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1. 发明授权

US09149470B2 Macrocyclic lactone compounds and methods for their use 有权
标题翻译：大环内酯化合物及其使用方法
公开(公告)号：US09149470B2
公开(公告)日：2015-10-06
申请号：US13302588
申请日：2011-11-22
申请人： John Yan , Xiaoxia Zheng , Vinayak D. Bhat
发明人： John Yan , Xiaoxia Zheng , Vinayak D. Bhat
IPC分类号： A61K31/4741 , A61K31/4525 , A61K31/365 , A61K31/436 , A61K31/427
CPC分类号： A61K31/436 , A61K9/0004 , A61K31/439 , A61K31/4525 , A61K45/06
摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the general formula:
摘要翻译：本发明提供药物组合物，其包含药学上可接受的赋形剂和通式如下的化合物：

2. 发明申请

US20120187606A1 BIODEGRADABLE ENDOPROSTHESES AND METHODS FOR THEIR FABRICATION 审中-公开
公开(公告)号：US20120187606A1
公开(公告)日：2012-07-26
申请号：US13434555
申请日：2012-03-29
申请人： Xiaoxia Zheng , John Yan , Vinayak Bhat
发明人： Xiaoxia Zheng , John Yan , Vinayak Bhat
IPC分类号： B29C71/04
CPC分类号： A61L31/14 , A61F2/82 , A61F2/915 , A61F2002/825 , A61F2230/0013 , A61F2250/0036 , A61L31/06 , A61L31/148 , C08G63/08 , Y10T428/13 , Y10T428/1352 , Y10T428/139 , C08L67/04
摘要： Biodegradable endoprostheses are formed from amorphous polymers having desirable biodegradation characteristics. The strength of such amorphous polymers is enhanced by annealing to increase crystallinity without substantially increasing the biodegradation time.

3. 发明申请

US20120071500A1 MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE 有权
标题翻译： MACROCYCLIC LACTONE化合物及其使用方法
公开(公告)号：US20120071500A1
公开(公告)日：2012-03-22
申请号：US13302588
申请日：2011-11-22
申请人： John Yan , Xiaoxia Zheng , Vinayak D. Bhat
发明人： John Yan , Xiaoxia Zheng , Vinayak D. Bhat
IPC分类号： A61K31/4741
CPC分类号： A61K31/436 , A61K9/0004 , A61K31/439 , A61K31/4525 , A61K45/06
摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.
摘要翻译：本发明提供包含药学上可接受的赋形剂和下式化合物的药物组合物：其中R1，R2，R3，R5，R6，R8，M1，M2，M3，M4，M5，M6和M7各自独立地为成员选自H，C 1-6烷基，OH和C 1-6羟基烷基; R 4，R 7和R 9各自独立地选自C 1-6烷氧基和OH; R 10是选自H，-OH，-OP（O）Me 2，-O-（CH 2）n -OH和-O-（CH 2）m -O-（CH 2）o -CH 3的成员，其中下标n和m各自独立地为2至8，下标o为1至6; L1和L4各自独立地选自：其中每个M8独立地是选自C 1-6烷基，OH和C 1-6羟基烷基的成员; L2和L3中的每一个独立地选自：其盐，水合物，异构体，代谢物，N-氧化物和前药。

4. 发明申请

US20100086579A1 MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE 审中-公开
标题翻译： MACROCYCLIC LACTONE化合物及其使用方法
公开(公告)号：US20100086579A1
公开(公告)日：2010-04-08
申请号：US12572529
申请日：2009-10-02
申请人： John Yan , Xiaoxia Zheng , Vinayak D. Bhat
发明人： John Yan , Xiaoxia Zheng , Vinayak D. Bhat
IPC分类号： A61K9/00 , A61K31/4353 , A61K39/395 , A61P31/00
CPC分类号： A61K31/436 , A61K45/06 , A61L29/041 , A61L29/148 , A61L29/16 , A61L31/048 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/426
摘要： The present invention provides a device for intracorporeal use including an implant or a temporary device and at least one source of a compound myolimus, or a derivative thereof. The present invention also provides a method of inhibiting cell proliferation by local administration of a therapeutically effective amount of a compound myolimus, or a derivative thereof. Further included in the present invention is a method of treating an ophthalmic condition or disease by administering a therapeutically effective amount of a compound myolimus, or a derivative thereof.
摘要翻译：本发明提供了一种用于体内使用的装置，包括植入物或临时装置和至少一种化合物myolimus的源或其衍生物。本发明还提供了通过局部施用治疗有效量的化合物肌醇酰胺或其衍生物来抑制细胞增殖的方法。本发明还包括通过施用治疗有效量的化合物myolimus或其衍生物来治疗眼科疾病或疾病的方法。

