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1. 发明授权

US5746980A Test sample card with improved air bubble evacuation 失效
标题翻译：测试样品卡，改善气泡排出
公开(公告)号：US5746980A
公开(公告)日：1998-05-05
申请号：US743843
申请日：1996-11-05
申请人： Raymond E. O'Bear , Bruno Colin , G. R. Tegeler , John L. Staples
发明人： Raymond E. O'Bear , Bruno Colin , G. R. Tegeler , John L. Staples
IPC分类号： G01N33/52 , B01L3/00 , B29C45/00 , G01N1/28 , G01N21/03 , G01N35/00 , G01N35/02 , C12M1/18
CPC分类号： B01L3/502715 , B01L3/502 , B01L3/5025 , B01L3/502723 , B29C45/0025 , B01L2200/025 , B01L2200/0684 , B01L2200/0689 , B01L2300/0816 , B01L2300/0864 , B01L2400/049 , G01N2035/00148 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332
摘要： An improved sample card is provided. The improved card, typically used in biochemical analysis, achieves high sample well capacity and improved fluid flow, including by means of a plurality of through-channels which route the fluid flow of samples along both the front and back surfaces of the card. Elevated bubble traps are provided, as are integral interrupt slots for sensing card position and alignment. A bezeled leading edge facilitates insertion.
摘要翻译：提供了一个改进的样品卡。通常用于生物化学分析的改进的卡片实现了高的样品孔容量和改进的流体流动，包括借助于多个通道，其沿着卡的前表面和后表面引导样品的流体流。提供了高气泡陷阱，作为用于感测卡位置和对准的整体中断槽。带边缘的前缘有助于插入。

2. 发明授权

US5609828A Sample card 失效
标题翻译：示例卡
公开(公告)号：US5609828A
公开(公告)日：1997-03-11
申请号：US455534
申请日：1995-05-31
申请人： Raymond E. O'Bear , Bruno Colin , G. R. Tegeler , John L. Staples
发明人： Raymond E. O'Bear , Bruno Colin , G. R. Tegeler , John L. Staples
IPC分类号： G01N33/52 , B01L3/00 , B29C45/00 , G01N1/28 , G01N21/03 , G01N35/00 , G01N35/02 , C12M1/18
CPC分类号： B01L3/502715 , B01L3/502 , B01L3/5025 , B01L3/502723 , B29C45/0025 , B01L2200/025 , B01L2200/0684 , B01L2200/0689 , B01L2300/0816 , B01L2300/0864 , B01L2400/049 , G01N2035/00148 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332
摘要： An improved sample card is provided. The improved card, typically used in biochemical analysis, achieves high sample well capacity and improved fluid flow, including by means of a plurality of through-channels which route the fluid flow of samples along both the front and back surfaces of the card. Elevated bubble traps are provided, as are integral interrupt slots for sensing card position and alignment. A bezeled leading edge facilitates insertion.
摘要翻译：提供了一个改进的样品卡。通常用于生物化学分析的改进的卡片实现了高的样品孔容量和改进的流体流动，包括借助于多个通道，其沿着卡的前表面和后表面引导样品的流体流。提供了高气泡陷阱，作为用于感测卡位置和对准的整体中断槽。带边缘的前缘有助于插入。

3. 发明授权

US5951952A Test sample card 失效
公开(公告)号：US5951952A
公开(公告)日：1999-09-14
申请号：US872813
申请日：1997-06-11
申请人： Raymond E. O'Bear , Bruno Colin , G. R. Tegeler , John L. Staples
发明人： Raymond E. O'Bear , Bruno Colin , G. R. Tegeler , John L. Staples
IPC分类号： G01N33/52 , B01L3/00 , B29C45/00 , G01N1/28 , G01N21/03 , G01N35/00 , G01N35/02 , C12Q1/02
CPC分类号： B01L3/502715 , B01L3/502 , B01L3/5025 , B01L3/502723 , B29C45/0025 , B01L2200/025 , B01L2200/0684 , B01L2200/0689 , B01L2300/0816 , B01L2300/0864 , B01L2400/049 , G01N2035/00148 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332
摘要： An improved sample card is provided. The improved card, typically used in biochemical analysis, achieves high sample well capacity and improved fluid flow, including by means of a plurality of through-channels which route the fluid flow of samples along both the front and back surfaces of the card. Elevated bubble traps are provided, as are integral interrupt slots for sensing card position and alignment. A bezeled leading edge facilitates insertion.

