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1. 发明授权

US4469398A Optical connector for use during photometric analysis 失效
标题翻译：用于光度分析的光连接器
公开(公告)号：US4469398A
公开(公告)日：1984-09-04
申请号：US315427
申请日：1981-10-27
申请人： Micheal C. De Baets , John M. Sperinde
发明人： Micheal C. De Baets , John M. Sperinde
IPC分类号： G01N21/01 , G01N21/85 , G02B6/42 , G02B7/26
CPC分类号： G01N21/8507
摘要： An optical connector for connecting photometric analysis equipment which includes a transmitting and receiving light pipe to a material such as flowing blood wherein the blood is not contaminated by the light pipe. The connector has a flow passage therethrough for connection to the blood flow conduit and a light pipe receiving passage extending at a right angle thereto. At the intersection of the passages there is provided an image transferring window, and the light pipe is arranged to be snugly received in the pipe receiving passage in abutment with the window. The image transferring properties of the window are such that no optical distortion occurs as light is transmitted from one face to the opposite face thereof. This is accomplished by forming the window of a coherent bundle of optical fibers of very small individual diameters in the order of 0.003 inches or less.
摘要翻译：一种用于连接测光分析设备的光学连接器，其包括发射和接收光管到诸如流血的材料，其中血液不被光管污染。连接器具有通过其的流动通道，用于连接到血流导管和与其成直角延伸的光管接收通道。在通道的交叉处设置有图像传送窗，并且光管被布置成紧密地容纳在与窗口邻接的管接收通道中。窗口的图像转印属性使得当光从一个面传递到其相对面时，不发生光学失真。这通过形成具有0.003英寸或更小数量级的非常小的单独直径的相干光纤束的窗口来实现。

2. 发明授权

US4623248A Apparatus and method for determining oxygen saturation levels with increased accuracy 失效
标题翻译：用于以更高的精度确定氧饱和度水平的装置和方法
公开(公告)号：US4623248A
公开(公告)日：1986-11-18
申请号：US467087
申请日：1983-02-16
申请人： John M. Sperinde
发明人： John M. Sperinde
IPC分类号： A61B5/00 , G01N21/31 , G02B6/28 , G01N33/48 , G01N33/72
CPC分类号： G01N21/3151 , A61B5/1459 , G02B6/2808 , G01N2021/3144 , G01N2021/3181
摘要： A catheter oximeter includes a fiber optic catheter for supplying radiation to blood under test at a plurality of wavelengths and detecting the intensities of the radiation back-scattered from the blood at each of the wavelengths. The oxygen saturation level of the blood is then computed by deriving it with a formula which uses the ratio of one pair of intensity signals when the oxygen saturation level is relatively low and with a formula which uses the ratio of another pair of intensity signals when the oxygen saturation level relatively is high.
摘要翻译：导管血氧计包括用于向多个波长处的被测血液提供辐射的光纤导管，并且检测在每个波长处从血液反向散射的辐射的强度。然后通过使用当氧饱和度水平相对较低时使用一对强度信号的比率的公式导出血液的氧饱和度水平，并且使用当使用另一对强度信号的比率时使用公式氧饱和度水平较高。

3. 发明授权

US4114604A Catheter oximeter apparatus and method 失效
标题翻译：导管血氧仪仪器及方法
公开(公告)号：US4114604A
公开(公告)日：1978-09-19
申请号：US733278
申请日：1976-10-18
申请人： Robert F. Shaw , John M. Sperinde
发明人： Robert F. Shaw , John M. Sperinde
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1459 , A61B5/15 , G01N21/31 , G01N33/49 , G01N33/16
CPC分类号： A61B5/1459 , G01N21/3151
摘要： An improved catheter oximeter operates on radiation at three or more different wavelengths applied to and scattered back from blood under test to provide an indication of oxygen saturation and is considerably less sensitive to accuracy-degrading variations in the blood and its environment and in the oximeter measuring system.
摘要翻译：改进的导管血氧计对于在被测试血液中施加和散射回来的三种或更多种不同波长的辐射进行操作，以提供氧饱和度的指示，并且对血液及其环境中的精度降低的变化以及血氧计测量系统。

4. 发明授权

US07082843B2 Fluid flow measurement device 失效
公开(公告)号：US07082843B2
公开(公告)日：2006-08-01
申请号：US11205929
申请日：2005-08-17
申请人： Gene E. Clark , Steve T. Cho , Harlow B. Christianson , John M. Sperinde
发明人： Gene E. Clark , Steve T. Cho , Harlow B. Christianson , John M. Sperinde
IPC分类号： G01F1/22
CPC分类号： G01F1/383 , A61M5/16813 , A61M5/16854 , A61M5/16886 , G01F1/363 , G01F1/40
摘要： The invention is directed to a device for obtaining flow rate measurements including a sensor assembly and a housing. The sensor assembly includes a body defining a first fluid flow passage having an inlet, an outlet, a flow restricting element in the first fluid flow passage between the inlet and the outlet, an upstream fluid pressure sensor, a downstream fluid pressure sensor, an upstream signal contact connected to the upstream fluid pressure sensor, and a downstream signal contact connected to the downstream fluid pressure sensor. The housing has an upstream portion defining an upstream port, a downstream portion defining a downstream port, and a probe access port configured to provide access of a probe to at least one of the upstream signal contact and downstream signal contact. The housing can also define a second fluid flow passage in parallel with the first fluid flow passage. The device can be disposable.

