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1. 发明申请

US20120326019A1 Method Of Mass Spectrometry 有权
标题翻译：质谱法
公开(公告)号：US20120326019A1
公开(公告)日：2012-12-27
申请号：US13146681
申请日：2010-02-08
申请人： Emmanuelle Claude , Marten F. Snel , Johannes Petrus Cornelis Vissers , Keith Richardson
发明人： Emmanuelle Claude , Marten F. Snel , Johannes Petrus Cornelis Vissers , Keith Richardson
IPC分类号： H01J49/26 , H01J49/40
CPC分类号： G01N33/6848 , H01J49/0004 , H01J49/0027
摘要： This invention comprises a method of imaging of a substrate in which a sample of interest is first ionized at multiple known positions whereafter a mass spectrum of the ionized sample at each of the multiple known positions is produced using a Mass Spectrometer. An overall spectrum for the whole sample is then created, and a number of peaks within the overall spectrum is selected. A scan distribution for at least some of the selected peaks is created, and the scan distributions are compared to identify correlations between different analytes within the sample.
摘要翻译：本发明包括一种基底成像方法，其中感兴趣的样品首先在多个已知位置离子化，之后使用质谱仪产生多个已知位置的每一个的离子化样品的质谱。然后创建整个样品的总谱，并选择整个谱中的数个峰。创建至少一些所选峰的扫描分布，并比较扫描分布以识别样品中不同分析物之间的相关性。

2. 发明申请

US20140051092A1 Method And Apparatus For The Analysis Of Biological Samples 审中-公开
标题翻译：生物样品分析方法与装置
公开(公告)号：US20140051092A1
公开(公告)日：2014-02-20
申请号：US14110258
申请日：2012-04-12
申请人： Jonathan Paul Williams , Christopher John Hughes , Johannes Petrus Cornelis Vissers
发明人： Jonathan Paul Williams , Christopher John Hughes , Johannes Petrus Cornelis Vissers
IPC分类号： G01N33/72
CPC分类号： G01N33/721 , G01N30/7233 , G01N30/8675 , G01N33/6848 , G01N33/72 , G01N2030/045 , G01N2030/8822 , G01N2560/00
摘要： A method for the detection and quantitation of analytes of interest and variants of the analyte of interest comprising the steps of: (i) providing a sample containing an analyte of interest; (ii) spiking sample with known amount of calibrant; (iii) performing an LCMS or LCMSMS analysis on the spiked sample to produce a data set; (iv) determining from said data set the relative quantity of analyte of interest to calibrant; (v) calculating the absolute quantity of the analyte of interest from said relative quantity of analyte of interest and said known amount of calibrant; (vi) searching for one or more previously identified candidate sequences for one or more known variants denoted by one or more specific peaks to identify the presence of said one or more known variants within the sample; (vii) determining the relative quantity or amount of said one or more variants to said analyte of interest; and (viii) calculating the absolute quantity or amount of any of said one or more variants present in the sample.
摘要翻译：用于检测和定量感兴趣的分析物的分析物和变体的方法，包括以下步骤：（i）提供含有感兴趣分析物的样品; （ii）用已知量的校准物加样样品; （iii）对加标样品进行LCMS或LCMSMS分析以产生数据集; （iv）从所述数据集确定感兴趣的分析物的相对量与校准物; （v）从所述感兴趣的分析物的相对量和所述已知量的校准物计算所关注的分析物的绝对量; （vi）搜索由一个或多个特定峰表示的一个或多个已知变体的一个或多个先前鉴定的候选序列，以鉴定样品中所述一个或多个已知变体的存在; （vii）确定所述感兴趣的分析物的所述一种或多种变体的相对数量或量; 和（viii）计算样品中存在的所述一种或多种变体中的任一种的绝对量或量。

3. 发明授权

US08426808B2 Method of mass spectrometry 有权
标题翻译：质谱法
公开(公告)号：US08426808B2
公开(公告)日：2013-04-23
申请号：US13146681
申请日：2010-02-08
申请人： Emmanuelle Claude , Marten F. Snel , Johannes Petrus Cornelis Vissers , Keith Richardson
发明人： Emmanuelle Claude , Marten F. Snel , Johannes Petrus Cornelis Vissers , Keith Richardson
IPC分类号： H01J49/00 , H01J37/256
CPC分类号： G01N33/6848 , H01J49/0004 , H01J49/0027
摘要： This invention comprises a method of imaging of a substrate in which a sample of interest is first ionized at multiple known positions whereafter a mass spectrum of the ionized sample at each of the multiple known positions is produced using a Mass Spectrometer. An overall spectrum for the whole sample is then created, and a number of peaks within the overall spectrum is selected. A scan distribution for at least some of the selected peaks is created, and the scan distributions are compared to identify correlations between different analytes within the sample.
摘要翻译：本发明包括一种基底成像方法，其中感兴趣的样品首先在多个已知位置离子化，之后使用质谱仪产生多个已知位置的每一个的离子化样品的质谱。然后创建整个样品的总谱，并选择整个谱中的数个峰。创建至少一些所选峰的扫描分布，并比较扫描分布以识别样品中不同分析物之间的相关性。

4. 发明授权

US5814742A Fully automated micro-autosampler for micro, capillary and nano high performance liquid chromatography 失效
标题翻译：用于微量，毛细管和纳米高效液相色谱的全自动微量自动进样器
公开(公告)号：US5814742A
公开(公告)日：1998-09-29
申请号：US729388
申请日：1996-10-11
申请人： Johannes Petrus Cornelis Vissers , Jean-Pierre Chervet , Pierre Salzmann
发明人： Johannes Petrus Cornelis Vissers , Jean-Pierre Chervet , Pierre Salzmann
IPC分类号： G01N30/18 , G01N30/24 , G01N30/40 , G01N1/10 , G01N1/18
CPC分类号： G01N30/24 , G01N2030/407 , G01N30/18
摘要： A liquid chromatography micro-autosampler is disclosed that permits the sampling of very small samples quantities at high accuracy, while minimizing extracolumn band broadening. The autosampler employ a sample intake tubing connected to the injection valve, that is further connected to an aspirating device. The intake tubing terminates within the hollow bore of a needle which is used to penetrate sample containers. Improved injection profiles are obtained by minimizing injection plug dispersion with back flushing of the injection plug and a low dispersion injection routine and extremely small sample quantities can be handled with a micro pick-up injection routine.
摘要翻译：公开了一种液相色谱微自动进样器，其允许以高精度对非常小的样品量进行采样，同时最小化柱外频带展宽。自动进样器采用连接到注射阀的样品进样管，其进一步连接到抽吸装置。进气管终止于用于穿透样品容器的针的中空孔内。通过使注射塞的反冲洗和低分散注射程序最小化注射塞分散体可以获得改进的注射分布，并且可以通过微注射程序处理极小的样品量。

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