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1. 发明授权

US06785411B1 Image analyzing apparatus and image analyzing method 失效
标题翻译：图像分析装置及图像分析方法
公开(公告)号：US06785411B1
公开(公告)日：2004-08-31
申请号：US09620648
申请日：2000-07-20
申请人： Shoko Kitajima , Hiroshi Shirouzu , Kanji Yahiro , Koji Yamaguchi
发明人： Shoko Kitajima , Hiroshi Shirouzu , Kanji Yahiro , Koji Yamaguchi
IPC分类号： G06K900
CPC分类号： G06T7/60
摘要： There are provided an image analyzing apparatus and an image analyzing method where, in analyzing a microscopic image of a microbe or a cell tissue, the manpower-independent observation and quantification are executed so as to enhance the analyzing performance. The configuration of the apparatus and the method is as follows: A frequency conversion processing, such as Wavelet transformation, is executed toward the microscopic image of the microbe or the cell tissue and, based on the result obtained, the quantitative analysis is executed. The configuration allows the automatic quantitative judgement to be executed concerning factors such as the position, the number, the magnitude, the degree of activity, the area ratio, the configuration, the direction, and the color. This condition makes it possible to reduce a burden imposed on a person who are in charge of the observation. Also, the noise can be eliminated, which also enhances the analyzing performance. Moreover, the converted regions are utilized for the analysis. This condition makes it possible to execute the analysis with the amount of calculation that is smaller than the resolution, thereby allowing the high-speed processing to be implemented.
摘要翻译：提供了一种图像分析装置和图像分析方法，其中，在分析微生物或细胞组织的微观图像时，执行人力无关的观察和定量，以提高分析性能。该装置和方法的结构如下：对微生物或细胞组织的微观图像执行诸如小波变换之类的变频处理，根据获得的结果，进行定量分析。该配置允许对诸如位置，数量，大小，活动程度，面积比，配置，方向和颜色等因素执行自动定量判断。这种情况可以减轻负责观察者的负担。此外，可以消除噪声，这也增强了分析性能。此外，转换的区域用于分析。该条件使得可以以小于分辨率的计算量执行分析，从而允许实现高速处理。

2. 发明授权

US06542293B2 Apparatus and method for observing biochemical substance 失效
标题翻译：观察生化物质的仪器和方法
公开(公告)号：US06542293B2
公开(公告)日：2003-04-01
申请号：US09829996
申请日：2001-04-11
申请人： Kanji Yahiro
发明人： Kanji Yahiro
IPC分类号： G02B2100
CPC分类号： B01L3/5085 , G02B21/34 , G02B27/40
摘要： A biochemical substance is efficiently observed with focusing accurately and rapidly on the substance disposed on an inside of a container. A focusing mark, which is used as a reference when a focal point of an optical system is adjusted, is disposed on the outside of a transparent bottom of each well in a micro plate. A focus-shift-distance corresponding to a distance between the mark and a desired position to be observed is determined. The optical system focuses on the mark, and then, the focal point the optical system is shifted by the focus-shift-distance. This shift allows an object to be focused on accurately and rapidly even when unclear images are obtained.
摘要翻译：有效地观察生物化学物质，并准确，快速地聚焦在容器内部的物质上。当调整光学系统的焦点时用作参考的聚焦标记设置在微孔的每个孔的透明底部的外侧。确定对应于标记与要观察的期望位置之间的距离的对焦移动距离。光学系统聚焦在标记上，然后聚焦光学系统偏移了焦点位移距离。即使获得不清楚的图像，这种移动也允许对象准确和快速地聚焦。

