8/4254 , A61B8/483 , A61B8/488 , A61B8/5238
摘要： A method of calibrating a transformation of ultrasound data in an imaging system from a first coordinate system into a second coordinate system, the method comprising applying a transformation having parameters. The parameters are calibrated by imaging a planar object, extracting points corresponding to ultrasound rays intersecting the planar object, and fitting the parameters such that the points when transformed by the transformation describe a planar surface in the second coordinate system.
摘要翻译：一种将成像系统中的超声数据从第一坐标系变换为第二坐标系的方法，所述方法包括应用具有参数的变换。参数通过对平面物体进行成像，提取与平面物体相交的超声射线的点进行成像，以及拟合参数进行校准，使得通过变换变换的点描述第二坐标系中的平面。

6. 发明授权

US07825667B2 Microwave imaging system and processes, and associated software products 有权
标题翻译：微波成像系统和流程以及相关的软件产品
公开(公告)号：US07825667B2
公开(公告)日：2010-11-02
申请号：US11316641
申请日：2005-12-21
申请人： Qianqian Fang , Paul M. Meaney , Keith D. Paulsen
发明人： Qianqian Fang , Paul M. Meaney , Keith D. Paulsen
IPC分类号： G01N23/02 , A61B5/05
CPC分类号： A61B5/05 , A61B5/0507
摘要： A microwave imaging process, and a system controlled by an associated software product, illuminate a target with microwaves from a transmitting antenna. Receiving antennas receive microwaves scattered by the target, and form microwave data. The illumination and receiving repeat over multiple transmitting antennas and multiple microwave frequencies. The microwave data is processed to form permittivity and conductivity images by selecting a background dispersion model for permittivity and conductivity. Permittivity and conductivity dispersion coefficients are determined, and permittivity and conductivity distributions are calculated, for each of the microwave frequencies. Forward solutions at multiple frequencies are determined from property distributions, and a dispersion coefficient based Jacobian matrix is determined. Dispersion coefficient updates are determined using the microwave data, and the dispersion coefficients are updated. Permittivity and conductivity distributions are recalculated for each of the frequencies, and the forward solutions are determined at multiple frequencies from property distributions.
摘要翻译：微波成像过程和由相关软件产品控制的系统利用来自发射天线的微波照射目标。接收天线接收目标分散的微波，形成微波数据。多个发射天线和多个微波频率的照明和接收重复。通过选择介电常数和电导率的背景色散模型，处理微波数据以形成介电常数和电导率图像。确定介电常数和电导率色散系数，并计算每个微波频率的介电常数和电导率分布。从属性分布确定多个频率的前向解，确定基于色散系数的雅可比矩阵。使用微波数据确定色散系数更新，并且更新色散系数。对于每个频率重新计算电导率和电导率分布，并且从属性分布的多个频率确定正向解。

7. 发明申请

US20100265493A1 Pulsed Lasers in Frequency Domain Diffuse Optical Tomography and Spectroscopy 有权
标题翻译：脉冲激光器在频域漫射光学层析成像和光谱学中的应用
公开(公告)号：US20100265493A1
公开(公告)日：2010-10-21
申请号：US12665518
申请日：2008-06-20
申请人： Shudong Jiang , Brian William Pogue , Jia Wang , Keith D. Paulsen
发明人： Shudong Jiang , Brian William Pogue , Jia Wang , Keith D. Paulsen
IPC分类号： G01N21/47 , G01N21/00 , G01J3/00
CPC分类号： G01N21/4795 , A61B5/0073
摘要： A diffuse optical tomography system incorporating a mode-locked, tunable laser produces pulsed light that may be used to interrogate tissue with high spatial and spectral resolution. The detection signal may be heterodyne shifted to lower frequencies to allow easy and accurate measurement of phase and amplitude. Embodiments incorporating wavelength-swept, tunable, lasers and embodiments using broadband photonic fiber lasers with spectrally-sensitive detectors are described.
摘要翻译：结合锁模的可调谐激光器的漫射光学断层扫描系统产生可用于以高空间和光谱分辨率询问组织的脉冲光。检测信号可以是外差偏移到较低频率，以便容易且准确地测量相位和振幅。描述了使用具有光谱敏感检测器的宽带光子激光器的波长扫描，可调谐，激光器和实施例的实施例。

8. 发明授权

US07319212B2 Non-invasive microwave analysis systems 失效
标题翻译：无创微波分析系统
公开(公告)号：US07319212B2
公开(公告)日：2008-01-15
申请号：US11589434
申请日：2006-10-30
申请人： Edward M Godshalk , Timothy Raynolds , Paul M. Meaney , Keith D. Paulsen , Greg Burke
发明人： Edward M Godshalk , Timothy Raynolds , Paul M. Meaney , Keith D. Paulsen , Greg Burke
IPC分类号： H05B6/64 , A61B5/05
CPC分类号： G01N22/00 , A61B5/05 , A61B5/0507 , A61B2562/02 , A61B2562/046
摘要： A non-invasive microwave analysis system determines scattered phase and/or amplitude data for a liquid in a container. A tank holds coupling liquid; the system includes a membrane for separating the liquid container from the coupling liquid. A transmitter antenna situated within the coupling liquid transmits microwaves. One or more receiver antennas within the coupling liquid convert microwave radiation that scatters from the liquid in the container into microwave electronic signals. Electronics process the microwave electronic signals to determine scattered phase and/or amplitude values of the microwave radiation.
摘要翻译：非侵入式微波分析系统确定容器中的液体的散射相位和/或振幅数据。储罐保持耦合液体; 该系统包括用于将液体容器与耦合液分离的膜。位于耦合液体内的发射器天线透射微波。耦合液体内的一个或多个接收器天线将从容器中的液体散射的微波辐射转换为微波电子信号。电子处理微波电子信号以确定微波辐射的散射相位和/或振幅值。

