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1. 发明申请

US20130046154A1 PPG IMAGING DEVICE AND PPG MEASURING METHOD 审中-公开
标题翻译： PPG成像装置和PPG测量方法
公开(公告)号：US20130046154A1
公开(公告)日：2013-02-21
申请号：US13306866
申请日：2011-11-29
申请人： Yue Der Lin , Shih Fan Wang , Hu Ying Ho , Ching Che Tsai , Kang Ping Lin , Hen Hong Chang , Yung Ching Chang
发明人： Yue Der Lin , Shih Fan Wang , Hu Ying Ho , Ching Che Tsai , Kang Ping Lin , Hen Hong Chang , Yung Ching Chang
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/02007
摘要： The present invention discloses a PPG imaging device and a PPG measuring method. The PPG imaging device comprises a light emitting unit, a collimator unit, a beam splitter unit, an image sensing unit, and an image analysis unit. The light emitting unit provides an incident light signal. The collimator unit receives the incident light signal and transforms the incident light signal into a parallel light signal. The beam splitter unit receives the parallel light signal and reflects it to a tested region. The image sensing unit receives a reflected light signal reflected from the tested region and converts it into image signals. The image analysis unit connects with the image sensing unit and analyzes the image signals to obtain PPG signals of the tested region. The PPG imaging device may be arranged in an anti-light pollution unit, whereby to prevent from optical interference and obtain higher measurement precision.
摘要翻译：本发明公开了一种PPG成像装置和PPG测定方法。 PPG成像装置包括发光单元，准直器单元，分束器单元，图像感测单元和图像分析单元。发光单元提供入射光信号。准直器单元接收入射光信号并将入射光信号转换成并行光信号。分束器单元接收平行光信号并将其反射到测试区域。图像感测单元接收从测试区域反射的反射光信号并将其转换为图像信号。图像分析单元与图像感测单元连接并分析图像信号以获得测试区域的PPG信号。 PPG成像装置可以布置在防光污染单元中，从而防止光学干扰并获得更高的测量精度。

2. 发明授权

US07030970B2 Optical apparatus for measuring the velocity of flowing biomaterials 失效
标题翻译：用于测量流动生物材料速度的光学装置
公开(公告)号：US07030970B2
公开(公告)日：2006-04-18
申请号：US10743878
申请日：2003-12-24
申请人： Kang-Ping Lin , Yuh-Ping Tong , Alex Hsieh , Mang-Yi Chen
发明人： Kang-Ping Lin , Yuh-Ping Tong , Alex Hsieh , Mang-Yi Chen
IPC分类号： G01P3/36 , G01N21/85
CPC分类号： G01P5/26 , A61B5/0261 , G01S17/58
摘要： An optical apparatus for measuring the velocity of flowing biomaterials is disclosed, which has a coherent light source for projecting a light beam with low coherent length; a reference member having mirrors for periodically reflecting lights thereon; a photo detector for receiving photo signals; a splitter for splitting said light beam from said coherent light source into a reference beam and a detecting beam. The disclosed optical apparatus can save the time for complicate computation and the cost of software or hardware for measuring the flowing velocity of biomaterials, especially the flowing velocity of flowing bloods in vessels.
摘要翻译：公开了一种用于测量流动生物材料的速度的光学装置，其具有用于投射具有低相干长度的光束的相干光源; 具有用于在其上周期性反射光的反射镜的参考构件; 用于接收光信号的光电检测器; 分离器，用于将来自所述相干光源的所述光束分成参考光束和检测光束。所公开的光学装置可以节省复杂计算的时间和用于测量生物材料的流动速度的软件或硬件的成本，特别是血管中流动的血液的流动速度。

