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1. 发明授权

US07998130B2 System for connecting a compatibility liner with a source of perishable therapeutic 失效
标题翻译：将兼容性衬垫与易腐食品来源连接的系统
公开(公告)号：US07998130B2
公开(公告)日：2011-08-16
申请号：US12030503
申请日：2008-02-13
申请人： Justin Crank , Timothy Ostroot
发明人： Justin Crank , Timothy Ostroot
IPC分类号： A61M25/00
CPC分类号： A61M39/12 , A61M5/142 , A61M25/0097
摘要： A system for connecting a compatibility liner with a source of perishable therapeutic is provided. In one exemplary system for connecting a reservoir of perishable therapeutic with a lumen, a hollow hub having a first end and a second end is provided. The first end of the hollow hub, which contains a bond port, is in fluid communication with the second end. The second end of the hollow hub may contain a docking groove that is sized to couple a reservoir to it. The system also includes an inner hypo-tube having a proximal tip and an inner lumen. This inner lumen is lined with a therapeutic compatible lining and is in fluid communication with the second end of the hub through the proximal tip of the inner hypo-tube. The inner lining and the proximal tip in this system are configured to shield therapeutic ejected from the reservoir from contacting materials that can diminish the integrity of the therapeutic.
摘要翻译：提供了一种用于将兼容性衬垫与易腐食品治疗源连接的系统。在用于将易腐烂治疗剂的储存器与管腔连接的一个示例性系统中，提供了具有第一端和第二端的中空毂。包含接合端口的中空毂的第一端与第二端流体连通。中空轮毂的第二端可以包含一个对接凹槽，其尺寸设置成将储存器连接到其上。该系统还包括具有近端和内腔的内管。该内腔内衬有治疗相容的内衬，并通过内管的近端与流体通过毂的第二端流体连通。该系统中的内衬和近侧尖端构造成屏蔽从储存器喷出的治疗物质可能会降低治疗剂完整性的接触材料。

2. 发明授权

US07163549B2 Filter membrane manufacturing method 失效
标题翻译：过滤膜制造方法
公开(公告)号：US07163549B2
公开(公告)日：2007-01-16
申请号：US10364597
申请日：2003-02-11
申请人： Justin Crank , Narin Anderson , James G. Hansen , Horng-Ban Lin , Mark Smith , The Thomas Trinh Tran , Kinh-Luan D. Dao , Yem Chin , Sheng-Ping Zhong , James M. Anderson , Jeffrey H. Vogel
发明人： Justin Crank , Narin Anderson , James G. Hansen , Horng-Ban Lin , Mark Smith , The Thomas Trinh Tran , Kinh-Luan D. Dao , Yem Chin , Sheng-Ping Zhong , James M. Anderson , Jeffrey H. Vogel
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/01 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection filter and method of making the same. An embolic protection filter may include a filter membrane or material having a plurality of holes. In some embodiments, the filter membrane may be manufactured by spray coating a filter material onto a forming member or spray mold.
摘要翻译：栓塞保护过滤器及其制作方法。栓塞保护过滤器可以包括具有多个孔的过滤膜或材料。在一些实施例中，过滤膜可以通过将过滤材料喷涂到成形构件或喷雾模具上来制造。

3. 发明授权

US06939322B2 Infusion devices and method 有权
标题翻译：输液装置及方法
公开(公告)号：US06939322B2
公开(公告)日：2005-09-06
申请号：US10621378
申请日：2003-07-18
申请人： Justin Crank , Scott Larson , Timothy J. Mickley
发明人： Justin Crank , Scott Larson , Timothy J. Mickley
IPC分类号： A61J1/00 , A61J1/14 , A61M5/46 , A61M25/00 , A61M25/01 , A61M25/06 , A61M25/098 , A61M5/00
CPC分类号： A61M25/0068 , A61J1/1406 , A61M5/46 , A61M25/0074 , A61M25/0084 , A61M25/0108 , A61M25/0662 , A61M2025/0008 , A61M2025/0081 , A61M2025/0085 , A61M2025/0086 , A61M2025/0091 , A61M2205/19 , A61M2210/125
摘要： Myocardial revascularization catheters and methods are provided herein. Catheters in accord with the present invention may include an outer shaft and an inner shaft where the inner shaft may be slidably and rotatably disposed in the outer shaft and the distal movement of the inner shaft may be arrested by the engagement of stops and catches located within the inner and outer shaft Methods in accord with the current invention may include providing a therapeutic, providing a radiopaque contrast media, injecting the therapeutic through a lumen into the myocardium of the heart, and injecting the radiopaque contrast media through a lumen into myocardium of the heart. In this example, the location of the injection the radiopaque material may be chosen to indicate the injection point of the injection of the therapeutic.
摘要翻译：本文提供了心肌血运重建导管和方法。根据本发明的导管可以包括外轴和内轴，其中内轴可以可滑动地和可旋转地设置在外轴中，并且内轴的远端运动可以通过位于内部的止动件和卡扣的接合来阻止根据本发明的内外轴方法可以包括提供治疗剂，提供不透射线的造影剂，通过内腔将治疗剂注射到心脏的心肌中，以及将不透射线的造影剂通过内腔注射到心脏的心肌中心。在该示例中，可以选择注射不透射线材料的位置以指示治疗剂的注射的注射点。