9. 发明授权

US07164105B2 Non-invasive microwave analysis systems 失效
标题翻译：无创微波分析系统
公开(公告)号：US07164105B2
公开(公告)日：2007-01-16
申请号：US11080726
申请日：2005-03-15
申请人： Edward M Godshalk , Timothy Raynolds , Paul M. Meaney , Keith D. Paulsen , Greg Burke
发明人： Edward M Godshalk , Timothy Raynolds , Paul M. Meaney , Keith D. Paulsen , Greg Burke
IPC分类号： H05B6/64 , A61B5/05
CPC分类号： G01N22/00 , A61B5/05 , A61B5/0507 , A61B2562/02 , A61B2562/046
摘要： Non-invasive microwave analysis systems and methods determine scattered phase data for a liquid in a container. A transmitter antenna situated within coupling liquid separated from the container by a flexible membrane transmits microwaves that scatter from the container and the liquid in the container. One or more receiver antennas within the coupling liquid convert the microwaves into microwave electronic signals that are processed to determine the scattered phase data.Non-invasive microwave analysis systems and methods image a portion of a biological subject. A transmitter antenna situated within coupling liquid separated from the subject by a flexible membrane transmits microwaves that scatter from the container and the subject. One or more receiver antennas within the coupling liquid convert the microwaves into microwave electronic signals that are processed to reconstruct a cross-sectional image of the subject.
摘要翻译：非侵入性微波分析系统和方法确定容器中液体的散射相数据。位于通过柔性膜从容器分离的耦合液体内的发射器天线透射从容器和容器中的液体散射的微波。耦合液体内的一个或多个接收器天线将微波转换成微波电子信号，其被处理以确定散射相位数据。非侵入式微波分析系统和方法对生物学科的一部分进行成像。位于通过柔性膜与被摄体分离的耦合液体内的发射器天线透射从容器和被摄体散射的微波。耦合液体内的一个或多个接收器天线将微波转换成微波电子信号，其被处理以重建对象的横截面图像。

10. 发明授权

US08948851B2 Method and apparatus for depth-resolved fluorescence, chromophore, and oximetry imaging for lesion identification during surgery 有权
标题翻译：手术中病变识别的深度分辨荧光，发色团和血氧定量成像的方法和装置
公开(公告)号：US08948851B2
公开(公告)日：2015-02-03
申请号：US13145505
申请日：2009-12-04
申请人： Frederic Leblond , David W. Roberts , Brian W. Pogue , Keith D. Paulsen , Alex Hartov , Scott C. Davis , Dax Kepshire
发明人： Frederic Leblond , David W. Roberts , Brian W. Pogue , Keith D. Paulsen , Alex Hartov , Scott C. Davis , Dax Kepshire
IPC分类号： A61B6/00 , A61B6/02 , A61B5/00 , G02B21/00 , G02B21/16 , A61B19/00
CPC分类号： A61B5/0073 , A61B5/0062 , A61B5/416 , A61B34/20 , A61B90/20 , G02B21/0064 , G02B21/16
摘要： A tomographic fluorescent imaging device for imaging fluorophores in biological tissues has a scanned laser for scanning the tissue and a camera for receiving light from the biological tissue at an angle to the beam at a second wavelength ten or more nanometers greater in wavelength than the wavelength of the laser. Use of both intrinsic and extrinsic fluorophores is described. Images are obtained at each of several positions of the beam. An image processing system receives the series of images, models a path of the beam through the tissue, and determines depth of fluorophore in tissue from intersections of the modeled path of the beam and the path of the received light. The laser is of 600 nm or longer wavelength, to provide penetration of tissue. The imaging device is used during surgery to visualize lesions of various types to ensure complete removal of malignant tumors. An alternative embodiment uses differences in intensity of fluorescent radiation from tissue as observed at different wavelengths to determine depth of fluorophore in tissue. An embodiment operates at multiple wavelengths to construct tomographic images of chromophores, such as hemoglobin, and is capable of dynamic imaging.
摘要翻译：用于在生物组织中成像荧光团的断层摄影荧光成像装置具有用于扫描组织的扫描激光器和用于以与波长成一定角度的波长的波长的第二波长以相对于波长的波长的波长激光。描述了内在和外在的荧光团的使用。在光束的几个位置的每一个处获得图像。图像处理系统接收一系列图像，模拟通过组织的光束的路径，并且确定组织中荧光团的深度，该距离来自光束的建模路径和接收光的路径的交叉点。激光器具有600nm或更长的波长，以提供组织的穿透。在手术期间使用成像装置可视化各种损伤以确保完全去除恶性肿瘤。替代实施例使用在不同波长处观察到的来自组织的荧光辐射的强度差来确定组织中荧光团的深度。一个实施例在多个波长下操作以构建诸如血红蛋白的发色团的断层图像，并且能够进行动态成像。

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