4. 发明授权

US5932177A Test sample card 失效
公开(公告)号：US5932177A
公开(公告)日：1999-08-03
申请号：US872812
申请日：1997-06-11
申请人： Raymond E. O'Bear , Bruno Colin , G. R. Tegeler , John L. Staples
发明人： Raymond E. O'Bear , Bruno Colin , G. R. Tegeler , John L. Staples
IPC分类号： G01N33/52 , B01L3/00 , B29C45/00 , G01N1/28 , G01N21/03 , G01N35/00 , G01N35/02 , C12M1/18
CPC分类号： B01L3/502715 , B01L3/502 , B01L3/5025 , B01L3/502723 , B29C45/0025 , B01L2200/025 , B01L2200/0684 , B01L2200/0689 , B01L2300/0816 , B01L2300/0864 , B01L2400/049 , G01N2035/00148 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332
摘要： An improved sample card is provided. The improved card, typically used in biochemical analysis, achieves high sample well capacity and improved fluid flow, including by means of a plurality of through-channels which route the fluid flow of samples along both the front and back surfaces of the card. Elevated bubble traps are provided, as are integral interrupt slots for sensing card position and alignment. A bezeled leading edge facilitates insertion.

5. 发明授权

US4118280A Automated microbial analyzer 失效
公开(公告)号：US4118280A
公开(公告)日：1978-10-03
申请号：US682664
申请日：1976-05-03
申请人： Ronald A. Charles , Paul W. Jones , John L. Staples , Joseph R. Wiegner
发明人： Ronald A. Charles , Paul W. Jones , John L. Staples , Joseph R. Wiegner
IPC分类号： G06K7/10 , C12M1/34 , C12Q1/04 , G01N21/00 , G01N21/13 , G01N33/48 , G01N35/00 , C12K1/04
CPC分类号： G01N35/00732 , G01N35/00029 , G01N2035/00039 , G01N2035/00089 , G01N2035/00099 , G01N2035/00148 , G01N2035/00772 , Y10S435/809
摘要： Medical specimens suspected of containing harmful microorganisms are diluted in saline solution and the dilution so formed is vacuum loaded into a cuvette or card containing viewing walls having dried selective culture media therein. The dilution rehydrates the culture media, each of which is selective in the sense that its optical characteristics will change when the organism to which it is specific metabolizes within it. A plurality of the cards are loaded into a tray, and the tray is placed on a rotatable carrousel of a card holder unit along with other trays. The carrousel is indexed at periodic intervals, and each time that it is indexed a different tray moves to a reading position facing a card reader unit. The carrousel has a center stack from which heated air is discharged such that it passes along both major surface areas of the cards in the tray, thus maintaining the cards at a temperature suitable for incubating microorganisms in them. The reader unit includes a reader head which moves vertically along that tray which is in the reading position, and this head has extractor and locator slides which move horizontally. The extractor slide engages each card and withdraws it individually from the tray, while the locator slide, which is spring loaded with respect to the extractor slide, bears against the card as it is withdrawn so as to maintain it in the proper orientation with respect to arrays of light emitters and corresponding detectors on the reader head. The emitters and detectors are arranged in pairs, with the detector of each pair being illuminated by the emitter, unless otherwise obscured. The card as it is withdrawn by the extractor slide moves between the pairs of emitters and detectors, and as it does some of the pairs register with identification segments on the card while other pairs register with the viewing wells. The former "read" identification numbers marked on the card with opaque ink, while the latter determine the light transmitting characteristics of the wells, this being achieved by projecting the light from the emitters through the wells and measuring the intensity of the light falling upon the detectors. A change in the light transmitting characteristics of a well indicates the presence of the specific microorganism in the well. That change provides a unique signature for the specific microorganism.

6. 发明授权

US5869005A Test sample card 失效
标题翻译：测试样品卡
公开(公告)号：US5869005A
公开(公告)日：1999-02-09
申请号：US681310
申请日：1996-07-22
申请人： Raymond E. O'Bear , Bruno Colin , G. R. Tegeler , John L. Staples
发明人： Raymond E. O'Bear , Bruno Colin , G. R. Tegeler , John L. Staples
IPC分类号： G01N33/52 , B01L3/00 , B29C45/00 , G01N1/28 , G01N21/03 , G01N35/00 , G01N35/02 , G01N21/01
CPC分类号： B01L3/502715 , B01L3/502 , B01L3/5025 , B01L3/502723 , B29C45/0025 , B01L2200/025 , B01L2200/0684 , B01L2200/0689 , B01L2300/0816 , B01L2300/0864 , B01L2400/049 , G01N2035/00148 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332
摘要： An improved sample card is provided. The improved card, typically used in biochemical analysis, achieves high sample well capacity and improved fluid flow, including by means of a plurality of through-channels which route the fluid flow of samples along both the front and back surfaces of the card. Elevated bubble traps are provided, as are integral interrupt slots for sensing card position and alignment. A bezeled leading edge facilitates insertion.
摘要翻译：提供了一个改进的样品卡。通常用于生物化学分析的改进的卡片实现了高的样品孔容量和改进的流体流动，包括借助于多个通道，其沿着卡的前表面和后表面引导样品的流体流。提供了高气泡陷阱，作为用于感测卡位置和对准的整体中断槽。带边缘的前缘有助于插入。