3. 发明授权

US06678391B2 Organism-specimen morphological-change detecting apparatus, and organism-specimen morphological-change detecting method 失效
标题翻译：有机体样本形态变化检测装置和生物体标本形态变化检测方法
公开(公告)号：US06678391B2
公开(公告)日：2004-01-13
申请号：US09835489
申请日：2001-04-17
申请人： Kanji Yahiro
发明人： Kanji Yahiro
IPC分类号： G06K900
CPC分类号： G01N15/1475 , G01N2015/0065
摘要： The present invention relates to an apparatus of optically detecting morphological change of an organism specimen such as an animal/plant cell. In a candidate compound screening for detecting a candidate compound among compounds, a camera of a microscope apparatus takes images of an organism specimen in a plate before and after a dosage of each compound-containing solution to the organism specimen by a dispensing head. An image processor processes the taken microscopic images and provides numerical data as a quantitative indicator of a state of the organism specimen. The screening apparatus judges whether each compound solved in each solution is the candidate compound by comparing numerical data before and after the dosage of the solution with each other.
摘要翻译：本发明涉及光学检测动物/植物细胞等有机体标本的形态变化的装置。在用于检测化合物中候选化合物的候选化合物筛选中，显微镜装置的照相机通过分配头将每种含化合物溶液的剂量前后的生物体标本的图像摄取到生物样本。图像处理器处理所拍摄的微观图像，并提供数值数据作为生物样本状态的定量指标。筛选装置通过比较溶液的剂量之前和之后的数值数据来判断每种溶液中溶解的每种化合物是候选化合物。

4. 发明授权

US06238626B1 Automatic distribution apparatus and method of distribution 失效
标题翻译：自动配送设备及配送方式
公开(公告)号：US06238626B1
公开(公告)日：2001-05-29
申请号：US09289607
申请日：1999-04-12
申请人： Akira Higuchi , Eiji Watanabe , Naoki Miyazaki , Kanji Yahiro , Kenichi Kuroda , Hideyoshi Kitahara , Kenji Ishiyama , Takashi Daikoku
发明人： Akira Higuchi , Eiji Watanabe , Naoki Miyazaki , Kanji Yahiro , Kenichi Kuroda , Hideyoshi Kitahara , Kenji Ishiyama , Takashi Daikoku
IPC分类号： B01L302
CPC分类号： G01N35/10 , B01L3/0275 , G01N2035/103 , Y10T436/2575
摘要： In a method for distributing liquids, in which a distribution tip attached detachably to the lower end of a distribution nozzle can be replaced at any time necessary, a tip rack having a plurality of unused distribution tips lined up thereon is placed on a fitting stage to have the distribution tips fitted with a distribution nozzles. Then, the existence, or non-existence, of a distribution tip left behind on the tip rack without being attached to a distribution nozzle after the fitting operation is finished is detected by a detection section formed of an interrupting-type light sensor, the targeted place of detection by the light sensor being the lower end of the distribution tip. Under the above-described structure, misfitting of a distribution tip can be detected with a high certainty at an early stage before an operation for sucking/discharging liquids is started.
摘要翻译：在分配液体的方法中，可以随时更换可分配到分配喷嘴的下端的分配末端，其中具有多个未分配的未分配尖端的末端齿条放置在装配台上具有配有分配喷嘴的分配头。然后，通过由中断型光传感器形成的检测部分来检测在装配操作完成后未附着在分配喷嘴上的尖端齿条上留下的分配尖端的存在或不存在，目标光传感器的检测位置是分配尖端的下端。在上述结构之前，可以在开始吸取/排出液体的操作之前的早期阶段高精度地检测分配尖端的错配。

5. 发明授权

US06299840B1 Automatic testing apparatus 失效
标题翻译：自动检测仪器
公开(公告)号：US06299840B1
公开(公告)日：2001-10-09
申请号：US09281223
申请日：1999-03-30
申请人： Eiji Watanabe , Kanji Yahiro , Akira Higuchi , Naoki Miyazaki , Kenichi Kuroda , Kenji Ishiyama , Takashi Daikoku , Hideyoshi Kitahara
发明人： Eiji Watanabe , Kanji Yahiro , Akira Higuchi , Naoki Miyazaki , Kenichi Kuroda , Kenji Ishiyama , Takashi Daikoku , Hideyoshi Kitahara
IPC分类号： G01N2100
CPC分类号： G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00356 , G01N2035/0425 , G01N2035/0498
摘要： In an automatic testing apparatus comprising, a specimen holder area adapted to hold thereon a specimen substrate for receiving therein a specimen, a reagent injector adapted to inject a reagent toward the specimen in the specimen substrate on the specimen holder area to mix the specimen with the reagent, a mixture reaction device adapted to hold thereon the specimen substrate including the mixture of the specimen and the reagent within a predetermined circumferential condition during a time period, and a transferring device for transferring the specimen substrate relative to the specimen holder area, the mixture reaction device has a take-in area to which the specimen substrate is transferred from the specimen holder area by the transferring device, and the take-in area is arranged adjacent to the specimen holder area.
摘要翻译：一种自动检测装置，其特征在于，包括：试样保持区域，其适于在其上容纳有用于容纳试样的试样基板，适于向试样保持体区域的试样基板上的试样注入试剂，将试样与试剂，混合反应装置，其适于在一段时间内在预定的周向状态下将包含试样和试剂的混合物的试样基板保持在其上，以及用于相对于试样保持器区域传送试样基板的转印装置，反应装置具有通过转印装置从试样保持体区域将试样基板从其移送到的入口区域，并且导入区域邻近试样保持器区域布置。

