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1. 发明授权

US09664701B2 System for handling slides having two coverslipper modules 有权
公开(公告)号：US09664701B2
公开(公告)日：2017-05-30
申请号：US13469657
申请日：2012-05-11
申请人： Bernhard Neef , Simon Keimer , Karl-Heinz Westerhoff
发明人： Bernhard Neef , Simon Keimer , Karl-Heinz Westerhoff
IPC分类号： H04N5/253 , G01N35/00 , G01N35/02
CPC分类号： G01N35/00029 , G01N35/026 , G01N2035/00079 , G01N2035/00138
摘要： The present invention relates to a system (10) for handling slides, including a first and at least a second module-receiving area (24 through 28) for receiving at least one module (30, 34) for handling slides each. The first module-receiving area (24) accommodates a coverslipper module (30, 32) for coverslipping thin sections on slides with a mounting medium and a cover slip (48).

2. 发明授权

US08722412B2 Identification system for specimen slides 有权
标题翻译：标本片识别系统
公开(公告)号：US08722412B2
公开(公告)日：2014-05-13
申请号：US13338289
申请日：2011-12-28
申请人： Markus Egle , Stefan Thiem , Simon Keimer , Karl-Heinz Westerhoff
发明人： Markus Egle , Stefan Thiem , Simon Keimer , Karl-Heinz Westerhoff
IPC分类号： G01N35/00 , G01N1/31
CPC分类号： G01N35/00732 , G01N1/312 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , G02B21/34 , Y10T436/112499
摘要： An apparatus for sensing specimen slides (38) has a specimen slide holder (42) holding specimen slides (38), each specimen slide (38) comprising an identification code. The specimen slides (38) are arranged inside the specimen slide holder (42) on a lifting element (50) in a lifted position. The apparatus includes a reading apparatus (40) for reading out the identification code, and a positioning apparatus that moves the specimen slide holder (42) with the specimen slides (38) relative to the lifting element (50) so that the specimen slides (38) drop successively from the lifted position on the lifting element (50). As one of the specimen slides (38) drops, the identification code of the specimen slide (38) or of the subsequent specimen slide (38) becomes readable for the reading apparatus (40). A triggering apparatus (67, 68) triggers the reading apparatus (40) to read the identification code.
摘要翻译：一种用于感测标本片（38）的装置，具有夹持标本片（38）的标本片保持架（42），每个标本片（38）包括识别码。试样滑动件（38）被布置在提升元件（50）的提升位置内的试样滑动架（42）的内部。该装置包括用于读出识别码的读取装置（40），以及使样本滑块（38）相对于提升元件（50）移动的试样滑动架（42）的定位装置，使试样滑动 38）从升降元件（50）上的提升位置依次下降。当标本片（38）中的一个下降时，对于读取装置（40），样本滑块（38）或随后的标本滑块（38）的识别码变得可读。触发装置（67,68）触发读取装置（40）读取识别码。

3. 发明授权

US08709360B2 Automated processing machine used for processing samples placed on slides and having an output device 有权
标题翻译：自动加工机用于处理放置在幻灯片上并具有输出装置的样品
公开(公告)号：US08709360B2
公开(公告)日：2014-04-29
申请号：US13362698
申请日：2012-01-31
申请人： Midhat Hajrovic , Bernhard Neef , Karl-Heinz Westerhoff , Simon Keimer
发明人： Midhat Hajrovic , Bernhard Neef , Karl-Heinz Westerhoff , Simon Keimer
IPC分类号： A61B10/00
CPC分类号： G01N1/312 , G01N35/00732 , G01N2035/00089 , G01N2035/00138 , G01N2035/0498
摘要： An automated processing machine, in particular an automated coverslipper or an automated stainer used for processing samples placed on slides and having an output device for outputting slides that have been processed by the automated processing machine. The output device includes an extensible and retractable drawer unit. The drawer unit includes at least one receiving channel for receiving a plurality of holders for slides. Holders received in any position in the receiving channel can be removed therefrom when the output device is in the open position. The automated processing machine is designed such that holders intended for output are inserted into the at least one receiving channel.
摘要翻译：一种自动化处理机，特别是用于处理放置在载玻片上的样品的自动化盖玻片或自动染色机，并具有用于输出由自动化处理机处理过的载玻片的输出装置。输出装置包括可伸缩抽屉单元。抽屉单元包括用于接收多个用于滑块的保持器的至少一个接收通道。当输出设备处于打开位置时，可以从接收通道中的任何位置接收到的保持器从中移除。自动化处理机被设计成使得用于输出的保持器被插入到至少一个接收通道中。

