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1. 再颁专利

USRE42143E1 Consumable tube for use with a flow cytometry-based hematology system 有权
标题翻译：用于流式细胞仪的血液系统的消耗管
公开(公告)号：USRE42143E1
公开(公告)日：2011-02-15
申请号：US11714721
申请日：2007-03-06
申请人： John W. Roche , Peter W. Hansen , Michelle L. Coleman , Harold R. Crews
发明人： John W. Roche , Peter W. Hansen , Michelle L. Coleman , Harold R. Crews
IPC分类号： G01N1/10 , G01N21/00
CPC分类号： H04L25/063 , G01N1/38 , G01N15/1434 , G01N15/1459 , G01N15/147 , G01N35/1095 , G01N2015/0069 , G01N2015/0076 , G01N2015/008 , G01N2015/0084 , G01N2015/1486 , G01N2015/1493
摘要： The present invention is a flow cytometry-based hematology system useful in the analysis of biological samples, particularly whole blood or blood-derived samples. The system is capable of determining at least a complete blood count (CBC), a five-part white blood cell differential, and a reticulocyte count from a whole blood sample. The system preferably uses a laser diode that emits a thin beam to illuminate cells in a flow cell and a lensless optical detection system to measure one or more of axial light loss, low-angle forward scattered light, high-angle forward scattered light, right angle scattered light, and time-of-flight measurements produced by the cells. The lensless optical detection system contains no optical components, other than photoreactive elements, and does not include any moving parts. Finally, the system uses a unique system of consumable reagent tubes that act as reaction chambers, mixing chambers, and waste chambers for the blood sample analyses. The consumable tubes incorporate reference particles, which act as internal standards to ensure that the dilutions made during processing of the samples have been carried out correctly, and to ensure that the instrument is working properly. The present invention also relates to methods for using the system.
摘要翻译：本发明是用于分析生物样品，特别是全血或血液衍生样品的基于流式细胞术的血液学系统。该系统能够从全血样品中确定至少一个完整的血细胞计数（CBC），五部分白细胞差异和网织红细胞计数。该系统优选使用发射细束以照射流动池中的细胞的激光二极管和无透镜光学检测系统，以测量轴向光损失，低角度前向散射光，高角度前向散射光，右角散射光和由细胞产生的飞行时间测量。透镜式光学检测系统不包含除光反应元件之外的光学部件，并且不包括任何移动部件。最后，该系统使用独特的消耗性试剂管系统作为反应室，混合室和废液室进行血液样品分析。消耗品管包含参考颗粒，其作为内部标准，以确保样品处理过程中进行的稀释度已经正确进行，并确保仪器正常工作。本发明还涉及使用该系统的方法。

2. 发明授权

US06784981B1 Flow cytometry-based hematology system 有权
标题翻译：基于流式细胞术的血液系统
公开(公告)号：US06784981B1
公开(公告)日：2004-08-31
申请号：US09715593
申请日：2000-11-17
申请人： John W. Roche , W. Peter Hansen , Marcus F. Julian , Harold C. Flynn, Jr.
发明人： John W. Roche , W. Peter Hansen , Marcus F. Julian , Harold C. Flynn, Jr.
IPC分类号： G01N3348
CPC分类号： H04L25/063 , G01N1/38 , G01N15/1434 , G01N15/1459 , G01N15/147 , G01N35/1095 , G01N2015/0069 , G01N2015/0076 , G01N2015/008 , G01N2015/0084 , G01N2015/1486 , G01N2015/1493
摘要： The present invention is a flow cytometry-based hematology system useful in the analysis of biological samples, particularly whole blood or blood-derived samples. The system is capable of determining at least a complete blood count (CBC), a five-part white blood cell differential, and a reticulocyte count from a whole blood sample. The system preferably uses a laser diode that emits a thin beam to illuminate cells in a flow cell and a lensless optical detection system to measure one or more of axial light loss, low-angle forward scattered light, high-angle forward scattered light, right angle scattered light, and time-of-flight measurements produced by the cells. The lensless optical detection system contains no optical components, other than photoreactive elements, and does not include any moving parts. Finally, the system uses a unique system of consumable reagent tubes that act as reaction chambers, mixing chambers, and waste chambers for the blood sample analyses. The consumable tubes incorporate reference particles, which act as internal standards to ensure that the dilutions made during processing of the samples have been carried out correctly, and to ensure that the instrument is working properly. The present invention also relates to methods for using the system.
摘要翻译：本发明是用于分析生物样品，特别是全血或血液衍生样品的基于流式细胞术的血液学系统。该系统能够从全血样品中确定至少一个完整的血细胞计数（CBC），五部分白细胞差异和网织红细胞计数。该系统优选使用发射细束以照射流动池中的细胞的激光二极管和无透镜光学检测系统，以测量轴向光损失，低角度前向散射光，高角度前向散射光，右角散射光和由细胞产生的飞行时间测量。透镜式光学检测系统不包含除光反应元件之外的光学部件，并且不包括任何移动部件。最后，该系统使用独特的消耗性试剂管系统作为反应室，混合室和废液室进行血液样品分析。消耗品管包含参考颗粒，其作为内部标准，以确保样品处理过程中进行的稀释度已经正确进行，并确保仪器正常工作。本发明还涉及使用该系统的方法。

