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1. 发明授权

US06372467B1 P54s6k and p85s6k genes, proteins, primers, probes, and detection methods 失效
标题翻译： P54s6k和p85s6k基因，蛋白质，引物，探针和检测方法
公开(公告)号：US06372467B1
公开(公告)日：2002-04-16
申请号：US09430564
申请日：1999-10-29
申请人： John Blenis , Kay K. Lee-Fruman , Calvin J. Kuo
发明人： John Blenis , Kay K. Lee-Fruman , Calvin J. Kuo
IPC分类号： C12N900
CPC分类号： C12N9/1205
摘要： Disclosed are novel mammalian kinases, p54S6K and p85S6K. Also disclosed are methods for identifying compounds that modulate, or which are modulated by, p54S6K or p85S6K. In addition, the invention discloses methods for diagnosing or treating a cellular proliferative disease.
摘要翻译：公开了新型哺乳动物激酶p54S6K和p85S6K。还公开了用于鉴定调节或由p54S6K或p85S6K调节的化合物的方法。此外，本发明公开了诊断或治疗细胞增殖性疾病的方法。

2. 发明申请

US20170184565A1 P13K-MTORC1-S6K1 SIGNALING PATHWAY BIOMARKERS PREDICTIVE OF ANTI-CANCER RESPONSES 审中-公开
公开(公告)号：US20170184565A1
公开(公告)日：2017-06-29
申请号：US15116319
申请日：2015-02-12
申请人： Thomas M. ROBERTS , Haoxuan TONG , Jean J. ZHAO , John BLENIS , Dana-Farber Cancer Institute, Inc. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： Thomas M. Roberts , Haoxuan Tong , Jean Zhao , John Blenis
IPC分类号： G01N33/50 , A61K45/06 , A61K31/58 , G01N33/574 , C12Q1/68
CPC分类号： G01N33/5011 , A61K31/58 , A61K45/06 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5088 , G01N33/57492 , G01N2333/91215 , G01N2500/10
摘要： The present invention is based, in part, on the identification of novel FI.3K-mTORCI-S6K 1 signaling pathway biomarkers predictive of responsiveness to anti-cancer therapies.

3. 发明申请

US20130252950A1 TARGETING MTOR SUBSTRATES IN TREATING PROLIFERATIVE DISEASES 审中-公开
标题翻译：靶向治疗增生性疾病的MTOR基质
公开(公告)号：US20130252950A1
公开(公告)日：2013-09-26
申请号：US13825723
申请日：2011-09-23
申请人： John Blenis , Steven P. Gygi , Yonghao Yu
发明人： John Blenis , Steven P. Gygi , Yonghao Yu
IPC分类号： C12Q1/48 , G01N33/68
CPC分类号： C12Q1/485 , G01N33/5011 , G01N33/68 , G01N33/74 , G01N2333/4703
摘要： Provided are over 300 mTOR kinase targets identified by a comprehensive phosphoproteomics assay. Methods of targeting mTOR kinase targets, methods to determine the level of mTOR activity by measuring the level of phosphorylation of an mTOR targeted phosphorylation site, methods for distinguishing different classes of mTOR activity in a cell based on phosphoproteomic analysis of mTOR-targeted proteins are also provided. Also provided is the classification of a hyperproliferative disease based on phosphoproteomic analysis of mTOR-targeted proteins, as well as the personalization of therapeutic methods for the treatment of hyperproliferative disease based on phosphoproteomics. Also provided are therapeutic methods including administering to a subject an mTOR inhibitor, an mTOR inhibitor and an additional kinase inhibitor, or a dual inhibitor of mTOR and an additional kinase based on the phosphorylation levels of mTOR targets determined in the subject. Some aspects of this invention relate to the discovery that GrblO is an mTOR-targeted tumor suppressor gene.
摘要翻译：提供了通过综合磷酸化蛋白质测定法鉴定的超过300个mTOR激酶靶标。靶向mTOR激酶靶标的方法，通过测量mTOR靶向磷酸化位点的磷酸化水平来测定mTOR活性水平的方法，基于mTOR靶向蛋白质的磷酸化蛋白质分析来区分细胞中不同种类的mTOR活性的方法也是提供。还提供了基于mTOR靶向蛋白质的磷酸化蛋白质组学分析的过度增殖性疾病的分类，以及基于磷酸化蛋白质处理过度增殖性疾病的治疗方法的个性化。还提供了治疗方法，包括向受试者施用mTOR抑制剂，mTOR抑制剂和另外的激酶抑制剂，或mTOR的双重抑制剂和基于受试者确定的mTOR靶标的磷酸化水平的另外的激酶。本发明的一些方面涉及GrblO是mTOR靶向的肿瘤抑制基因的发现。

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