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1. 发明申请

US20130324905A1 DEVICES AND METHODS FOR GASTROINTESTINAL BYPASS 有权
公开(公告)号：US20130324905A1
公开(公告)日：2013-12-05
申请号：US13485898
申请日：2012-05-31
申请人： Jesse N. NELSON , Justin SCHWAB
发明人： Jesse N. NELSON , Justin SCHWAB
IPC分类号： A61F2/04
CPC分类号： A61F5/0076 , A61B17/0401 , A61B17/064 , A61B17/068 , A61B17/1114 , A61B90/39 , A61B2017/00818 , A61B2017/0404 , A61B2017/0409 , A61B2017/0419 , A61B2017/0464 , A61B2017/047 , A61B2017/06052 , A61B2017/0647 , A61B2090/3908 , A61B2090/395 , A61B2090/3966 , A61F2/04 , A61F5/0036 , A61F5/0079 , A61F5/0089 , A61F2002/045 , A61F2250/0097
摘要： Devices and methods for gastrointestinal bypass are described. A gastrointestinal bypass device includes a gastrointestinal cuff and a gastrointestinal sleeve. The cuff may be configured to be attached in the esophagus, and may be sufficiently flexible to expand and collapse to conform with the inside of the esophagus to allow the esophagus to function substantially normally. The sleeve is configured to be coupled to the cuff, and may be made of a material that is floppy or flaccid but does not substantially expand radially.

2. 发明申请

US20110264214A1 Voice Prosthesis Device 审中-公开
标题翻译：语音假肢装置
公开(公告)号：US20110264214A1
公开(公告)日：2011-10-27
申请号：US13174945
申请日：2011-07-01
申请人： Jesse N. Nelson
发明人： Jesse N. Nelson
IPC分类号： A61F2/20
CPC分类号： A61F2/203
摘要： A voice prosthesis device includes a barrel defining a passageway, a tracheal flange adjacent a tracheal end of the barrel and an esophageal flange adjacent an esophageal end of the barrel. The passageway includes a first stop extending inwardly from a sidewall of the passageway between the tracheal and esophageal ends and a plurality of second stops extending inwardly from the sidewall of the passageway between the first stop and the esophageal end of the passageway. A valve mechanism is located between the first and second stops and permits flow through the passageway from the tracheal end and impedes flow through the passageway from the esophageal end.
摘要翻译：声音假体装置包括限定通道的筒，邻近筒的气管端的气管法兰和邻近食管端的食管法兰。通道包括从气管和食管端之间的通道的侧壁向内延伸的第一止动件和从通道的第一止动件和食道端之间的通道的侧壁向内延伸的多个第二止动件。阀机构位于第一和第二止动件之间，并且允许从气管端流过通道并阻止从食管端流过通道。

3. 发明授权

US07520897B2 Medical devices having antimicrobial properties 有权
标题翻译：具有抗菌性能的医疗器械
公开(公告)号：US07520897B2
公开(公告)日：2009-04-21
申请号：US10990168
申请日：2004-11-15
申请人： Edmund V. Seder , Jesse N. Nelson
发明人： Edmund V. Seder , Jesse N. Nelson
IPC分类号： A61F2/20
CPC分类号： A61L27/54 , A61F2/203 , A61L2300/104 , A61L2300/202 , A61L2300/21 , A61L2300/404
摘要： Microbial growth on the surface of a valve of a voice prosthesis and optionally the cartridge or ring supporting the valve, is inhibited by providing antimicrobial activity at a level sufficient to retard growth of a microbial film by dispersing an inorganic antimicrobial agent such as silver oxide or an organic antimicrobial agent such as triclosan or butyl paraben dispersed in a medical grade silicone elastomer. The valve, ring or cartridge is in contact with body fluids containing microorganisms and nutrients therefor. The antimicrobial surface can interfere with or inhibit the growth of a biofilm, bacterial layer or a yeast layer. The body of the prosthesis may also contain an antimicrobial surface as long as it is non-toxic to the tissue it contacts.
摘要翻译：通过提供足够的抗微生物活性以抑制微生物膜的生长，通过分散无机抗微生物剂如氧化银或氧化银的方式抑制语音假体的瓣膜表面和任选地支撑瓣膜的药筒或环的表面上的微生物生长分散在医用级硅橡胶弹性体中的有机抗微生物剂如三氯生或对羟基苯甲酸丁酯。阀，环或药筒与含有微生物和营养物的体液接触。抗微生物表面可以干扰或抑制生物膜，细菌层或酵母层的生长。假体的主体也可以含有抗微生物表面，只要它对其接触的组织无毒。

