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1. 发明申请

US20090291998A1 EPONEMYCIN AND EPOXOMICIN ANALOGS AND USES THEREOF 审中-公开
标题翻译： EPONEMYCIN和EPOXOMICIN类似物及其用途
公开(公告)号：US20090291998A1
公开(公告)日：2009-11-26
申请号：US12396849
申请日：2009-03-03
申请人： Sergei Agoulnik , Kozo Akasaka , Francis Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuinness , Erin A. Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
发明人： Sergei Agoulnik , Kozo Akasaka , Francis Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuinness , Erin A. Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
IPC分类号： A61K31/4035 , C07D303/36 , C07D317/06 , C07D307/78 , C07D209/04 , C07D311/04 , A61K31/336 , A61K31/357 , A61K31/343 , A61K31/352 , A61P35/00
CPC分类号： C07D209/48 , A61K38/00 , C07D303/36 , C07D405/12 , C07D407/12 , C07F5/025 , C07F9/65502 , C07K5/06139
摘要： The present invention provides compounds having formula (1): wherein R1-R6, A, J, D, A, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.
摘要翻译：本发明提供具有式（1）的化合物：其中R 1 -R 6，A，J，D，A，G，Q，w，x，y和z如本文中所述的类别和亚类所述，其药物组合物及其用于治疗癌症和/或炎症性疾病的方法，更一般地，作为蛋白酶体抑制剂。

2. 发明申请

US20170100368A1 USE OF ERIBULIN AND POLY (ADP RIBOSE) POLYMERASE (PARP) INHIBITORS AS COMBINATION THERAPY FOR THE TREATMENT OF CANCER 审中-公开
公开(公告)号：US20170100368A1
公开(公告)日：2017-04-13
申请号：US15314200
申请日：2015-05-28
申请人： David COX , Alton KRAMER , Sharon MCGONIGLE , Jiayi WU , Eisai R&D Management Co., Ltd.
发明人： David COX , Alton KREMER , Sharon MCGONIGLE , Jiayi WU
IPC分类号： A61K31/357 , A61K31/555 , A61K31/519
CPC分类号： A61K31/357 , A61K31/519 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The invention features methods for treating cancer in a patient in need thereof by administering eribulin, in combination with one or more PARP inhibitors, and, optionally, a platinum-based antineoplastic drug, and kits therefor. The invention is based in part on the observation that combinations of eribulin mesylate, a PARP inhibitor (e.g., E7449), and, optionally, a platinum-based antineo-plastic drug (e.g., carboplatin), show improved (e.g., synergistic) antitumor effects. Therefore, the present invention features methods of preventing and treating cancer (e.g., homologous recombination (HR)-deficient cancer by the use of combinations of eribulin (e.g., eribulin mesylate) and one or more PARP inhibitors (e.g., E7449 or a pharmaceutically acceptable salt thereof (e.g., the tartrate salt), optionally in combination with a platinum-based antineoplastic drug (e.g., carboplatin).

3. 发明授权

US08609640B2 Multikinase inhibitors for use in the treatment of cancer 有权
公开(公告)号：US08609640B2
公开(公告)日：2013-12-17
申请号：US12180408
申请日：2008-07-25
申请人： Sergei Agoulnik , Bruce Decosta , Hong Du , Yimin Jiang , Xiang-Yi Li , Kenichi Nomoto , John (Yuan) Wang , Huiming Zhang , Jiayi Wu
发明人： Sergei Agoulnik , Bruce Decosta , Hong Du , Yimin Jiang , Xiang-Yi Li , Kenichi Nomoto , John (Yuan) Wang , Huiming Zhang , Jiayi Wu
IPC分类号： A01N57/00 , A61K31/665 , A01N43/02 , A61K31/335 , A01N43/76 , A61K31/42 , A61K31/415 , A61K31/497 , A61K31/535
CPC分类号： A61K31/365 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4523 , A61K31/496 , A61K31/5377 , A61K31/665 , A61K45/06
摘要： The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