5. 发明授权

US5995208A Intravascular oximetry catheter 失效
标题翻译：血管内血氧饱和度测定导管
公开(公告)号：US5995208A
公开(公告)日：1999-11-30
申请号：US86789
申请日：1998-05-28
申请人： Jeffrey A. Sarge , Scott T. Tsuchitani , Harlow B. Christianson , Gerald G. Vurek , John M. Sperinde , Darrell H. Ogi
发明人： Jeffrey A. Sarge , Scott T. Tsuchitani , Harlow B. Christianson , Gerald G. Vurek , John M. Sperinde , Darrell H. Ogi
IPC分类号： A61B5/00 , G01N33/48
CPC分类号： A61B5/1459
摘要： Apparatus and a method for monitoring a percentage of the oxygen saturation in the hemoglobin of blood flowing through a blood vessel. An optical sensor that detects the percentage oxygen saturation in blood is disposed proximate a proximal end of the catheter. A thermistor is disposed adjacent to the distal end of the catheter and it is employed to detect changes in blood temperature that indicate the position of the catheter's distal end in the blood vessel. Indicia or marks visible at intervals on the outer surface of the catheter enable a medical practitioner to determine the length of the catheter that has been introduced into the blood vessel. A strain relief that is flexible and resists stretching extends along the length of the catheter. For flushing the distal end of the catheter, a fluid supply may be connected to a lumen running through the catheter to provide the flushing fluid. A removable guide wire is inserted in the lumen when positioning the distal end of the catheter at a location in the blood vessel and provides enhanced rigidity for this purpose. The catheter may be coated with an anticoagulant such as heparin, to prevent blood from coagulating on the exterior surface of the catheter.
摘要翻译：用于监测流过血管的血液的血红蛋白中的氧饱和度百分比的装置和方法。检测血液中氧饱和度百分比的光学传感器设置在导管近端附近。热敏电阻设置在导管的远端附近，并且用于检测指示导管远端在血管中的位置的血液温度变化。在导管的外表面上以间隔可见的标记或标记使医生能够确定已经被导入血管的导管的长度。柔韧且抗拉伸的应变消除部沿着导管的长度延伸。为了冲洗导管的远端，流体供应可以连接到穿过导管的内腔，以提供冲洗液。当将导管的远端定位在血管中的位置时，将可移除的导丝线插入内腔，并为此提供增强的刚性。导管可以用抗凝血剂如肝素涂覆，以防止血液凝结在导管的外表面上。

6. 发明授权

US5611338A Multi-purpose multi-parameter cardiac catheter 失效
标题翻译：多功能多参数心脏导管
公开(公告)号：US5611338A
公开(公告)日：1997-03-18
申请号：US315033
申请日：1994-09-29
申请人： David A. Gallup , John M. Sperinde , William A. Ambrisco , Timothy J. Hughes , Anthony J. Pantages , Jeffrey A. Sarge , Scott T. Tsuchitani
发明人： David A. Gallup , John M. Sperinde , William A. Ambrisco , Timothy J. Hughes , Anthony J. Pantages , Jeffrey A. Sarge , Scott T. Tsuchitani
IPC分类号： A61B5/00 , A61B5/028 , A61B5/145 , A61B5/1459
CPC分类号： A61B5/028 , A61B5/1459
摘要： A multi-lumen, multi-purpose cardiac catheter which incorporates optical filaments and an optical coupler for use with external apparatus for determining the oxygen concentration in the blood of a patient under critical care conditions, as well as incorporating therein a thermal element useable with a second external apparatus for measurement of continuous cardiac output. The thermal element is disposed at a necked down portion of the catheter at the distal end thereof, with at least one of the lumens of the catheter substantially compressed at the necked down portion thereof. The catheter also includes a thermistor and at least one injectate port for enabling the user to also conduct thermal dilution readings and obtain intermittent measurements of cardiac output. The combination of a thermal dilution catheter with a SVO.sub.2 catheter and a continuous cardiac output catheter gives the multi-purpose catheter above described substantial versatility as well as providing the user with a versatile cardiac catheter device which enables him to conduct multiple evaluations of disparate blood-related parameters which require the use of separate apparatus. Simply by switching from one external apparatus to the other, the user can obtain readings for different blood-related parameters useful in the treatment of the cardiac patient.
摘要翻译：一种多腔多用途心脏导管，其包含光纤丝和用于外部设备的光耦合器，用于确定在危重护理条件下患者血液中的氧浓度，以及在其中结合使用的热元件用于测量连续心输出量的第二外部装置。热元件设置在导管的远端处的颈缩部分，其中导管的至少一个腔在其颈缩部分基本上被压缩。导管还包括热敏电阻和至少一个注射口，用于使用户能够进行热稀释读数并获得心输出量的间歇测量。热稀释导管与SVO2导管和连续心输出导管的组合给出了多用途导管以上描述的实质性多功能性，并为使用者提供了多功能心脏导管装置，使他能够进行不同血液 - 需要使用分离设备的相关参数。简单地通过从一个外部设备切换到另一个外部设备，用户可以获得用于治疗心脏病人的不同血液相关参数的读数。