4. 发明授权

US06800073B2 Biocompatible pharmaceutical articles 有权
标题翻译：生物相容的药物制品
公开(公告)号：US06800073B2
公开(公告)日：2004-10-05
申请号：US09845092
申请日：2001-04-27
申请人： Maria Palasis , Wendy Naimark , Timothy Mickley , Justin Crank
发明人： Maria Palasis , Wendy Naimark , Timothy Mickley , Justin Crank
IPC分类号： A61M2500
CPC分类号： A61L31/10 , A61L2/18 , A61L29/08 , A61L29/085 , A61L29/103 , A61L29/106 , A61L29/14 , A61L31/088 , A61L33/0076
摘要： Many conventional pharmaceutical articles contain seemingly inert components that come into contact with a pharmaceutically active material during use, which contact substantially reduces the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to these incompatible components, which are effective to diminish the reduction in pharmaceutical effectiveness.
摘要翻译：许多常规药物制品含有在使用期间与药物活性物质接触的看似惰性的成分，该接触显着降低了药物活性物质的药物有效性。本文描述的发明涉及对这些不相容组分的各种修改，其有效减少药物效力的降低。

5. 发明授权

US06663606B1 Biocompatible medical devices 有权
标题翻译：生物相容性医疗器械
公开(公告)号：US06663606B1
公开(公告)日：2003-12-16
申请号：US09503586
申请日：2000-02-14
申请人： James Barry , Maria Palasis , Louis Ellis , Timothy Mickley , Brian Berg , Justin Crank
发明人： James Barry , Maria Palasis , Louis Ellis , Timothy Mickley , Brian Berg , Justin Crank
IPC分类号： A61M2500
CPC分类号： A61L31/10 , A61L2/18 , A61L29/08 , A61L29/085 , A61L29/103 , A61L29/106 , A61L29/14 , A61L29/16 , A61L31/16 , A61L33/0076 , A61L2300/00 , C23C22/50
摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic or polymeric component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to the metallic or polymeric component that are effective to diminish such a substantial reduction in pharmaceutical effectiveness.
摘要翻译：描述了用于递送药物活性物质的改进的医疗装置。本发明人已经发现许多常规医疗器械含有在使用过程中与药物活性物质接触的金属或聚合物组分，并且接触显着降低了药物活性物质的药物有效性。本文描述的发明涉及对金属或聚合物组分的各种修饰，其有效地减少药物有效性的这种显着降低。

6. 发明授权

US06616626B2 Infusion devices and method 失效
公开(公告)号：US06616626B2
公开(公告)日：2003-09-09
申请号：US09747157
申请日：2000-12-21
申请人： Justin Crank , Scott Larson , Timothy J. Mickley
发明人： Justin Crank , Scott Larson , Timothy J. Mickley
IPC分类号： A61M3100
CPC分类号： A61M25/0068 , A61J1/1406 , A61M5/46 , A61M25/0074 , A61M25/0084 , A61M25/0108 , A61M25/0662 , A61M2025/0008 , A61M2025/0081 , A61M2025/0085 , A61M2025/0086 , A61M2025/0091 , A61M2205/19 , A61M2210/125
摘要： Devices and methods for performing improved percutaneous myocardial revascularization (PMR) procedures. One device includes a preassembled PMR drug delivery catheter and a drug neutralizing vial. The vial assembly allows prepping the PMR catheter by flushing drug through distal needle, and into a vial cavity where the drug is neutralized by a neutralizing agent. One set of devices includes needles having protrusions secured to the distal regions of drug delivery tubes. One needle has outward protruding barbs engaging the inner tube wall while another needle has outward threads which can screw into the tube inner wall. Radiopaque marker bands are also included in the present invention which are asymmetrically distributed on the catheter shaft, allowing a treating physician to determine under fluoroscopy whether the catheter distal region is pointed away or toward the treating physician, as well as determining whether the catheter distal region is rotated toward or away from the treating physician. PMR devices include catheters having dual injection needles, for both injecting a drug into the heart wall and a radiopaque contrast media to mark the already treated sites. One PMR injection device has multiple stops for allowing controlled, variable needle depth penetration with a single distal needle tip.

