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1. 发明授权

US08534031B2 Packaging solutions 有权
标题翻译：包装解决方案
公开(公告)号：US08534031B2
公开(公告)日：2013-09-17
申请号：US12641483
申请日：2009-12-18
申请人： Joseph A. McGee , David Paul Vanderbilt , Paul L. Valint, Jr.
发明人： Joseph A. McGee , David Paul Vanderbilt , Paul L. Valint, Jr.
IPC分类号： B65B55/18
CPC分类号： A61L12/086 , A61L12/00 , G02B1/043 , C08L85/04 , C08L51/085 , C08L83/10
摘要： Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed.
摘要翻译：公开了用于存储诸如隐形眼镜的眼科装置的包装系统，以及用于包装这些眼科装置的方法以提供穿戴期间镜片的舒适度的解决方案。

2. 发明申请

US20120329905A1 High Refractive Index Lenses 审中-公开
$High Refractive Index Lenses$
标题翻译：高折射率镜片
公开(公告)号：US20120329905A1
公开(公告)日：2012-12-27
申请号：US13483397
申请日：2012-05-30
申请人： Ivan M. Nunez , Jay F. Kunzler , Jennifer Hunt , Joseph A. McGee
发明人： Ivan M. Nunez , Jay F. Kunzler , Jennifer Hunt , Joseph A. McGee
IPC分类号： C08G63/688 , C07C333/20 , C07C333/04 , C08L81/00
CPC分类号： C07C333/04
摘要： An optical copolymer comprising: a constituent derived from a sulfated lens monomer of general formula I [PG-R1—NHC(Y)S—R2]n—R3 I PG is a polymerizable group selected from the group consisting of vinyl, acryloyl, acryoyloxy, methacryoyl and methacryoyloxy; acrylamido and methacrylamido; Y is oxygen or sulfur; and n is 2, 3 or 4. Also, R1 is an organic group of one to eight carbon atoms and optionally with one or more oxygen atoms or an aromatic ring. R2 is a bond or an organic group of one to six carbon atoms. R3 is a bond, an organic group of one to ten carbons atoms, carbon, oxygen, sulfur or a disulfide; and a lens monomer. The sulfated lens monomer is derived from a first component of formula, PG-R1—NC(Y), and a polythiol of formula, R3—[R2—SH]n.
摘要翻译：一种光学共聚物，其包含：衍生自通式I的硫酸化透镜单体的组分[PG-R 1 -NHC（Y）S-R 2] n -R 3 I PG是选自乙烯基，丙烯酰基，丙烯酰氧基，甲基丙烯酰基和甲基丙烯酰氧基; 丙烯酰胺和甲基丙烯酰胺; Y是氧或硫; n为2,3或4.另外，R 1为碳原子数为1〜8的有机基团，且可以具有一个以上的氧原子或芳香环。 R2是1-6个碳原子的键或有机基团。 R3是一个键，一至十个碳原子的有机基团，碳，氧，硫或二硫键; 和透镜单体。硫酸化透镜单体衍生自式的第一组分PG-R1-NC（Y）和式R3- [R2-SH] n的多硫醇。

3. 发明授权

US08053489B2 Crosslink agents and dual radical cure polymer 有权
标题翻译：交联剂和双自由基固化聚合物
公开(公告)号：US08053489B2
公开(公告)日：2011-11-08
申请号：US12168944
申请日：2008-07-08
申请人： Ivan M. Nunez , Joseph A. McGee , David E. Seelye
发明人： Ivan M. Nunez , Joseph A. McGee , David E. Seelye
IPC分类号： C08F26/10 , C08F220/28 , C08F12/28 , C07C69/602 , C07C211/36
CPC分类号： C08F226/10 , C08F216/125 , C08F220/18 , C08F230/08
摘要： Crosslink agents used to copolymerize at least one hydrophilic monomer with at least one lens monomer typically used to prepare polymeric materials for ophthalmic lenses. The crosslink agents have a relatively high selectivity for the hydrophilic monomer and limited reactivity with the crosslink agent used to polymerize the lens monomer. Accordingly, the invention is also directed to a hydrophilic crosslinked polymer that comprises at least two monomeric units and at least two different crosslink units. The use of the dual crosslink system provides an improved means to control the final chemical, physical and structural characteristics of the resulting polymer.
摘要翻译：用于将至少一种亲水性单体与至少一种通常用于制备用于眼科镜片的聚合物材料的透镜单体共聚的交联剂。交联剂对亲水性单体具有较高的选择性，并且与用于聚合透镜单体的交联剂的反应性受限。因此，本发明还涉及包含至少两个单体单元和至少两个不同交联单元的亲水性交联聚合物。双重交联体系的使用提供了一种改进的方法来控制所得聚合物的最终化学，物理和结构特征。

