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1. 发明申请

US20060025479A1 Agents with leukotriene B4-like antiviral (enveloped RNA) activities 有权
标题翻译：具有白三烯B4样抗病毒（包膜RNA）活性的试剂
公开(公告)号：US20060025479A1
公开(公告)日：2006-02-02
申请号：US11011016
申请日：2004-12-13
申请人： Jean Gosselin , Pierre Borgeat
发明人： Jean Gosselin , Pierre Borgeat
IPC分类号： A61K38/19 , A61K31/551 , A61K31/522 , A61K31/557 , A61K31/202
CPC分类号： A61K31/202 , A61K31/522 , A61K31/551 , A61K31/557
摘要： The present invention relates to the use of the antiviral activity of exogenous leukotriene B4 (LTB4), variants and derivatives thereof as a therapeutic agent in viral infections caused by human and animal enveloped RNA viruses. The human and animal enveloped RNA viruses are RNA viruses, such as togaviridae, orthomyxoviridae, paramyxoviridae, coronaviridae, filoviridae, arenaviridae, bunyaviridae, rhabdoviridae and flaviviridae in general, and Retroviridae such as HIV-1 and HIV-2.
摘要翻译：本发明涉及外源性白三烯B 4（LTB 4 S）的抗病毒活性，其变体和衍生物作为治疗剂在人类和动物包膜RNA病毒。人和动物包膜RNA病毒一般为RNA病毒，例如披膜病毒科，正粘病毒科，副粘病毒科，冠状病毒科，箭尾病毒科，斑驳病毒科，布尼亚病毒科，弹状病毒科和黄病毒科，以及逆转录病毒科如HIV-1和HIV-2。

2. 发明申请

US20050239889A1 In vivo release of endogenous anti-microbial mediators by leukotriene B4 (LTB4) administration 审中-公开
标题翻译：通过白三烯B4（LTB4）给药体内释放内源性抗微生物介质
公开(公告)号：US20050239889A1
公开(公告)日：2005-10-27
申请号：US11114899
申请日：2005-04-26
申请人： Jean Gosselin , Louis Flamand , Pierre Borgeat
发明人： Jean Gosselin , Louis Flamand , Pierre Borgeat
IPC分类号： A61K31/16 , A61K31/202 , A61K31/232 , A61K31/41
CPC分类号： A61K31/232 , A61K31/16 , A61K31/202 , A61K31/41
摘要： The invention relates to the in vivo release of endogenous anti-microbial mediators using leukotriene B4 administration. The present invention furthermore relates to the use of leukotriene B4 for the treatment and/or prophylaxis of diseases that are positively influenced by such anti-microbial mediators.
摘要翻译：本发明涉及使用白三烯B4给药的内源性抗微生物介质的体内释放。本发明还涉及白三烯B4用于治疗和/或预防受这种抗微生物介质积极影响的疾病的用途。

3. 发明授权

US5727793A Packing box for fluid displacement device 失效
标题翻译：流体排量装置包装箱
公开(公告)号：US5727793A
公开(公告)日：1998-03-17
申请号：US571958
申请日：1996-02-12
申请人： Jean Gosselin
发明人： Jean Gosselin
IPC分类号： F16J15/18 , F16J15/00
CPC分类号： F16J15/184
摘要： A packing box (10) is provided for housing a packing seal (48) between a rotating shaft (32) and the casing (18) of a pump. The packing box (10) comprises walls defining an enclosed chamber for accommodating the packing. An annular plate (36) is provided between the pump housing (18) and the packing (48) in order to compress the packing against the shaft (32) in a direction essentially orthogonal to and away from the pump housing (18).
摘要翻译： PCT No.PCT / CA95 / 00263 Sec。 371日期：1996年2月12日 102（e）日期1996年2月12日PCT提交1995年5月3日PCT公布。第WO95 / 30850号公报日期1995年11月16日提供一种用于容纳在泵的旋转轴（32）和壳体（18）之间的填料密封件（48）的包装盒（10）。包装箱（10）包括限定用于容纳包装的封闭室的壁。在泵壳体（18）和密封件（48）之间设置环形板（36），以便在基本上垂直于和远离泵壳体（18）的方向上将衬垫压靠在轴（32）上。

