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1. 发明授权

US5209926A Aminosteroids for ophthalmic use 失效
公开(公告)号：US5209926A
公开(公告)日：1993-05-11
申请号：US933574
申请日：1992-08-24
申请人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C. Si , Santosh K. Chandrasekaran
发明人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C. Si , Santosh K. Chandrasekaran
IPC分类号： A61K9/00 , A61K31/56 , A61K31/58 , A61K38/08 , A61K47/48
CPC分类号： A61K9/0048 , A61K31/56 , A61K31/58 , A61K38/08 , A61K47/48969 , B82Y5/00 , Y10S514/801 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/944
摘要： Methods and compositions for preventing or treating ophthalmic diseases or disorders wherein an ophthalmically effective amount of the C.sub.20 through C.sub.26 aminosteroids of formula XI and their pharmaceutical, acceptable salts, hydrates or solvates is administered in an inert vehicle to arrest oxidation processes damaging to the eye.

2. 发明授权

US5188826A Topical ophthalmic suspensions 失效
标题翻译：局部眼用悬浮液
公开(公告)号：US5188826A
公开(公告)日：1993-02-23
申请号：US549093
申请日：1990-07-06
申请人： Santosh K. Chandrasekaran , Margaret J. Reents , John C. Babcock , Lyle M. Bowman , Roy D. Archibald , Joseph R. Robinson
发明人： Santosh K. Chandrasekaran , Margaret J. Reents , John C. Babcock , Lyle M. Bowman , Roy D. Archibald , Joseph R. Robinson
IPC分类号： A61F2/14 , A61K8/81 , A61K9/00 , A61K9/10 , A61K9/107 , A61K31/765 , A61K31/78 , A61K47/30 , A61K47/32 , A61K47/36 , A61K47/38 , A61Q11/00 , A61Q19/00
CPC分类号： A61K9/0034 , A61K31/765 , A61K31/78 , A61K47/32 , A61K9/0048 , A61K9/006 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/944 , Y10S514/953 , Y10S514/954 , Y10S514/955
摘要： A topical, aqueous ophthalmic gel suspension for dry eye is administrable to the eye in drop form, remains as a gel in the eye for a prolonged time, and releases water and one or more ophthalmic demulcents or vasoconstrictors. It comprises water and from 0.1% to 6.5% by weight of lightly cross-linked carboxyl-containing polymer having a particle size of not more than about 50 .mu.m in equivalent spherical diameter. The suspension is at a pH of from 6.6 to 8.0, has an osmolality of from 50 to 400 mOsM, and a viscosity of from about 500 to about 4,000 centipoise (0.5 to 4 Pa.s).
摘要翻译：用于干眼的局部用水性眼用凝胶悬浮液以滴剂形式施用于眼睛，在眼睛中长时间保留为凝胶，并释放水和一种或多种眼用液体或血管收缩剂。其包含水和0.1重量％至6.5重量％的具有相当球形直径的不超过约50μm的粒径的轻度交联的含羧基聚合物。悬浮液的pH为6.6至8.0，重量克分子渗透浓度为50至400mOsM，粘度为约500至约4,000厘泊（0.5至4Pa.s）。

3. 发明授权

US3980638A Testosterone derivatives 失效
标题翻译：睾酮衍生物
公开(公告)号：US3980638A
公开(公告)日：1976-09-14
申请号：US507690
申请日：1974-09-20
申请人： John C. Babcock , J. Allan Campbell
发明人： John C. Babcock , J. Allan Campbell
IPC分类号： C07J1/00 , C07J21/00 , C07J41/00 , C07J71/00 , C07J17/00
CPC分类号： C07J71/0063 , C07J1/0029 , C07J21/006 , C07J41/0094
摘要： Novel testosterone 17-ether 2,3-isoxazole and 2-cyano derivatives are disclosed as useful steroid enzyme inhibitors and for other pharmaceutical purposes.
摘要翻译：公开了新型睾酮17-醚2,3-异恶唑和2-氰基衍生物作为有用的类固醇酶抑制剂和其它药物目的。

4. 发明授权

US5252319A Aminosteroids for ophthalmic use 失效
公开(公告)号：US5252319A
公开(公告)日：1993-10-12
申请号：US836866
申请日：1992-02-19
申请人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C.-C. Si , Santosh K. Chandrasekaran
发明人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C.-C. Si , Santosh K. Chandrasekaran
IPC分类号： A61K9/00 , A61K31/58 , A61K47/28 , A61K37/22
CPC分类号： B82Y5/00 , A61K31/58 , A61K9/0048 , Y10S514/801 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/944
摘要： Methods and compositions for preventing or treating ophthalmic diseases or disorders wherein an ophthalmically effective amount of the C.sub.20 through C.sub.26 aminosteroids of formula XI and their pharmaceutical, acceptable salts, hydrates or solvates is administered in an inert vehicle to arrest oxidation processes damaging to the eye.

