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1. 发明授权

US09034635B2 Thermocycler and sample vessel for rapid amplification of DNA 有权
标题翻译：用于快速扩增DNA的热循环仪和样品容器
公开(公告)号：US09034635B2
公开(公告)日：2015-05-19
申请号：US12918594
申请日：2009-02-19
申请人： Joel R. Termaat , Hendrik J. Viljoen , Scott E. Whitney
发明人： Joel R. Termaat , Hendrik J. Viljoen , Scott E. Whitney
IPC分类号： C12P19/34 , B01L7/00 , B01L3/00
CPC分类号： B01L7/52 , B01L3/505 , B01L2300/043 , B01L2300/0627 , B01L2300/0838 , B01L2300/18 , B01L2300/1822 , B01L2300/1844
摘要： A thermocycler apparatus and method for rapidly performing the PCR process employs at least two thermoelectric modules which are in substantial spatial opposition with an interior space present between opposing modules. One or multiple sample vessels are placed in between the modules such that the vessels are subjected to temperature cycling by the modules. The sample vessels have a minimal internal dimension that is substantially perpendicular to the modules that facilitates rapid temperature cycling. In embodiments of the invention the sample vessels may be deformable between: a) a shape having a wide mouth to facilitate filling and removing of sample fluids from the vessel, and b) a shape which is thinner for conforming to the sample cavity or interior space between the thermoelectric modules of the thermocycler for more rapid heat transfer.
摘要翻译：用于快速执行PCR过程的热循环仪装置和方法采用至少两个热电模块，其与存在于相对模块之间的内部空间实质上空间相对。将一个或多个样品容器放置在模块之间，使得容器经过模块的温度循环。样品容器具有基本垂直于促进快速温度循环的模块的最小内部尺寸。在本发明的实施例中，样品容器可以在以下之间变形：a）具有宽口的形状，以便于从容器中填充和除去样品流体，以及b）更薄的形状，以符合样品腔或内部空间在热循环器的热电模块之间用于更快速的热传递。

2. 发明授权

US08889086B2 Sample tube having particular utility for nucleic acid amplification 有权
标题翻译：样品管具有用于核酸扩增的特异性用途
公开(公告)号：US08889086B2
公开(公告)日：2014-11-18
申请号：US13452419
申请日：2012-04-20
申请人： Hendrik J. Viljoen , Scott E. Whitney , Joel R. TerMaat , Matthew R. Kreifels
发明人： Hendrik J. Viljoen , Scott E. Whitney , Joel R. TerMaat , Matthew R. Kreifels
IPC分类号： B01L3/14 , B01L9/06 , B01L3/00 , B01L7/00
CPC分类号： B01L3/50825 , B01L7/52 , B01L2300/022 , B01L2300/043 , B01L2300/123 , B01L2300/168
摘要： An improved tube including a closure portion, a strap integrally connected to the closure portion and being configured for defining a living hinge, a body portion having a longitudinal axis and an outer wall generally circumscribing the longitudinal axis, and being integrally and hingedly connected with the closure portion by way of the strap. The body portion including a sample portion being generally elongated along the longitudinal axis and being configured for elastic deformation along a portion of its length, including in a direction that is generally transverse to the longitudinal axis so that at least a portion of the wall structure compressively and resiliently deforms and engages a wall defining an opening in a sample block of a polymerase chain reaction amplification device, and the first outer wall dimension of the sample portion reduces to a smaller second outer wall dimension.
摘要翻译：一种改进的管，其包括封闭部分，整体地连接到所述封闭部分并且构造成用于限定活动铰链的带，具有纵向轴线的主体部分和通常围绕所述纵向轴线的外壁，并且与所述主体部分整体地和铰接地连接通过带子的封闭部分。主体部分包括沿着纵向轴线大致细长的样本部分，并且构造成沿其长度的一部分弹性变形，包括沿大致横向于纵向轴线的方向弹性变形，使得壁结构的至少一部分被压缩并且弹性变形并且接合限定聚合酶链式反应扩增装置的样品块中的开口的壁，并且样品部分的第一外壁尺寸减小到更小的第二外壁尺寸。