5. 发明申请

US20090289101A1 METHOD FOR BALL GRID ARRAY (BGA) SOLDER ATTACH FOR SURFACE MOUNT 审中-公开
标题翻译：球形阵列（BGA）焊接方法用于表面安装
公开(公告)号：US20090289101A1
公开(公告)日：2009-11-26
申请号：US12126600
申请日：2008-05-23
申请人： Yong Du , John Yan , Niranjan Vijayaragavan
发明人： Yong Du , John Yan , Niranjan Vijayaragavan
IPC分类号： B23K31/02
CPC分类号： H05K3/3436 , H01L2924/15311 , H01L2924/3511 , H05K2201/09136 , H05K2201/10734 , H05K2203/159 , Y02P70/613
摘要： A method is provided for solder reflow which includes the steps of providing a receptacle having receptacle pads formed on an upper surface and placing a component on the receptacle, the component having a ball grid array of solder balls attached thereto. The component is placed on the receptacle in a manner which aligns the solder balls with the receptacle pads on the receptacle. The method further includes the steps of placing a weight having a predetermined size and a predetermined mass on top of the component to form a stack of the receptacle, the component and the weight, and reflowing the stack to attach the component to the receptacle by exposing the stack to high temperature to reflow the solder balls.
摘要翻译：提供了一种用于焊料回流的方法，其包括以下步骤：提供具有形成在上表面上的插座衬垫并将部件放置在插座上的插座，该组件具有附接到其上的焊球的球栅阵列。将组件以将焊球与插座上的插座垫对准的方式放置在插座上。该方法还包括以下步骤：将具有预定尺寸和预定质量的重物放置在部件的顶部上以形成容器，部件和重物的堆叠，以及回流堆叠，以通过暴露来将部件附接到容器堆叠到高温回流焊球。

6. 发明申请

US20060212109A1 Delivery of therapeutic capable agents 审中-公开
公开(公告)号：US20060212109A1
公开(公告)日：2006-09-21
申请号：US11437358
申请日：2006-05-19
申请人： Motasim Sirhan , John Yan
发明人： Motasim Sirhan , John Yan
IPC分类号： A61F2/90
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2002/91583 , A61F2230/0054 , A61F2250/0067 , A61F2250/0068 , A61L31/16 , A61L2300/416
摘要： The present invention provides improved stents and other prostheses for delivering substances to vascular and other luminal and intracorporeal environments. In particular, the present invention provides for therapeutic capable agent eluting stents with minimized undesirable loss of the therapeutic capable agent during expansion of the stent.

7. 发明授权

US07018405B2 Intravascular delivery of methylprednisolone 失效
公开(公告)号：US07018405B2
公开(公告)日：2006-03-28
申请号：US09782804
申请日：2001-02-13
申请人： Motasim Sirhan , John Yan
发明人： Motasim Sirhan , John Yan
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2210/0076 , A61F2250/0067 , A61L27/54 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/602
摘要： The present invention provides improved devices and methods for minimizing and/or inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides luminal prostheses which allow for programmed and controlled methylprednisolone delivery with increased efficacy to selected locations within a patient's vasculature to inhibit restenosis. An intraluminal delivery prosthesis may comprise an expansible structure and means on or within the structure for releasing methylprednisolone into the body lumen to inhibit smooth muscle cell proliferation.

