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1. 发明授权

US09167804B2 Recirculating fish brooding and filtration system 有权
标题翻译：循环鱼养殖和过滤系统
公开(公告)号：US09167804B2
公开(公告)日：2015-10-27
申请号：US13906194
申请日：2013-05-30
申请人： John Musser
发明人： John Musser
IPC分类号： A01K63/04 , A01K61/00
CPC分类号： A01K63/045 , A01K61/17 , Y02A40/816
摘要： Embodiments disclosed herein disclose a fish brooding and filtration system. The system includes a brooding tank configured to contain water and fish for breeding. The brooding tank is in fluid communication a filtration tank, which is configured to extract nitrites from the water circulating through the system. A pump circulates the water through at least one conduit and an injector that receives a flow of water generated by the pump and draws air into the injector. The injector is further operable to inject a mixture of the drawn air and the water into the brooding tank.
摘要翻译：本文公开的实施方案公开了鱼类育雏和过滤系统。该系统包括配置成容纳水和鱼进行育种的育雏箱。沉积槽与过滤罐流体连通，其被配置成从循环通过系统的水中提取亚硝酸盐。泵将水循环通过至少一个管道和喷射器，该喷射器接收由泵产生的水流并将空气吸入喷射器。喷射器还可操作以将抽吸的空气和水的混合物注入到育雏箱中。

2. 发明申请

US20130319342A1 RECIRCULATING FISH BROODING AND FILTRATION SYSTEM 审中-公开
标题翻译：循环血液清洗和过滤系统
公开(公告)号：US20130319342A1
公开(公告)日：2013-12-05
申请号：US13906194
申请日：2013-05-30
申请人： John Musser
发明人： John Musser
IPC分类号： A01K63/04
CPC分类号： A01K63/045 , A01K61/17 , Y02A40/816
摘要： Embodiments disclosed herein disclose a fish brooding and filtration system. The system includes a brooding tank configured to contain water and fish for breeding. The brooding tank is in fluid communication a filtration tank, which is configured to extract nitrites from the water circulating through the system. A pump circulates the water through at least one conduit and an injector that receives a flow of water generated by the pump and draws air into the injector. The injector is further operable to inject a mixture of the drawn air and the water into the brooding tank.
摘要翻译：本文公开的实施方案公开了鱼类育雏和过滤系统。该系统包括配置成容纳水和鱼进行育种的育雏箱。沉积槽与过滤罐流体连通，其被配置成从循环通过系统的水中提取亚硝酸盐。泵将水循环通过至少一个管道和喷射器，该喷射器接收由泵产生的水流并将空气吸入喷射器。喷射器还可操作以将抽吸的空气和水的混合物注入到育雏箱中。

3. 发明申请

US20070191284A1 Compounds for enzyme inhibition 有权
公开(公告)号：US20070191284A1
公开(公告)日：2007-08-16
申请号：US11786217
申请日：2007-04-11
申请人： Mark Smyth , Guy Laidig , Ronald Borchardt , Barry Bunin , Craig Crews , John Musser
发明人： Mark Smyth , Guy Laidig , Ronald Borchardt , Barry Bunin , Craig Crews , John Musser
IPC分类号： A61K38/04 , C07K5/04
CPC分类号： C07K5/1016 , A61K38/00 , A61K38/07 , C07K5/0812 , C07K5/1008 , C07K5/1024
摘要： Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.

