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1. 发明授权

US07238483B2 Method for detecting catalytic activity 有权
标题翻译：检测催化活性的方法
公开(公告)号：US07238483B2
公开(公告)日：2007-07-03
申请号：US10855952
申请日：2004-05-28
申请人： Jean-Louis Reymond , Denis Wahler
发明人： Jean-Louis Reymond , Denis Wahler
IPC分类号： C12Q1/48 , C12Q1/52 , C12Q1/68 , C12N1/42 , G01N33/53
CPC分类号： C12Q1/48 , C12Q1/26 , C12Q1/34 , C12Q1/44 , C12Q1/527 , C12Q1/533
摘要： This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the catalytic activity that it is desired to detect, the addition of a reagent (X) that can react either with a chemical group of unconsumed substrate (S) or with a chemical group of product (P) that is formed after an incubation period with the sample, the addition of a developer (R) that can react with reagent (X), and the detection of the transformation of developer (R).
摘要翻译：本发明的目的是检测样品的催化活性的方法，其特征在于其包括：将底物（S）与可能具有希望检测的催化活性的样品一起孵育，加入试剂（X），其可以与未消耗底物（S）的化学基团或与样品在孵育期后形成的化学基团（P）反应，加入可以反应的显影剂（R）用试剂（X）和显影剂（R）的转化的检测。

2. 发明授权

US5429941A Process for antibody combining site-catalyzed epoxide formation from 1-benzyl-1-hydrocarbyl alkene molecules 失效
标题翻译：用于从1-苄基-1-烃基烯烃分子形成的位点催化的环氧化物的抗体的方法
公开(公告)号：US5429941A
公开(公告)日：1995-07-04
申请号：US186002
申请日：1994-01-24
申请人： Richard A. Lerner , Andreas Koch , Jean-Louis Reymond
发明人： Richard A. Lerner , Andreas Koch , Jean-Louis Reymond
IPC分类号： C07D301/14 , C07D303/46 , C12N9/00 , C12P17/02
CPC分类号： C07D301/14 , C07D303/46 , C12N9/0002 , C12P17/02
摘要： A process is disclosed by which a 1-benzyl-1-hydrocarbyl alkene substrate is catalytically converted to an epoxide. The catalyst is a monoclonal antibody or paratope-containing molecule that binds to the substrate as well as to an N-benzyl-N-hydrocarbylpiperidinium compound that is an analog to the substrate. The chemical reaction is carried out in an aqueous medium using a peroxycarboximic acid as the oxidant.
摘要翻译：公开了1-苄基-1-烃基烯烃底物被催化转化成环氧化物的方法。该催化剂是与底物以及与底物类似的N-苄基-N-烃基哌啶鎓化合物结合的单克隆抗体或包含阿拉伯糖的分子。化学反应在过氧羧甲酸作为氧化剂的水性介质中进行。

3. 发明授权

US5576174A Catalytic antibody with primary amine cofactor 失效
标题翻译：具有伯胺辅因子的催化抗体
公开(公告)号：US5576174A
公开(公告)日：1996-11-19
申请号：US417370
申请日：1995-04-05
申请人： Jean-Louis Reymond , Yuanwei Chen
发明人： Jean-Louis Reymond , Yuanwei Chen
IPC分类号： C12N9/00 , C12N9/88 , C12P7/26 , C12Q1/25
CPC分类号： C12P7/26 , C12N9/0002 , C12N9/88 , G01N2333/901
摘要： Antibodies raised against the quaternary piperidinium haptens are shown to catalyze the aldol stereoselective addition of acetone to aldehydes using the primary benzylamine as a cofactor.
摘要翻译：显示针对四哌啶鎓半抗原产生的抗体催化丙酮立体选择性加成醛，使用伯胺作为辅因子。

4. 发明授权

US5500358A Antibody catalysis of cyclohexadienone rearrangments 失效
标题翻译：抗体催化环己二烯酮重排
公开(公告)号：US5500358A
公开(公告)日：1996-03-19
申请号：US292934
申请日：1994-08-18
申请人： Jean-Louis Reymond , Yuanwei Chen , Richard A. Lerner
发明人： Jean-Louis Reymond , Yuanwei Chen , Richard A. Lerner
IPC分类号： C12N9/00 , C12P7/22
CPC分类号： C12N9/0002 , C12P7/22
摘要： Catalytic antibodies are employed for catalyzing rearrangement reactions involving carbon-carbon bonds. The catalytic antibodies are generated using haptens that are transition state analogs of the such rearrangement reactions. More particularly, the haptens dispslay an electrostatic complementarity with the transition state. Since the formation of a transient positive charge in the migrating bond is a general feature of nucleophilic 1,2-shifts, it is disclosed that haptens for generating catalytic antibody directed to such reactions must incorporate such charge. Antibody catalysis of the dienone-phenol rearrangement is shown to catalyze both the hydronium ion promoted pathway and the spontaneous rearrangement pathway, indicating that the antibody stabilizes the localized positive charge of the transition state.
摘要翻译：催化抗体用于催化涉及碳 - 碳键的重排反应。使用作为这种重排反应的过渡态类似物的半抗原产生催化抗体。更具体地，半抗原与过渡态分解静电互补。由于迁移键中的瞬时正电荷的形成是亲核1,2-位移的一般特征，因此公开了用于产生针对这种反应的催化抗体的半抗原必须包含这种电荷。显示了二烯酮 - 苯酚重排的抗体催化催化水合氢离子促进途径和自发重排途径，表明抗体稳定了过渡态的局部正电荷。

