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1. 发明授权

US07164947B2 Heart stimulator with stimulation controlled by analysis of an average impedance morphology curve 失效
标题翻译：通过分析平均阻抗形态曲线控制刺激的心脏刺激器
公开(公告)号：US07164947B2
公开(公告)日：2007-01-16
申请号：US10619354
申请日：2003-07-14
申请人： Nils Holmström , Anders Björling , Kjell Norén , Karin Ljungström , Sven Kalling
发明人： Nils Holmström , Anders Björling , Kjell Norén , Karin Ljungström , Sven Kalling
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61N1/3627
摘要： A heart stimulator for electric stimulation of a patient's heart has an impedance measuring unit that measures the impedance between at least two measurement electrodes implanted in a patient such that volume changes of at least one of the chambers of the left heart result in changes in the measured impedance. An analyzer analyzes the measured impedance for the control of the stimulation of the heart. A calculation unit calculates an average impedance morphology curve during a time interval of several cardiac cycles. The analyzer analyzes the average impedance morphology curve for use for the control of the stimulation to optimize the patient hemodynamics.
摘要翻译：用于对患者心脏进行电刺激的心脏刺激器具有阻抗测量单元，其测量植入患者体内的至少两个测量电极之间的阻抗，使得左心脏的至少一个腔室的体积变化导致测量的变化阻抗。分析仪分析测量的阻抗以控制心脏的刺激。计算单元在几个心动周期的时间间隔内计算平均阻抗形态曲线。分析仪分析用于控制刺激的平均阻抗形态曲线，以优化患者的血液动力学。

2. 发明授权

US06886411B2 Piezoelectric sensor in a living organism for fluid pressure measurement 失效
标题翻译：用于流体压力测量的活体中的压电传感器
公开(公告)号：US06886411B2
公开(公告)日：2005-05-03
申请号：US10399813
申请日：2001-10-24
申请人： Charlotte Kjellman , Johan Lidman , Karin Ljungström , Kenth Nilsson
发明人： Charlotte Kjellman , Johan Lidman , Karin Ljungström , Kenth Nilsson
IPC分类号： A61B5/0215 , A61B19/00 , G01L9/06 , G01L9/08 , G01L7/00
CPC分类号： G01L9/08 , A61B5/0215 , A61B2090/064 , A61B2562/0247 , A61M2025/0002 , G01L9/06
摘要： A fluid pressure sensor for a lead or catheter intended for placement in a living organism, such as a human heart, includes a rigid annular or tubular supporting structure and a piezoelectric element disposed on at least a portion of the outer surface thereof. The piezoelectric element delivers an electrical signal when subjected to a pressure variation, and exhibits circumferential sensitivity. The rigidity of the sensor is defined to satisfy predetermined criteria to ensure that the sensor, when sensing pressure transferred to the sensor through an on-growth of tissue on the sensor, which is at least 90% of the signal which the sensor would emit without the on-growth.
摘要翻译：用于放置在诸如人心脏的生物体中的用于引导或导管的流体压力传感器包括刚性环形或管状支撑结构和设置在其外表面的至少一部分上的压电元件。当经受压力变化时，压电元件传递电信号，并且具有周向灵敏度。传感器的刚度被定义为满足预定的标准，以确保传感器在通过传感器上的组织的增长传感到传感器的压力时，其传感器将不会发射的信号的至少90％增长。