4. 发明授权

US08431091B2 Tissue embedding apparatus, and method for operating a tissue embedding apparatus 有权
标题翻译：组织嵌入装置和组织嵌入装置的操作方法
公开(公告)号：US08431091B2
公开(公告)日：2013-04-30
申请号：US12599050
申请日：2008-04-23
申请人： Hermann Ulbrich , Karl-Heinz Westerhoff , Stefan Künkel
发明人： Hermann Ulbrich , Karl-Heinz Westerhoff , Stefan Künkel
IPC分类号： A61B10/00
CPC分类号： G01N1/31 , G01N1/36
摘要： The invention relates to a tissue embedding apparatus (1) for automatic embedding at least one tissue sample (8). Said tissue embedding device (1) comprises an input unit (2), an image recording unit (3), an embedding unit (4), at least one output unit (5, 6), and a control unit (7). A cassette (9) containing at least one tissue sample (8) can be transferred to the input unit (2) of the tissue embedding device (1). The embedding unit (4) allows the tissue sample (8) to be embedded in an embedding medium, while the at least one output unit (5) allows the embedded tissue sample to be output. The image recording unit (3) makes it possible to record at least one image of the tissue sample (8). In order to be able to embed tissue in an automated manner also when different cassettes are used, a tissue embedding device (1) according to the invention is characterized in that the recorded image of the tissue sample (8) can be evaluated while further processing of the tissue sample (8) in the tissue embedding device (1) can be predefined in accordance with the evaluation of the image.
摘要翻译：本发明涉及一种用于自动包埋至少一个组织样品（8）的组织包埋装置（1）。所述组织嵌入装置（1）包括输入单元（2），图像记录单元（3），嵌入单元（4），至少一个输出单元（5,6）和控制单元（7）。包含至少一个组织样本（8）的盒（9）可以被传送到组织嵌入装置（1）的输入单元（2）。嵌入单元（4）允许组织样本（8）嵌入到嵌入介质中，而至少一个输出单元（5）允许输出嵌入的组织样本。图像记录单元（3）使得可以记录组织样本（8）的至少一个图像。为了能够在使用不同的盒子时能够以自动方式嵌入组织，根据本发明的组织包埋装置（1）的特征在于可以进一步处理组织样本（8）的记录图像，可以根据图像的评估来预先确定组织包埋装置（1）中的组织样本（8）。