3. 发明申请

US20120269703A1 Sample Tube Having Particular Utility For Nucleic Acid Amplification 有权
标题翻译：用于核酸扩增的样品管具有特殊用途
公开(公告)号：US20120269703A1
公开(公告)日：2012-10-25
申请号：US13452419
申请日：2012-04-20
申请人： Hendrik J. Viljoen , Scott E. Whitney , Joel R. TerMaat , Matthew Robert Kreifels
发明人： Hendrik J. Viljoen , Scott E. Whitney , Joel R. TerMaat , Matthew Robert Kreifels
IPC分类号： B01L3/14
CPC分类号： B01L3/50825 , B01L7/52 , B01L2300/022 , B01L2300/043 , B01L2300/123 , B01L2300/168
摘要： An improved tube including a closure portion, a strap integrally connected to the closure portion and being configured for defining a living hinge, a body portion having a longitudinal axis and an outer wall generally circumscribing the longitudinal axis, and being integrally and hingedly connected with the closure portion by way of the strap. The body portion including a sample portion being generally elongated along the longitudinal axis and being configured for elastic deformation along a portion of its length, including in a direction that is generally transverse to the longitudinal axis so that at least a portion of the wall structure compressively and resiliently deforms and engages a wall defining an opening in a sample block of a polymerase chain reaction amplification device, and the first outer wall dimension of the sample portion reduces to a smaller second outer wall dimension.
摘要翻译：一种改进的管，其包括封闭部分，整体地连接到所述封闭部分并且构造成用于限定活动铰链的带，具有纵向轴线的主体部分和通常围绕所述纵向轴线的外壁，并且与所述主体部分整体地和铰接地连接通过带子的封闭部分。主体部分包括沿着纵向轴线大致细长的样本部分，并且构造成沿其长度的一部分弹性变形，包括沿大致横向于纵向轴线的方向弹性变形，使得壁结构的至少一部分被压缩并且弹性变形并且接合限定聚合酶链式反应扩增装置的样品块中的开口的壁，并且样品部分的第一外壁尺寸减小到更小的第二外壁尺寸。

4. 发明申请

US20100291536A1 SAMPLE PROCESSING CASSETTE, SYSTEM, AND METHOD 审中-公开
标题翻译：样品加工CASSETTE，系统和方法
公开(公告)号：US20100291536A1
公开(公告)日：2010-11-18
申请号：US12780345
申请日：2010-05-14
申请人： Hendrik J. Viljoen , Scott E. Whitney , Joel R. Termaat , Alison Freifeld , Elsje Pienaar
发明人： Hendrik J. Viljoen , Scott E. Whitney , Joel R. Termaat , Alison Freifeld , Elsje Pienaar
IPC分类号： C12P19/34 , C12N1/06 , C12Q1/00 , C12M1/00
CPC分类号： A61B10/0096 , A61B10/0051 , A61B90/98 , B01L3/505 , B01L2200/0689 , B01L2300/021 , B01L2300/0864 , G01N2001/005
摘要： The present invention provides a method and device for collecting treating and analysis of biological or chemical material by introducing a source material into a specimen container, transferring the source material to a processing device and thermally, chemically and/or mechanically treating the source material to alter at least one constitutive characteristic of the source material and to release or create a target material from the source material.
摘要翻译：本发明提供了一种通过将源材料引入到样本容器中来收集生物或化学材料的处理和分析的方法和装置，将源材料转移到处理装置，并且热，化学和/或机械地处理源材料以改变源材料的至少一个构成特征并且从源材料释放或产生靶材料。

5. 发明申请

US20110039305A1 THERMOCYCLER AND SAMPLE VESSEL FOR RAPID AMPLIFICATION OF DNA 有权
标题翻译：热释放器和样品容器用于快速扩增DNA
公开(公告)号：US20110039305A1
公开(公告)日：2011-02-17
申请号：US12918594
申请日：2009-02-19
申请人： Joel R. Termaat , Hendrik J. Viljoen , Scott E. Whitney
发明人： Joel R. Termaat , Hendrik J. Viljoen , Scott E. Whitney
IPC分类号： C12P19/34 , C12M1/00 , C12M1/38
CPC分类号： B01L7/52 , B01L3/505 , B01L2300/043 , B01L2300/0627 , B01L2300/0838 , B01L2300/18 , B01L2300/1822 , B01L2300/1844
摘要： A thermocycler apparatus and method for rapidly performing the PCR process employs at least two thermoelectric modules which are in substantial spatial opposition with an interior space present between opposing modules. One or multiple sample vessels are placed in between the modules such that the vessels are subjected to temperature cycling by the modules. The sample vessels have a minimal internal dimension that is substantially perpendicular to the modules that facilitates rapid temperature cycling. In embodiments of the invention the sample vessels may be deformable between: a) a shape having a wide mouth to facilitate filling and removing of sample fluids from the vessel, and b) a shape which is thinner for conforming to the sample cavity or interior space between the thermoelectric modules of the thermocycler for more rapid heat transfer.
摘要翻译：用于快速执行PCR过程的热循环仪装置和方法采用至少两个热电模块，其与存在于相对模块之间的内部空间实质上空间相对。将一个或多个样品容器放置在模块之间，使得容器经过模块的温度循环。样品容器具有基本垂直于促进快速温度循环的模块的最小内部尺寸。在本发明的实施例中，样品容器可以在以下之间变形：a）具有宽口的形状，以便于从容器中填充和除去样品流体，以及b）更薄的形状，以符合样品腔或内部空间在热循环器的热电模块之间用于更快速的热传递。