4. 发明授权

US07393547B2 Antimicrobial elastomer composition and method for making 有权
标题翻译：抗菌弹性体组合物及其制造方法
公开(公告)号：US07393547B2
公开(公告)日：2008-07-01
申请号：US10923138
申请日：2004-08-19
申请人： Jesse N. Nelson
发明人： Jesse N. Nelson
IPC分类号： A61K33/38 , A61K9/14 , A01N59/16
CPC分类号： A61K31/28 , A61F2/203 , A61L27/18 , A61L27/54 , A61L2300/104 , A61L2300/404 , A61L2300/606 , C08F290/06 , C08G77/04 , C08L83/04
摘要： A method for making an elastomeric material containing an antimicrobial composition such as a dispersion of silver oxide that is suitable for implantation within the body. The elastomer made in accordance with this method extends the amount of work-time available for processing the elastomer into an article as compared with the work-time available when using prior art compounding methods.
摘要翻译：制备含有抗微生物组合物的弹性体材料的方法，所述抗微生物组合物例如适于植入体内的氧化银分散体。与使用现有技术的复合方法相比，根据该方法制造的弹性体将可加工弹性体的工作时间量与可用的工作时间相比延长。

5. 发明授权

US08317861B2 Antimicrobial indwelling voice prosthesis 有权
标题翻译：抗生素留置声假体
公开(公告)号：US08317861B2
公开(公告)日：2012-11-27
申请号：US11093351
申请日：2005-03-29
申请人： Jeffrey L. Goldberg , Edmund V. Seder , Jesse N. Nelson , Juan M. Madrigal
发明人： Jeffrey L. Goldberg , Edmund V. Seder , Jesse N. Nelson , Juan M. Madrigal
IPC分类号： A61F2/20
CPC分类号： A61F2/203 , A61L27/54 , A61L2300/404 , A61L2300/606
摘要： A voice prosthesis comprising a tubular body portion, a valve and a valve seat disposed within the body portion. The valve seat is further comprised of a medical grade elastomer containing a dispersion of an antimicrobial agent. This valve seat extends the life of the prosthesis by retarding the growth of microorganisms. The body portion of the prosthesis may also contain an antimicrobial agent at a concentration that is non-toxic to the tissue it contacts.
摘要翻译：一种声音假体，包括管状主体部分，阀和设置在主体部分内的阀座。阀座还包含含有抗微生物剂分散体的医用级弹性体。该阀座通过延缓微生物的生长来延长假体的寿命。假体的身体部分还可以含有与其接触的组织无毒的浓度的抗微生物剂。