3. 发明授权

US08308649B2 Implantable cardiac device and method for monitoring the status of a cardiovascular disease 有权
标题翻译：可植入的心脏装置和监测心血管疾病状态的方法
公开(公告)号：US08308649B2
公开(公告)日：2012-11-13
申请号：US12528653
申请日：2007-03-23
申请人： Nils Holmström , Malin Öhlander , Kjell Norén , Andreas Blomqvist , Karin Ljungström
发明人： Nils Holmström , Malin Öhlander , Kjell Norén , Andreas Blomqvist , Karin Ljungström
IPC分类号： A61B5/02
CPC分类号： A61N1/36521 , A61B5/0215 , A61B5/02405 , A61B5/053 , A61B5/4035 , A61B5/4836 , A61B5/7257 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702
摘要： An implantable cardiac device has a heart stimulator for electrically stimulating the heart of a patient, detector that measures a physiologic parameter that is affected by the status of a cardiovascular disease associated with sympathetic activation, a signal processor that determines at least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the measured parameter, and analyzer that automatically analyzes the determined Mayer wave component in relation to a predetermined reference value to determine the status of the cardiovascular disease. The detector is a cardio-mechanical parameter detector that measures, as said physiologic parameter, a mechanical change in at least one of the four chambers of the heart. In a corresponding method for monitoring the status of a cardiovascular disease associated with sympathetic activation of a patient having an implantable electric heart stimulator a physiologic parameter affected by the cardiac disease is measured. At least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the parameter is determined, and the wave component is analyzed in relation to a predetermined reference value to determine the status of the cardiovascular disease. A mechanical change in at least one of the four chambers of the heart is measured as the physiologic parameter.
摘要翻译：可植入心脏装置具有用于电刺激患者心脏的心脏刺激器，所述心脏刺激器测量受到与交感神经激活相关的心血管疾病状态影响的生理参数的检测器，信号处理器确定低频 LF，以及在测量参数中的非常低频VLF，Mayer波分量，以及分析仪，其自动分析与预定参考值相关的确定的Mayer波分量，以确定心血管疾病的状态。检测器是心机械参数检测器，其作为所述生理参数测量心脏的四个腔室中的至少一个中的机械变化。在用于监测与具有可植入电心脏刺激器的患者的交感神经激活相关的心血管疾病的状态的相应方法中，测量受心脏病影响的生理参数。确定参数中的低频，低频和极低频VLF，迈耶波分量中的至少一个，并且相对于预定参考值分析波分量以确定心血管疾病的状态。心脏的四个腔室中的至少一个的机械变化被测量为生理参数。

4. 发明授权

US07959576B2 Apparatus for detecting diastolic heart failure 有权
标题翻译：用于检测舒张性心力衰竭的装置
公开(公告)号：US07959576B2
公开(公告)日：2011-06-14
申请号：US10562302
申请日：2004-05-06
申请人： Maria Torpo , Malin Öhlander , Anders Björling , Karin Ljungström
发明人： Maria Torpo , Malin Öhlander , Anders Björling , Karin Ljungström
IPC分类号： A61B5/021
CPC分类号： A61N1/3627 , A61B8/06 , A61B8/13
摘要： An implantable medical apparatus for detecting diastolic heart failure, DHF, has a DHF determining device for determining at least one DHF parameter for detecting a DHF state of the heart of a patient. The DHF includes circuitry for determining, as the DHF parameter, the time duration of a predetermined phase of diastole. A pacemaker has such an apparatus and a control unit that optimizes pacing therapy and pacemaker settings depending on the determined time duration. A corresponding method of detecting diastolic heart failure, DHF, includes determining at least one DHF parameter for detecting a DHF state of the heart of a patient. As the DHF parameter, the time duration of a predetermined phase of diastole is determined.
摘要翻译：用于检测舒张性心力衰竭的可植入医疗装置DHF具有DHF确定装置，用于确定用于检测患者心脏的DHF状态的至少一个DHF参数。 DHF包括用于确定舒张期的预定阶段的持续时间作为DHF参数的电路。起搏器具有这样的装置和控制单元，其根据确定的持续时间优化起搏治疗和起搏器设置。检测舒张性心力衰竭DHF的相应方法包括确定用于检测患者心脏的DHF状态的至少一个DHF参数。作为DHF参数，确定舒张期的预定相位的持续时间。

5. 发明授权

US06571130B1 Medical implant with piezoelectric material in contact with body tissue 失效
标题翻译：医疗植入物与压电材料接触身体组织
公开(公告)号：US06571130B1
公开(公告)日：2003-05-27
申请号：US09673747
申请日：2000-10-20
申请人： Karin Ljungström , Kenth Nilsson , Johan Lidman , Charlotte Kjellman
发明人： Karin Ljungström , Kenth Nilsson , Johan Lidman , Charlotte Kjellman
IPC分类号： A61N105
CPC分类号： C04B35/495 , A61L31/028 , A61N1/0565
摘要： A medical implant has an element with at least a part thereof which is composed of piezoelectric material. The piezoelectric material is suitable for contact with body tissue and/or body fluids, and has the formula NaxKyNbO3, with 0≦x≦0.8, 0.2≦y≦1, and x+y=1.
摘要翻译：医疗植入物具有至少一部分由压电材料构成的元件。压电材料适于与身体组织和/或体液接触，并且具有公式NaxKyNbO3，其中0 <= x <= 0.8,0.2 <= y <= 1，x + y = 1。