6. 发明授权

US06228636B1 Incubator 失效
标题翻译：孵化器
公开(公告)号：US06228636B1
公开(公告)日：2001-05-08
申请号：US09401040
申请日：1999-09-21
申请人： Kanji Yahiro , Akira Higuchi
发明人： Kanji Yahiro , Akira Higuchi
IPC分类号： C12M100
CPC分类号： C12M27/10 , C12M23/48 , C12M41/14 , G01N35/0092 , G01N35/025 , G01N35/028 , G01N2035/00356 , G01N2035/0093 , G01N2035/0441 , G01N2035/0465 , G01N2035/0487
摘要： An incubator includes (a) a housing, (b) a sample shelf holding at least one plate accommodating a sample, (c) a controller maintaining an environment inside of the housing at a given condition, (d) a first opening provided on the housing, (e) a first door for closing the first opening, (f) a second opening provided on the housing and smaller than the first opening and yet large enough for at least one plate being passed through, and (g) a second door for closing the second opening. This construction allows the incubator to minimize opening when the plate is taken out or restored during a test or a culture so that environment changes in the housing can be restrained. As a result, the incubator produces reliable data.
摘要翻译：培养箱包括（a）壳体，（b）容纳样品的至少一个板的样品架，（c）在给定条件下保持壳体内的环境的控制器，（d）设置在所述壳体上的第一开口壳体，（e）用于封闭第一开口的第一门，（f）设置在壳体上并小于第一开口的第二开口，并且足够大以使至少一个板通过，以及（g）第二门关闭第二个开口。这种结构允许培养箱在测试或培养期间取出或恢复板时使开口最小化，从而可以抑制壳体中的环境变化。因此，孵化器产生可靠的数据。

7. 发明授权

US06182719B2 Distribution apparatus, distribution method and method of fitting distribution tips 失效
标题翻译：配送设备，配送方法及配套方法
公开(公告)号：US06182719B2
公开(公告)日：2001-02-06
申请号：US09300919
申请日：1999-04-28
申请人： Kanji Yahiro
发明人： Kanji Yahiro
IPC分类号： G01N3500
CPC分类号： B01L9/543 , G01N35/1074 , G01N2035/0494 , G01N2035/103
摘要： A distribution apparatus for distributing liquid samples using distribution tips, which distribution tips are held in a tip rack placed in a feeder section and fitted relative to a distribution head. The distribution apparatus has a fitting stage, provided in a space between the feeder section and a distribution stage, for supporting the tip rack and fitting the distribution tips. A distribution tip alignment device is provided in the fitting stage, which aligns dislocated distribution tips at the bottom ends to a correct formation by making contact with the side wall surfaces of the distribution tips. The tip ends of the distribution tips, which are attached to nozzles of the distribution head, are aligned by the distribution tip alignment device at a certain specific pitch, at the time when the distribution tips are attached to the nozzles, or after they are attached to the nozzles. By so doing, a liquid sample can be distributed to small diameter wells without having a dislocation problem.
摘要翻译：一种用于使用分配头分配液体样品的分配装置，该分配尖端保持在放置在馈送器部分中并相对于分配头安装的尖端架中。分配装置具有装配台，其设置在供给部和分配台之间的空间中，用于支撑末端齿条并配合分配头。分配头部对准装置设置在装配台中，其通过与分配尖端的侧壁表面接触将底端的脱位分配尖端对准正确的结构。附着在分配头的喷嘴上的分配尖端的末端在分配尖端附接到喷嘴时或者在它们被连接之后以分配尖端对准装置以特定间距对准到喷嘴。通过这样做，可以将液体样品分配到小直径的孔而不产生位错问题。

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