5. 发明授权

US3937827A Therapeutic composition and method of treating advanced or disseminated mammary cancer 失效
标题翻译：治疗组合物及治疗先天性或传染性乳腺癌的方法
公开(公告)号：US3937827A
公开(公告)日：1976-02-10
申请号：US501885
申请日：1974-08-30
申请人： John C. Babcock , Roman P. Holysz
发明人： John C. Babcock , Roman P. Holysz
IPC分类号： A61K31/565 , C07J1/00 , A61K31/56
CPC分类号： C07J1/0037 , A61K31/565
摘要： Compounds of the formula: ##SPC1##Wherein R is hydrogen prepared in unit dosage form with appropriate pharmaceutical carrier for oral and parenteral administration and process of producing regression in subjects with advanced or disseminated mammary cancer in woman.

6. 发明授权

US4004003A 25-Hydroxycalciferol compounds for treatment of steroid-induced osteoporosis 失效
标题翻译： 25-羟基钙化合物用于治疗类固醇诱导的骨质疏松症
公开(公告)号：US4004003A
公开(公告)日：1977-01-18
申请号：US619647
申请日：1975-10-06
申请人： John C. Babcock , J. Allan Campbell
发明人： John C. Babcock , J. Allan Campbell
IPC分类号： C07C401/00 , C07J9/00
CPC分类号： A61K31/593
摘要： A process for the prevention or treatment of osteoporosis induced as a side effect of the administration of glucocorticoid steroids by the administration of a compound of the formula: ##STR1## WHEREIN R.sub.1 and R.sub. 2 are the same or different radicals selected from the group consisting of hydrogen, alkyl of less than 9 carbon atoms, and phenyl; R.sub.3 and R.sub. 5 are selected from the group consisting of hydrogen and lower acyl; n is an integer, selected from the group consisting of 2, 3, and 4; or a hydrate thereof in association with a pharmaceutical carrier to a human or animal being treated or having been treated with a gluco-corticoid hormone.
摘要翻译：作为通过施用下式化合物施用糖皮质激素类固醇的副作用诱发的骨质疏松症的预防或治疗的方法：其中R1和R2是相同或不同的选自下组的基团由氢，小于9个碳原子的烷基和苯基组成; R 3和R 5选自氢和低级酰基; n是选自2,3和4的整数; 或其水合物与药物载体结合至被治疗或已经用葡糖 - 皮质激素激素治疗的人或动物。

7. 发明授权

US5918394A Picture frame suitable for binding with printed matter 失效
标题翻译：相框适合与印刷品结合
公开(公告)号：US5918394A
公开(公告)日：1999-07-06
申请号：US876946
申请日：1997-06-16
申请人： John C. Babcock
发明人： John C. Babcock
IPC分类号： B42D5/04 , G09D3/04
CPC分类号： B42D5/047
摘要： A paperboard picture frame is described which is particularly suitable for binding with calendar pages to provide personalized photocalendars. The picture frame includes a backing panel including slits formed therein, a frame panel with a window defined therein, and a base panel, all of which are preferably made of paperboard, e.g., cardstock. The frame panel is attached to the backing panel at a first folding edge, and the base panel is attached to the frame panel at a second folding edge. The slits in the backing panel may accommodate the edges of a photograph so that the photograph is held against the backing panel. A generally transparent cover sheet is then provided which may have its edges inserted within the slits of the backing panel so that the cover sheet rests above the photograph for protective purposes. The frame panel is folded over the backing panel at the first folding edge, and the base panel is then folded over the backing panel at the second folding edge so that the photograph on the backing panel is displayed through the window in the frame panel.
摘要翻译：描述了一种纸板相框，其特别适用于与日历页面的绑定以提供个性化的光卡片。相框包括其中形成有狭缝的背板，具有限定在其中的窗口的框架板和底板，所有这些优选地由纸板例如卡片纸制成。框架面板在第一折叠边缘处附接到背衬面板，并且基板在第二折叠边缘处附接到框架面板。背衬面板中的狭缝可以容纳照片的边缘，使得照片被保持抵靠背衬面板。然后提供通常透明的覆盖片，其可以将其边缘插入背衬面板的狭缝内，使得盖片搁置在照片上方用于保护目的。框架面板在第一折叠边缘处折叠在背板上，然后在第二折叠边缘处将基板折叠在背板上，使得背板上的照片通过框架面板中的窗口显示。