6. 外观设计

USD690025S1 Sample tube 有权
标题翻译：样品管
公开(公告)号：USD690025S1
公开(公告)日：2013-09-17
申请号：US29424290
申请日：2012-06-11
申请人： Joel R. TerMaat , Matthew R. Kreifels , Scott E. Whitney , Troy M. Just , Jamee Thieman
设计人： Joel R. TerMaat , Matthew R. Kreifels , Scott E. Whitney , Troy M. Just , Jamee Thieman

7. 发明申请

US20100288059A1 SPECIMEN CONTAINER, SYSTEM, AND METHOD 审中-公开
标题翻译：样品容器，系统和方法
公开(公告)号：US20100288059A1
公开(公告)日：2010-11-18
申请号：US12780508
申请日：2010-05-14
申请人： Hendrik J. Viljoen , Scott E. Whitney , Joel R. Termaat , Alison Freifeld
发明人： Hendrik J. Viljoen , Scott E. Whitney , Joel R. Termaat , Alison Freifeld
IPC分类号： G01N1/12 , B01L3/00
CPC分类号： A61B10/0096 , A61B10/0051 , A61B90/98 , B01L3/505 , B01L2200/0689 , B01L2300/021 , B01L2300/0864 , G01N2001/005
摘要： This invention relates to the collection and handling of biological or chemical specimens. The invention provides a device and a method for collecting and preparing patient samples, such as sputum, to be used in downstream diagnostics tests. The invention reduces the handling and exposure of healthcare workers to the sample by the use of a bag in which hermetic seals are utilized to separate sample aliquots.
摘要翻译：本发明涉及生物或化学样品的收集和处理。本发明提供了用于收集和制备用于下游诊断测试中的患者样品（例如痰液）的装置和方法。本发明通过使用其中使用气密封来分离样品等分试样的袋子来减少医护人员对样品的处理和暴露。

8. 发明授权

US06547852B2 Transverse thermal modulation 有权
标题翻译：横向热调制
公开(公告)号：US06547852B2
公开(公告)日：2003-04-15
申请号：US09760508
申请日：2001-01-12
申请人： Edward B. Ledford, Jr. , Chris A. Billesbach , Joel R. Termaat
发明人： Edward B. Ledford, Jr. , Chris A. Billesbach , Joel R. Termaat
IPC分类号： B01D1508
CPC分类号： G01N30/463 , G01N30/30 , G01N30/461 , G01N30/465 , G01N2030/3023 , G01N2030/623 , G01N30/46 , G01N2030/121
摘要： A method of thermally modulating a tubular member carrying a sample substance therethrough is provided. The method includes the steps of (a) directing at least one gas stream toward a tubular member in a direction substantially transverse to the tubular member, wherein the temperature of the gas stream differs from the temperature of the tubular member; and (b) varying the gas flow rate of the at least one gas stream as a function of time to thermally modulate the tubular member. An apparatus is also provided for thermal modulation and includes: a tubular member for carrying a sample substance therethrough in a fluid medium; a gas stream source for directing a gas stream toward the tubular member in a direction substantially transverse to the tubular member; a gas stream supplied from the source with a temperature that differs from the temperature of the tubular member; and a gas stream of varying gas flow rate supplied from the gas stream source as a function of time to thermally modulate the tubular member.
摘要翻译：提供了一种通过热调制携带样品物质的管状构件的方法。该方法包括以下步骤：（a）在基本上横向于管状构件的方向上将至少一种气流引向管状构件，其中气流的温度与管状构件的温度不同; 和（b）根据时间的函数改变至少一种气流的气体流速，以对管状构件进行热调节。还提供了用于热调制的装置，包括：用于在流体介质中携带样品物质通过其的管状构件; 气流源，用于沿基本横向于所述管状构件的方向将气流引向所述管状构件; 从所述源供应的气流与所述管状构件的温度不同的温度; 以及从气流源供应的不同气体流速的气流作为时间的函数来热管道管状构件。

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