4. 发明授权

US4276292A Triazolobenzoxazin-4-ones 失效
标题翻译：三唑并苯恶嗪-4-酮
公开(公告)号：US4276292A
公开(公告)日：1981-06-30
申请号：US149080
申请日：1980-05-12
申请人： Vasil St. Georgiev , Bernard Loev , Robert Mack , John Musser
发明人： Vasil St. Georgiev , Bernard Loev , Robert Mack , John Musser
IPC分类号： C07D498/04 , A61K31/535
CPC分类号： C07D498/04
摘要： New triazolobenzoxazinones are described as well as the use thereof as anti-allergenic agents.
摘要翻译：描述了新的三唑并苯并嗪酮及其作为抗过敏剂的用途。

5. 发明申请

US20050288364A1 Halogenated triptolide derivatives as immunomodulators and anticancer agents 失效
标题翻译：卤代雷公藤内酯衍生物作为免疫调节剂和抗癌剂
公开(公告)号：US20050288364A1
公开(公告)日：2005-12-29
申请号：US11210677
申请日：2005-08-23
申请人： Dongcheng Dai , John Musser
发明人： Dongcheng Dai , John Musser
IPC分类号： A61K20060101 , A61K31/34 , A61K31/36 , A61K31/365 , C07D307/77 , C07D407/00 , C07D491/14 , C07D493/14 , C07D493/22
CPC分类号： C07D493/22
摘要： Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, CR1R2 is selected from CHOH, C═O, CHF, CF2 and C(CF3)OH; CR6 and CR13 are selected from CH, COH and CF; CR7R8, CR9R10 and CR11R12 are selected from CH2, CHOH, C═O, CHF and CF2; and CR3R4R5 is selected from CH3, CH2OH, C═O, COOH, CH2F, CHF2 and CF3; such that: at least one of R1-R13 comprises fluorine; no more than two of CR3R4R5, CR6, CR7R8, CR9R10, CR11R12, and CR13 comprises fluorine or oxygen; and, when CR1R2 is CHOH, CR3R4R5 is not CH2F.
摘要翻译：具有结构I的化合物可用于诱导细胞死亡（凋亡）和免疫抑制。在结构I中，CR 1，R 2选自CHOH，CO，CHF，CF 2和C（CF 3） OH）; CR 6和CR 13选自CH，COH和CF; R＆lt; 9＆gt; 8＆lt; 9＆gt;＆lt; 9＆lt; 10＆gt;和＆lt; 11＆gt; > 12 选自CH 2，CHOH，CO，CHF和CF 2; 和CR 3 R 4选自CH 3，CH 2，CH 2， OH，CO，COOH，CH 2，F，CHF 2和CF 3; 使得：R 1〜R 13中的至少一个包含氟; 不超过两个CR 3，R 4，R 5，CR 6，CR 7，其中，R 8，R 9，R 10，R 11，R 12，并且CR 13包括氟或氧; 当CR <1> 2 2时为CHOH时，CR 3 R 4 R 5 O >不是CH 2。

6. 发明申请

US20070249048A1 Triptolide 5,6-Derivatives as Immunomodulators and Anticancer Agents 失效
标题翻译：雷公藤内酯5,6-衍生物作为免疫调节剂和抗癌剂
公开(公告)号：US20070249048A1
公开(公告)日：2007-10-25
申请号：US10584114
申请日：2004-12-20
申请人： Dongcheng Dai , John Musser , Hongwei Yuan
发明人： Dongcheng Dai , John Musser , Hongwei Yuan
IPC分类号： A61K31/56 , A61P37/06 , C07D307/77 , C12N5/00
CPC分类号： C07D493/22
摘要： Compounds useful as immunosuppressive, anti-inflammatory and anticancer agents and methods of their preparation and use are described. The compounds are analogs or derivatives of triptolide and related compounds, modified at the 5- and/or 6-position relative to the naturally occurring compounds.
摘要翻译：描述了可用作免疫抑制，抗炎和抗癌剂的化合物及其制备和用途的方法。化合物是相对于天然存在的化合物在5位和/或6位修饰的雷公藤内酯和相关化合物的类似物或衍生物。