6. 发明授权

US07998200B2 Voice prosthesis device 有权
标题翻译：声音假体装置
公开(公告)号：US07998200B2
公开(公告)日：2011-08-16
申请号：US11145791
申请日：2005-06-06
申请人： Jesse N. Nelson
发明人： Jesse N. Nelson
IPC分类号： A61F2/20
CPC分类号： A61F2/203
摘要： A voice prosthesis device includes a barrel defining a passageway, a tracheal flange adjacent a tracheal end of the barrel and an esophageal flange adjacent an esophageal end of the barrel. The passageway includes a first stop extending inwardly from a sidewall of the passageway between the tracheal and esophageal ends and a plurality of second stops extending inwardly from the sidewall of the passageway between the first stop and the esophageal end of the passageway. A valve mechanism is located between the first and second stops and permits flow through the passageway from the tracheal end and impedes flow through the passageway from the esophageal end.
摘要翻译：声音假体装置包括限定通道的筒，邻近筒的气管端的气管法兰和邻近食管端的食管法兰。通道包括从气管和食管端之间的通道的侧壁向内延伸的第一止动件和从通道的第一止动件和食道端之间的通道的侧壁向内延伸的多个第二止动件。阀机构位于第一和第二止挡之间，并且允许从气管端流过通道并阻止从食管端流过通道。

7. 发明申请

US20090026660A1 METHODS OF MAKING ANTIMICROBIAL VOICE PROTHESIS DEVICES 审中-公开
标题翻译：制作抗生素语音识别装置的方法
公开(公告)号：US20090026660A1
公开(公告)日：2009-01-29
申请号：US12164800
申请日：2008-06-30
申请人： Jesse N. Nelson , Edmund V. Seder
发明人： Jesse N. Nelson , Edmund V. Seder
IPC分类号： B29C45/00
CPC分类号： A61F2/203 , A61L27/18 , A61L27/54 , A61L2300/104 , A61L2300/202 , A61L2300/404 , C08L83/04
摘要： Microbial growth on the surface of a valve of a voice prosthesis and optionally the cartridge or ring supporting the valve, is inhibited by providing antimicrobial activity at a level sufficient to retard growth of a microbial film by dispersing an inorganic antimicrobial agent such as silver oxide or an organic antimicrobial agent such as triclosan or butyl paraben dispersed in a medical grade silicone elastomer. The valve, ring or cartridge is in contact with body fluids containing microorganisms and nutrients therefor. The antimicrobial surface can interfere with or inhibit the growth of a biofilm, bacterial layer or a yeast layer. The body of the prosthesis may also contain an antimicrobial surface as long as it is non-toxic to the tissue it contacts. Methods of making such antimicrobial components for voice prosthesis devices are also provided.
摘要翻译：通过提供足够的抗微生物活性以抑制微生物膜的生长，通过分散无机抗微生物剂如氧化银或氧化银的方式抑制语音假体的瓣膜表面和任选地支撑瓣膜的药筒或环的表面上的微生物生长分散在医用级硅橡胶弹性体中的有机抗微生物剂如三氯生或对羟基苯甲酸丁酯。阀，环或药筒与含有微生物和营养物的体液接触。抗微生物表面可以干扰或抑制生物膜，细菌层或酵母层的生长。假体的主体也可以含有抗微生物表面，只要它对其接触的组织无毒。还提供了制造用于语音修复装置的这种抗微生物组分的方法。

8. 发明授权

US09566181B2 Devices and methods for gastrointestinal bypass 有权
标题翻译：胃肠旁路装置和方法
公开(公告)号：US09566181B2
公开(公告)日：2017-02-14
申请号：US13485896
申请日：2012-05-31
申请人： Jesse N. Nelson , Heather Benoit , Christopher Thierfelder
发明人： Jesse N. Nelson , Heather Benoit , Christopher Thierfelder
IPC分类号： A61M5/42 , A61F5/00 , A61B17/11 , A61F2/04 , A61B17/064 , A61B17/068 , A61B17/04 , A61B17/00 , A61B17/06
CPC分类号： A61F5/0076 , A61B17/0401 , A61B17/064 , A61B17/068 , A61B17/1114 , A61B90/39 , A61B2017/00818 , A61B2017/0404 , A61B2017/0409 , A61B2017/0419 , A61B2017/0464 , A61B2017/047 , A61B2017/06052 , A61B2017/0647 , A61B2090/3908 , A61B2090/395 , A61B2090/3966 , A61F2/04 , A61F5/0036 , A61F5/0079 , A61F5/0089 , A61F2002/045 , A61F2250/0097
摘要： Devices and methods for gastrointestinal bypass are described. A gastrointestinal bypass device includes a gastrointestinal cuff and a gastrointestinal sleeve. The cuff may be configured to be attached in the esophagus, and may be sufficiently flexible to expand and collapse to conform with the inside of the esophagus to allow the esophagus to function substantially normally. The sleeve is configured to be coupled to the cuff, and may be made of a material that is floppy or flaccid but does not substantially expand radially.
摘要翻译：描述了胃肠旁路的装置和方法。胃肠旁路装置包括胃肠套和胃肠套。袖带可以构造成附接在食道中，并且可以具有足够的柔性以膨胀和折叠以与食道内部一致以允许食道基本上正常地起作用。套筒被配置为联接到袖带，并且可以由软盘或松弛材料制成，但是基本上不会径向扩张。