3. 发明授权

US06618143B2 High numerical aperture flow cytometer and method of using same 有权
公开(公告)号：US06618143B2
公开(公告)日：2003-09-09
申请号：US09969242
申请日：2001-10-02
申请人： John W. Roche , W. Peter Hansen , Harold C. Flynn, Jr.
发明人： John W. Roche , W. Peter Hansen , Harold C. Flynn, Jr.
IPC分类号： G01N2100
CPC分类号： G01N15/1434 , G01N15/1456 , G01N2015/0065 , G01N2021/4704
摘要： The high numerical aperture flow cytometer of the present invention includes a flow cell and a laser input. The laser input emits a beam of light that is oriented substantially orthogonally to the flow of blood cells through the flow cell such that laser light impinges upon the blood cells as they pass through the flow cell. A portion of the beam from the laser input that impinges upon the blood cells in the flow cell is scattered at a substantially right angle to the beam of laser input (“right angle scatter”). A second portion of the beam from the laser input that impinges upon the cells in the flow cell is scattered at a much lower angle than 90°. This scatter is termed forward scatter light” and is collected on two distinct photo detectors, that represent ‘forward scatter low’ (FSL) which has an angle of from about 1° to about 3°, and ‘forward scatter high’ (FSH) which has an angle of from about 9° to about 12° from the orientation of the original beam from laser input. A third photo detector is placed in between these two forward scatter detectors, that is axial with the impinging laser light. This detector measures axial light loss, or light extinction (EXT) which is the sum of all the light that is absorbed and scattered by the blood cells. A right angle scatter light detector is oriented to receive the previously mentioned right angle scatter light. A forward scatter light detector is oriented to capture the previously mentioned forward scatter light oriented different angles from the beam of the laser input.

4. 发明授权

US08748186B2 Method for performing a blood count and determining the morphology of a blood smear 有权
标题翻译：用于进行血液计数并确定血液涂片形态的方法
公开(公告)号：US08748186B2
公开(公告)日：2014-06-10
申请号：US12644410
申请日：2009-12-22
申请人： Richard Kendall , John W. Roche
发明人： Richard Kendall , John W. Roche
IPC分类号： G01N33/72
CPC分类号： G01N15/1434 , G01N1/2813 , G01N15/1475 , G01N21/27 , G01N21/49 , G01N21/59 , G01N33/721 , G01N2001/282 , G01N2015/0073 , G01N2015/008 , G01N2015/1486 , G01N2333/805
摘要： A method for counting blood cells in a sample of whole blood. The method comprises the steps of: (a) providing a sample of whole blood; (b) depositing the sample of whole blood onto a slide, e.g., a microscope slide; (c) employing a spreader to create a blood smear; (d) allowing the blood smear to dry on the slide; (e) measuring absorption or reflectance of light attributable to the hemoglobin in the red blood cells in the blood smear on the slide; (f) recording a magnified two-dimensional digital image of the area of analysis identified by the measurement in step (e) as being of suitable thickness for analysis; and (g) collecting, analyzing, and storing data from the magnified two-dimensional digital image. Optionally, steps of fixing and staining of blood cells on the slide can be employed in the method.
摘要翻译：一种全血样品中血细胞计数的方法。该方法包括以下步骤：（a）提供全血样品; （b）将全血样品沉积在载玻片上，例如显微镜载片上; （c）使用吊具产生血液涂片; （d）允许血液涂片在载玻片上干燥; （e）测量归因于载玻片上血液涂片中红细胞中血红蛋白的光的吸光度或反射率; （f）将通过步骤（e）中的测量识别的分析区域的放大二维数字图像记录为具有适于分析的厚度; 和（g）从放大的二维数字图像中收集，分析和存储数据。任选地，可以在该方法中使用在载玻片上固定和染色血细胞的步骤。

