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1. 发明授权

US09173452B2 Foot shape measurer 有权
标题翻译：脚形测量仪
公开(公告)号：US09173452B2
公开(公告)日：2015-11-03
申请号：US14152930
申请日：2014-01-10
申请人： Jianxin Ye
发明人： Jianxin Ye
IPC分类号： G06K9/00 , A43D1/02 , G06T7/60
CPC分类号： A43D1/02 , A43B1/0027 , A43B23/027 , A43D1/027 , A61B5/1074 , G06T2207/30196
摘要： An apparatus for measuring feet, for the purpose of gathering measurements for custom shoes, is disclosed. The apparatus is shaped like a shoe, and has an opening where the shoe lace opening is normally present on the shoe, in addition to openings near the big toe and the little toe. Each opening has holes for laces that are tightened so that the gap, or overlap, of the openings can be measured. Additionally, mats of known thickness can be used to measure the distance between the heel of the shoe and the heel of the foot. Furthermore, markings are used to identify the different shoe lace holes so measurements can be taken at multiple places along the top of the foot. Furthermore, a size indicator can be shown on the shoe, so that measurements can be taken on a picture of the foot in the shoe rather than on the foot and shoe themselves, and then scaled to actual size with reference to the size indicator.
摘要翻译：公开了一种用于测量脚的装置，用于收集定制鞋的尺寸。该装置的形状像鞋子，并且除了在大脚趾附近的开口和小脚趾之外，还具有通常存在于鞋上的鞋带开口的开口。每个开口具有用于装饰的鞋带的孔，以便可以测量开口的间隙或重叠。此外，已知厚度的垫可以用于测量鞋跟和鞋跟之间的距离。此外，标记用于识别不同的鞋带孔，因此可以在沿着脚的顶部的多个位置进行测量。此外，尺寸指示器可以在鞋上显示，使得可以对鞋中的脚的图片进行测量，而不是在脚和鞋本身上进行测量，然后参考尺寸指示器将尺寸指示器缩放到实际尺寸。

2. 发明申请

US20160194660A1 EXPRESSION VECTORS FOR RECOMBINANT PROTEIN PRODUCTION IN MAMMALIAN CELLS 审中-公开
标题翻译：哺乳动物细胞中重组蛋白生产的表达载体
公开(公告)号：US20160194660A1
公开(公告)日：2016-07-07
申请号：US14653872
申请日：2013-12-18
申请人： Jianxin YE , MERCK SHARP & DOHME CORP.
发明人： Jianxin YE
IPC分类号： C12N15/85 , C12N15/70 , C07K16/00 , C12N15/64 , C12P21/00
CPC分类号： C12N15/85 , A01K2207/12 , C07K16/00 , C07K2317/14 , C12N15/64 , C12N15/70 , C12N2800/101 , C12N2800/107 , C12N2800/50 , C12N2820/55 , C12P21/00 , C12P21/02
摘要： The invention provides expression vectors that support high levels of polypeptide expression in mammalian cells. The vectors contain at least one expression cassette for a target polypeptide; an expression cassette for a eukaryotic selectable marker protein; an expression cassette for a bacterial selectable marker protein, and a bacterial plasmid origin of replication.
摘要翻译：本发明提供支持哺乳动物细胞中高水平多肽表达的表达载体。载体含有至少一种靶多肽的表达盒; 用于真核选择标记蛋白的表达盒; 用于细菌选择性标记蛋白的表达盒和细菌质粒复制起点。

3. 发明授权

US07615758B2 Laser confocal microarray scanner 有权
标题翻译：激光共焦微阵列扫描仪
公开(公告)号：US07615758B2
公开(公告)日：2009-11-10
申请号：US11795660
申请日：2005-06-02
申请人： Xianhua Wang , Hui Xu , Jianxin Ye , Yelei Sun , Guoliang Huang , Jing Cheng
发明人： Xianhua Wang , Hui Xu , Jianxin Ye , Yelei Sun , Guoliang Huang , Jing Cheng
IPC分类号： F21V9/16
CPC分类号： G01N21/6458 , G01N21/6428 , G01N21/6452 , G01N2021/6421 , G01N2201/10 , G01N2201/103
摘要： The invention provides a laser microarray scanner for microarray scanning, comprising an optical system, a scanning platform, and a data processing system. During scanning, the optical system remains fixed, and the microarray placed on the scanning platform moves relative to the optical system. The microarray scanner disclosed herein has high scanning speed, high sensitivity, high resolution, and high signal-to-noise ratio, thus is ideal for use in microarray scanning
摘要翻译：本发明提供一种用于微阵列扫描的激光微阵列扫描器，包括光学系统，扫描平台和数据处理系统。在扫描期间，光学系统保持固定，并且放置在扫描平台上的微阵列相对于光学系统移动。本文公开的微阵列扫描器具有高扫描速度，高灵敏度，高分辨率和高信噪比，因此是理想的用于微阵列扫描