7. 发明申请

US20080051671A1 INTRAVASCULAR FILTER MONITORING 审中-公开
标题翻译：血管内滤器监测
公开(公告)号：US20080051671A1
公开(公告)日：2008-02-28
申请号：US11929007
申请日：2007-10-30
申请人： Thomas Broome , Anthony Vrba , Narin Anderson , Justin Crank , James Hansen , Horng-Ban Lin , Mark Smith
发明人： Thomas Broome , Anthony Vrba , Narin Anderson , Justin Crank , James Hansen , Horng-Ban Lin , Mark Smith
IPC分类号： A61B5/026
CPC分类号： A61B5/02158 , A61B5/02156 , A61F2/013
摘要： Devices and methods for monitoring the flow of blood through an intravascular device are disclosed. An apparatus for monitoring blood flow in accordance with an exemplary embodiment of the present invention includes an intravascular device coupled to an elongated member, a first sensor adapted to measure fluidic pressure proximal the intravascular device, a second sensor adapted to measure fluidic pressure distal the intravascular device, and a control unit for comparing the signals received from the first and second sensors to determine the pressure drop across the intravascular device.
摘要翻译：公开了通过血管内装置监测血流的装置和方法。根据本发明的示例性实施例的用于监测血流的装置包括联接到细长构件的血管内装置，适于测量血管内装置近侧的流体压力的第一传感器，适于测量血管内远端的流体压力的第二传感器装置和控制单元，用于比较从第一和第二传感器接收的信号，以确定穿过血管内装置的压降。

8. 发明申请

US20060206093A1 System for connecting a compatibility liner with a source of perishable therapeutic 失效
标题翻译：将兼容性衬垫与易腐食品来源连接的系统
公开(公告)号：US20060206093A1
公开(公告)日：2006-09-14
申请号：US11433584
申请日：2006-05-15
申请人： Justin Crank , Timothy Ostroot
发明人： Justin Crank , Timothy Ostroot
IPC分类号： A61B19/00
CPC分类号： A61M39/12 , A61M5/142 , A61M25/0097
摘要： A system for connecting a compatibility liner with a source of perishable therapeutic is provided. In one exemplary system for connecting a reservoir of perishable therapeutic with a lumen, a hollow hub having a first end and a second end is provided. The first end of the hollow hub, which contains a bond port, is in fluid communication with the second end. The second end of the hollow hub may contain a docking groove that is sized to couple a reservoir to it. The system also includes an inner hypo-tube having a proximal tip and an inner lumen. This inner lumen is lined with a therapeutic compatible lining and is in fluid communication with the second end of the hub through the proximal tip of the inner hypo-tube. The inner lining and the proximal tip in this system are configured to shield therapeutic ejected from the reservoir from contacting materials that can diminish the integrity of the therapeutic.
摘要翻译：提供了一种用于将兼容性衬垫与易腐食品治疗源连接的系统。在用于将易腐烂治疗剂的储存器与管腔连接的一个示例性系统中，提供了具有第一端和第二端的中空毂。包含接合端口的中空毂的第一端与第二端流体连通。中空轮毂的第二端可以包含一个对接凹槽，其尺寸设置成将储存器连接到其上。该系统还包括具有近端和内腔的内管。该内腔内衬有治疗相容的内衬，并通过内管的近端与流体通过毂的第二端流体连通。该系统中的内衬和近侧尖端构造成屏蔽从储存器喷出的治疗物质可能会降低治疗剂完整性的接触材料。