5. 发明申请

US20120171003A1 IDENTIFICATION SYSTEM FOR SPECIMEN SLIDES 有权
标题翻译：标本识别系统
公开(公告)号：US20120171003A1
公开(公告)日：2012-07-05
申请号：US13338289
申请日：2011-12-28
申请人： Markus EGLE , Stefan THIEM , Simon KEIMER , Karl-Heinz WESTERHOFF
发明人： Markus EGLE , Stefan THIEM , Simon KEIMER , Karl-Heinz WESTERHOFF
IPC分类号： G01N21/00 , B65G47/74
CPC分类号： G01N35/00732 , G01N1/312 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , G02B21/34 , Y10T436/112499
摘要： An apparatus for sensing specimen slides (38) has a specimen slide holder (42) holding specimen slides (38), each specimen slide (38) comprising an identification code. The specimen slides (38) are arranged inside the specimen slide holder (42) on a lifting element (50) in a lifted position. The apparatus includes a reading apparatus (40) for reading out the identification code, and a positioning apparatus that moves the specimen slide holder (42) with the specimen slides (38) relative to the lifting element (50) so that the specimen slides (38) drop successively from the lifted position on the lifting element (50). As one of the specimen slides (38) drops, the identification code of the specimen slide (38) or of the subsequent specimen slide (38) becomes readable for the reading apparatus (40). A triggering apparatus (67, 68) triggers the reading apparatus (40) to read the identification code.
摘要翻译：一种用于感测标本片（38）的装置，具有夹持标本片（38）的标本片保持架（42），每个标本片（38）包括识别码。试样滑动件（38）被布置在提升元件（50）的提升位置内的试样滑动架（42）的内部。该装置包括用于读出识别码的读取装置（40）和使样本滑块（38）相对于提升元件（50）移动的试样滑动架（42）的定位装置，使得试样滑动 38）从升降元件（50）上的提升位置依次下降。当标本片（38）中的一个下降时，对于读取装置（40），样本滑块（38）或随后的标本滑块（38）的识别码变得可读。触发装置（67,68）触发读取装置（40）读取识别码。

6. 发明申请

US20100099199A1 METHOD AND APPARATUS FOR ASCERTAINING REAGENT QUALITY 审中-公开
标题翻译：用于测定试剂质量的方法和装置
公开(公告)号：US20100099199A1
公开(公告)日：2010-04-22
申请号：US12580203
申请日：2009-10-15
申请人： Markus Egle , Robert Gropp , Stefan Künkel , Karl-Heinz Westerhoff
发明人： Markus Egle , Robert Gropp , Stefan Künkel , Karl-Heinz Westerhoff
IPC分类号： G01N1/00 , C12M1/34
CPC分类号： G01N35/00663 , G01N1/312 , G01N2035/00673 , Y10T436/25
摘要： A method for determining reagent quality in a device having multiple treatment stations for the treatment of at least one of cytological and histological prepared specimens and an apparatus for performing this method are described. The method comprises providing a carrier element that comprises at least one test material; transferring and treating the carrier element having test material according to a predefined sequence in a plurality of the treatment stations together with the specimens; and evaluating the test material by means of an evaluation device after treatment in the last treatment station in sequence. The described method and apparatus achieve that reagent quality can be determined automatically and the reagents can be replaced at an optimum point in time.
摘要翻译：描述了一种用于确定具有用于治疗细胞学和组织学制备的样本中的至少一个的多个治疗站的装置中的试剂质量的方法和用于执行该方法的装置。该方法包括提供包括至少一种测试材料的载体元件; 在多个处理站中按照预定的顺序，将样品转移和处理具有测试材料的载体元件; 并且在最后一个处理站中依次用处理后的评价装置对试验材料进行评价。所描述的方法和装置实现了可以自动确定试剂质量，并且可以在最佳时间点更换试剂。

