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1. 发明申请

US20060247213A1 Plasma carboxypeptidase b inhibitors 失效
标题翻译：血浆羧肽酶b抑制剂
公开(公告)号：US20060247213A1
公开(公告)日：2006-11-02
申请号：US10508169
申请日：2003-03-21
申请人： Brad Buckman , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendong Yuan
发明人： Brad Buckman , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendong Yuan
IPC分类号： A61K31/66 , C07D211/26 , C07F9/22 , C07F9/28 , A61K31/445
CPC分类号： C07F9/655345 , C07C323/58 , C07C327/34 , C07D211/34 , C07F9/301 , C07F9/302 , C07F9/306 , C07F9/3211 , C07F9/3241 , C07F9/3882 , C07F9/4006 , C07F9/4056 , C07F9/4087 , C07F9/6524
摘要： Compounds of the following formula (I), for example: (1), wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译：下式（I）的化合物，例如：（1）其中R 1，R 2，R 3和R 3，本文描述的这些化合物可用作血浆羧肽酶B的抑制剂。本文还描述了含有这些化合物的药物组合物，使用这些化合物作为抗血栓形成剂的方法和合成这些化合物的方法。

2. 发明授权

US06772891B1 Comfort grip bottle holder 失效
标题翻译：舒适握持瓶架
公开(公告)号：US06772891B1
公开(公告)日：2004-08-10
申请号：US10337022
申请日：2003-01-06
申请人： Karen May Song
发明人： Karen May Song
IPC分类号： A61J900
CPC分类号： A01K9/00
摘要： An artificial nursing system for use by an infant animal is disclosed. The nursing system comprises a feeding bottle, a nipple and a sleeve. The feeding bottle has a top end and a bottom end, the top end of the feeding bottle is attached to the nipple. A sleeve envelopes the feeding bottle, the sleeve comprises a first section made from an elastic material, wherein the elastic material constricts around the feeding bottle and a second section fixedly attached to the first section, the second section is made from a scent accepting fabric and surrounds the nipple. The first and second sections allow the infant animal to grip the feeding bottle and nipple and the constriction of the first section of the sleeve attaches the sleeve to the feeding bottle.
摘要翻译：公开了一种用于婴儿动物的人造护理系统。护理系统包括喂奶瓶，乳头和套管。喂奶瓶具有顶端和底端，奶瓶的顶端连接到乳头。套筒包围进料瓶，套筒包括由弹性材料制成的第一部分，其中弹性材料围绕进料瓶收缩，第二部分固定地附接到第一部分，第二部分由气味接受织物制成，围绕乳头。第一和第二部分允许婴儿动物夹住喂奶瓶和乳头，并且套筒的第一部分的收缩将套筒附接到喂奶瓶。

3. 发明申请

US20080265576A1 DEVICES FOR TEACHING OR AIDING IN THE MAKING OF KNOTS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：教学或辅导教学设备及其制作与使用方法
公开(公告)号：US20080265576A1
公开(公告)日：2008-10-30
申请号：US12015900
申请日：2008-01-17
申请人： Karen MAY-NEWMAN , Peter NEWMAN , Edward BEAIL , Meral DEMIR
发明人： Karen MAY-NEWMAN , Peter NEWMAN , Edward BEAIL , Meral DEMIR
IPC分类号： B65H69/00 , G09B21/00
CPC分类号： G09B19/003 , G09B21/00
摘要： This invention provides a device, or product of manufacture, for use as a teaching device for tying knots, or as an aid in tying knots, e.g., as for use by handicapped or disabled individuals. The invention provides device, or product of manufacture, completely automated for tying knots using the device and/or methods of the invention. The invention also provides methods for making and using these devices of the invention.
摘要翻译：本发明提供了一种用于作为用于捆扎结的教学装置的装置或制造产品，或作为例如用于残疾人或残疾人使用的结的帮助。本发明提供了使用本发明的装置和/或方法用于捆扎结的完全自动化的装置或制造产品。本发明还提供了制造和使用本发明的这些装置的方法。

4. 发明授权

US08008325B2 Plasma carboxypeptidase B inhibitors 失效
标题翻译：血浆羧肽酶B抑制剂
公开(公告)号：US08008325B2
公开(公告)日：2011-08-30
申请号：US12332619
申请日：2008-12-11
申请人： Brad O. Buckman , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendong Yuan
发明人： Brad O. Buckman , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendong Yuan
IPC分类号： A61K31/445 , C07D211/00
CPC分类号： C07F9/655345 , C07C323/58 , C07C327/34 , C07D211/34 , C07F9/301 , C07F9/302 , C07F9/306 , C07F9/3211 , C07F9/3241 , C07F9/3882 , C07F9/4006 , C07F9/4056 , C07F9/4087 , C07F9/6524
摘要： Compounds of the following formula (I), for example: wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译：下列通式（I）的化合物，其中R1，R2，R3和R4如本文所述，可用作血浆羧肽酶B的抑制剂。含有这些化合物的药物组合物，使用这些化合物作为抗血栓形成剂和方法用于合成这些化合物也在本文中描述。