4. 发明授权

US4516226A Acoustic positioning system 失效
标题翻译：声学定位系统
公开(公告)号：US4516226A
公开(公告)日：1985-05-07
申请号：US423321
申请日：1982-09-24
申请人： Francois Peynaud , Jean Gosselin , Andre Farcy , Bernard Grandvaux
发明人： Francois Peynaud , Jean Gosselin , Andre Farcy , Bernard Grandvaux
IPC分类号： G01S5/30 , G01S11/16 , G01S1/72 , G01S15/88
CPC分类号： G01S5/30 , G01S11/16
摘要： Acoustic positioning device for a vessel comprising N transponders (B.sub.1 . . . B.sub.i . . . B.sub.N).A fixed acoustic transmitting means (E) periodically transmits acoustic pulses at frequency f. The responses of the transponders (B.sub.1 . . . B.sub.i . . . B.sub.N) are received by the acoustic array (A.sub.1, A.sub.2) of the vessels. The time origins are transmitted by a radio antenna to the surface vessel. In the case of submarines, two stable clocks are used, one of which is on board the submarine. Processing circuits make it possible to know the position of submarines.Application to the positioning of vessels in an oil production field or for oceanographic research.
摘要翻译：用于包括N个转发器（B1 ... Bi。BN）的容器的声学定位装置。固定声发射装置（E）周期性地以频率f发射声脉冲。应答器（B1 ... Bi。。BN）的响应由容器的声阵（A1，A2）接收。时间来源通过无线电天线传输到地面船。在潜艇的情况下，使用两个稳定的时钟，其中一个在潜艇上。处理电路使得有可能知道潜艇的位置。适用于油田在油田或海洋学研究中的定位。

5. 发明申请

US20130236496A1 USE OF LEUKOTRIENE B4 IN COMBINATION WITH A TOLL-LIKE RECEPTOR LIGAND, A RIG-I-LIKE RECEPTOR LIGAND, OR A NOD-LIKE RECEPTOR LIGAND TO ENHANCE THE INNATE IMMUNE RESPONSE 审中-公开
标题翻译：与胆碱样受体配体，RIG-I样受体配体或类似NOS样受体配体组合使用白介素B4与增强免疫应答
公开(公告)号：US20130236496A1
公开(公告)日：2013-09-12
申请号：US13807020
申请日：2011-06-20
申请人： Jean Gosselin , Eric Gaudreault
发明人： Jean Gosselin , Eric Gaudreault
IPC分类号： A61K31/557 , A61K38/08 , A61K38/14 , A61K31/7125 , A61K38/17 , A61K31/713 , A61K31/7032 , A61K31/739
CPC分类号： A61K31/202 , A61K31/557 , A61K31/7032 , A61K31/7125 , A61K31/713 , A61K31/739 , A61K38/08 , A61K38/14 , A61K38/177 , A61K39/39 , A61K45/06 , A61K2039/55511 , A61K2039/5555 , A61K2039/55561 , A61K2039/55572 , A61K2300/00
摘要： The present invention relates to the use of leukotriene B4 to enhance the response of Toll-like receptor (TLR), RIG-I-like receptor (RLR), and NOD-like receptor (NLR) when stimulated simultaneously with respective proper ligands. The use in combination of LTB4 with those ligands is useful to potentiate immune response for the treatment of autoimmune diseases, immunosuppressive diseases, as well as immunological disorders.
摘要翻译：本发明涉及当与相应的适当配体同时刺激时，白细胞三烯B4用于增强Toll样受体（TLR），RIG-1样受体（RLR）和NOD样受体（NLR）的应答。将LTB4与这些配体组合的用途可用于增强免疫应答，用于治疗自身免疫性疾病，免疫抑制性疾病以及免疫疾病。