3. 发明申请

US20080241963A1 BIOCHEMICAL LABELING MATERIALS AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：生物标记材料及其制造方法
公开(公告)号：US20080241963A1
公开(公告)日：2008-10-02
申请号：US11967648
申请日：2007-12-31
申请人： Chin-I Lin , Kang-Ping Lin , Yuh-Jiuan Lin , Sheng-Ming Shih , Abraham Joseph K , Chao-Kang Chang
发明人： Chin-I Lin , Kang-Ping Lin , Yuh-Jiuan Lin , Sheng-Ming Shih , Abraham Joseph K , Chao-Kang Chang
IPC分类号： G01N33/543
CPC分类号： B82Y15/00 , G01N33/532 , G01N33/543 , G01N33/553 , G01N33/588
摘要： A biochemical labeling material and manufacturing method thereof. The manufacturing method provides a plurality of nanoparticles, bonding the nanoparticles to template molecules by molecular imprinting, polymerizing the nanoparticles to form a matrix with uniformly-distributed template molecules, finally removing the template molecules from the matrix to reveal a detection group of the matrix, leaving a cavity with specific area.
摘要翻译：生物化学标签材料及其制造方法。该制造方法提供多个纳米颗粒，通过分子印迹将纳米颗粒结合到模板分子上，聚合纳米颗粒以形成具有均匀分布的模板分子的基质，最后从基质中除去模板分子以显示基质的检测基团，留下具有特定面积的空腔。

4. 发明申请

US20050201941A1 Magnetic nanoparticle 审中-公开
标题翻译：磁性纳米颗粒
公开(公告)号：US20050201941A1
公开(公告)日：2005-09-15
申请号：US11125990
申请日：2005-05-10
申请人： Hui-Ju Cho , Sheng-Ming Shih , Yuh-Jiuan Lin , Hong-Dun Lin , Kang-Ping Lin
发明人： Hui-Ju Cho , Sheng-Ming Shih , Yuh-Jiuan Lin , Hong-Dun Lin , Kang-Ping Lin
IPC分类号： A61K47/48 , A61K49/18 , A61K49/00
CPC分类号： B82Y5/00 , A61K47/6923 , A61K49/1818 , A61K49/183 , Y10T428/2991
摘要： A magnetic nanoparticle applicable in imaging, diagnosis, therapy and biomaterial separation. The magnetic nanoparticle is characterized as comprising at least an inner-transition element, represented as FexMavZy, wherein Ma is an inner-transition element, Z is an element of the group VIa, x is greater or equal to 0, and both v and y are positive numbers. The magnetic nanoparticle may further comprise a shell to form a core-shell structure, wherein the shell is an inner-transition element Mb or the compound thereof.
摘要翻译：适用于成像，诊断，治疗和生物材料分离的磁性纳米颗粒。磁性纳米颗粒的特征在于至少包含一个内部过渡元素，其表示为Fe x Z y， SUB>，其中M a A是内部过渡元素，Z是组VIa的元素，x大于或等于0，并且v和y均为正数。磁性纳米颗粒还可以包含壳形成核 - 壳结构，其中壳是内部过渡元素M b或其化合物。

5. 发明申请

US20050154324A1 Device for measuring electrocardiogram with tapeless format and its method 有权
标题翻译：用无磁带格式测量心电图的装置及其方法
公开(公告)号：US20050154324A1
公开(公告)日：2005-07-14
申请号：US10753388
申请日：2004-01-09
申请人： Kang-Ping Lin , Chih-Hui Hsieh
发明人： Kang-Ping Lin , Chih-Hui Hsieh
IPC分类号： A61B5/04 , A61B5/0402 , A61B5/0404 , A61B5/0408 , A61B5/0464
CPC分类号： A61B5/0404 , A61B5/04085 , A61B5/0464
摘要： The present invention is in relative to a a device for measuring electrocardiogram with tapeless format and its method, especially the electrocardiogram measure device which measures electrocardiogram signals via electrodes with flat shape touching with two roots between total four fingers of two hands or electrodes embedded-in thereon only touching with two fingers for two hands, the invention can display the electrocardiogram measured directly without adding any conductive material. The present invention comprises a shell, shaped as a thin and long cube and having at least one operating panel, the operating panel further comprising at least one button for setting and transferring functions; at least two gelless electrodes with thin foil shape, slightly embedded and fixed in the operating panel and extended and surrounded at least one edge of the shell to a surface opposite to the operating panel; at least one information display, located on the operating panel to display a plurality of measured values; a calculation system, connecting with two gelless electrodes and the information display located in the shell in order to calculate relative electrical information measured from the gelless electrodes and display results on the information display.
摘要翻译：本发明涉及一种用于无磁带格式的心电图测量装置及其方法，特别是通过具有平面形状的电极测量心电图信号的心电图测量装置，其中两根手指或两只手的电极嵌入其中，只用两只手指触摸双手，本发明可以显示直接测量的心电图而不添加任何导电材料。本发明包括成形为薄且长的立方体并具有至少一个操作面板的外壳，操作面板还包括用于设置和传递功能的至少一个按钮; 具有薄箔形状的至少两个不凝胶电极，稍微嵌入并固定在操作面板中，并且将壳体的至少一个边缘延伸并包围到与操作面板相对的表面; 至少一个信息显示器，位于操作面板上以显示多个测量值; 计算系统，与两个无凝胶电极连接，信息显示位于壳体中，以计算从无胶体电极测量的相对电信息，并在信息显示屏上显示结果。