9. 发明授权

US09173759B2 Devices and methods for gastrointestinal bypass 有权
公开(公告)号：US09173759B2
公开(公告)日：2015-11-03
申请号：US13485898
申请日：2012-05-31
申请人： Jesse N. Nelson , Justin Schwab
发明人： Jesse N. Nelson , Justin Schwab
IPC分类号： A61M5/00 , A61F5/00 , A61B17/11 , A61F2/04 , A61B17/064 , A61B17/068 , A61B19/00 , A61B17/04 , A61B17/00 , A61B17/06
CPC分类号： A61F5/0076 , A61B17/0401 , A61B17/064 , A61B17/068 , A61B17/1114 , A61B90/39 , A61B2017/00818 , A61B2017/0404 , A61B2017/0409 , A61B2017/0419 , A61B2017/0464 , A61B2017/047 , A61B2017/06052 , A61B2017/0647 , A61B2090/3908 , A61B2090/395 , A61B2090/3966 , A61F2/04 , A61F5/0036 , A61F5/0079 , A61F5/0089 , A61F2002/045 , A61F2250/0097
摘要： Devices and methods for gastrointestinal bypass are described. A gastrointestinal bypass device includes a gastrointestinal cuff and a gastrointestinal sleeve. The cuff may be configured to be attached in the esophagus, and may be sufficiently flexible to expand and collapse to conform with the inside of the esophagus to allow the esophagus to function substantially normally. The sleeve is configured to be coupled to the cuff, and may be made of a material that is floppy or flaccid but does not substantially expand radially.

10. 发明申请

US20130324926A1 DEVICES AND METHODS FOR GASTROINTESTINAL BYPASS 有权
公开(公告)号：US20130324926A1
公开(公告)日：2013-12-05
申请号：US13485896
申请日：2012-05-31
申请人： Jesse N. NELSON , Heather BENOIT , Christopher THIERFELDER
发明人： Jesse N. NELSON , Heather BENOIT , Christopher THIERFELDER
IPC分类号： A61M5/42
CPC分类号： A61F5/0076 , A61B17/0401 , A61B17/064 , A61B17/068 , A61B17/1114 , A61B90/39 , A61B2017/00818 , A61B2017/0404 , A61B2017/0409 , A61B2017/0419 , A61B2017/0464 , A61B2017/047 , A61B2017/06052 , A61B2017/0647 , A61B2090/3908 , A61B2090/395 , A61B2090/3966 , A61F2/04 , A61F5/0036 , A61F5/0079 , A61F5/0089 , A61F2002/045 , A61F2250/0097
摘要： Devices and methods for gastrointestinal bypass are described. A gastrointestinal bypass device includes a gastrointestinal cuff and a gastrointestinal sleeve. The cuff may be configured to be attached in the esophagus, and may be sufficiently flexible to expand and collapse to conform with the inside of the esophagus to allow the esophagus to function substantially normally. The sleeve is configured to be coupled to the cuff, and may be made of a material that is floppy or flaccid but does not substantially expand radially.

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