5. 发明申请

US20090093520A1 PLASMA CARBOXYPEPTIDASE B INHIBITORS 失效
标题翻译：等离子体羧化酶B抑制剂
公开(公告)号：US20090093520A1
公开(公告)日：2009-04-09
申请号：US12332619
申请日：2008-12-11
申请人： Brad BUCKMAN , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendon Yuan
发明人： Brad BUCKMAN , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendon Yuan
IPC分类号： A61K31/445 , C07D211/60 , A61P7/02
CPC分类号： C07F9/655345 , C07C323/58 , C07C327/34 , C07D211/34 , C07F9/301 , C07F9/302 , C07F9/306 , C07F9/3211 , C07F9/3241 , C07F9/3882 , C07F9/4006 , C07F9/4056 , C07F9/4087 , C07F9/6524
摘要： Compounds of the following formula (I), for example: wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译：下列通式（I）的化合物，其中R1，R2，R3和R4如本文所述，可用作血浆羧肽酶B的抑制剂。含有这些化合物的药物组合物，使用这些化合物作为抗血栓形成剂和方法用于合成这些化合物也在本文中描述。

6. 发明申请

US20110319366A1 Plasma Carboxypeptidase B Inhibitors 审中-公开
标题翻译：血浆羧肽酶B抑制剂
公开(公告)号：US20110319366A1
公开(公告)日：2011-12-29
申请号：US13220333
申请日：2011-08-29
申请人： Brad Buckman , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendong Yuan
发明人： Brad Buckman , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendong Yuan
IPC分类号： A61K31/662 , C07F9/40 , A61P7/02 , C07F9/30
CPC分类号： C07F9/655345 , C07C323/58 , C07C327/34 , C07D211/34 , C07F9/301 , C07F9/302 , C07F9/306 , C07F9/3211 , C07F9/3241 , C07F9/3882 , C07F9/4006 , C07F9/4056 , C07F9/4087 , C07F9/6524
摘要： Compounds of the following formula (I), for example: wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译：下列通式（I）的化合物，其中R1，R2，R3和R4如本文所述，可用作血浆羧肽酶B的抑制剂。含有这些化合物的药物组合物，使用这些化合物作为抗血栓形成剂和方法用于合成这些化合物也在本文中描述。

7. 发明授权

US07762413B2 Nursing bottle holder 失效
标题翻译：护理瓶架
公开(公告)号：US07762413B2
公开(公告)日：2010-07-27
申请号：US11396523
申请日：2006-04-03
申请人： Karen May Song
发明人： Karen May Song
IPC分类号： A61J9/08
CPC分类号： A61J9/0607 , A01K9/00 , A01K9/005 , A61J9/0615 , A61J9/08
摘要： A holder for use with a nipple-topped nursing bottle includes a sleeve portion for covering the nursing bottle. Surrounding the sleeve portion is a ring portion. The ring portion may be grabbed and squeezed by the animal being nursed during the nursing process. Such grabbing and squeezing during the nursing process overcomes the reluctance of the animal to take nourishment through the nipple of nipple-tipped nursing bottle and shortens the time during which an animal may be weaned to a nipple-tipped nursing bottle.
摘要翻译：用于乳头顶部护理瓶的保持器包括用于覆盖护理瓶的套筒部分。套筒部分周围是环形部分。在护理过程中，护理部分可以被哺乳动物抓住并挤压。护理过程中的这种抓取和挤压克服了动物通过乳头护理瓶的乳头而不愿意将其营养，并缩短了一只动物可以断奶到乳头护理瓶的时间。

8. 发明授权

US07528173B2 Plasma carboxypeptidase B inhibitors 失效
标题翻译：血浆羧肽酶B抑制剂
公开(公告)号：US07528173B2
公开(公告)日：2009-05-05
申请号：US10508169
申请日：2003-03-21
申请人： Brad Buckman , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendong Yuan
发明人： Brad Buckman , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendong Yuan
IPC分类号： A61K31/155 , C07C61/00
CPC分类号： C07F9/655345 , C07C323/58 , C07C327/34 , C07D211/34 , C07F9/301 , C07F9/302 , C07F9/306 , C07F9/3211 , C07F9/3241 , C07F9/3882 , C07F9/4006 , C07F9/4056 , C07F9/4087 , C07F9/6524
摘要： Compounds of the following formula (I), for example: (1), wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译：下述式（I）的化合物，例如：（1）其中R1，R2，R3和R4如本文所述，可用作血浆羧肽酶B的抑制剂。含有这些化合物的药物组合物，使用这些化合物的方法抗凝血剂和合成这些化合物的方法也在本文中描述。

9. 发明申请

US20060135487A1 Piperazine derivatives and their use as anti-inflammatory agents 失效
公开(公告)号：US20060135487A1
公开(公告)日：2006-06-22
申请号：US11248618
申请日：2005-10-13
申请人： John Bauman , Brad Buckman , Ameen Ghannam , Joseph Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen May , Sean Monahan , Michael Morrissey , Howard Ng , Kenneth Shaw , Guo Wei , Wei Xu , Zuchun Zhao , Wei Zheng
发明人： John Bauman , Brad Buckman , Ameen Ghannam , Joseph Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen May , Sean Monahan , Michael Morrissey , Howard Ng , Kenneth Shaw , Guo Wei , Wei Xu , Zuchun Zhao , Wei Zheng
IPC分类号： A61K31/655 , A61K31/496 , A61K31/495
CPC分类号： C07D295/185 , C07D215/18 , C07D241/04 , C07D241/38 , C07D261/14 , C07D295/192 , C07D307/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.

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