6. 发明授权

US6093741A Agents with leukotriene B4-like activity as antiherpes viral agents 失效
标题翻译：具有白细胞三烯B4样活性的药物作为抗血清病毒剂
公开(公告)号：US6093741A
公开(公告)日：2000-07-25
申请号：US014553
申请日：1998-01-28
申请人： Jean Gosselin , Pierre Borgeat
发明人： Jean Gosselin , Pierre Borgeat
IPC分类号： A61K38/21 , A61K31/00 , A61K31/20 , A61K31/23 , A61K31/231 , A61K31/232 , A61K31/557 , A61K45/06 , A61P31/00 , A61P31/12 , A61P31/14 , A61P31/18 , A61P31/20 , A61P31/22 , C07C69/587
CPC分类号： A61K31/232 , A61K31/231 , A61K31/557
摘要： The present invention relates to the use of the antiviral activity of exogenous leukotriene B.sub.4 (LTB.sub.4), variants and derivatives thereof as a therapeutic agent in viral infections caused by human and animal viruses. The present invention also relates to the use of LTB.sub.4 as an anti-neoplastic agent in the prophylaxis and treatment of cancers induced by tumor viruses and in other neoplasic diseases. The human and animal viruses are DNA viruses, such as parvoviridae, papovaviridae, adenoviridae, herpesviridae, poxviridae and hepadnaviridae; RNA viruses, such as picornaviridae, togaviridae, orthomyxoviridae, paramyxoviridae, coronaviridae, reoviridae, and filoviridae in general, and Retroviridae such as HIV-1 and HIV-2.
摘要翻译：本发明涉及外源白三烯B4（LTB4）的抗病毒活性，其变体和衍生物作为由人和动物病毒引起的病毒感染中的治疗剂的用途。本发明还涉及LTB4作为抗肿瘤剂在预防和治疗由肿瘤病毒和其他肿瘤病变诱导的癌症中的用途。人和动物病毒是DNA病毒，如细小病毒科，乳突病毒科，腺病毒科，疱疹病毒科，痘病毒科和肝素病毒科; RNA病毒，例如微核心病毒科，披膜病毒科，正粘病毒科，副粘病毒科，冠状病毒科，呼肠孤病毒科和螺病毒科，以及逆转录病毒科如HIV-1和HIV-2。

7. 发明授权

US5789441A Leukotriene B4 as an antiviral and anti-neoplastic agent 失效
标题翻译：白细胞三烯B4作为抗病毒和抗肿瘤剂
公开(公告)号：US5789441A
公开(公告)日：1998-08-04
申请号：US798937
申请日：1997-02-11
申请人： Jean Gosselin , Pierre Borgeat
发明人： Jean Gosselin , Pierre Borgeat
IPC分类号： A61K38/21 , A61K31/00 , A61K31/20 , A61K31/23 , A61K31/231 , A61K31/232 , A61K31/557 , A61K45/06 , A61P31/00 , A61P31/12 , A61P31/14 , A61P31/18 , A61P31/20 , A61P31/22 , C07C69/587
CPC分类号： A61K31/232 , A61K31/231 , A61K31/557
摘要： The present invention relates to the use of the antiviral activity of leukotriene B.sub.4 (LTB.sub.4), variants and derivatives thereof as a therapeutic agent in viral infections caused by human and animal viruses. The present invention also relates to the use of LTB.sub.4 as an anti-neoplastic agent in the prophylaxis and treatment of cancers induced by tumor viruses and in other neoplasic diseases. The human and animal viruses are DNA viruses, such as parvoviridae, papovaviridae, adenoviridae, herpesviridae, poxviridae and hepadnaviridae; RNA viruses, such as picornaviridae, togaviridae, orthomyxoviridae, paramyxoviridae, coronaviridae, reoviridae, oncornaviridae and filoviridae in general, and Retroviridae such as HIV-1 and HIV-2.
摘要翻译：本发明涉及白三烯B4（LTB4）的抗病毒活性，其变体和衍生物作为由人和动物病毒引起的病毒感染中的治疗剂的用途。本发明还涉及LTB4作为抗肿瘤剂在预防和治疗由肿瘤病毒和其他肿瘤病变诱导的癌症中的用途。人和动物病毒是DNA病毒，如细小病毒科，乳突病毒科，腺病毒科，疱疹病毒科，痘病毒科和肝素病毒科; RNA病毒，例如微小核糖核酸病毒科，披膜病毒科，正粘病毒科，副粘病毒科，冠状病毒科，呼肠孤病毒科，鹦鹉螺菌科和螺病毒科，以及逆转录病毒科如HIV-1和HIV-2。