7. 发明授权

US06267929B1 Textured surface for test sample cards 失效
标题翻译：纹理表面用于测试样品卡
公开(公告)号：US06267929B1
公开(公告)日：2001-07-31
申请号：US08931647
申请日：1997-09-16
申请人： John L. Staples , William L. DiMieri
发明人： John L. Staples , William L. DiMieri
IPC分类号： C12M124
CPC分类号： B01L3/5085 , G01N2035/00148
摘要： A test sample card is produced from a mold machined in accordance with an electronic discharge machining (EDM) process, with a resulting finely textured surface of the mold left intact. The mold produces a test sample card that has an even finely textured surface which improves the adhesion of a membrane to the card surface. The card is better able to withstand prolonged incubation periods without separation of the adhesive membrane from the card surface, as compared to prior art cards.
摘要翻译：测试样品卡由根据电子放电加工（EDM）工艺加工的模具生产，所得模具的精细纹理表面保持原样。模具产生具有均匀精细纹理表面的测试样品卡，其改善了膜与卡表面的粘附性。与现有技术的卡相比，该卡能够更好地承受长时间的孵育期，而不会将粘合膜与卡表面分离。

8. 发明授权

US4116775A Machine and process for reading cards containing medical specimens 失效
标题翻译：读取含有医用标本的卡的机器和过程
公开(公告)号：US4116775A
公开(公告)日：1978-09-26
申请号：US682728
申请日：1976-05-03
申请人： Ronald A. Charles , Paul W. Jones , John L. Staples , Joseph R. Wiegner
发明人： Ronald A. Charles , Paul W. Jones , John L. Staples , Joseph R. Wiegner
IPC分类号： G01N21/59 , C12M1/34 , C12Q1/04 , C12Q1/06 , G01N35/00 , C12K1/04
CPC分类号： G01N35/00029 , C12M41/36 , G01N2035/00099 , G01N2035/00148 , Y10S435/808
摘要： Medical specimens suspected of containing certain microorganisms are introduced into cards containing wells having culture media therein. A reduction in the light transmitting characteristics of any well indicates the presence of a microorganism. Each well is examined at periodic intervals by projecting a light through it. This light is monitored by a plurality of detectors located beyond, but nevertheless, in alignment with the well, and each detector provides a signal which is proportional to the intensity of the light cast upon it. If a detector registers an unduly large decrease in light transmission, whereas others associated with the same emitter do not, this probably indicates the presence of a bubble in the well, and the unduly large decrease is ignored. This enables the machine to look around bubbles. Adjustments are made for the change in light transmission caused by distortion of the flexible walls at the ends of the wells. Each card has identification segments which are composed of different bars, and each bar is read by an emitter which projects light through it and a plurality of detectors which are illuminated by the emitter, unless the bar is blocked out with a marking. A predetermined number of the detectors must register a light intensity above a prescribed threshold value to establish the absence of a marking in the bar which is read, and this enables the machine to disregard stray marks and foreign particles on the card. The card is moved incrementally through a reading head as the viewing wells and identification segments on it are read.
摘要翻译：怀疑含有某些微生物的医学标本被引入含有其中具有培养基的孔的卡中。任何孔的透光特性的降低表明存在微生物。通过投射光通过它们来定期检查每个井。该光被位于超过但仍然与阱对准的多个检测器监控，并且每个检测器提供与其上投射的光的强度成比例的信号。如果一个检测器记录了光传输的过大的减少，而与同一个发射极相关的其他发射器不能，这可能表明井中有一个气泡存在，而忽略了不适当的减小。这使机器能够看到气泡。对孔的端部的柔性壁的变形引起的光透射变化做出了调整。每个卡具有由不同的条构成的标识段，并且每个条由通过其投射光的发射器和由发射器照射的多个检测器读取，除非条被标记阻挡。预定数量的检测器必须注册高于规定阈值的光强度，以确定在读取的条中不存在标记，并且这使得机器能够忽视卡上的杂散痕和异物。读卡头随着观察井和其上的识别段被读取而逐渐移动读取头。

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