8. 发明授权

US5538721A Stabilization of aminosteroids for topical ophthalmic and other applications 失效
标题翻译：用于局部眼科和其他应用的氨基甾体的稳定化
公开(公告)号：US5538721A
公开(公告)日：1996-07-23
申请号：US202469
申请日：1994-02-28
申请人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C. C. Si , Santosh K. Chandrasekaran
发明人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C. C. Si , Santosh K. Chandrasekaran
IPC分类号： A61K9/107 , A61K9/00 , A61K9/127 , A61K31/56 , A61K31/58 , A61K38/08 , A61K47/48 , A61P27/02 , C07J41/00 , A61K31/74 , A61K47/28
CPC分类号： B82Y5/00 , A61K31/56 , A61K31/58 , A61K38/08 , A61K47/48969 , A61K9/0048 , Y10S514/801 , Y10S514/887 , Y10S514/912 , Y10S514/913 , Y10S514/944
摘要： The invention provides methods for stabilizing amino-substituted steroid therapeutic agents in topical ophthalmic and other pharmaceutical formulations using effective stabilizing amounts of lightly cross-linked carboxy-containing polymers; and methods for stabilizing and solubilizing amino-substituted steroid therapeutic agents in such pharmaceutical formulations using effective stabilizing amounts of lightly cross-linked carboxy-containing polymers and amounts of selected cyclodextrin derivatives sufficient to at least partially solubilize the therapeutic agents. The cyclodextrin derivatives are selected from the group consisting of the hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of .beta.- and .gamma.-cyclodextrin. Stabilized and stabilized/solubilized pharmaceutical compositions adapted for various routes of administration are also described.
摘要翻译：本发明提供了使用有效稳定量的轻度交联的含羧基聚合物在局部眼用和其它药物制剂中稳定氨基取代的类固醇治疗剂的方法; 以及使用有效稳定量的轻度交联的含羧基聚合物和足以使治疗剂至少部分溶解的选择的环糊精衍生物的量在这种药物制剂中稳定和增溶氨基取代的类固醇治疗剂的方法。环糊精衍生物选自β-和γ-环糊精的羟丙基，羟乙基，葡糖基，麦芽糖基和麦芽三糖基衍生物。还描述了适用于各种给药途径的稳定和稳定/溶解的药物组合物。

9. 发明授权

US4013688A Radioimmunoassay agents 失效
标题翻译：无线电通讯代理
公开(公告)号：US4013688A
公开(公告)日：1977-03-22
申请号：US316974
申请日：1972-12-20
申请人： John C. Babcock , J. Allan Campbell
发明人： John C. Babcock , J. Allan Campbell
IPC分类号： C07J1/00 , C07J5/00 , C07J7/00 , C07J41/00 , C07J53/00
CPC分类号： C07J41/0094 , C07J1/0011 , C07J1/0022 , C07J1/0037 , C07J1/0059 , C07J1/007 , C07J41/005 , C07J41/0072 , C07J5/0015 , C07J53/00 , C07J7/002 , C07J7/0045 , C07J7/007
摘要： Novel steroid derivatives containing a tyrosine ester amide group linked to an 11-hydroxysteroid alkylene dicarboxylic hemi-ester are described, suitable for iodination with radioactive iodine, useful in radioimmunoassay.

10. 发明授权

US5332582A Stabilization of aminosteroids for topical ophthalmic and other applications 失效
标题翻译：用于局部眼科和其他应用的氨基甾体的稳定化
公开(公告)号：US5332582A
公开(公告)日：1994-07-26
申请号：US984445
申请日：1992-12-02
申请人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C. Si , Santosh K. Chandrasekaran
发明人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C. Si , Santosh K. Chandrasekaran
IPC分类号： A61K9/107 , A61K9/00 , A61K9/127 , A61K31/56 , A61K31/58 , A61K38/08 , A61K47/48 , A61P27/02 , C07J41/00 , A61K47/28 , A61K31/59 , A61K37/22 , A61K37/52
CPC分类号： B82Y5/00 , A61K31/56 , A61K31/58 , A61K38/08 , A61K47/48969 , A61K9/0048 , Y10S514/801 , Y10S514/887 , Y10S514/912 , Y10S514/913 , Y10S514/944
摘要： The invention provides methods for stabilizing amino-substituted steroid therapeutic agents in topical ophthalmic and other pharmaceutical formulations using effective stabilizing amounts of lightly cross-linked carboxy-containing polymers; Stabilized and stabilized/solubilized pharmaceutical compositions adapted for various routes of administration are also described.
摘要翻译：本发明提供了使用有效稳定量的轻度交联的含羧基聚合物在局部眼用和其它药物制剂中稳定氨基取代的类固醇治疗剂的方法; 还描述了适用于各种给药途径的稳定和稳定/溶解的药物组合物。

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