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1. 发明申请

US20130131323A1 METHOD FOR STORAGE AND STABILIZATION OF A TARGET SUBSTANCE 有权
标题翻译：目标物质的储存和稳定化方法
公开(公告)号：US20130131323A1
公开(公告)日：2013-05-23
申请号：US13813800
申请日：2011-04-28
申请人： James Van Alstine , Johan Ohman , Philippe Busson , Ronnie Palmgren , Klas Allmer , John Daicic
发明人： James Van Alstine , Johan Ohman , Philippe Busson , Ronnie Palmgren , Klas Allmer , John Daicic
IPC分类号： C07K1/22
CPC分类号： G01N30/56 , B01D15/206 , B01D15/22 , C07K1/14 , C07K1/18 , C07K1/20 , C07K1/22 , G01N30/6069 , G01N2030/562
摘要： The invention relates to a system and method for the stable storage of sensitive biological or chemical target substance, in a bound form on certain capture media. The method comprised providing a sample containing the target substance in a suitable buffer; combining the sample with a capture media to effect reversible binding of the target substance to the capture media; and storing the capture media with the target substance at between about −20 and 20° C.; and recovering the target substance from the capture media. The target substance recovered maintains the desired activity. Also provides are methods for reducing aggregates in the sensitive biological or chemical target substance.
摘要翻译：本发明涉及用于在某些捕获介质上以结合形式稳定储存敏感的生物或化学目标物质的系统和方法。该方法包括在合适的缓冲液中提供含有目标物质的样品; 将样品与捕获介质结合以实现目标物质与捕获介质的可逆结合; 并将目标物质的捕获介质储存在约-20至20℃之间; 并从捕获介质中回收目标物质。回收的目标物质保持所需的活性。还提供了减少敏感生物或化学物质中的聚集体的方法。

2. 发明申请

US20100294977A1 SEPARATION OF BIOMOLECULES 有权
标题翻译：生物分子的分离
公开(公告)号：US20100294977A1
公开(公告)日：2010-11-25
申请号：US12864070
申请日：2009-02-12
申请人： Anders Larsson , Ulrika Meyer , Nils Norrman , Johan Ohman
发明人： Anders Larsson , Ulrika Meyer , Nils Norrman , Johan Ohman
IPC分类号： H01F1/00 , C09K3/00
CPC分类号： B01J20/28026 , B01D15/34 , B01J20/06 , B01J20/223 , B01J20/28009 , B01J20/282 , C07K1/22
摘要： The present invention relates to separation of biomolecules. More closely, the invention relates to a method for production of a separation medium comprising hybrid particles of inorganic and organic material as well as the hybrid particles produced by this method. Finally, the invention relates to use of the hybrid particles for separation of biomolecules, preferably phosphoproteins. The method comprises the following steps: addition of inorganic metal oxide particles to an organic solution to form a mixture; and emulsification of the mixture to form porous hybrid particles, wherein the density of the porous hybrid particles is between 1.0 and 1.5 g/ml, and wherein the inorganic particles have a shape and size that maximizes their active surface area enabling the inorganic particles to interact with biomolecules.
摘要翻译：本发明涉及分离生物分子。更详细地说，本发明涉及一种生产包含无机和有机材料的混合颗粒的分离介质的方法以及通过该方法制备的杂化颗粒。最后，本发明涉及杂交颗粒用于分离生物分子，优选磷蛋白的用途。该方法包括以下步骤：将无机金属氧化物颗粒加入到有机溶液中以形成混合物; 并且混合物乳化以形成多孔混合颗粒，其中多孔混合颗粒的密度为1.0-1.5g / ml，并且其中无机颗粒具有使其无机颗粒相互作用的活性表面积最大化的形状和尺寸与生物分子。

3. 发明授权

US09797871B2 Method for storage and stabilization of a target substance 有权
公开(公告)号：US09797871B2
公开(公告)日：2017-10-24
申请号：US13813800
申请日：2011-04-28
申请人： James Van Alstine , Johan Ohman , Philippe Busson , Ronnie Palmgren , Klas Allmer , John Daicic
发明人： James Van Alstine , Johan Ohman , Philippe Busson , Ronnie Palmgren , Klas Allmer , John Daicic
IPC分类号： C07K16/00 , G01N30/56 , C07K1/14 , C07K1/18 , C07K1/20 , C07K1/22 , B01D15/20 , B01D15/22 , G01N30/60
CPC分类号： G01N30/56 , B01D15/206 , B01D15/22 , C07K1/14 , C07K1/18 , C07K1/20 , C07K1/22 , G01N30/6069 , G01N2030/562
摘要： The invention relates to a system and method for the stable storage of sensitive biological or chemical target substance, in a bound form on certain capture media. The method comprised providing a sample containing the target substance in a suitable buffer; combining the sample with a capture media to effect reversible binding of the target substance to the capture media; and storing the capture media with the target substance at between about −20 and 20° C.; and recovering the target substance from the capture media. The target substance recovered maintains the desired activity. Also provides are methods for reducing aggregates in the sensitive biological or chemical target substance.

4. 发明授权

US08632883B2 Separation media for biomolecules comprising porous hybrid particles containing inorganic metal oxide nanoparticles 有权
标题翻译：用于生物分子的分离介质包括含有无机金属氧化物纳米颗粒的多孔混合颗粒
公开(公告)号：US08632883B2
公开(公告)日：2014-01-21
申请号：US12864070
申请日：2009-02-12
申请人： Anders Larsson , Ulrika Meyer , Nils Norrman , Johan Ohman
发明人： Anders Larsson , Ulrika Meyer , Nils Norrman , Johan Ohman
IPC分类号： B32B5/16 , C08J9/35 , C08L5/00 , C08L5/02
CPC分类号： B01J20/28026 , B01D15/34 , B01J20/06 , B01J20/223 , B01J20/28009 , B01J20/282 , C07K1/22
摘要： The present invention relates to separation of biomolecules. More closely, the invention relates to a method for production of a separation medium comprising hybrid particles of inorganic and organic material as well as the hybrid particles produced by this method. Finally, the invention relates to use of the hybrid particles for separation of biomolecules, preferably phosphoproteins. The method comprises the following steps: addition of inorganic metal oxide particles to an organic solution to form a mixture; and emulsification of the mixture to form porous hybrid particles, wherein the density of the porous hybrid particles is between 1.0 and 1.5 g/ml, and wherein the inorganic particles have a shape and size that maximizes their active surface area enabling the inorganic particles to interact with biomolecules.
摘要翻译：本发明涉及分离生物分子。更详细地说，本发明涉及一种生产包含无机和有机材料的混合颗粒的分离介质的方法以及通过该方法制备的杂化颗粒。最后，本发明涉及杂交颗粒用于分离生物分子，优选磷蛋白的用途。该方法包括以下步骤：将无机金属氧化物颗粒加入到有机溶液中以形成混合物; 并且混合物乳化以形成多孔混合颗粒，其中多孔混合颗粒的密度为1.0-1.5g / ml，并且其中无机颗粒具有使其无机颗粒相互作用的活性表面积最大化的形状和尺寸与生物分子。

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