7. 发明授权

US06964204B2 Fluid flow measurement device 有权
公开(公告)号：US06964204B2
公开(公告)日：2005-11-15
申请号：US10978866
申请日：2004-10-29
申请人： Gene E. Clark , Steve T. Cho , Harlow B. Christianson , John M. Sperinde
发明人： Gene E. Clark , Steve T. Cho , Harlow B. Christianson , John M. Sperinde
IPC分类号： A61M5/168 , G01F1/00 , G01F1/36 , G01F1/37 , G01F1/38 , G01F1/40
CPC分类号： G01F1/383 , A61M5/16813 , A61M5/16854 , A61M5/16886 , G01F1/363 , G01F1/40
摘要： The invention is directed to a device for obtaining flow rate measurements including a sensor assembly and a housing. The sensor assembly includes a body defining a first fluid flow passage having an inlet, an outlet, a flow restricting element in the first fluid flow passage between the inlet and the outlet, an upstream fluid pressure sensor, a downstream fluid pressure sensor, an upstream signal contact connected to the upstream fluid pressure sensor, and a downstream signal contact connected to the downstream fluid pressure sensor. The housing has an upstream portion defining an upstream port, a downstream portion defining a downstream port, and a probe access port configured to provide access of a probe to at least one of the upstream signal contact and downstream signal contact. The housing can also define a second fluid flow passage in parallel with the first fluid flow passage. The device can be disposable.

8. 发明授权

US06813964B1 Fluid flow measurement device 有权
标题翻译：流体流量测量装置
公开(公告)号：US06813964B1
公开(公告)日：2004-11-09
申请号：US10442575
申请日：2003-05-21
申请人： Gene E. Clark , Steve T. Cho , Harlow B. Christianson , John M. Sperinde
发明人： Gene E. Clark , Steve T. Cho , Harlow B. Christianson , John M. Sperinde
IPC分类号： G01F137
CPC分类号： G01F1/383 , A61M5/16813 , A61M5/16854 , A61M5/16886 , G01F1/363 , G01F1/40
摘要： The invention is directed to a device for obtaining flow rate measurements including a sensor assembly and a housing. The sensor assembly includes a body defining a first fluid flow passage having an inlet, an outlet, a flow restricting element in the first fluid flow passage between the inlet and the outlet, an upstream fluid pressure sensor, a downstream fluid pressure sensor, an upstream signal contact connected to the upstream fluid pressure sensor, and a downstream signal contact connected to the downstream fluid pressure sensor. The housing has an upstream portion defining an upstream port, a downstream portion defining a downstream port, and a probe access port configured to provide access of a probe to at least one of the upstream signal contact and downstream signal contact. The housing can also define a second fluid flow passage in parallel with the first fluid flow passage. The device can be disposable.
摘要翻译：本发明涉及一种用于获得包括传感器组件和壳体的流量测量的装置。传感器组件包括主体，其限定第一流体流动通道，该第一流体流动通道在入口和出口之间的第一流体流动通道中具有入口，出口，流动限制元件，上游流体压力传感器，下游流体压力传感器，上游连接到上游流体压力传感器的信号触点和连接到下游流体压力传感器的下游信号触点。壳体具有限定上游端口的上游部分，限定下游端口的下游部分和被配置为提供探头到达上游信号接触和下游信号接触中的至少一个的探测器访问端口。壳体还可以限定与第一流体流动通道平行的第二流体流动通道。该设备可以是一次性的。

9. 发明授权

US4322164A Sterilizable, disposable optical scattering reference medium and container assembly 失效
标题翻译：可灭菌，一次性光散射参考介质和容器组件
公开(公告)号：US4322164A
公开(公告)日：1982-03-30
申请号：US52065
申请日：1979-06-25
申请人： Robert F. Shaw , John M. Sperinde
发明人： Robert F. Shaw , John M. Sperinde
IPC分类号： A61B5/00 , G01N21/47 , G01J1/02
CPC分类号： A61B5/1459 , A61B5/1495 , G01N21/4785 , A61B2560/0233
摘要： An optical scattering reference medium is formed of a plurality of scattering particles substantially uniformly dispersed in a substantially compliant, non-compressable transparent solid medium which is selectively positionable against the distal end of an optical catheter for use therewith within a sterilizable disposable package for performing repeatable photometric measurements to standardize the performance of the photometric measuring instrument.
摘要翻译：光学散射参考介质由基本上均匀分散在基本上柔顺的不可压缩透明固体介质中的多个散射颗粒形成，所述透明固体介质可选择性地抵靠光导管的远端定位在可灭菌的一次性包装内以用于可再生的一次性包装光度测量，以使光度测量仪器的性能标准化。

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