4. 发明申请

US20080252954A1 Laser Confocal Microarray Scanner 有权
标题翻译：激光共聚焦微阵列扫描仪
公开(公告)号：US20080252954A1
公开(公告)日：2008-10-16
申请号：US11795660
申请日：2005-06-02
申请人： Xianhua Wang , Hui Xu , Jianxin Ye , Yelei Sun , Guoliang Huang , Jing Cheng
发明人： Xianhua Wang , Hui Xu , Jianxin Ye , Yelei Sun , Guoliang Huang , Jing Cheng
IPC分类号： G02B26/08
CPC分类号： G01N21/6458 , G01N21/6428 , G01N21/6452 , G01N2021/6421 , G01N2201/10 , G01N2201/103
摘要： The invention provides a laser microarray scanner for microarray scanning, comprising an optical system, a scanning platform, and a data processing system. During scanning, the optical system remains fixed, and the microarray placed on the scanning platform moves relative to the optical system. The microarray scanner disclosed herein has high scanning speed, high sensitivity, high resolution, and high signal-to-noise ratio, thus is ideal for use in microarray scanning
摘要翻译：本发明提供一种用于微阵列扫描的激光微阵列扫描器，包括光学系统，扫描平台和数据处理系统。在扫描期间，光学系统保持固定，并且放置在扫描平台上的微阵列相对于光学系统移动。本文公开的微阵列扫描器具有高扫描速度，高灵敏度，高分辨率和高信噪比，因此是理想的用于微阵列扫描

5. 发明申请

US20150131865A1 Foot Shape Measurer 审中-公开
标题翻译：脚形测量仪
公开(公告)号：US20150131865A1
公开(公告)日：2015-05-14
申请号：US14152930
申请日：2014-01-10
申请人： Jianxin Ye
发明人： Jianxin Ye
IPC分类号： A43D1/02 , G01B11/24 , G06T7/60 , G01B5/20
CPC分类号： A43D1/02 , A43B1/0027 , A43B23/027 , A43D1/027 , A61B5/1074 , G06T2207/30196
摘要： An apparatus for measuring feet, for the purpose of gathering measurements for custom shoes, is disclosed. The apparatus is shaped like a shoe, and has an opening where the shoe lace opening is normally present on the shoe, in addition to openings near the big toe and the little toe. Each opening has holes for laces that are tightened so that the gap, or overlap, of the openings can be measured. Additionally, mats of known thickness can be used to measure the distance between the heel of the shoe and the heel of the foot. Furthermore, markings are used to identify the different shoe lace holes so measurements can be taken at multiple places along the top of the foot. Furthermore, a size indicator can be shown on the shoe, so that measurements can be taken on a picture of the foot in the shoe rather than on the foot and shoe themselves, and then scaled to actual size with reference to the size indicator.
摘要翻译：公开了一种用于测量脚的装置，用于收集定制鞋的尺寸。该装置的形状像鞋子，并且除了在大脚趾附近的开口和小脚趾之外，还具有通常存在于鞋上的鞋带开口的开口。每个开口具有用于装饰的鞋带的孔，以便可以测量开口的间隙或重叠。此外，已知厚度的垫可以用于测量鞋跟和鞋跟之间的距离。此外，标记用于识别不同的鞋带孔，因此可以在沿着脚的顶部的多个位置进行测量。此外，尺寸指示器可以在鞋上显示，使得可以对鞋中的脚的图片进行测量，而不是在脚和鞋本身上进行测量，然后参考尺寸指示器将尺寸指示器缩放到实际尺寸。