6. 发明申请

US20100106210A1 IMPLANTABLE MEDICAL SYSTEM FOR DETECTING INCIPIENT EDEMA 有权
标题翻译：用于检测机动车辆的可植入医疗系统
公开(公告)号：US20100106210A1
公开(公告)日：2010-04-29
申请号：US12531793
申请日：2007-04-24
申请人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindqvist , Urban Lönn
发明人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindqvist , Urban Lönn
IPC分类号： A61N1/365 , A61B6/00 , A61B5/00
CPC分类号： A61N1/05 , A61B5/0084 , A61B5/0086 , A61B5/08 , A61B5/1116 , A61B5/1118 , A61B5/4878 , A61B5/7207 , A61N1/025 , A61N1/056 , A61N1/362
摘要： An implantable medical system for detecting incipient edema has an implantable medical lead including an optical sensor having a light source and a light detector. The medical system further has an edema detection circuit that activates the light source to emit light, the light being directed into lung tissue of a patient and that obtains a light intensity value corresponding to an intensity of light received by the light detector, and that evaluates the light intensity value to detect a consistency with incipient edema.
摘要翻译：用于检测初期水肿的可植入医疗系统具有包括具有光源和光检测器的光学传感器的可植入医疗引线。医疗系统还具有水肿检测电路，其激活光源发光，将光引导到患者的肺组织，并获得与由光检测器接收的光的强度对应的光强度值，并且评估光强值检测与初期水肿的一致性。

7. 发明授权

US07483742B2 Detection of diastolic heart failure 有权
标题翻译：舒张性心力衰竭的检测
公开(公告)号：US07483742B2
公开(公告)日：2009-01-27
申请号：US10562109
申请日：2004-04-26
申请人： Sven-Erik Hedberg , Anders Björling , Maria Torpo , Karin Ljungström
发明人： Sven-Erik Hedberg , Anders Björling , Maria Torpo , Karin Ljungström
IPC分类号： A61N1/00
CPC分类号： A61B5/021 , A61B5/02154 , A61N1/3627 , A61N1/36564 , A61N1/3702 , G06F19/00
摘要： An implantable medical apparatus for detecting diastolic heart failure, DHF, has a DHF determining device for determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient. The DHF determining device includes a pressure measuring unit for measuring pulse pressure in a cardiac cycle for a predetermined workload situation of the patient as the blood pressure parameter, and a comparator compares the measured pulse pressure with a predetermined reference value. A pacemaker includes such an apparatus and a control unit that optimizes pacing therapy depending on the result of the comparison of the measured pulse pressures with the predetermined reference values. A corresponding method of detecting diastolic heart failure, DHF, includes the step of determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient by determining, as said blood pressure parameter, the pulse pressure in a cardiac cycle for a predetermined workload situation of the patient, and the determined pulse pressure is compared with a predetermined reference value.
摘要翻译：用于检测舒张性心力衰竭的可植入医疗装置DHF具有用于确定用于检测患者心脏的DHF状态的至少一个血压参数的DHF确定装置。 DHF确定装置包括：压力测量单元，用于在患者的预定工作情况下测量心动周期中的脉搏压力作为血压参数，并且比较器将测量的脉搏压力与预定参考值进行比较。起搏器包括这样的装置和控制单元，其根据所测量的脉搏压力与预定参考值的比较结果优化起搏治疗。检测舒张性心力衰竭DHF的相应方法包括以下步骤：通过将作为所述血压参数的心脏周期中的脉搏压力确定为心动周期中的脉搏压力来确定用于检测患者心脏的DHF状态的至少一个血压参数患者的预定工作情况，并将确定的脉搏压力与预定的参考值进行比较。