8. 发明申请

US20050268573A1 Package of sensitive articles 审中-公开
标题翻译：敏感物品包装
公开(公告)号：US20050268573A1
公开(公告)日：2005-12-08
申请号：US11038377
申请日：2005-01-19
申请人： John Yan
发明人： John Yan
IPC分类号： A61B19/02 , A61F2/00 , A61F2/86 , A61L2/20 , A61L2/26 , B65B55/18 , B65B55/19 , B65D75/38 , B65D81/20 , B65D81/26 , B65B55/02
CPC分类号： B65D81/266 , A61B50/30 , A61B2050/314 , A61F2/0095 , A61F2/86 , A61L2/206 , A61L2/208 , A61L2/26 , A61L2202/181 , A61L2202/24 , B65B55/18 , B65B55/19 , B65D75/38 , B65D81/2084
摘要： The invention is directed to the treating, e.g. sterilizing and packaging of medical devices and other articles, particularly such devices and articles which are reactive to oxygen or moisture containing atmospheres. The sterilized package has a container which includes at least one portion which is gas permeable and at least one portion which is gas impermeable and an interior in fluid communication with the gas permeable portion. The container may be sealed by applying an impermeable patch to the permeable portion thereof or by disposing the container in an enclosure formed of impermeable material and sealing the enclosure. After exposing the container to a sterilizing gas, the gas permeable portion may be removed or sealed off from the gas impermeable portion of the container in order to provide a package which is gas impermeable and can protect one or more articles within the interior of the container against environmental gases and moisture.
摘要翻译：本发明涉及治疗，例如，消毒和包装医疗器械和其他物品，特别是对含氧气体或含有气体的物质具有反应性的器具和制品。无菌包装具有容器，该容器包括至少一部分，其是气体可透过的，至少一个部分是气体不可渗透的，以及与气体可透过部分流体连通的内部。可以通过将不透水贴片施加到其可渗透部分或通过将容器设置在由不可渗透材料形成的外壳中并密封外壳来密封容器。在将容器暴露于灭菌气体之后，气体可渗透部分可以从容器的气体不可渗透部分去除或密封，以提供不透气的包装，并可以保护容器内部的一个或多个物品防止环境气体和水分。

9. 发明授权

US06602282B1 Flexible stent structure 失效
标题翻译：柔性支架结构
公开(公告)号：US06602282B1
公开(公告)日：2003-08-05
申请号：US09565560
申请日：2000-05-04
申请人： John Yan
发明人： John Yan
IPC分类号： A61F206
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91533 , A61F2002/91558 , A61F2230/0054
摘要： Luminal prostheses comprise adjacent expansible segments, typically serpentine ring segments joined by sigmoidal links. By properly orienting the sigmoidal links and aligning hinge regions on adjacent serpentine rings, enhanced opening characteristics can be obtained. Additionally, by varying the mechanical characteristics of adjacent serpentine rings, program expansion of the luminal prostheses over their lengths may be obtained. The disclosed prostheses also have controllable opening characteristics and can be crimped to small diameters.
摘要翻译：腔内假体包括相邻的可膨胀段，通常是通过S形连接连接的蛇形环段。通过适当地定向S形连杆并使相邻蛇形环上的铰链区域对准，可以获得增强的开口特性。另外，通过改变相邻蛇形环的机械特性，可以获得腔体假体在其长度上的程序膨胀。所公开的假体还具有可控的开启特性，并且可以卷曲成小直径。

10. 发明授权

US06471980B2 Intravascular delivery of mycophenolic acid 失效
标题翻译：霉酚酸的血管内输送
公开(公告)号：US06471980B2
公开(公告)日：2002-10-29
申请号：US09782927
申请日：2001-02-13
申请人： Motasim Sirhan , John Yan
发明人： Motasim Sirhan , John Yan
IPC分类号： A61F202
CPC分类号： A61F2/90 , A61F2/91 , A61F2/915 , A61F2/95 , A61F2002/91533 , A61F2210/0076 , A61F2250/0067 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/602
摘要： The present invention provides improved devices and methods for minimizing and/or inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides luminal prostheses which allow for programmed and controlled mycophenolic acid delivery with increased efficacy to selected locations within a patient's vasculature to inhibit restenosis. An intraluminal delivery prosthesis may comprise an expansible structure and means on or within the structure for releasing mycophenolic acid at a rate selected to inhibit smooth muscle cell proliferation.
摘要翻译：本发明提供了用于在血管内干预后最小化和/或抑制再狭窄和增生的改进的装置和方法。特别地，本发明提供了腔内假体，其允许编程和控制的霉酚酸递送，其具有增加的功效，在患者的脉管系统内的选定位置以抑制再狭窄。腔内递送假体可以包含可膨胀的结构，并且在结构上或内部包含用于以抑制平滑肌细胞增殖的速率释放霉酚酸的装置。

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