专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100331554A1 TRIPTOLIDE LACTONE RING DERIVATIVES AS IMMUNOMODULATORS AND ANTICANCER AGENTS 有权
公开(公告)号：US20100331554A1
公开(公告)日：2010-12-30
申请号：US12874434
申请日：2010-09-02
申请人： Hongwei Yuan , John H. Musser , Dongcheng Dai
发明人： Hongwei Yuan , John H. Musser , Dongcheng Dai
IPC分类号： C07D407/14
CPC分类号： C07D493/22
摘要： Disclosed are compounds based on lactone ring modifications of triptolide and hydroxylated triptolide, for use in therapy, such as antiproliferative, anticancer, and immunosuppressive therapy.
摘要翻译：公开了基于雷公藤内酯和羟基化的雷公藤内酯的内酯环修饰的化合物，用于治疗，如抗增殖，抗癌和免疫抑制治疗。

2. 发明授权

US06420571B2 Methods for preparing antiviral calanolide compounds 失效
标题翻译：制备抗病毒胼cal体化合物的方法
公开(公告)号：US06420571B2
公开(公告)日：2002-07-16
申请号：US09918674
申请日：2001-07-31
申请人： Ze-Qi Xu , Hongwei Yuan , Jennifer Crabb , Raghu Samy , Ailing Li , Hua Cao
发明人： Ze-Qi Xu , Hongwei Yuan , Jennifer Crabb , Raghu Samy , Ailing Li , Hua Cao
IPC分类号： C07D49304
CPC分类号： C07D493/04 , C07D493/14
摘要： The present invention relates to methods for preparing 2,2-dimethyl-5-acyloxy -10-propyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-8-one (5) and 2,2-dimethyl-5-hydroxy-10 -propyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-8-one (6) and their use as intermediates for the synthesis of antiviral calanolide compounds. For example, Fries rearrangement on compound 5 or Friedel-Crafts reaction on 6, yields intermediate 2,2-dimethyl-5-hydroxy -6-propionyl-10-propyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-8-one (4), which, in turn, can be converted to (+)-calanolide A and (−)-calanolide B. The coupling of compound 6 with the appropriate chiral molecule under Mitsunobu or nucleophilic displacement leads to the asymmetric synthesis of antiviral calanolide compounds.
摘要翻译：本发明涉及制备2,2-二甲基-5-酰氧基-10-丙基-2H，8H-苯并[1,2-b：3,4-b']二吡喃-8-酮（5）的方法和 2,2-二甲基-5-羟基-10-丙基-2H，8H-苯并[1,2-b：3,4-b']二吡喃-8-酮（6）及其作为合成抗病毒胼cal体化合物。例如，化合物5上的Fries重排或6上的Friedel-Crafts反应产生中间体2,2-二甲基-5-羟基-6-丙酰基-10-丙基-2H，8H-苯并[1,2-b：3， 4-b']二吡喃-8-酮（4），其依次可以转化为（+） - 卡立拉内酯A和（ - ） - 甘露糖苷B。化合物6与适当的手性分子在Mitsunobu或亲核取代导致抗病毒胼cal体化合物的不对称合成。

3. 发明申请

US20110271859A1 THERMOSENSITIVE IMAGING COMPOSITION AND LITHOGRAPHIC PLATE COMPRISING THE SAME 审中-公开
标题翻译：耐热成像组合物和包含该组合物的平版印刷板
公开(公告)号：US20110271859A1
公开(公告)日：2011-11-10
申请号：US13142213
申请日：2009-12-24
申请人： Shiyou Li , Hongwei Yuan
发明人： Shiyou Li , Hongwei Yuan
IPC分类号： B41N1/08
CPC分类号： C08G14/06 , B41C1/1008 , B41C2210/02 , B41C2210/06 , B41C2210/22 , B41C2210/262 , B41M5/368 , C08G14/08 , C08L61/34
摘要： The present application relates to a positive-working heat-sensitive lithographic plate. The infrared heat-sensitive image recording composition of the plate comprises a resin having self-dissolution inhibiting property and an infrared absorber. The resin having self-dissolution inhibiting property is an alkali-soluble resin that contains phenolic hydroxyl group, and carbamate or thiocarbamate group that has strong electron-absorbing ability. The advantage of the present application is that it requires no dissolution inhibitor when preparing the infrared positive-working heat-sensitive CTP plate. The mechanism could be understood but not limited to that the carbamate or thiocarbamate group contained in the resin has a dissolution inhibiting effect on the phenolic hydroxyl group in the resin, reducing the solubility of the resin in an alkali solution. When the plate is irradiated by an infrared laser, the infrared radiation transformed into heat, and since the above dissolution inhibiting effect would be impaired under high temperature, the solubility of the resin in an alkali solution can be restored.
摘要翻译：本申请涉及一种正性热敏平版印刷版。板的红外热敏图像记录组合物包括具有自溶性抑制性质的树脂和红外吸收剂。具有自溶性抑制性的树脂是含有酚羟基的碱溶性树脂和具有强电子吸收能力的氨基甲酸酯或硫代氨基甲酸酯基。本申请的优点是在制备红外线正性热敏CTP板时不需要溶解抑制剂。该机理可以理解为但不限于树脂中所含的氨基甲酸酯或硫代氨基甲酸酯基对树脂中的酚羟基具有溶解抑制作用，降低了树脂在碱溶液中的溶解度。当通过红外激光器照射板时，红外辐射转变成热，并且由于上述溶解抑制作用在高温下会受损，所以可以恢复树脂在碱溶液中的溶解度。

