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1. 发明授权

US06508814B2 Method and apparatus for rupturing targeted cells 失效
标题翻译：用于破坏靶细胞的方法和装置
公开(公告)号：US06508814B2
公开(公告)日：2003-01-21
申请号：US09188915
申请日：1998-11-09
申请人： Proserfina R. Tortal , Grace Tortal-Quirong , Rolando A. Quirong , Eleazar R. Tortal , Jocelyn F. Tortal
发明人： Proserfina R. Tortal , Grace Tortal-Quirong , Rolando A. Quirong , Eleazar R. Tortal , Jocelyn F. Tortal
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2018/0262 , Y10S128/27
摘要： A probe contacts targeted tissue, sometimes while positioned adjacent to nontargeted live tissues. In preferred forms, the probe includes a support that only minimally conducts heat from nontargeted tissues. A very conductive targeted-tissue-contacting element, at an end of the support, is immersed in a liquid cryogen (preferably nitrogen) and then removed for contacting with (e. g., insertion into) the targeted tissue. An ultrathin highly thermoconductive polymeric tubing holds both a very conductive, cold material, forming the targeted-tissue-contacting element, and fine insulating material (e. g. highly insulating elastomer) forming part of the support. The targeted-tissue-contacting element is fashioned to fit the targeted tissue in at least one dimension, and the support to fit nontargeted live tissues (if any) adjacent to which the probe is positioned while contacting the targeted tissue. The probe provides for confined heat exchange with the targeted tissue—as by matching dimensions of probe and targeted tissue, or of support and nontargeted tissue, or insulating the support against heat flow into the probe or from nontargeted tissues; and preferably all of these. The best targeted-tissue-contacting element is a solid cryogen, roughly at liquid-nitrogen temperature; ideally it is solid carbon dioxide, particularly super-sublimated carbon dioxide—cooled to a temperature range characterized by extremely tight crystal bonds.
摘要翻译：探针接触目标组织，有时位于非靶向活组织附近。在优选形式中，探针包括仅从非靶向组织最低限度地传导热量的支架。将支撑体末端的非常导电的靶向组织接触元件浸入液体冷冻剂（优选氮气）中，然后除去以与（例如，插入）目标组织接触。超薄高导热聚合物管保持形成目标组织接触元件的非常导电的冷材料和形成支撑体的一部分的精细绝缘材料（例如高度绝缘的弹性体）。靶向组织接触元件的形状是将目标组织装配在至少一个维度上，并且支撑件适合与探针定位的邻近的非靶向活组织（如果有的话）接触目标组织。探针提供与目标组织的局限热交换，如通过匹配探针和靶组织或支撑和非靶向组织的尺寸，或绝缘支撑件抵抗热流入探针或非靶向组织; 并且优选所有这些。最好的靶组织接触元件是固体冷冻剂，大致处于液氮温度; 理想情况下，它是固体二氧化碳，特别是超升华的二氧化碳，冷却到特征在于非常紧密的结晶键的温度范围。

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