4. 发明申请

US20110105779A1 CROSSLINK AGENTS 有权
标题翻译： CROSSLINK代理
公开(公告)号：US20110105779A1
公开(公告)日：2011-05-05
申请号：US13004228
申请日：2011-01-11
申请人： Ivan M. Nunez , Joseph A. McGee , David E. Seelye
发明人： Ivan M. Nunez , Joseph A. McGee , David E. Seelye
IPC分类号： C07F7/10 , C07F7/08
CPC分类号： C08F226/10 , C08F216/125 , C08F222/1006 , C08F230/08
摘要： Novel crosslink agents are described that provide for the copolymerization of at least one hydrophilic monomer with at least one lens monomer typically used to prepare materials for ophthalmic lenses. The new crosslink agents have a relatively high selectivity for the hydrophilic monomer and limited reactivity with the crosslink agent used to polymerize the lens monomer.
摘要翻译：描述了提供至少一种亲水性单体与通常用于制备眼科镜片材料的至少一种透镜单体共聚的新型交联剂。新的交联剂对亲水性单体具有较高的选择性，并且与用于聚合透镜单体的交联剂的反应性受限。

5. 发明申请

US20100317817A1 Biomedical devices 有权
标题翻译：生物医学装置
公开(公告)号：US20100317817A1
公开(公告)日：2010-12-16
申请号：US12456421
申请日：2009-06-16
申请人： Jeffrey G. Linhardt , Joseph A. McGee , Ivan M. Nunez
发明人： Jeffrey G. Linhardt , Joseph A. McGee , Ivan M. Nunez
IPC分类号： C08G77/00 , C08G75/00
CPC分类号： A61L27/26 , A61L27/52 , G02B1/043 , C08L81/00 , C08L83/10 , C08L33/04 , C08L71/02
摘要： Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising (a) a random copolymer comprising hydrophilic units and hydrophobic units, wherein the random copolymer has at least one thio carbonyl thio fragment of a reversible addition fragmentation chain transfer (“RAFT”) agent are disclosed.
摘要翻译：生物医学装置如由混合物的聚合产物形成的隐形眼镜，所述混合物包含（a）包含亲水单元的无规共聚物和疏水单元，其中所述无规共聚物具有至少一个可逆加成断裂链转移的硫代羰基硫代片段（“RAFT “）代理。

6. 发明授权

US07270678B2 Surface modification of functional group-containing medical devices with catalyst-containing reactive polymer system 失效
标题翻译：含有催化剂的反应性聚合物体系的含官能团医疗器械的表面改性
公开(公告)号：US07270678B2
公开(公告)日：2007-09-18
申请号：US10187154
申请日：2002-06-28
申请人： Paul L. Valint, Jr. , Joseph A. McGee , Joseph C. Salamone
发明人： Paul L. Valint, Jr. , Joseph A. McGee , Joseph C. Salamone
IPC分类号： A61F2/16 , A61F2/14
CPC分类号： C08J7/12 , A61F2/16 , A61L27/34 , A61L2400/18 , C08J2333/00
摘要： Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers with catalyst functionality for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminating silicone oil absorption upon subsequent surgical exposure and/or reducing implantation inserter friction is provided herein. Additionally, a method of making and using surface modified intraocular lens implants is provided.
摘要翻译：使用具有催化剂官能团的反应性亲水性聚合物由一种或多种含官能团的材料形成的表面改性的医疗装置，例如用于减少或消除其上的镜片上皮细胞生长的目的，减少或消除随后手术暴露时的硅油吸收和/或减少植入插入物摩擦。另外，提供了制造和使用表面改性的眼内透镜植入物的方法。

7. 发明授权

US07083646B2 Surface modification of functional group-containing intraocular lenses 失效
标题翻译：含官能团的眼内透镜的表面改性
公开(公告)号：US07083646B2
公开(公告)日：2006-08-01
申请号：US10187056
申请日：2002-06-28
申请人： Paul L. Valint, Jr. , Joseph A. McGee , Wenyan Yan , Joseph C. Salamone , Daniel M. Ammon, Jr. , Jay F. Kunzler
发明人： Paul L. Valint, Jr. , Joseph A. McGee , Wenyan Yan , Joseph C. Salamone , Daniel M. Ammon, Jr. , Jay F. Kunzler
IPC分类号： A61F2/16
CPC分类号： C08J7/12 , A61F2/14 , A61F2/16 , A61L27/34 , A61L2400/18 , A61L2430/16
摘要： Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminating silicone oil absorption upon subsequent surgical exposure and/or reducing or eliminating implantation inserter friction is provided herein. Additionally, a method of making and using surface modified intraocular lens implants is provided.
摘要翻译：表面改性的医疗装置，例如由一种或多种含官能团的材料形成的眼内透镜植入物，其使用反应性亲水性聚合物，用于减少或消除其上的晶状体上皮细胞生长，减少或消除随后手术暴露时的硅油吸收和/或本文提供减少或消除植入插入物摩擦。另外，提供了制造和使用表面改性的眼内透镜植入物的方法。