8. 发明授权

US08246929B2 Synthesis of sodium potassium niobate by sol-gel 有权
标题翻译：通过溶胶 - 凝胶合成铌酸钠钠
公开(公告)号：US08246929B2
公开(公告)日：2012-08-21
申请号：US11920380
申请日：2005-05-31
申请人： Tom Eriksson , Kenth Nilsson , Anna-Karin Johansson , Karin Ljungström , Koroush Lashgari , Annika Pohl , Gunnar Westin
发明人： Tom Eriksson , Kenth Nilsson , Anna-Karin Johansson , Karin Ljungström , Koroush Lashgari , Annika Pohl , Gunnar Westin
IPC分类号： C04B35/00
CPC分类号： C04B35/495 , A61N1/056 , A61N1/0565 , A61N1/36542 , A61N1/36564 , C01G33/00 , C01G33/006 , C01P2002/72 , C01P2002/77 , C01P2002/82 , C01P2002/88 , C01P2004/03 , C04B35/624 , C04B35/62645 , C04B35/62675 , C04B2235/3201 , C04B2235/3251 , C04B2235/3255 , C04B2235/441 , C04B2235/6562 , C04B2235/768 , C04B2235/80 , C23C18/1216 , C23C18/1225 , C23C18/1254 , C23C18/1283 , H01L41/1873 , H01L41/318
摘要： A method for producing a biocompatible material of the formula NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.
摘要翻译：一种制备式NaxKyNbO3,0和nlE; x和nlE; 0.8,0.2＆nlE; y＆nlE; 1，x + y = 1的生物相容性材料的方法包括以下步骤：a）提供NaxKyNbO3的Na前体和K-前体，b 将前体混合在溶液中，其中所述前体首先反应形成溶胶，然后进行凝胶，c）热处理该凝胶以获得材料NaxKyNbO3,0和nlE; x和nlE; 0.8,0.2和nlE; y和nlE; 1，x + y = 1。该材料可以作为膜制造，并且材料或膜可以设置在将在其植入时将与身体组织和/或体液接触的医用植入物的外表面上。

9. 发明申请

US20100041970A1 IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：US20100041970A1
公开(公告)日：2010-02-18
申请号：US12532186
申请日：2007-11-27
申请人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindkvist , Urban Lönn , Nils Holmström
发明人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindkvist , Urban Lönn , Nils Holmström
IPC分类号： A61B5/1459
CPC分类号： A61N1/3702 , A61B5/14542 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： An implantable medical device has an oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison. The, indication signal is indicative of the lung functionality of the patient.
摘要翻译：可植入医疗装置具有适于测量氧合血液中的氧气水平的氧传感器，并且根据氧气水平产生氧测量信号。氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。将获得的氧测量信号与预定阈值电平进行比较，并根据比较产生指示信号。该指示信号表示患者的肺功能。

10. 发明授权

US07215996B2 Bi-ventricular heart stimulating device, system and method 有权
标题翻译：双心室心脏刺激装置，系统及方法
公开(公告)号：US07215996B2
公开(公告)日：2007-05-08
申请号：US10499253
申请日：2002-10-04
申请人： Kjell Norén , Karin Ljungström , Sven Kalling , Lars Mandal , Anders Björling
发明人： Kjell Norén , Karin Ljungström , Sven Kalling , Lars Mandal , Anders Björling
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： In an implantable heart stimulating device, system and method, electrical stimulation pulses are delivered to first and second ventricles of a heart with a variable time interval therebetween, and signals are sensed at two different positions in the heart, from which an impedance value is derived. A minimum value and a maximum value of the impedance value are determined during a heart cycle, and a relationship between the minimum and maximum values also is determined. The time interval is varied and the relationship is monitored over a number of heart cycles. The time interval is set so that the relationship satisfies a predetermined requirement.
摘要翻译：在可植入心脏刺激装置，系统和方法中，将电刺激脉冲以其间具有可变时间间隔输送到心脏的第一和第二心室，并且在心脏中的两个不同位置处感测信号，从其中导出阻抗值。在心脏周期期间确定阻抗值的最小值和最大值，并且还确定最小值与最大值之间的关系。时间间隔变化，并且在许多心脏周期上监测关系。设定时间间隔使得该关系满足预定的要求。

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