8. 发明授权

US07914800B2 LTB4 as vaccine adjuvant 有权
标题翻译： LTB4作为疫苗佐剂
公开(公告)号：US07914800B2
公开(公告)日：2011-03-29
申请号：US10482393
申请日：2002-06-26
申请人： Louis Flamand , Jean Gosselin , Pierre Borgeat
发明人： Louis Flamand , Jean Gosselin , Pierre Borgeat
IPC分类号： A61A45/00 , A61A31/20 , C07C69/587
CPC分类号： A61K39/39 , A61K31/557 , A61K39/04 , A61K39/12 , A61K39/145 , A61K39/245 , A61K2039/5252 , A61K2039/55511 , A61K2039/55516 , A61K2039/70 , C12N2710/16134 , C12N2760/16134 , C12N2760/16234
摘要： The present invention relates to a vaccine adjuvant for enhancing immune response of an individual to a vaccine, which comprises an immune-enhancing effective amount of an LTB4 agent in association with a pharmaceutically effective vaccine carrier.
摘要翻译：本发明涉及用于增强个体对疫苗的免疫应答的疫苗佐剂，其包含与药学上有效的疫苗载体相结合的免疫增强有效量的LTB4药剂。

9. 发明授权

US07473708B2 Agents with leukotriene B4-like antiviral (enveloped RNA) activities 有权
标题翻译：具有白三烯B4样抗病毒（包膜RNA）活性的试剂
公开(公告)号：US07473708B2
公开(公告)日：2009-01-06
申请号：US11011016
申请日：2004-12-13
申请人： Jean Gosselin , Pierre Borgeat
发明人： Jean Gosselin , Pierre Borgeat
IPC分类号： A61K31/20 , C07C69/587
CPC分类号： A61K31/202 , A61K31/522 , A61K31/551 , A61K31/557
摘要： The present invention relates to the use of the antiviral activity of exogenous leukotriene B4 (LTB4), variants and derivatives thereof as a therapeutic agent in viral infections caused by human and animal enveloped RNA viruses. The human and animal enveloped RNA viruses are RNA viruses, such as togaviridae, orthomyxoviridae, paramyxoviridae, coronaviridae, filoviridae, arenaviridae, bunyaviridae, rhabdoviridae and flaviviridae in general, and Retroviridae such as HIV-1 and HIV-2.
摘要翻译：本发明涉及外源性白三烯B4（LTB4）的抗病毒活性，其变体和衍生物作为由人和动物包膜RNA病毒引起的病毒感染中的治疗剂的用途。人和动物包膜RNA病毒一般为RNA病毒，例如披膜病毒科，正粘病毒科，副粘病毒科，冠状病毒科，箭尾病毒科，斑驳病毒科，布尼亚病毒科，弹状病毒科和黄病毒科，以及逆转录病毒科如HIV-1和HIV-2。

10. 发明授权

US5900235A Interleukin-8 as an antiviral and antitumor agent 失效
标题翻译：白介素-8作为抗病毒和抗肿瘤剂
公开(公告)号：US5900235A
公开(公告)日：1999-05-04
申请号：US674633
申请日：1996-07-05
申请人： Jean Gosselin , Bassam Damaj , Pierre Borgeat
发明人： Jean Gosselin , Bassam Damaj , Pierre Borgeat
IPC分类号： A61K38/00 , A61K38/20 , A61P31/12 , A61P31/14 , A61P31/20 , A61P31/22 , A61P37/02 , A61P43/00 , A61K45/05
CPC分类号： A61K38/2053 , Y10S930/141
摘要： Interleukin-8 (IL-8) and analogs thereof is useful in the treatment of viral infections, caused by human and animal viruses, and cancers caused by oncoviruses.
摘要翻译：白细胞介素-8（IL-8）及其类似物可用于治疗由人和动物病毒引起的病毒感染以及由甲基病毒引起的癌症。

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