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1. 发明授权

US08481313B2 Retinal pigment epithelial stem cells 有权
标题翻译：视网膜色素上皮干细胞
公开(公告)号：US08481313B2
公开(公告)日：2013-07-09
申请号：US12428456
申请日：2009-04-22
申请人： Sally Temple , Jeffrey Stern , Enrique L. Salero-Coca
发明人： Sally Temple , Jeffrey Stern , Enrique L. Salero-Coca
IPC分类号： C12N5/00 , C12N5/079 , C12N5/0797 , C12N5/077 , C12N5/0775 , C12N5/0789 , A01N1/00
CPC分类号： A61K38/1825 , C12N5/0607 , C12N5/0619 , C12N5/0621 , C12N2501/115 , C12N2501/119 , C12N2501/385 , C12N2501/41 , C12N2506/02 , C12N2506/08 , C12N2533/52
摘要： The present invention relates to a retinal pigment epithelial stem cell isolated from a posterior region of the retinal pigment epithelium of an adult mammal. The invention also relates to a method of inducing differentiation of retinal epithelial stem and progenitor cells in vitro, wherein the cells of the invention are highly plastic, multipotential stem cells. The invention also includes methods for the treatment of retinal diseases and vision loss involving the transplantation of retinal pigment epithelial stem cells or cells differentiated from retinal pigment epithelial stem cells to the retina of a patient in need of treatment.
摘要翻译：本发明涉及从成年哺乳动物的视网膜色素上皮的后部区域分离的视网膜色素上皮干细胞。本发明还涉及在体外诱导视网膜上皮干细胞和祖细胞分化的方法，其中本发明的细胞是高度塑性的，多能干细胞。本发明还包括治疗视网膜疾病和视力丧失的方法，涉及将视网膜色素上皮干细胞或从视网膜色素上皮干细胞分化的细胞移植到需要治疗的患者的视网膜中。

2. 发明申请

US20070118873A1 Methods and apparatus for merging media content 审中-公开
标题翻译：合并媒体内容的方法和设备
公开(公告)号：US20070118873A1
公开(公告)日：2007-05-24
申请号：US11446543
申请日：2006-06-02
申请人： Henry Houh , Jeffrey Stern
发明人： Henry Houh , Jeffrey Stern
IPC分类号： H04N7/16 , G06F15/00 , G11B27/00 , G06F17/00
CPC分类号： G06F16/43 , G06F16/41 , G06F16/639 , G06F16/68 , G06F16/685 , G06F16/738 , G06F16/7844 , G06F16/951 , H04N21/435 , H04N21/44016 , H04N21/4828 , H04N21/8549
摘要： A computerized method and apparatus is disclosed for merging content segments from a number of discrete media content (e.g., audio/video podcasts) in preparation for playback. The method and apparatus obtain metadata corresponding to a plurality of discrete media content. The metadata identifies the content segments and their corresponding timing information, such that the metadata of at least one of the plurality of discrete media content is derived using one or more media processing techniques. A number of the content segments are selected to be merged for playback using the timing information from the metadata. The merged media content can be implemented as a playlist identifying the content segments to be merged for playback. The merged media content can also be generated by extracting the content segments to be merged for playback from each of the media files/streams and then merging the extracted segments into one or more merged media files/streams.
摘要翻译：公开了一种计算机化的方法和装置，用于从准备播放的多个离散媒体内容（例如，音频/视频播客）中合并内容片段。所述方法和装置获得对应于多个离散媒体内容的元数据。元数据识别内容片段及其对应的定时信息，使得使用一种或多种媒体处理技术导出多个离散媒体内容中的至少一个的元数据。使用来自元数据的定时信息来选择多个内容段被合并以进行回放。合并的媒体内容可以被实现为标识要合并用于回放的内容片段的播放列表。也可以通过从每个媒体文件/流中提取要被合并以进行再现的内容片段，然后将提取的片段合并到一个或多个合并的媒体文件/流中来生成合并的媒体内容。