7. 发明申请

US20070282114A1 Methods For Isolation Of Triptolide Compounds From Tripterygium WilfordII 失效
标题翻译：雷公藤雷公藤红素分离方法
公开(公告)号：US20070282114A1
公开(公告)日：2007-12-06
申请号：US10588883
申请日：2005-02-07
申请人： Jinhua An , Rensheng Xu , John Musser
发明人： Jinhua An , Rensheng Xu , John Musser
IPC分类号： C07D307/77
CPC分类号： A61K36/36
摘要： Methods for extraction, isolation, and purification of therapeutically useful compounds from Tripterygium wilfordii are described. Extraction steps employing aqueous base and a hydrocarbon solvent, respectively, are found to increase the efficiency of the process and reduce the amount of material that must be removed by chromatography.
摘要翻译：描述了从雷公藤雷公藤提取，分离和纯化治疗有用的化合物的方法。发现分别使用含水碱和烃溶剂的萃取步骤可提高该方法的效率并减少必须通过色谱法去除的物质的量。

8. 发明申请

US20070244080A1 Method for Treatment of Inflammatory Disorders Using Triptolide Compounds 审中-公开
标题翻译：使用雷公藤内酯化合物治疗炎性疾病的方法
公开(公告)号：US20070244080A1
公开(公告)日：2007-10-18
申请号：US11629747
申请日：2005-06-23
申请人： John Fidler , John Musser
发明人： John Fidler , John Musser
IPC分类号： A61K31/56 , A61P29/00
CPC分类号： A61K31/365 , A61K31/56
摘要： Inflammatory disorders, including obliterative airway disease, renal fibrosis, diabetic nephropathy, and liver fibrosis are treated with immunosuppressive triptolide compounds, in particular triptolide compounds effective to inhibit TGF-β production in a patient afflicted with such a disorder.
摘要翻译：包括闭塞性气道疾病，肾纤维化，糖尿病肾病和肝纤维化在内的炎性疾病用免疫抑制雷公藤内酯化合物，特别是有效抑制患有这种病症的患者中TGF-β产生的雷公藤内酯化合物进行治疗。

9. 发明申请

US20060128975A1 Triptolide derivatives as immunomodulators and anticancer agents 失效
公开(公告)号：US20060128975A1
公开(公告)日：2006-06-15
申请号：US11340928
申请日：2006-01-27
申请人： Dongcheng Dai , John Musser
发明人： Dongcheng Dai , John Musser
IPC分类号： A61K31/365 , C07D493/14
CPC分类号： C07D493/22
摘要： Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, R1 is H or R, R being selected from lower alkyl, alkenyl, alkynyl, and allenyl, or, R1 together with R2=O (oxo); R2=OH, or, R1 and R2 together=O (oxo); CR3R5 and CR4R6 are selected from CH2, CHOH and CROH; at least one of R1, R5 and R6 is R; and at least one of CR3R5 and CR4R6 is CH2.

10. 发明申请

US20050245435A1 Compounds for enzyme inhibition 有权
标题翻译：用于酶抑制的化合物
公开(公告)号：US20050245435A1
公开(公告)日：2005-11-03
申请号：US11106879
申请日：2005-04-14
申请人： Mark Smyth , Guy Laidig , Ronald Borchardt , Barry Bunin , Craig Crews , John Musser , John Schneekloth , John Chabala
发明人： Mark Smyth , Guy Laidig , Ronald Borchardt , Barry Bunin , Craig Crews , John Musser , John Schneekloth , John Chabala
IPC分类号： A61K38/00 , A61K38/04 , C07K5/04 , C07K5/087
CPC分类号： C07K5/1016 , A61K38/00 , A61K38/07 , C07K5/0812 , C07K5/1008 , C07K5/1024
摘要： Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.
摘要翻译：包括含杂原子的三元环的基于肽的化合物有效地选择性地抑制N末端亲核试剂（Ntn）水解酶的比活性。具有多种活性的那些Ntn的活性可被所描述的化合物差别地抑制。例如，本发明化合物可以选择性地抑制20S蛋白酶体的胰凝乳蛋白酶样活性。基于肽的化合物包括至少三个肽单元，环氧化物或氮丙啶，并且在N-末端官能化。除了其他治疗用途之外，预期基于肽的化合物显示抗炎性质和抑制细胞增殖。

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