6. 发明授权

US07504082B2 Magnetic nanoparticles comprising Gadolinium and method of fabrication 有权
标题翻译：包含钆的磁性纳米颗粒及制造方法
公开(公告)号：US07504082B2
公开(公告)日：2009-03-17
申请号：US11336347
申请日：2006-01-20
申请人： Hui-Ju Cho , Sheng-Ming Shih , Yuh-Jiuan Lin , Hong-Dun Lin , Kang-Ping Lin
发明人： Hui-Ju Cho , Sheng-Ming Shih , Yuh-Jiuan Lin , Hong-Dun Lin , Kang-Ping Lin
IPC分类号： B32B5/16 , C01F17/00 , C01G1/02
CPC分类号： B82Y5/00 , A61K47/6923 , A61K47/6929 , A61K49/183 , Y10S977/777 , Y10S977/904 , Y10S977/915 , Y10T428/2982
摘要： Magnetic nanoparticles are applicable in imaging, diagnosis, therapy, and biomaterial separation. The magnetic nanoparticles are represented as (FewGdx)vZy, wherein w is from 99.9% to 97.5%, x is from 0.1% to 2.5%, Z is an element of the group VIa, and v, y are positive numbers.
摘要翻译：磁性纳米颗粒适用于成像，诊断，治疗和生物材料分离。磁性纳米颗粒表示为（FewGdx）vZy，其中w为99.9％至97.5％，x为0.1％至2.5％，Z为VIa族元素，v，y为正数。

7. 发明授权

US07396589B2 Core-shell magnetic nanoparticles comprising an inner-transition element 有权
标题翻译：包含内部过渡元素的核 - 壳磁性纳米颗粒
公开(公告)号：US07396589B2
公开(公告)日：2008-07-08
申请号：US11687697
申请日：2007-03-19
申请人： Hui-Ju Cho , Sheng-Ming Shih , Yuh-Jiuan Achuan Lin , Hong-Dun Lin , Kang-Ping Lin
发明人： Hui-Ju Cho , Sheng-Ming Shih , Yuh-Jiuan Achuan Lin , Hong-Dun Lin , Kang-Ping Lin
IPC分类号： B32B5/16
CPC分类号： A61K49/183 , B82Y5/00 , Y10S977/773 , Y10S977/777 , Y10S977/904 , Y10T428/2991
摘要： Magnetic nanoparticles are applicable in imaging, diagnosis, therapy, and biomaterial separation. The magnetic nanoparticles comprise a core represented as FexMavZy and a shell of an inner-transition element Mb or the compound thereof, wherein Ma is an inner-transition element, Z is an element of the group Vla, x is greater or equal to 0, and v, y are positive numbers. The surface of the shell is optionally modified by liposome, polymer, aliphatic compound, aromatic compound or combinations thereof.
摘要翻译：磁性纳米颗粒适用于成像，诊断，治疗和生物材料分离。磁性纳米颗粒包含一个表示为Fe x Si x Z y的核，过渡元素M b或其化合物，其中M a是内部过渡元素，Z是基团Vla的元素，x大于或等于0， v，y为正数。壳的表面任选地被脂质体，聚合物，脂族化合物，芳族化合物或其组合改性。