5. 发明授权

US08741593B2 Method for releasing a product comprising chemical oxidation, method for detecting said product and uses thereof 有权
标题翻译：用于释放包含化学氧化物的产品的方法，用于检测所述产品的方法及其用途
公开(公告)号：US08741593B2
公开(公告)日：2014-06-03
申请号：US11601649
申请日：2006-11-20
申请人： Jean-Louis Reymond , Denis Wahler , Frabrizzio Badalassi , Hong-Khanh Nguyen
发明人： Jean-Louis Reymond , Denis Wahler , Frabrizzio Badalassi , Hong-Khanh Nguyen
IPC分类号： C12Q1/26 , C12Q1/00 , G01N33/00 , C12P13/00 , C12P11/00 , C12P7/00 , C12P7/24 , C12P7/26 , C12N13/00
CPC分类号： C07D407/12 , C07D311/16 , C12Q1/26 , C12Q1/34 , C12Q1/37 , C12Q2326/00 , C12Q2334/00 , C12Q2334/20 , G01N2333/918
摘要： This invention has as its object a method for releasing a product by subjecting a compound of Formula (II′): R′7R′8(HX)C1-C2(YH)R′9R′10 to a chemical oxidation that cleaves the bond C1-C2 to obtain the product. In the compound of Formula (II′): R′7 to R′10, which are identical or different, correspond to a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted functional group; X and Y, which are identical or different, are an oxygen atom, a sulfur atom, or an amine of Formula —NR11R12, wherein R11 is a hydrogen atom, an alkyl group, or a substituted or unsubstituted aryl group, and R12 is not a hydrogen atom. The invention also has as its object a method for releasing a product that comprises, before the chemical oxidation stage, a first step for preparing the compound of Formula (II′). The released product can be a volatile molecule or an active substance or else a specific product. The invention also relates to a method for detecting the released product as well as its applications, in particular for detecting catalytic or enzymatic activities.
摘要翻译：本发明的目的是通过使式（II'）的化合物：R'7R'8（HX）C1-C2（YH）R'9R'10进行切割键的化学氧化来释放产物的方法 C1-C2获得产品。在式（II'）的化合物中：相同或不同的R'7至R'10对应于氢原子，取代或未取代的烷基或取代或未取代的官能团; X和Y相同或不同，是式-NR11R12的氧原子，硫原子或胺，其中R11是氢原子，烷基或取代或未取代的芳基，R12不是氢原子。本发明的目的还有一种释放产品的方法，该方法包括在化学氧化阶段之前制备式（II'）化合物的第一步骤。释放的产物可以是挥发性分子或活性物质或特定产物。本发明还涉及用于检测释放产物及其应用的方法，特别是用于检测催化或酶活性。

6. 发明申请

US20070099257A1 Method for releasing a product comprising chemical oxidation, method for detecting said product and uses thereof 有权
标题翻译：用于释放包含化学氧化物的产品的方法，用于检测所述产品的方法及其用途
公开(公告)号：US20070099257A1
公开(公告)日：2007-05-03
申请号：US11601649
申请日：2006-11-20
申请人： Jean-Louis Reymond , Denis Wahler , Frabrizzio Badalassi , Hong-Khanh Nguyen
发明人： Jean-Louis Reymond , Denis Wahler , Frabrizzio Badalassi , Hong-Khanh Nguyen
IPC分类号： C12Q1/26
CPC分类号： C07D407/12 , C07D311/16 , C12Q1/26 , C12Q1/34 , C12Q1/37 , C12Q2326/00 , C12Q2334/00 , C12Q2334/20 , G01N2333/918
摘要： This invention has as its object a method for releasing a product by subjecting a compound of Formula (II′): R′7R′8(HX)C1-C2(YH)R′9R′10 to a chemical oxidation that cleaves the bond C1-C2 to obtain the product. In the compound of Formula (II′): R′7 to R′10, which are identical or different, correspond to a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted functional group; X and Y, which are identical or different, are an oxygen atom, a sulfur atom, or an amine of Formula —NR11R12, wherein R11 is a hydrogen atom, an alkyl group, or a substituted or unsubstituted aryl group, and R12 is not a hydrogen atom. The invention also has as its object a method for releasing a product that comprises, before the chemical oxidation stage, a first step for preparing the compound of Formula (II′). The released product can be a volatile molecule or an active substance or else a specific product. The invention also relates to a method for detecting the released product as well as its applications, in particular for detecting catalytic or enzymatic activities.
摘要翻译：本发明的目的是通过使式（II'）的化合物：R'，R“8（HX）C（C）（YH）R'9 R 10与化学氧化反应，其切割键C 1 C 2以获得产物。在式（II'）的化合物中：R'7至R'10相同或不同，相当于氢原子，取代或未取代的烷基，或取代或未取代的官能团; X和Y相同或不同，是氧原子，硫原子或式-NR 11 R 12的胺，其中R 11 R 2是氢原子，烷基或取代或未取代的芳基，R 12不是氢原子。本发明的目的还有一种释放产品的方法，该方法包括在化学氧化阶段之前制备式（II'）化合物的第一步骤。释放的产物可以是挥发性分子或活性物质或特定产物。本发明还涉及用于检测释放产物及其应用的方法，特别是用于检测催化或酶活性。