5. 发明申请

US20110151502A1 METHOD FOR PERFORMING A BLOOD COUNT AND DETERMINING THE MORPHOLOGY OF A BLOOD SMEAR 有权
标题翻译：实施血液计数和确定血液样本的形态学方法
公开(公告)号：US20110151502A1
公开(公告)日：2011-06-23
申请号：US12644410
申请日：2009-12-22
申请人： Richard Kendall , John W. Roche
发明人： Richard Kendall , John W. Roche
IPC分类号： C12Q1/06 , C12M1/34
CPC分类号： G01N15/1434 , G01N1/2813 , G01N15/1475 , G01N21/27 , G01N21/49 , G01N21/59 , G01N33/721 , G01N2001/282 , G01N2015/0073 , G01N2015/008 , G01N2015/1486 , G01N2333/805
摘要： A method for counting blood cells in a sample of whole blood. The method comprises the steps of: (a) providing a sample of whole blood; (b) depositing the sample of whole blood onto a slide, e.g., a microscope slide; (c) employing a spreader to create a blood smear; (d) allowing the blood smear to dry on the slide; (e) measuring absorption or reflectance of light attributable to the hemoglobin in the red blood cells in the blood smear on the slide; (f) recording a magnified two-dimensional digital image of the area of analysis identified by the measurement in step (e) as being of suitable thickness for analysis; and (g) collecting, analyzing, and storing data from the magnified two-dimensional digital image. Optionally, steps of fixing and staining of blood cells on the slide can be employed in the method.
摘要翻译：一种全血样品中血细胞计数的方法。该方法包括以下步骤：（a）提供全血样品; （b）将全血样品沉积在载玻片上，例如显微镜载片上; （c）使用吊具产生血液涂片; （d）允许血液涂片在载玻片上干燥; （e）测量归因于载玻片上血液涂片中红细胞中血红蛋白的光的吸光度或反射率; （f）将通过步骤（e）中的测量识别的分析区域的放大二维数字图像记录为具有适于分析的厚度; 和（g）从放大的二维数字图像中收集，分析和存储数据。任选地，可以在该方法中使用在载玻片上固定和染色血细胞的步骤。

6. 发明授权

US07064823B2 Consumable tube for use with a flow cytometry-based hematology system 有权
公开(公告)号：US07064823B2
公开(公告)日：2006-06-20
申请号：US10159944
申请日：2002-05-31
申请人： John W. Roche , W. Peter Hansen , Michelle L. Coleman , Harold R. Crews
发明人： John W. Roche , W. Peter Hansen , Michelle L. Coleman , Harold R. Crews
IPC分类号： G01N1/10 , G01N21/00
CPC分类号： H04L25/063 , G01N1/38 , G01N15/1434 , G01N15/1459 , G01N15/147 , G01N35/1095 , G01N2015/0069 , G01N2015/0076 , G01N2015/008 , G01N2015/0084 , G01N2015/1486 , G01N2015/1493
摘要： The present invention is a flow cytometry-based hematology system useful in the analysis of biological samples, particularly whole blood or blood-derived samples. The system is capable of determining at least a complete blood count (CBC), a five-part white blood cell differential, and a reticulocyte count from a whole blood sample. The system preferably uses a laser diode that emits a thin beam to illuminate cells in a flow cell and a lensless optical detection system to measure one or more of axial light loss, low-angle forward scattered light, high-angle forward scattered light, right angle scattered light, and time-of-flight measurements produced by the cells. The lensless optical detection system contains no optical components, other than photoreactive elements, and does not include any moving parts. Finally, the system uses a unique system of consumable reagent tubes that act as reaction chambers, mixing chambers, and waste chambers for the blood sample analyses. The consumable tubes incorporate reference particles, which act as internal standards to ensure that the dilutions made during processing of the samples have been carried out correctly, and to ensure that the instrument is working properly. The present invention also relates to methods for using the system.

7. 发明授权

US07324194B2 Flow-cytometry-based hematology system 有权
标题翻译：基于流式细胞术的血液系统
公开(公告)号：US07324194B2
公开(公告)日：2008-01-29
申请号：US11432041
申请日：2006-05-10
申请人： John W. Roche , Harold C. Flynn, Jr. , James W. Russell
发明人： John W. Roche , Harold C. Flynn, Jr. , James W. Russell
IPC分类号： G01N21/03
CPC分类号： H04L25/063 , G01N1/38 , G01N15/1434 , G01N15/1459 , G01N15/147 , G01N35/1095 , G01N2015/0069 , G01N2015/0076 , G01N2015/008 , G01N2015/0084 , G01N2015/1486 , G01N2015/1493
摘要： A hydraulic system for a flow cytometry having a reservoir for a sheath solution, at least one syringe connected to the reservoir, the at least one syringe being driven by a motor, a single HGB module connected on an inlet side to a sample inlet which is connected to the flow cell by a single flow path passing through the HGB module, a single flow cell connected to the HGB module and at least one syringe on an inlet side of the flow cell, and to a waste container on an outlet side of said flow cell.
摘要翻译：一种用于流式细胞术的液压系统，其具有用于鞘液的储存器，连接到储存器的至少一个注射器，由马达驱动的至少一个注射器，在入口侧连接到样品入口的单个HGB模块，通过穿过HGB模块的单个流动路径连接到流动池，连接到HGB模块的单个流动池和流动池的入口侧上的至少一个注射器以及所述流动池的出口侧的废物容器流动池。