4. 发明授权

US07863464B2 Triptolide lactone ring derivatives as immunomodulators and anticancer agents 有权
标题翻译：雷公藤内酯环衍生物作为免疫调节剂和抗癌剂
公开(公告)号：US07863464B2
公开(公告)日：2011-01-04
申请号：US10591358
申请日：2005-03-02
申请人： Hongwei Yuan , John H. Musser , Dongcheng Dai
发明人： Hongwei Yuan , John H. Musser , Dongcheng Dai
IPC分类号： C07D307/77 , A01N43/08
CPC分类号： C07D493/22
摘要： Disclosed are compounds based on lactone ring modifications of triptolide and hydroxylated triptolide, for use in therapy, such as antiproliferative, anticancer, and immunosuppressive therapy.
摘要翻译：公开了基于雷公藤内酯和羟基化的雷公藤内酯的内酯环修饰的化合物，用于治疗，如抗增殖，抗癌和免疫抑制治疗。

5. 发明申请

US20070249048A1 Triptolide 5,6-Derivatives as Immunomodulators and Anticancer Agents 失效
标题翻译：雷公藤内酯5,6-衍生物作为免疫调节剂和抗癌剂
公开(公告)号：US20070249048A1
公开(公告)日：2007-10-25
申请号：US10584114
申请日：2004-12-20
申请人： Dongcheng Dai , John Musser , Hongwei Yuan
发明人： Dongcheng Dai , John Musser , Hongwei Yuan
IPC分类号： A61K31/56 , A61P37/06 , C07D307/77 , C12N5/00
CPC分类号： C07D493/22
摘要： Compounds useful as immunosuppressive, anti-inflammatory and anticancer agents and methods of their preparation and use are described. The compounds are analogs or derivatives of triptolide and related compounds, modified at the 5- and/or 6-position relative to the naturally occurring compounds.
摘要翻译：描述了可用作免疫抑制，抗炎和抗癌剂的化合物及其制备和用途的方法。化合物是相对于天然存在的化合物在5位和/或6位修饰的雷公藤内酯和相关化合物的类似物或衍生物。

6. 发明授权

US06369241B1 Methods for preparing antiviral calanolide compounds 失效
标题翻译：制备抗病毒胼cal体化合物的方法
公开(公告)号：US06369241B1
公开(公告)日：2002-04-09
申请号：US09557821
申请日：2000-04-25
申请人： Ze-Qi Xu , Hongwei Yuan , Jennifer Crabb , Raghu Samy , Ailing Li , Hua Cao
发明人： Ze-Qi Xu , Hongwei Yuan , Jennifer Crabb , Raghu Samy , Ailing Li , Hua Cao
IPC分类号： C07D31122
CPC分类号： C07D493/04 , C07D493/14
摘要： The present invention relates to methods for preparing 2,2-dimethyl-5-acyloxy-10-propyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-8-one (5) and 2,2-dimethyl-5-hydroxy-10-propyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-8-one (6) and their use as intermediates for the synthesis of antiviral calanolide compounds. For example, Fries rearrangement on compound 5 or Friedel-Crafts reaction on 6, yields intermediate 2,2-dimethyl-5-hydroxy-6-propionyl-10-propyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-8-one (4), which, in turn, can be converted to (+)-calanolide A and (−)-calanolide B. The coupling of compound 6 with the appropriate chiral molecule under Mitsunobu or nucleophilic displacement leads to the asymmetric synthesis of antiviral calanolide compounds.
摘要翻译：本发明涉及制备2,2-二甲基-5-酰氧基-10-丙基-2H，8H-苯并[1,2-b：3,4-b']二吡喃-8-酮（5）的方法和 2,2-二甲基-5-羟基-10-丙基-2H，8H-苯并[1,2-b：3,4-b']二吡喃-8-酮（6）及其作为合成中间体的用途抗病毒胼cal体化合物。例如，化合物5上的Fries重排或6上的Friedel-Crafts反应产生中间体2,2-二甲基-5-羟基-6-丙酰基-10-丙基-2H，8H-苯并[1,2-b：3， 4-b']二吡喃-8-酮（4），其依次可以转化为（+） - 卡立拉内酯A和（ - ） - 甘露糖苷B。化合物6与适当的手性分子在Mitsunobu或亲核取代导致抗病毒胼cal体化合物的不对称合成。