7. 发明授权

US07258972B2 Process for generating the idiosyncratic catalytic imprint of a sample, the processing of said imprint and the systems for implementation thereof 失效
标题翻译：用于产生样品的特异性催化印记，所述印记的处理和用于实施的系统的方法
公开(公告)号：US07258972B2
公开(公告)日：2007-08-21
申请号：US10841568
申请日：2004-05-10
申请人： Jean-Louis Reymond , Denis Wahler
发明人： Jean-Louis Reymond , Denis Wahler
IPC分类号： C12Q1/00
CPC分类号： C12Q1/34 , C12Q1/42
摘要： This invention has as its object a process for generating the idiosyncratic catalytic imprint of a sample, characterized in that it comprises the following stages: the sample that is likely to have the catalytic activity is brought into contact with a group of substrates; the signals that are generated after said contact are captured in some way. Advantageously, after the signals are captured, a processing of the latter that consists of assigning to each signal a digital value constituting a component of a graphic display, for example a color display, of the idiosyncratic imprint is carried out.
摘要翻译：本发明的目的是产生样品的特异性催化印迹的方法，其特征在于它包括以下阶段：可能具有催化活性的样品与一组底物接触; 在所述接触之后产生的信号以某种方式被捕获。有利地，在捕获信号之后，执行后者的处理，其包括将构成特殊印记的图形显示（例如彩色显示）的分量的数字值分配给每个信号。

8. 发明申请

US20050014212A1 Method for detecting catalytic activity 有权
标题翻译：检测催化活性的方法
公开(公告)号：US20050014212A1
公开(公告)日：2005-01-20
申请号：US10855952
申请日：2004-05-28
申请人： Jean-Louis Reymond , Denis Wahler
发明人： Jean-Louis Reymond , Denis Wahler
IPC分类号： C12Q1/26 , C12Q1/34 , C12Q1/44 , C12Q1/48 , C12Q1/527 , C12Q1/533 , C12Q1/68 , C12Q1/52
CPC分类号： C12Q1/48 , C12Q1/26 , C12Q1/34 , C12Q1/44 , C12Q1/527 , C12Q1/533
摘要： This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the catalytic activity that it is desired to detect, the addition of a reagent (X) that can react either with a chemical group of unconsumed substrate (S) or with a chemical group of product (P) that is formed after an incubation period with the sample, the addition of a developer (R) that can react with reagent (X), and the detection of the transformation of developer (R).
摘要翻译：本发明的目的是检测样品的催化活性的方法，其特征在于其包括：将底物（S）与可能具有希望检测的催化活性的样品一起孵育，加入试剂（X），其可以与未消耗底物（S）的化学基团或与样品在孵育期后形成的化学基团（P）反应，加入可以反应的显影剂（R）用试剂（X）和显影剂（R）的转化的检测。

9. 发明申请

US20050009098A1 Process for generating the idiosyncratic catalytic imprint of a sample, the process of said imprint and the systems for implementation thereof 失效
标题翻译：产生样品的特异性催化印记的过程，所述印记的过程及其实施的系统
公开(公告)号：US20050009098A1
公开(公告)日：2005-01-13
申请号：US10841568
申请日：2004-05-10
申请人： Jean-Louis Reymond , Denis Wahler
发明人： Jean-Louis Reymond , Denis Wahler
IPC分类号： C12Q1/34 , C12Q1/42 , C12Q1/68 , C12Q1/26 , G01N33/53
CPC分类号： C12Q1/34 , C12Q1/42
摘要： This invention has as its object a process for generating the idiosyncratic catalytic imprint of a sample, characterized in that it comprises the following stages: the sample that is likely to have the catalytic activity is brought into contact with a group of substrates; the signals that are generated after said contact are captured in some way. Advantageously, after the signals are captured, a processing of the latter that consists of assigning to each signal a digital value constituting a component of a graphic display, for example a color display, of the idiosyncratic imprint is carried out.
摘要翻译：本发明的目的是产生样品的特异性催化印迹的方法，其特征在于它包括以下阶段：可能具有催化活性的样品与一组底物接触; 在所述接触之后产生的信号以某种方式被捕获。有利地，在捕获信号之后，执行后者的处理，其包括将构成特殊印记的图形显示（例如彩色显示）的分量的数字值分配给每个信号。

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