4. 发明申请

US20100080645A1 Whiteboard marker 审中-公开
标题翻译：白板标记
公开(公告)号：US20100080645A1
公开(公告)日：2010-04-01
申请号：US12380413
申请日：2009-02-26
申请人： Jiayi Wu
发明人： Jiayi Wu
IPC分类号： B43K29/00
CPC分类号： B43K8/02 , B43K8/03 , B43K8/06 , B43K11/005 , B43K23/12 , B43K25/00 , B43K29/02 , B43L19/00 , B43L19/0068
摘要： A whiteboard marker, comprises a lid; a body provided with an ink reservoir cotton inside and an ink introducing core at the penpoint portion; wherein the lid is hollow, a seal cap for sealing the body is provided at an end of the body adjacent to the lid, and one end of the seal cap away from the body extends into the lid to be connected with the lower end of a rotation element by screwing, an eraser retainer is provided at the upper end of the rotation element, an eraser is provided at the front end of the eraser retainer, and the penpoint portion is inserted into the other end of the seal cap. The whiteboard marker may be used for writing and erasing easily, and can be recycled to save resource and be environment-protected.
摘要翻译：白板标记，包括盖子; 设置有油墨储存器棉花的主体和在所述笔尖部分处的墨水引入芯部; 其中所述盖是中空的，用于密封所述主体的密封盖设置在所述主体的与所述盖相邻的端部处，并且所述密封帽远离所述主体的一端延伸到所述盖中以与所述盖的下端连接通过旋转旋转元件，在旋转元件的上端设置有橡皮擦保持器，在橡皮擦保持器的前端设置有橡皮擦，并且笔尖部分插入密封帽的另一端。白板标记可以轻松地用于写入和擦除，可以循环使用以节省资源并进行环境保护。

5. 发明授权

US07524883B2 Eponemycin and epoxomicin analogs and uses thereof 失效
标题翻译：环孢霉素和环氧素类似物及其用途
公开(公告)号：US07524883B2
公开(公告)日：2009-04-28
申请号：US10501120
申请日：2003-01-08
申请人： Sergei Agoulnik , Kozo Akasaka , Frank Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuiness , Erin A. Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
发明人： Sergei Agoulnik , Kozo Akasaka , Frank Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuiness , Erin A. Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
IPC分类号： C07D303/46 , A61K31/336
CPC分类号： C07D209/48 , A61K38/00 , C07D303/36 , C07D405/12 , C07D407/12 , C07F5/025 , C07F9/65502 , C07K5/06139
摘要： The present invention provides compounds having formula (1): wherein R1-R6, A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.
摘要翻译：本发明提供了具有式（1）的化合物：其中R 1 -R 6，A，J，D，E，G，Q，w，x，y和z如本文中所述的类别和亚类所述，其药物组合物及其用于治疗癌症和/或炎症性疾病的方法，更一般地，作为蛋白酶体抑制剂。

6. 发明申请

US20050101781A1 Eponemycin and epoxomicin analogs and uses thereof 失效
标题翻译：环孢霉素和环氧素类似物及其用途
公开(公告)号：US20050101781A1
公开(公告)日：2005-05-12
申请号：US10501120
申请日：2003-01-08
申请人： Sergei Agoulnik , Kozo Akasaka , Francis Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuinness , Erin Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
发明人： Sergei Agoulnik , Kozo Akasaka , Francis Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuinness , Erin Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
IPC分类号： C07D303/14 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/336 , A61K31/343 , A61K31/353 , A61K31/36 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/4045 , A61K31/4427 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/662 , A61K31/69 , A61K38/00 , A61P29/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/00 , A61P43/00 , C07C233/76 , C07C235/82 , C07C237/06 , C07C237/08 , C07C271/22 , C07D209/48 , C07D303/36 , C07D405/12 , C07D407/12 , C07F5/02 , C07F9/655 , C07K5/078 , A61K31/382 , C07D43/02 , C07D49/02
CPC分类号： C07D209/48 , A61K38/00 , C07D303/36 , C07D405/12 , C07D407/12 , C07F5/025 , C07F9/65502 , C07K5/06139
摘要： The present invention provides compounds haviang formula (1): wherein R1-R6, A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.
摘要翻译：本发明提供了式（1）化合物：其中R 1 -R 6，A，J，D，E，G，Q，w，x，y，和z如本文中所述的一般和类别和亚类所述，并且另外提供其药物组合物，以及其用于治疗癌症和/或炎症性疾病的方法，更一般地，作为蛋白酶体抑制剂。

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