7. 发明授权

US09063099B2 System for handling slides having a linear transport mechanism for transporting the racks 有权
标题翻译：用于处理具有用于运送机架的线性传送机构的滑块的系统
公开(公告)号：US09063099B2
公开(公告)日：2015-06-23
申请号：US13469621
申请日：2012-05-11
申请人： Bernhard Neef , Simon Keimer , Karl-Heinz Westerhoff
发明人： Bernhard Neef , Simon Keimer , Karl-Heinz Westerhoff
IPC分类号： G06F7/00 , G01N35/00 , G01N35/02
CPC分类号： G01N35/00029 , G01N35/026 , G01N2035/00079 , G01N2035/00138
摘要： The present invention relates to a system (10, 100) for handling slides, including an input compartment (14) for inputting racks (16) and the slides held therein, and a coverslipper module (30, 32) for coverslipping slides. The system (10, 100) further includes an output compartment (22) for outputting racks (16), a transport unit (20) for transporting the racks (16), and a control unit (52) for controlling the transport unit (20). The transport unit (20) is designed to be capable of transporting the racks (16) between the input compartment (14), the coverslipper module (30, 32) and the output compartment (22).
摘要翻译：本发明涉及一种用于处理幻灯片的系统（10,100），包括用于输入齿条（16）的输入隔室（14）和保持在其中的滑块以及用于盖玻片的盖板模块（30,32）。该系统（10,100）还包括用于输出机架（16）的输出隔间（22），用于运送机架（16）的传送单元（20）和用于控制运输单元（20）的控制单元）。传送单元（20）被设计成能够在输入隔间（14），盖玻片模块（30,32）和输出隔间（22）之间传送机架（16）。

8. 发明授权

US08277730B2 Tissue infiltration method 有权
标题翻译：组织浸润法
公开(公告)号：US08277730B2
公开(公告)日：2012-10-02
申请号：US13271953
申请日：2011-10-12
申请人： Hermann Ulbrich , Karl-Heinz Westerhoff , Stefan Künkel , Janet Minshew
发明人： Hermann Ulbrich , Karl-Heinz Westerhoff , Stefan Künkel , Janet Minshew
IPC分类号： G01N21/00
CPC分类号： G01N1/31 , Y10T436/2575
摘要： A tissue infiltration apparatus (1) for specimens present in cassettes (5) comprises at least two liquid containers (7, 11, 13, 15) and a transport apparatus (6). Multiple cassettes (5) are receivable in a transport basket (4). The transport apparatus (6) is configured in such a way that at least two transport baskets (4) are transportable in the tissue infiltration apparatus (1). A transport basket (4) is deliverable to, and/or movable away from, a liquid container (7, 11, 13, 15) with the transport apparatus (6). An execution sequence (21) in which the transport baskets (4) pass through the liquid containers (7, 11, 13, 15) is definable. To enable accelerated or preferred processing of a transport basket (4) with the tissue infiltration apparatus (1), at least one means (8) is provided with which the order of two transport baskets (4) is definably modifiable.
摘要翻译：用于盒（5）中的样本的组织浸渗装置（1）包括至少两个液体容器（7,11,13,15）和输送装置（6）。多个盒（5）可接收在运输篮（4）中。输送装置（6）构造成使得至少两个输送筐（4）能够在组织浸渗装置（1）中运输。运输篮（4）可与运输设备（6）一起运送到和/或移动离开液体容器（7,11,13,15）。运输篮（4）通过液体容器（7,11,13,15）的执行顺序（21）是可定义的。为了能够利用组织渗透装置（1）加速或优选地加工运输篮（4），提供至少一个装置（8），两个运输篮（4）的顺序是可定义地可修改的。