9. 发明申请

US20050261667A1 Infusion device and method 审中-公开
标题翻译：输液装置及方法
公开(公告)号：US20050261667A1
公开(公告)日：2005-11-24
申请号：US11191053
申请日：2005-07-28
申请人： Justin Crank , Scott Larson , Timothy Mickley
发明人： Justin Crank , Scott Larson , Timothy Mickley
IPC分类号： A61J1/00 , A61J1/14 , A61M5/46 , A61M25/00 , A61M25/01 , A61M25/06 , A61M25/098
CPC分类号： A61M25/0068 , A61J1/1406 , A61M5/46 , A61M25/0074 , A61M25/0084 , A61M25/0108 , A61M25/0662 , A61M2025/0008 , A61M2025/0081 , A61M2025/0085 , A61M2025/0086 , A61M2025/0091 , A61M2205/19 , A61M2210/125
摘要： Devices and methods for performing improved percutaneous myocardial revascularization (PMR) procedures. One device includes a preassembled PMR drug delivery catheter and a drug neutralizing vial. The vial assembly allows prepping the PMR catheter by flushing drug through distal needle, and into a vial cavity where the drug is neutralized by a neutralizing agent. One set of devices includes needles having protrusions secured to the distal regions of drug delivery tubes. One needle has outward protruding barbs engaging the inner tube wall while another needle has outward threads which can screw into the tube inner wall. Radiopaque marker bands are also included in the present invention which are asymmetrically distributed on the catheter shaft, allowing a treating physician to determine under fluoroscopy whether the catheter distal region is pointed away or toward the treating physician, as well as determining whether the catheter distal region is rotated toward or away from the treating physician. PMR devices include catheters having dual injection needles, for both injecting a drug into the heart wall and a radiopaque contrast media to mark the already treated sites. One PMR injection device has multiple stops for allowing controlled, variable needle depth penetration with a single distal needle tip.
摘要翻译：用于进行改善的经皮心肌血运重建（PMR）手术的装置和方法。一个装置包括预组装的PMR药物递送导管和药物中和小瓶。小瓶组件允许通过将药物通过远端针头冲洗并进入药物中和药物的小瓶腔中来准备PMR导管。一组装置包括具有固定到药物输送管的远侧区域的突起的针。一针具有与内管壁接合的向外突出的倒钩，而另一针具有能够拧入管内壁的外螺纹。不透射线标记带也包括在本发明中，其不对称地分布在导管轴上，允许治疗医师在透视下确定导管远端区域是指尖的还是朝向治疗医师，以及确定导管远端区域被转向或远离治疗医师。 PMR装置包括具有双注射针的导管，用于将药物注射到心脏壁中，以及不透射线造影剂以标记已经治疗的部位。一个PMR注射装置具有多个止动件，用于允许用单个远端针尖进行可控的，可变的针深度穿透。

10. 发明申请

US20050251198A1 Intravascular filter membrane and method of forming 审中-公开
标题翻译：血管内滤膜及其形成方法
公开(公告)号：US20050251198A1
公开(公告)日：2005-11-10
申请号：US10841684
申请日：2004-05-06
申请人： Mark Smith , James Hansen , Justin Crank , Narin Anderson , Horng-Ban Lin
发明人： Mark Smith , James Hansen , Justin Crank , Narin Anderson , Horng-Ban Lin
IPC分类号： A61F2/01 , B01D63/00 , B01D67/00 , B01D69/00 , A61M29/00
CPC分类号： B01D69/00 , A61F2/01 , A61F2002/018 , A61F2230/0006 , A61F2230/008 , B01D63/00 , B01D67/002 , B01D69/10 , B01D2323/24
摘要： Intravascular filters formed by a molding process can have a plurality of integrally formed apertures. A molding process can utilize a mold assembly that includes a mold having a mold surface and a die having a die surface. The mold assembly includes plurality of protrusions that extend from at least one of the mold surface and the die surface. A molten material is placed within a portion of the mold, and the die is then inserted into the mold such that the plurality of protrusions span a distance between the die surface and the mold surface. The molten material is allowed to solidify, thereby forming a filter membrane that includes a plurality of integrally formed apertures.
摘要翻译：通过模制工艺形成的血管内过滤器可以具有多个一体形成的孔。模制工艺可以利用包括具有模具表面的模具和具有模具表面的模具的模具组件。模具组件包括从模具表面和模具表面中的至少一个延伸的多个突起。将熔融材料放置在模具的一部分内，然后将模具插入模具中，使得多个突起跨过模具表面和模具表面之间的距离。允许熔融材料固化，从而形成包括多个一体形成的孔的过滤膜。

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