3. 发明申请

US20070112837A1 Method and apparatus for timed tagging of media content 失效
标题翻译：用于定时标记媒体内容的方法和装置
公开(公告)号：US20070112837A1
公开(公告)日：2007-05-17
申请号：US11444989
申请日：2006-06-01
申请人： Henry Houh , Jeffrey Stern
发明人： Henry Houh , Jeffrey Stern
IPC分类号： G06F7/00
CPC分类号： G06F17/3002 , G06F17/30044 , G06F17/30247 , G06F17/30746 , G06F17/30787 , G06F17/30796 , G06F17/30817 , G06F17/30852
摘要： A method and apparatus for timed tagging of content is featured. The method and apparatus can include the steps of, or structure for, obtaining at least one keyword tag associated with discrete media content; generating a timed segment index of discrete media content, the timed segment index identifying content segments of the discrete media content and corresponding timing boundaries of the content segments; searching the timed segment index for a match to the at least one keyword tag, the match corresponding to at least one of the content segments identified in the segment index; and generating a timed tag index that includes the at least one keyword tag and the timing boundaries corresponding to the least one content segment of the discrete media content containing the match.
摘要翻译：特征是用于定时标记内容的方法和装置。该方法和装置可以包括获得至少一个与离散媒体内容相关联的关键词标签的步骤或结构，生成离散媒体内容的定时片段索引，定时片段索引，标识离散媒体内容的内容片段和内容片段的相应定时边界; 搜索所述定时段索引以匹配所述至少一个关键字标签，所述匹配对应于所述段索引中标识的至少一个内容段; 以及生成包括所述至少一个关键字标签和对应于包含所述匹配的所述离散媒体内容的所述至少一个内容片段的定时边界的定时标签索引。

4. 发明授权

US08481308B2 Methods for culturing undifferentiated cells using sustained release compositions 有权
标题翻译：使用持续释放组合物培养未分化细胞的方法
公开(公告)号：US08481308B2
公开(公告)日：2013-07-09
申请号：US13175667
申请日：2011-07-01
申请人： Jeffrey Stern , Sally Temple Stern
发明人： Jeffrey Stern , Sally Temple Stern
IPC分类号： C12N5/00
CPC分类号： C12N5/0696 , C12N5/0606 , C12N5/0607 , C12N5/0621 , C12N5/0623 , C12N2500/16 , C12N2500/34 , C12N2501/115 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/1307 , C12N2531/00 , C12N2533/40
摘要： Methods for culturing undifferentiated mammalian cells, such as stem and progenitor cells, are provided. The methods involve incubating the cell in the presence of a sustained release composition containing at least one growth factor, wherein the sustained release composition continuously releases the growth factor(s), and wherein the presence of the sustained level of growth factor maintains the cell in an undifferentiated state.
摘要翻译：提供了培养未分化的哺乳动物细胞如茎和祖细胞的方法。所述方法包括在存在含有至少一种生长因子的持续释放组合物的情况下孵育细胞，其中持续释放组合物连续释放生长因子，并且其中持续水平的生长因子的存在将细胞维持在未分化状态。

5. 发明申请

US20100021422A1 METHODS AND COMPOSITIONS FOR DELIVERY OF EXOGENOUS FACTORS TO NERVOUS SYSTEM SITES 审中-公开
标题翻译：将异源因子输送到神经系统网站的方法和组合
公开(公告)号：US20100021422A1
公开(公告)日：2010-01-28
申请号：US12398888
申请日：2009-03-05
申请人： Sally Temple , Natalia Lowry , Jeffrey Stern , Susan K. Goderie , Ravindra Kane , Supriya Punyani , Akhilesh Banerjee
发明人： Sally Temple , Natalia Lowry , Jeffrey Stern , Susan K. Goderie , Ravindra Kane , Supriya Punyani , Akhilesh Banerjee
IPC分类号： A61K38/20 , A61K38/16 , A61K35/12 , A61K38/46 , A61P25/00
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/19 , A61K35/30 , A61K38/18 , C12N5/0623
摘要： The present invention relates to treatment methods and methods for sustained delivery of one or more exogenous factors to desired nervous system sites. In certain embodiments, the invention relates to the use of biodegradable microspheres to deliver exogenous factors, such as the morphogenic factor, sonic hedgehog (Shh), to the site of spinal cord injury. In certain embodiments, the Shh-releasing microspheres are administered together with stem cells, which may be spinal cord neural stem cells. In certain embodiments, the invention relates to regrowth of neural cells in both the central and peripheral nervous systems.
摘要翻译：本发明涉及用于将一种或多种外源因子持续递送至所需神经系统部位的治疗方法和方法。在某些实施方案中，本发明涉及生物可降解微球体将外源性因子（例如形态发生因子，声波刺猬（Shh））递送至脊髓损伤部位的用途。在某些实施方案中，将释放Shh的微球与干细胞一起施用，所述干细胞可以是脊髓神经干细胞。在某些实施方案中，本发明涉及神经细胞在中枢神经系统和外周神经系统中的再生长。