9. 发明授权

US08052928B2 Tissue infiltration apparatus 有权
标题翻译：组织浸润装置
公开(公告)号：US08052928B2
公开(公告)日：2011-11-08
申请号：US12031800
申请日：2008-02-15
申请人： Hermann Ulbrich , Karl-Heinz Westerhoff , Stefan Künkel , Janet I. Minshew
发明人： Hermann Ulbrich , Karl-Heinz Westerhoff , Stefan Künkel , Janet I. Minshew
IPC分类号： G01N21/00
CPC分类号： G01N1/31 , Y10T436/2575
摘要： A tissue infiltration apparatus (1) for specimens present in cassettes (5). comprises at least two liquid containers (7, 11, 13, 15) and a transport apparatus (6). A liquid having a definable property is introducible into a liquid container (7, 11, 13, 15). Multiple cassettes (5) are receivable in a transport basket (4). The transport apparatus (6) is configured in such a way that with it, at least two transport baskets (4) are transportable in the tissue infiltration apparatus (1). A transport basket (4) is deliverable to a liquid container (7, 11, 13, 15) and/or movable away from a liquid container (7, 11, 13, 15) with the transport apparatus (6). An execution sequence (21) in which the transport baskets (4) pass through the liquid containers (7, 11, 13, 15) of the tissue infiltration apparatus (1) is definable. To enable accelerated or preferred processing of a transport basket (4) with the tissue infiltration apparatus (1), but without using an additional liquid container provided only for that purpose, at least one means (8) is provided with which the order of two transport baskets (4) is definably modifiable.
摘要翻译：用于盒（5）中存在的标本的组织浸润装置（1）。包括至少两个液体容器（7,11,13,15）和输送装置（6）。具有可定义特性的液体可引入液体容器（7,11,13,15）。多个盒（5）可接收在运输篮（4）中。输送装置（6）以这样的方式配置：至少两个输送篮（4）可在组织浸渗装置（1）中运输。运输篮（4）可输送到液体容器（7,11,13,15）和/或可与运输设备（6）一起离开液体容器（7,11,13,15）移动。输送筐（4）通过组织浸渗装置（1）的液体容器（7,11,13,15）的执行顺序（21）是可定义的。为了能够利用组织浸渗装置（1）加速或优选地处理运输篮（4），但是不使用仅为此目的提供的另外的液体容器，提供至少一个装置（8），其具有两个运输篮（4）是可定义的。

10. 发明申请

US20100248301A1 Tissue Embedding Apparatus, And Method For Operating A Tissue Embedding Apparatus 有权
标题翻译：组织嵌入装置及操作组织嵌入装置的方法
公开(公告)号：US20100248301A1
公开(公告)日：2010-09-30
申请号：US12599050
申请日：2008-04-23
申请人： Hermann Ulbrich , Karl-Heinz Westerhoff , Stefan Künkel
发明人： Hermann Ulbrich , Karl-Heinz Westerhoff , Stefan Künkel
IPC分类号： G01N1/30 , G01N1/31
CPC分类号： G01N1/31 , G01N1/36
摘要： The present invention relates to a tissue embedding apparatus (1) for automatic embedding of at least one tissue sample (8). The tissue embedding apparatus (1) encompasses an input unit (2), an image acquisition unit (3), an embedding unit (4), at least one output unit (5, 6), and a control unit (7). A cassette (9) containing at least one tissue sample (8) is transferable to the input unit (2) of the tissue embedding apparatus (1). The tissue sample (8) is embeddable in an embedding medium by means of the embedding unit (4). The embedded tissue sample is outputtable with the at least one output unit (5). At least one image of the tissue sample (8) is acquirable with the image acquisition unit (3). In order for automated tissue embedding to be achievable even with the use of different cassettes, a tissue embedding apparatus (1) according to the present invention is characterized in that the image acquired of the tissue sample (8) is evaluatable, and the further processing of the tissue sample (8) in the tissue embedding apparatus (1) is definable as a function of the image evaluation.
摘要翻译：本发明涉及一种用于自动嵌入至少一个组织样品（8）的组织包埋装置（1）。组织嵌入装置（1）包括输入单元（2），图像获取单元（3），嵌入单元（4），至少一个输出单元（5,6）和控制单元（7）。包含至少一个组织样本（8）的盒（9）可转移到组织嵌入装置（1）的输入单元（2）。组织样品（8）可以通过嵌入单元（4）嵌入嵌入介质中。所述嵌入的组织样本可与所述至少一个输出单元（5）一起输出。所述组织样本（8）的至少一个图像可与所述图像获取单元（3）进行获取。为了即使使用不同的盒也能够实现自动组织包埋，根据本发明的组织包埋装置（1）的特征在于，可以评估获取的组织样品（8）的图像，并且进一步处理作为图像评价的函数来定义组织嵌入装置（1）中的组织样本（8）。

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