6. 发明申请

US20100190663A1 DEVICE FOR WASHING AND HYBRIDIZATION OF BIOCHIPS 有权
标题翻译： BIOCHIPS洗涤和杂交装置
公开(公告)号：US20100190663A1
公开(公告)日：2010-07-29
申请号：US12527184
申请日：2007-10-09
申请人： Hang Li , Jianxin Ye , Xingling Al , Xianhua Wang , Liang Zhang , Jing Cheng
发明人： Hang Li , Jianxin Ye , Xingling Al , Xianhua Wang , Liang Zhang , Jing Cheng
IPC分类号： C40B60/00
CPC分类号： B08B3/044 , B01F11/0028 , B01J2219/00326 , B01J2219/00328 , B01J2219/00527 , B01J2219/00659 , B01L7/00 , B01L2300/0819 , B08B11/02 , Y10S435/809
摘要： A device for biochip hybridization or washing is provided, which comprises a carousel (12), a translational movement controller, a revolving movement controller, and optionally a heating chamber (13). The revolving movement controller controls the revolving movement of the carousel and allows it to move in a wobbling fashion, allowing liquid movement of the hybridization or washing boxes (11) during hybridization and/or washing of biochips on the carousel. The translational movement controller brings the carousel back to horizontal position once the revolving movement controller stops, thereby ensures that the liquid do not spill out. The heating chamber circulates hot air within the device, thereby ensures that the hybridization and washing in a thermostatic condition.
摘要翻译：提供了用于生物芯片杂交或洗涤的装置，其包括圆盘传送带（12），平移运动控制器，旋转运动控制器和可选的加热室（13）。旋转运动控制器控制圆盘传送带的旋转运动，并允许其以摆动的方式移动，允许杂交或洗涤盒（11）在传送带上的生物芯片的杂交和/或洗涤期间的液体移动。一旦旋转运动控制器停止，平移运动控制器将转盘回到水平位置，从而确保液体不会溢出。加热室在装置内循环热空气，从而确保在恒温条件下进行杂交和洗涤。

7. 发明申请

US20170226550A1 INHIBITORY RNA FOR ENHANCED PROTEIN PRODUCTION IN RECOMBINANT MAMMALIAN CELLS 审中-公开
公开(公告)号：US20170226550A1
公开(公告)日：2017-08-10
申请号：US15501503
申请日：2015-08-04
申请人： Jianxin Ye , Krista Alvin , Siyan Zhang
发明人： Jianxin Ye , Krista Alvin , Siyan Zhang
IPC分类号： C12P21/00 , C12N15/113
CPC分类号： C12P21/00 , C12N15/111 , C12N15/113 , C12N15/85 , C12N2310/14 , C12N2310/531 , C12N2320/12 , C12P21/02
摘要： The invention provides methods and compositions for improving production of exogenous polypeptides in large scale culture of mammalian host cells. The methods and compositions utilize RNA interference to inhibit expression of one or more specific host cell proteins. The present invention is based on the identification of specific mammalian genes and sequences therein that are useful as RNAi targets to enhance the production of exogenous proteins in mammalian cell culture.

8. 发明授权

US08137622B2 Device for washing and hybridization of biochips 有权
标题翻译：用于生物芯片的洗涤和杂交的装置
公开(公告)号：US08137622B2
公开(公告)日：2012-03-20
申请号：US12527184
申请日：2007-10-09
申请人： Hang Li , Jianxin Ye , Xingling Al , Xianhua Wang , Liang Zhang , Jing Cheng
发明人： Hang Li , Jianxin Ye , Xingling Al , Xianhua Wang , Liang Zhang , Jing Cheng
IPC分类号： B01F11/00 , B01F11/04
CPC分类号： B08B3/044 , B01F11/0028 , B01J2219/00326 , B01J2219/00328 , B01J2219/00527 , B01J2219/00659 , B01L7/00 , B01L2300/0819 , B08B11/02 , Y10S435/809
摘要： A device for biochip hybridization or washing is provided, which comprises a carousel (12), a translational movement controller, a revolving movement controller, and optionally a heating chamber (13). The revolving movement controller controls the revolving movement of the carousel and allows it to move in a wobbling fashion, allowing liquid movement of the hybridization or washing boxes (11) during hybridization and/or washing of biochips on the carousel. The translational movement controller brings the carousel back to horizontal position once the revolving movement controller stops, thereby ensures that the liquid do not spill out. The heating chamber circulates hot air within the device, thereby ensures that the hybridization and washing in a thermostatic condition.
摘要翻译：提供了用于生物芯片杂交或洗涤的装置，其包括圆盘传送带（12），平移运动控制器，旋转运动控制器和可选的加热室（13）。旋转运动控制器控制圆盘传送带的旋转运动，并允许其以摆动的方式移动，允许杂交或洗涤盒（11）在传送带上的生物芯片的杂交和/或洗涤期间的液体移动。一旦旋转运动控制器停止，平移运动控制器将转盘回到水平位置，从而确保液体不会溢出。加热室在装置内循环热空气，从而确保在恒温条件下进行杂交和洗涤。

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