6. 发明申请

US20070106760A1 Methods and apparatus for dynamic presentation of advertising, factual, and informational content using enhanced metadata in search-driven media applications 有权
标题翻译：用于在搜索驱动媒体应用中使用增强的元数据来动态呈现广告，事实和信息内容的方法和装置
公开(公告)号：US20070106760A1
公开(公告)日：2007-05-10
申请号：US11395608
申请日：2006-03-31
申请人： Henry Houh , Jeffrey Stern
发明人： Henry Houh , Jeffrey Stern
IPC分类号： G06F15/16
CPC分类号： G06F17/30247 , G06F17/30787 , G06F17/30796 , G06F17/30817 , G06F17/30852
摘要： A computerized method and apparatus is disclosed for dynamic presentation of advertising, factual, informational content and combinations thereof. In particular, the advertising content is dynamically presented according to the playback of corresponding segments identified within a media file or stream.
摘要翻译：公开了用于广告，事实，信息内容及其组合的动态呈现的计算机化方法和装置。特别地，根据在媒体文件或流中标识的相应片段的回放来动态呈现广告内容。

7. 发明申请

US20110217264A1 METHODS AND COMPOSITIONS FOR DELIVERY OF EXOGENOUS FACTORS TO NERVIOUS SYSTEM SITES 审中-公开
标题翻译：用于将外源因子递送到神经系统网站的方法和组合
公开(公告)号：US20110217264A1
公开(公告)日：2011-09-08
申请号：US13108552
申请日：2011-05-16
申请人： Sally Temple , Natalia Lowry , Jeffrey Stern , Susan K. Goderie
发明人： Sally Temple , Natalia Lowry , Jeffrey Stern , Susan K. Goderie
IPC分类号： A61K38/20 , A61K38/18 , A61K38/30 , A61K35/12 , A61K35/30 , A61P25/00
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/19 , A61K35/30 , A61K38/18 , C12N5/0623
摘要： The present invention relates to treatment methods and methods for sustained delivery of one or more exogenous factors to desired nervous system sites. In certain embodiments, the invention relates to the use of biodegradable microspheres to deliver exogenous factors, such as the morphogenic factor, sonic hedgehog (Shh), to the site of spinal cord injury. In certain embodiments, the Shh-releasing microspheres are administered together with stem cells, which may be spinal cord neural stem cells. In certain embodiments, the invention relates to regrowth of neural cells in both the central and peripheral nervous systems.
摘要翻译：本发明涉及用于将一种或多种外源因子持续递送至所需神经系统部位的治疗方法和方法。在某些实施方案中，本发明涉及生物可降解微球体将外源性因子（例如形态发生因子，声波刺猬（Shh））递送至脊髓损伤部位的用途。在某些实施方案中，将释放Shh的微球与干细胞一起施用，所述干细胞可以是脊髓神经干细胞。在某些实施方案中，本发明涉及神经细胞在中枢神经系统和外周神经系统中的再生长。

8. 发明申请

US20070106693A1 Methods and apparatus for providing virtual media channels based on media search 有权
标题翻译：基于媒体搜索提供虚拟媒体频道的方法和装置
公开(公告)号：US20070106693A1
公开(公告)日：2007-05-10
申请号：US11446549
申请日：2006-06-02
申请人： Henry Houh , Jeffrey Stern , Robert Spina , Marie Meteer
发明人： Henry Houh , Jeffrey Stern , Robert Spina , Marie Meteer
IPC分类号： G06F17/00
CPC分类号： G06F17/30247 , G06F17/30817
摘要： A computerized method and apparatus for providing a virtual media channel based on media search is featured. The method and apparatus features the steps of, or structure for, obtaining a set of rules that define instructions for obtaining media content that comprise the content for a media channel, the set including at least one rule with instructions to include media content resulting from a search; searching for candidate media content according to a search query defined by the at least one rule; and merging one or more of the candidate media content resulting from the search into the content for the media channel. The candidate media content can include segments of the media content resulting from the search. The set of rules can additionally include a rule with instructions to add media content from a predetermined location.
摘要翻译：特征在于提供基于媒体搜索的虚拟媒体信道的计算机化方法和装置。该方法和装置的特征在于获得一组规则的步骤或结构，该组规则定义用于获得媒体内容的指令，该媒体内容包括媒体信道的内容，该集合包括至少一个规则，该规则具有包括由搜索; 根据由至少一个规则定义的搜索查询来搜索候选媒体内容; 以及将从搜索产生的一个或多个候选媒体内容合并到媒体频道的内容中。候选媒体内容可以包括从搜索产生的媒体内容的片段。规则集还可以包括具有从预定位置添加媒体内容的指令的规则。