8. 发明申请

US20130046191A1 SYSTEM AND METHOD TO MEASURE ARTERIAL PULSE PRESSURE SIGNALS 审中-公开
标题翻译：系统和方法来测量脉搏压力信号
公开(公告)号：US20130046191A1
公开(公告)日：2013-02-21
申请号：US13306882
申请日：2011-11-29
申请人： Kang Ping Lin , Hen Hong Chang , Wen Chen Lin , Geng Hong Lin
发明人： Kang Ping Lin , Hen Hong Chang , Wen Chen Lin , Geng Hong Lin
IPC分类号： A61B5/02
CPC分类号： A61B5/02141 , A61B5/02233
摘要： The present invention discloses a system and method to measure the pulse pressure signals, which inflates and deflates at least one air bag to detect pulse pressure signals of a human limb. The system comprises a detection device and a host device. The detection device is place on an artery of a human limb and includes one or more air bags. The host device controls inflation and deflation of the air bags, measures pressure variation of the air bags, and records and analyzes pulse pressure signals. The system and method of the present invention can simulate the three-finger technique of pulse diagnostics of the traditional Chinese medicine and provide physicians with more reliable pulse-diagnostics information.
摘要翻译：本发明公开了一种用于测量脉压信号的系统和方法，该系统和方法使至少一个气囊膨胀和放气以检测人体肢体的脉压信号。该系统包括检测装置和主机装置。检测装置位于人肢动脉上，并包括一个或多个气囊。主机控制气囊的通气和通气，测量气囊的压力变化，并记录和分析脉搏压力信号。本发明的系统和方法可以模拟中医脉搏诊断的三指技术，为医生提供更可靠的脉搏诊断信息。

9. 发明授权

US07338812B2 Biochemical labeling materials and manufacturing method thereof 有权
标题翻译：生化标签材料及其制造方法
公开(公告)号：US07338812B2
公开(公告)日：2008-03-04
申请号：US10600830
申请日：2003-06-23
申请人： Chin-I Lin , Kang-Ping Lin , Yuh-Jiuan Lin , Sheng-Ming Shih , K Abraham Joseph , Chao-Kang Chang
发明人： Chin-I Lin , Kang-Ping Lin , Yuh-Jiuan Lin , Sheng-Ming Shih , K Abraham Joseph , Chao-Kang Chang
IPC分类号： G01N33/544
CPC分类号： B82Y15/00 , G01N33/532 , G01N33/543 , G01N33/553 , G01N33/588
摘要： A biochemical labeling material and manufacturing method thereof. The manufacturing method provides a plurality of nanoparticles, bonding the nanoparticles to template molecules by molecular imprinting, polymerizing the nanoparticles to form a matrix with uniformly-distributed template molecules, finally removing the template molecules from the matrix to reveal a detection group of the matrix, leaving a cavity with specific area.
摘要翻译：生物化学标签材料及其制造方法。该制造方法提供多个纳米颗粒，通过分子印迹将纳米颗粒结合到模板分子上，聚合纳米颗粒以形成具有均匀分布的模板分子的基质，最后从基质中除去模板分子以显示基质的检测基团，留下具有特定面积的空腔。

10. 发明申请

US20060224073A1 INTEGRATED PHYSIOLOGICAL SIGNAL ASSESSING DEVICE 审中-公开
标题翻译：综合生理信号评估装置
公开(公告)号：US20060224073A1
公开(公告)日：2006-10-05
申请号：US10907355
申请日：2005-03-30
申请人： Kang-Ping Lin , Hao Jan , Bor-Iuan Jan
发明人： Kang-Ping Lin , Hao Jan , Bor-Iuan Jan
IPC分类号： A61B5/0402
CPC分类号： A61B5/6826 , A61B5/02007 , A61B5/02125 , A61B5/0472 , A61B5/14551 , A61B5/6838
摘要： An integrated physiological signal assessing device integrates electrical signal detecting technology and optical detecting technology to design a sensing interface module for simultaneously measuring ECG signals and PPG signals, and utilizes multiple algorithm processing methods to obtain ECG parameters, such as rhythm of a heart, ST segment, and QRS interval, as well as vascular parameters, such as vascular stiffness index (SI), vascular reflection index (RI), pulse wave velocity (PWV), and pulse oxygen saturation (SpO2), so as to simplify the conventional vascular functions measuring devices, easily understand physiological conditions of a subject, and helpfully apply on diagnosis and prevention of cardiovascular diseases.
摘要翻译：综合生理信号评估装置集成了电信号检测技术和光检测技术，设计了同时测量心电信号和PPG信号的感应接口模块，并利用多种算法处理方法获得心电图参数，如心律，ST段，QRS间隔以及血管参数，如血管刚度指数（SI），血管反射指数（RI），脉搏波速度（PWV）和脉搏血氧饱和度（SpO <2> 2 ），简化常规的血管功能测量装置，容易理解受试者的生理状况，有力地应用于心血管疾病的诊断和预防。

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