8. 发明授权

US08797527B2 Biologic fluid sample analysis cartridge 有权
标题翻译：生物液样品分析盒
公开(公告)号：US08797527B2
公开(公告)日：2014-08-05
申请号：US13594439
申请日：2012-08-24
申请人： Kyle Hukari , Igor Nikonorov , Ralph W. Dowdell , Douglas Olson , Niten V. Lalpuria , Darryn Unfricht , Benjamin Ports , Vu Phan , Robin A. Levy , John W. Roche
发明人： Kyle Hukari , Igor Nikonorov , Ralph W. Dowdell , Douglas Olson , Niten V. Lalpuria , Darryn Unfricht , Benjamin Ports , Vu Phan , Robin A. Levy , John W. Roche
IPC分类号： G01N21/01 , G01N33/50
CPC分类号： G01N21/01 , B01L3/502715 , B01L3/502738 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0652 , B01L2200/0684 , B01L2200/142 , B01L2300/042 , B01L2300/044 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0858 , B01L2300/0867 , B01L2300/087 , B01L2300/0877 , B01L2300/0883 , B01L2300/089 , B01L2300/161 , B01L2400/024 , B01L2400/0406 , B01L2400/0457 , B01L2400/086 , B01L2400/088
摘要： A biological fluid sample analysis cartridge, analysis system, and method for analyzing a biologic fluid sample are provided. The cartridge includes a collection port, at least one channel within the cartridge in fluid communication with the collection port, a passage in fluid communication with the at least one channel, and an analysis chamber mounted on a tray. The tray is mounted relative to the cartridge and selectively positionable relative to the passage in a first position where the analysis chamber will engage a bolus of sample extending out from the passage to permit selective transfer of sample from the bolus to the analysis chamber.
摘要翻译：提供了生物流体样品分析盒，分析系统和分析生物流体样品的方法。所述盒包括收集端口，所述盒内的至少一个通道与所述收集端口流体连通，与所述至少一个通道流体连通的通道以及安装在托盘上的分析室。托盘相对于盒被安装并且在第一位置中相对于通道可选择性地定位，其中分析室将与从通道延伸出来的样品推注接合，以允许样品从推注到分析室的选择性转移。

9. 发明申请

US20130114075A1 BIOLOGIC FLUID SAMPLE ANALYSIS CARTRIDGE 有权
标题翻译：生物流体样品分析盒
公开(公告)号：US20130114075A1
公开(公告)日：2013-05-09
申请号：US13594439
申请日：2012-08-24
申请人： Kyle Hukari , Igor Nikonorov , Ralph W. Dowdell , Douglas Olson , Niten V. Lalpuria , Darryn Unfricht , Benjamin Ports , Vu Phan , Robin A. Levy , John W. Roche
发明人： Kyle Hukari , Igor Nikonorov , Ralph W. Dowdell , Douglas Olson , Niten V. Lalpuria , Darryn Unfricht , Benjamin Ports , Vu Phan , Robin A. Levy , John W. Roche
IPC分类号： G01N21/01
CPC分类号： G01N21/01 , B01L3/502715 , B01L3/502738 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0652 , B01L2200/0684 , B01L2200/142 , B01L2300/042 , B01L2300/044 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0858 , B01L2300/0867 , B01L2300/087 , B01L2300/0877 , B01L2300/0883 , B01L2300/089 , B01L2300/161 , B01L2400/024 , B01L2400/0406 , B01L2400/0457 , B01L2400/086 , B01L2400/088
摘要： A biological fluid sample analysis cartridge, analysis system, and method for analyzing a biologic fluid sample are provided. The cartridge includes a collection port, at least one channel within the cartridge in fluid communication with the collection port, a passage in fluid communication with the at least one channel, and an analysis chamber mounted on a tray. The tray is mounted relative to the cartridge and selectively positionable relative to the passage in a first position where the analysis chamber will engage a bolus of sample extending out from the passage to permit selective transfer of sample from the bolus to the analysis chamber.
摘要翻译：提供了生物流体样品分析盒，分析系统和分析生物流体样品的方法。所述盒包括收集端口，所述盒内的至少一个通道与所述收集端口流体连通，与所述至少一个通道流体连通的通道以及安装在托盘上的分析室。托盘相对于盒被安装并且在第一位置中相对于通道可选择性地定位，其中分析室将与从通道延伸出来的样品推注接合，以允许样品从推注到分析室的选择性转移。

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