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    • 3. 发明申请
    • IL-21 PRODUCTION IN PROKARYOTIC HOSTS
    • IL-21在原始生物中的生产
    • US20070048263A1
    • 2007-03-01
    • US11539055
    • 2006-10-05
    • Jeffrey Meyer
    • Jeffrey Meyer
    • A61K38/20
    • C07K14/54
    • The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Using the expression vectors, the IL-21 gene was produced in E. coli to a level of greater than 1 g/L in fed batch fermentation. Also included are OmpT deficient E. coli strains transformed with an IL-2 1 expression vector.
    • 描述了用于大规模生产IL-21的大肠杆菌表达系统的表达载体和方法。 载体利用具有核苷酸特异性变化的IL-21编码序列,以优化用于大肠杆菌翻译的密码子和mRNA二级结构。 使用表达载体,在补料分批发酵中,在大肠杆菌中产生IL-21基因至大于1g / L的水平。 还包括用IL-21表达载体转化的OmpT缺陷型大肠杆菌菌株。
    • 6. 发明申请
    • ROLE-BASED ATTRIBUTE BASED ACCESS CONTROL (RABAC)
    • 基于角色属性的访问控制(RABAC)
    • US20120060207A1
    • 2012-03-08
    • US13226325
    • 2011-09-06
    • Upendra S. MardikarJeffrey Meyer
    • Upendra S. MardikarJeffrey Meyer
    • G06F21/00G06F7/04G06F15/16
    • H04L63/20G06F21/31G06F21/33G06F21/62G07C9/00031H04L63/08H04L63/105H04L63/12H04L63/1433
    • Systems and methods are disclosed for receiving an access request from a user device, the access request including an identity claim for a user; evaluating a risk of access based on matching an attribute of the user device with attributes stored in a user information database; authenticating the access request based on the identity claim and the risk evaluation to determine an authentication confidence level; generating a token based on the confidence level and the attribute matched; producing an authorization response based on inputs from the token, a risk based access control, a role based access control, and an attribute based access control, in which the authorization response determines whether to allow access to a system, deny access to the system, or request additional input from the user device.
    • 公开了用于从用户设备接收访问请求的系统和方法,所述访问请求包括用户的身份声明; 基于将用户设备的属性与存储在用户信息数据库中的属性进行匹配来评估访问风险; 基于所述身份声明和所述风险评估来认证所述访问请求以确定认证置信水平; 基于置信水平和匹配的属性生成令牌; 基于来自令牌的输入,基于风险的访问控制,基于角色的访问控制和基于属性的访问控制来产生授权响应,其中授权响应确定是否允许访问系统,拒绝对系统的访问, 或从用户设备请求附加输入。