9. 发明申请

US20070106685A1 Method and apparatus for updating speech recognition databases and reindexing audio and video content using the same 审中-公开
标题翻译：用于更新语音识别数据库的方法和装置，以及使用其来重建索引音频和视频内容
公开(公告)号：US20070106685A1
公开(公告)日：2007-05-10
申请号：US11522645
申请日：2006-09-18
申请人： Henry Houh , Jeffrey Stern , Nina Zinovieva , Marie Meteer
发明人： Henry Houh , Jeffrey Stern , Nina Zinovieva , Marie Meteer
IPC分类号： G06F7/00
CPC分类号： G06F16/43 , G06F16/23 , G06F16/41 , G06F16/438 , G06F16/738 , G06F16/7844
摘要： A method and apparatus for reindexing media content for search applications that includes steps and structure for providing a speech recognition database that include entries defining acoustical representations for a plurality of words; providing a searchable database containing a plurality of metadata documents descriptive of a plurality of media resources, each of the plurality of metadata documents including a sequence of speech recognized text indexed using the speech recognition database; updating the speech recognition database with at least one word candidate; and reindexing the sequence of speech recognized text for a subset of the plurality of metadata documents using the updated speech recognition database.
摘要翻译：一种用于重新索引用于搜索应用的媒体内容的方法和装置，包括用于提供语音识别数据库的步骤和结构，所述语音识别数据库包括定义多个单词的声学表示的条目; 提供包含描述多个媒体资源的多个元数据文件的可搜索数据库，所述多个元数据文档中的每一个包括使用语音识别数据库索引的语音序列; 用至少一个词候选更新语音识别数据库; 以及使用所述更新的语音识别数据库重新索引所述多个元数据文档的子集的语音识别文本的序列。

10. 发明申请

US20090274667A1 RETINAL PIGMENT EPITHELIAL STEM CELLS 有权
标题翻译： RETINAL PIGMENT上皮干细胞
公开(公告)号：US20090274667A1
公开(公告)日：2009-11-05
申请号：US12428456
申请日：2009-04-22
申请人： Sally Temple , Jeffrey Stern , Enrique L. Salero-Coca
发明人： Sally Temple , Jeffrey Stern , Enrique L. Salero-Coca
IPC分类号： A61K35/12 , C12N5/06 , C12Q1/02 , C12Q1/68
CPC分类号： A61K38/1825 , C12N5/0607 , C12N5/0619 , C12N5/0621 , C12N2501/115 , C12N2501/119 , C12N2501/385 , C12N2501/41 , C12N2506/02 , C12N2506/08 , C12N2533/52
摘要： The present invention relates to a retinal pigment epithelial stem cell isolated from a posterior region of the retinal pigment epithelium of an adult mammal. The invention also relates to a method of inducing differentiation of retinal epithelial stem and progenitor cells in vitro, wherein the cells of the invention are highly plastic, multipotential stem cells. The invention also includes methods for the treatment of retinal diseases and vision loss involving the transplantation of retinal pigment epithelial stem cells or cells differentiated from retinal pigment epithelial stem cells to the retina of a patient in need of treatment.
摘要翻译：本发明涉及从成年哺乳动物的视网膜色素上皮的后部区域分离的视网膜色素上皮干细胞。本发明还涉及在体外诱导视网膜上皮干细胞和祖细胞分化的方法，其中本发明的细胞是高度塑性的，多能干细胞。本发明还包括治疗视网膜疾病和视力丧失的方法，涉及将视网膜色素上皮干细胞或从视网膜色素上皮干细胞分化的细胞移植到需要治疗的患者的视网膜中。

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