8. 发明授权

US06902812B2 Surface treatment for silicone hydrogel contact lenses comprising hydrophilic polymer chains attached to an intermediate carbon coating 失效
标题翻译：硅氧烷水凝胶隐形眼镜的表面处理包括连接到中间碳涂层的亲水性聚合物链
公开(公告)号：US06902812B2
公开(公告)日：2005-06-07
申请号：US10430826
申请日：2003-05-06
申请人： Paul L. Valint, Jr. , Daniel M. Ammon, Jr. , Joseph A. McGee , George L. Grobe, III , Richard M. Ozark
发明人： Paul L. Valint, Jr. , Daniel M. Ammon, Jr. , Joseph A. McGee , George L. Grobe, III , Richard M. Ozark
IPC分类号： G02C7/04 , A61F9/00 , A61L27/00 , C08J7/00 , C08J7/04 , C08L43/04 , G02B1/04 , G02B1/10 , B32B7/04
CPC分类号： C08J7/045 , B29D11/00192 , C08J2383/04 , G02B1/043 , Y10T428/249921 , Y10T428/31504 , Y10T428/31536 , Y10T428/3154 , Y10T428/31663 , C08L83/10
摘要： The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone medical device by sequentially subjecting the surface of the lens to plasma polymerization in a hydrocarbon-containing atmosphere and then covalently attaching a preformed hydrophilic polymer to the surface of the carbon coating. The invention is especially useful for forming a biocompatible coating on a silicone contact lens.
摘要翻译：本发明通过依次使透镜表面在含烃气氛中进行等离子体聚合，然后将预先形成的亲水性聚合物共价连接到碳涂层的表面上，在硅树脂医疗装置的表面上提供光学透明的亲水涂层。本发明特别适用于在硅酮隐形眼镜上形成生物相容性涂层。

9. 发明授权

US5563184A Macromonomers 失效
公开(公告)号：US5563184A
公开(公告)日：1996-10-08
申请号：US333441
申请日：1994-11-02
申请人： Joseph A. McGee , Paul L. Valint, Jr.
发明人： Joseph A. McGee , Paul L. Valint, Jr.
IPC分类号： G02C7/04 , C08F2/38 , C08F30/08 , C08F290/00 , C08F290/04 , C08F299/00 , G02B1/04 , C08F228/02 , C08F230/08
CPC分类号： C08F290/04 , C08F2/38 , G02B1/043
摘要： Novel siloxane macromonomers are disclosed which can be copolymerized with hydrophilic monomers or hydrophobic monomers to prepare polymeric materials useful as biomedical devices. The copolymers made from hydrophilic monomers exhibit good oxygen permeability and are particularly suitable for use in contact lenses.

10. 发明授权

US5177165A Surface-active macromonomers 失效
标题翻译：表面活性大分子单体
公开(公告)号：US5177165A
公开(公告)日：1993-01-05
申请号：US806936
申请日：1991-12-11
申请人： Paul L. Valint, Jr. , Joseph A. McGee
发明人： Paul L. Valint, Jr. , Joseph A. McGee
IPC分类号： C08F2/38 , C08F290/04 , C08F299/00
CPC分类号： C08F2/38 , C08F290/04 , C08F299/00
摘要： A new class of polymerizable surfactants, useful for modifying the surfaces of polymeric objects, which are described by the formula:DC[A.sub.x B.sub.y ]wherein A is at least one ethylenically unsaturated hydrophilic monomer, B is at least one ethylenically unsaturated hydrophobic monomer, C is a functional chain transfer agent, D is an ethylenically unsaturated end group, y is within the range from about 0.1 to about 0.9, and x+y=1. Also disclosed are random copolymer precursors of such polymerizable surfactants.
摘要翻译：一类新型可聚合表面活性剂，其可用于改性聚合物的表面，其由下式描述：DC [AxBy]其中A是至少一种烯属不饱和亲水性单体，B是至少一种烯属不饱和疏水单体，C是功能链转移剂，D是烯键式不饱和端基，y在约0.1至约0.9的范围内，x + y = 1。还公开了这种可聚合表面活性剂的无规共聚物前体。

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