7. 发明授权

US06548537B1 Triptolide prodrugs having high aqueous solubility 失效
标题翻译：具有高溶解度的雷公藤内酯前药
公开(公告)号：US06548537B1
公开(公告)日：2003-04-15
申请号：US09798319
申请日：2001-03-02
申请人： Dongcheng Dai , Hongwei Yuan , John H. Musser
发明人： Dongcheng Dai , Hongwei Yuan , John H. Musser
IPC分类号： A61K3343
CPC分类号： C07D493/20 , C07D493/14 , C07D493/22
摘要： Compounds useful in immunosuppressive, anti-inflammatory and anticancer treatment are described. The compounds are triptolide analogs with improved water solubility and generally lower toxicity than the parent compound.
摘要翻译：描述了可用于免疫抑制，抗炎和抗癌治疗的化合物。化合物是具有改善的水溶性并且通常比母体化合物低的毒性的雷公藤内酯类似物。

8. 发明授权

US08426616B2 Triptolide lactone ring derivatives as immunomodulators and anticancer agents 有权
标题翻译：雷公藤内酯环衍生物作为免疫调节剂和抗癌剂
公开(公告)号：US08426616B2
公开(公告)日：2013-04-23
申请号：US12874434
申请日：2010-09-02
申请人： Hongwei Yuan , John H. Musser , Dongcheng Dai
发明人： Hongwei Yuan , John H. Musser , Dongcheng Dai
IPC分类号： C07D307/77
CPC分类号： C07D493/22
摘要： Disclosed are compounds based on lactone ring modifications of triptolide and hydroxylated triptolide, for use in therapy, such as antiproliferative, anticancer, and immunosuppressive therapy.
摘要翻译：公开了基于雷公藤内酯和羟基化的雷公藤内酯的内酯环修饰的化合物，用于治疗，如抗增殖，抗癌和免疫抑制治疗。

9. 发明授权

US07820834B2 Triptolide 5,6-derivatives as immunomodulators and anticancer agents 失效
标题翻译：雷公藤内酯5,6衍生物作为免疫调节剂和抗癌剂
公开(公告)号：US07820834B2
公开(公告)日：2010-10-26
申请号：US10584114
申请日：2004-12-20
申请人： Dongcheng Dai , John H. Musser , Hongwei Yuan
发明人： Dongcheng Dai , John H. Musser , Hongwei Yuan
IPC分类号： C07D493/22
CPC分类号： C07D493/22
摘要： Compounds useful as immunosuppressive, anti-inflammatory and anticancer agents and methods of their preparation and use are described. The compounds are analogs or derivatives of triptolide and related compounds, modified at the 5- and/or 6-position relative to the naturally occurring compounds.
摘要翻译：描述了可用作免疫抑制，抗炎和抗癌剂的化合物及其制备和用途的方法。化合物是相对于天然存在的化合物在5位和/或6位修饰的雷公藤内酯和相关化合物的类似物或衍生物。

10. 发明申请

US20080287530A1 Tripolide Lactone Ring Derivatives as Immunomodulators and Anticancer Agents 有权
标题翻译： Tripolide内酯环衍生物作为免疫调节剂和抗癌剂
公开(公告)号：US20080287530A1
公开(公告)日：2008-11-20
申请号：US10591358
申请日：2005-03-02
申请人： Hongwei Yuan , John H. Musser , Dongcheng Dai
发明人： Hongwei Yuan , John H. Musser , Dongcheng Dai
IPC分类号： A61K31/365 , C07D493/22 , A61P37/06
CPC分类号： C07D493/22
摘要： Disclosed are compounds based on lactone ring modifications of triptolide and hydroxylated triptolide, for use in therapy, such as antiproliferative, anticancer, and immunosuppressive therapy.
摘要翻译：公开了基于雷公藤内酯和羟基化的雷公藤内酯的内酯环修饰的化合物，用于治疗，如抗增殖，抗癌和免疫抑制治疗。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式